The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Microtubules tune mechanotransduction through NOX2 and TRPV4 to decrease sclerostin abundance in osteocytes
Open accessAbstract
Cytoskeleton stiffness, which is affected by the abundance of detyrosinated tubulin, regulates mechanosensitivity in osteocytes.
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“The deformation of the osteocyte cytoskeleton elicits Ca2+ influx signaling via the activation of TRPV4.34”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [34]
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Cites
Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling
Li, X., Zhang, Y., Kang, H., Liu, W., Liu, P., Zhang, J., Harris, S. E., & Wu, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413274200 · Cited by 1,366 · cited 1×
“Sclerostin (which is encoded by Sost) is an osteocyte-specific secreted glycoprotein that suppresses bone formation by antagonizing canonical Wnt/b-catenin signaling, reducing osteoblast differentiation andbone formation (4, 5).”
BackgroundMechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin
Robling, A. G., Niziolek, P. J., Baldridge, L. A., Condon, K. W., Allen, M. R., Alam, I., Mantila, S. M., Gluhak-Heinrich, J., Bellido, T. M., Harris, S. E., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705092200 · Cited by 1,350
Romosozumab in Postmenopausal Women with Low Bone Mineral Density
McClung, M. R., Grauer, A., Boonen, S., Bolognese, M. A., Brown, J. P., Diez-Perez, A., Langdahl, B. L., Reginster, J.-Y., Zanchetta, J. R., Wasserman, S. M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1305224 · Cited by 1,258
Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)
Balemans, W. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.5.537 · Cited by 1,147
The Osteocyte: An Endocrine Cell … and More
Dallas, S. L., Prideaux, M., & Bonewald, L. F. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1026 · Cited by 1,042
Li, X., Ominsky, M. S., Niu, Q., Sun, N., Daugherty, B., D’Agostin, D. M., Kurahara, C., Gao, Y., Cao, J., Gong, J., et al. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080216 · Cited by 941
Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions
Janke, C., & Bulinski, J. C. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3227 · Cited by 896
Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease
Balemans, W., Patel, N., Ebeling, M., Van Hul, E., Wuyts, W., Lacza, C., Dioszegi, M., Dikkers, F. G., Hildering, P., Willems, P. J., et al. (2002) · Journal of Medical Genetics · doi:10.1136/jmg.39.2.91 · Cited by 698
Lin, C., Jiang, X., Dai, Z., Guo, X., Weng, T., Wang, J., Li, Y., Feng, G., Gao, X., & He, L. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.090411 · Cited by 648
X-ROS Signaling: Rapid Mechano-Chemo Transduction in Heart
Prosser, B. L., Ward, C. W., & Lederer, W. J. (2011) · Science · doi:10.1126/science.1202768 · Cited by 564
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Unloading and Disuse Osteopenia
Pajevic, P. D. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11217-6
Microtubule‐Dependent Ca 2+ Spark Recruitment in the Heart
Zhao, G., & Lederer, W. J. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.125.044345
Microtubule stability modulates Schlemm’s canal cell mechanobiology and outflow facility in glaucomaPreprint
Li, H., Guzmán, N. S. F., Perkumas, K. M., Chrenek, M. A., Feola, A., Stamer, W. D., & Ethier, C. R. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.27.721135
Role of NOX2 in bone homeostasis and its application against bone diseases
Bao-Kai, T. I. A. N., Meng-Huan, L. I., Chang, B., & Xue-Jie, Y. I. (2026) · Shengming kexue · doi:10.3724/cbls.2026053
Guan, Z., Fu, X., Zhang, P., Luo, Z., Wu, H., Liu, Q., & Xu, Y. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2026.1923562
Liu, Z., Teng, F., Xie, D., Wang, X., Liu, Z., Wen, L., Sun, Y., 盛晓贇, Geng, B., Wu, M., et al. (2026) · Cellular Signalling · doi:10.1016/j.cellsig.2026.112975
Metadata
- Authors
- Lyons, J. S., Joca, H. C., Law, R. A., Williams, K. M., Kerr, J. P., Shi, G., Khairallah, R. J., Martin, S. S., Konstantopoulos, K., Ward, C. W., & Stains, J. P.
- Affiliations
- University of Maryland, Baltimore (US)
- Johns Hopkins University (US)
- Myologica, LLC, New Market, MD 21212, USA.
- Department of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
- Corresponding author
- Ward, Christopher W.
- Stains, Joseph P.
- ORCID
- Venue
- Science Signaling
- Published
- 2017-11-21
- Volume
- 10
- Issue
- 506
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC5858867
- OpenAlex
- W2770362770
- Cited by
- 106
- References
- 70
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 19 · 2023: 10 · 2022: 7 · 2021: 23 · 2020: 16 · 2019: 11 · 2018: 6
- FWCI
- 3.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (award313408, T32 GM008181)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (award313406, R01-AR063631, award313407, R01-AR062554)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- microtubules, mechanotransduction, osteocytes, sclerostin, NOX2, TRPV4, CaMKII, bone quality, mechanosensing
- MeSH terms
- NADPH Oxidase 2, Animals, Calcium, Cell Line, Glycoproteins, Microtubules, Osteocytes, Tubulin, Reactive Oxygen Species, Intercellular Signaling Peptides and Proteins, Mechanotransduction, Cellular, Adaptor Proteins, Signal Transducing, TRPV Cation Channels, Mice, Calcium-Calmodulin-Dependent Protein Kinase Type 2
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