Cited by 106Bone Metabolism and DiseasesBone health and osteoporosis researchIon Channels and Receptors

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Microtubules tune mechanotransduction through NOX2 and TRPV4 to decrease sclerostin abundance in osteocytes

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Lyons, James S., Joca, Humberto C., Law, Robert A., Williams, Katrina M., Kerr, Jaclyn P., Shi, Guoli, Khairallah, Ramzi J., Martin, Stuart S., Konstantopoulos, Konstantinos, Ward, Christopher W., Stains, Joseph P.·2017·Science Signaling

DOI 10.1126/scisignal.aan5748PMC PMC5858867

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Abstract

Cytoskeleton stiffness, which is affected by the abundance of detyrosinated tubulin, regulates mechanosensitivity in osteocytes.

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Authors: Lyons, J. S., Joca, H. C., Law, R. A., Williams, K. M., Kerr, J. P., Shi, G., Khairallah, R. J., Martin, S. S., Konstantopoulos, K., Ward, C. W., & Stains, J. P.
Affiliations: University of Maryland, Baltimore (US)
Johns Hopkins University (US)
Myologica, LLC, New Market, MD 21212, USA.
Department of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Corresponding author: Ward, Christopher W.
Stains, Joseph P.
ORCID: Lyons, James S.
Joca, Humberto C.
Law, Robert A.
Williams, Katrina M.
Kerr, Jaclyn P.
Khairallah, Ramzi J.
Martin, Stuart S.
Ward, Christopher W.
Stains, Joseph P.
Venue: Science Signaling
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2017-11-21
Volume: 10
Issue: 506
ISSN: 1937-9145 (ISSN-L)
1945-0877
DOI: 10.1126/scisignal.aan5748
PMC: PMC5858867
OpenAlex: W2770362770
Cited by: 106
References: 70
Citations by year: 2026: 7 · 2025: 7 · 2024: 19 · 2023: 10 · 2022: 7 · 2021: 23 · 2020: 16 · 2019: 11 · 2018: 6
FWCI: 3.68
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science Signaling (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (award313408, T32 GM008181)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (award313406, R01-AR063631, award313407, R01-AR062554)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: microtubules, mechanotransduction, osteocytes, sclerostin, NOX2, TRPV4, CaMKII, bone quality, mechanosensing
MeSH terms: NADPH Oxidase 2, Animals, Calcium, Cell Line, Glycoproteins, Microtubules, Osteocytes, Tubulin, Reactive Oxygen Species, Intercellular Signaling Peptides and Proteins, Mechanotransduction, Cellular, Adaptor Proteins, Signal Transducing, TRPV Cation Channels, Mice, Calcium-Calmodulin-Dependent Protein Kinase Type 2

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Microtubules tune mechanotransduction through NOX2 and TRPV4 to decrease sclerostin abundance in osteocytes

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