Microtubules tune mechanotransduction through NOX2 and TRPV4 to decrease sclerostin abundance in osteocytes

Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling

Li, X., Zhang, Y., Kang, H., Liu, W., Liu, P., Zhang, J., Harris, S. E., & Wu, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413274200 · Cited by 1,366 · cited 1×

Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin

Robling, A. G., Niziolek, P. J., Baldridge, L. A., Condon, K. W., Allen, M. R., Alam, I., Mantila, S. M., Gluhak-Heinrich, J., Bellido, T. M., Harris, S. E., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705092200 · Cited by 1,350

Romosozumab in Postmenopausal Women with Low Bone Mineral Density

McClung, M. R., Grauer, A., Boonen, S., Bolognese, M. A., Brown, J. P., Diez-Perez, A., Langdahl, B. L., Reginster, J.-Y., Zanchetta, J. R., Wasserman, S. M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1305224 · Cited by 1,258

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

Balemans, W. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.5.537 · Cited by 1,147

The Osteocyte: An Endocrine Cell … and More

Dallas, S. L., Prideaux, M., & Bonewald, L. F. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1026 · Cited by 1,042

Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength

Li, X., Ominsky, M. S., Niu, Q., Sun, N., Daugherty, B., D’Agostin, D. M., Kurahara, C., Gao, Y., Cao, J., Gong, J., et al. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080216 · Cited by 941

Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions

Janke, C., & Bulinski, J. C. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3227 · Cited by 896

Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease

Balemans, W., Patel, N., Ebeling, M., Van Hul, E., Wuyts, W., Lacza, C., Dioszegi, M., Dikkers, F. G., Hildering, P., Willems, P. J., et al. (2002) · Journal of Medical Genetics · doi:10.1136/jmg.39.2.91 · Cited by 698

Sclerostin Mediates Bone Response to Mechanical Unloading Through Antagonizing Wnt/β-Catenin Signaling

Lin, C., Jiang, X., Dai, Z., Guo, X., Weng, T., Wang, J., Li, Y., Feng, G., Gao, X., & He, L. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.090411 · Cited by 648

X-ROS Signaling: Rapid Mechano-Chemo Transduction in Heart

Prosser, B. L., Ward, C. W., & Lederer, W. J. (2011) · Science · doi:10.1126/science.1202768 · Cited by 564

The Osteocyte: New Insights

Robling, A. G., & Bonewald, L. F. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034332 · Cited by 539

Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk

Wang, L., You, X., Lotinun, S., Zhang, L., Wu, N., & Zou, W. (2020) · Nature Communications · doi:10.1038/s41467-019-14146-6 · Cited by 535

Molecular mechanosensors in osteocytes

Qin, L., Liu, W., Cao, H., & Xiao, G. (2020) · Bone Research · doi:10.1038/s41413-020-0099-y · Cited by 484

Bone remodeling: an operational process ensuring survival and bone mechanical competence

Bolamperti, S., Villa, I., & Rubinacci, A. (2022) · Bone Research · doi:10.1038/s41413-022-00219-8 · Cited by 482

Mechano-induced cell metabolism promotes microtubule glutamylation to force metastasis

Torrino, S., Grasset, E. M., Audebert, S., Belhadj, I., Lacoux, C., Haynes, M., Pisano, S., Abélanet, S., Brau, F., Chan, S. Y., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.05.009 · Cited by 145

Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx

Xiang, Z., Zhang, P., Jia, C., Xu, R., Cao, D., Xu, Z., Lu, T., Liu, J., Wang, X., Qiu, C., et al. (2024) · Bone Research · doi:10.1038/s41413-024-00317-9 · Cited by 119

Regulation of bone homeostasis: signaling pathways and therapeutic targets

Wu, Z., Li, W., Jiang, K., Lin, Z., Qian, C., Wu, M., Xia, Y., Li, N., Zhang, H., Xiao, H.-X., et al. (2024) · MedComm · doi:10.1002/mco2.657 · Cited by 129

NADPH oxidases in bone homeostasis and osteoporosis

Schröder, K. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.08.036 · Cited by 108

Club Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation

Wiesner, D. L., Merkhofer, R. M., Ober, C., Kujoth, G. C., Niu, M., Keller, N. P., Gern, J. E., Brockman‐Schneider, R. A., Evans, M. D., Jackson, D. J., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.02.006 · Cited by 94

A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction

Sato, T., Verma, S., Andrade, C. D. C., Omeara, M., Campbell, N., Wang, J. S., Cetinbas, M., Lang, A., Ausk, B. J., Brooks, D. J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17099-3 · Cited by 86

Osteocytes and Estrogen Deficiency

McNamara, L. M. (2021) · Current Osteoporosis Reports · doi:10.1007/s11914-021-00702-x · Cited by 93

Osteocyte-derived sclerostin impairs cognitive function during ageing and Alzheimer’s disease progression

Shi, T., Shen, S., Shi, Y., Wang, Q., Zhang, G., Lin, J., Chen, J., Bai, F., Zhang, L., Wang, Y., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-00989-x · Cited by 87

Integrins in Osteocyte Biology and Mechanotransduction

Geoghegan, I. P., Hoey, D. A., & McNamara, L. M. (2019) · Current Osteoporosis Reports · doi:10.1007/s11914-019-00520-2 · Cited by 87

Mechanistic Insight into Orthodontic Tooth Movement Based on Animal Studies: A Critical Review

Jeon, H. H., Teixeira, H. S., & Tsai, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081733 · Cited by 89

New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology

Rosdah, A. A., Smiles, W. J., Oakhill, J. S., Scott, J. W., Langendorf, C. G., Delbridge, L. M. D., Holien, J. K., & Lim, S. Y. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107594 · Cited by 79

Study of Electrical Stimulation with Different Electric-Field Intensities in the Regulation of the Differentiation of PC12 Cells

Wei, J., Zhang, Y., Cai, Q., Chen, G., Wang, L., Yang, X., & Zhong, W. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00286 · Cited by 73

Transient receptor potential ion-channel subfamily V member 4: a potential target for cancer treatment

Yu, S., Huang, S., Ding, Y., Wang, W., Wang, A., & Lu, Y. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1708-9 · Cited by 71

The role of osteocytes-specific molecular mechanism in regulation of mechanotransduction – A systematic review

Li, M. C. M., Chow, S. K., Wong, R. M. Y., Qin, L., & Cheung, W. (2021) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2021.04.005 · Cited by 63

The Diverse Physiological Functions of Mechanically Activated Ion Channels in Mammals

Poole, K. (2021) · Annual Review of Physiology · doi:10.1146/annurev-physiol-060721-100935 · Cited by 58

Estrogen and estrogen receptors mediate the mechanobiology of bone disease and repair

Shi, V. Y., & Morgan, E. F. (2024) · Bone · doi:10.1016/j.bone.2024.117220 · Cited by 64

Mechanoelectrical transduction in chondrocytes

Servin‐Vences, M. R., Richardson, J., Lewin, G. R., & Poole, K. (2018) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12917 · Cited by 59

Cardiomyocyte Microtubules: Control of Mechanics, Transport, and Remodeling

Uchida, K., Scarborough, E. A., & Prosser, B. L. (2021) · Annual Review of Physiology · doi:10.1146/annurev-physiol-062421-040656 · Cited by 59

The cytoskeleton and connected elements in bone cell mechano-transduction

Gould, N. R., Torre, O. M., Leser, J. M., & Stains, J. P. (2021) · Bone · doi:10.1016/j.bone.2021.115971 · Cited by 56

Estrogen deficiency impairs integrin αvβ3-mediated mechanosensation by osteocytes and alters osteoclastogenic paracrine signalling

Geoghegan, I. P., Hoey, D. A., & McNamara, L. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-41095-3 · Cited by 52

New Advances in Osteocyte Mechanotransduction

Li, X., Kordsmeier, J., & Xiong, J. (2021) · Current Osteoporosis Reports · doi:10.1007/s11914-020-00650-y · Cited by 61

Advanced Piezoelectric Materials, Devices, and Systems for Orthopedic Medicine

Zhang, J., Liu, C., Li, J., Yu, T., Ruan, J., & Yang, F. (2024) · Advanced Science · doi:10.1002/advs.202410400 · Cited by 60

Flow-induced mechanotransduction in skeletal cells

Alfieri, R. R., Vassalli, M., & Viti, F. (2019) · Biophysical Reviews · doi:10.1007/s12551-019-00596-1 · Cited by 51

The Mechanical Microenvironment in Breast Cancer

Pratt, S. J. P., Lee, R., & Martin, S. S. (2020) · Cancers · doi:10.3390/cancers12061452 · Cited by 52

Bone-muscle crosstalk under physiological and pathological conditions

Dong, Y., Yuan, H., Ma, G., & Cao, H. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05331-y · Cited by 52

Osteocyte Dysfunction in Joint Homeostasis and Osteoarthritis

Zhang, L., & Wen, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126522 · Cited by 47

The physiological sensor channels TRP and piezo: Nobel Prize in Physiology or Medicine 2021

Earley, S., Santana, L. F., & Lederer, W. J. (2022) · Physiological Reviews · doi:10.1152/physrev.00057.2021 · Cited by 45

Tunnels in the rock: Dynamics of osteocyte morphogenesis

Moharrer, Y., & Boerckel, J. D. (2021) · Bone · doi:10.1016/j.bone.2021.116104 · Cited by 43

Mechanotransduction in tissue engineering: Insights into the interaction of stem cells with biomechanical cues

Bakhshandeh, B., Sorboni, S. G., Ranjbar, N., Deyhimfar, R., Abtahi, M. S., Izady, M., Kazemi, N., Noori, A., & Pennisi, C. P. (2023) · Experimental Cell Research · doi:10.1016/j.yexcr.2023.113766 · Cited by 45

The Osteocyte Transcriptome Is Extensively Dysregulated in Mouse Models of Osteogenesis Imperfecta

Zimmerman, S. M., Dimori, M., Heard‐Lipsmeyer, M. E., & Morello, R. (2019) · JBMR Plus · doi:10.1002/jbm4.10171 · Cited by 41

Disparate bone anabolic cues activate bone formation by regulating the rapid lysosomal degradation of sclerostin protein

Gould, N. R., Williams, K. M., Joca, H. C., Torre, O. M., Lyons, J. S., Leser, J. M., Srikanth, M. P., Hughes, M., Khairallah, R. J., Feldman, R. A., et al. (2021) · eLife · doi:10.7554/elife.64393 · Cited by 40

Molecular Regulators of Cellular Mechanoadaptation at Cell–Material Interfaces

Jo, J., Nansa, S. A., & Kim, D. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.608569 · Cited by 40

Modulating the Mechanical Activation of TRPV4 at the Cell-Substrate Interface

Sianati, S., Schroeter, L., Richardson, J., Tay, A. K. P., Lamandé, S. R., & Poole, K. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.608951 · Cited by 39

Modulation of TRPV4 protects against degeneration induced by sustained loading and promotes matrix synthesis in the intervertebral disc

Easson, G. W. D., Savadipour, A., Anandarajah, A., Iannucci, L. E., Lake, S. P., Guilak, F., & Tang, S. Y. (2022) · The FASEB Journal · doi:10.1096/fj.202201388r · Cited by 41

Activation of transient receptor potential vanilloid 4 is involved in pressure overload-induced cardiac hypertrophy

Zou, Y., Zhang, M., Wu, Q., Zhao, N., Chen, M., Yang, C. B., Du, Y., & Han, B. (2022) · eLife · doi:10.7554/elife.74519 · Cited by 37

Mesenchymal stem cell mechanotransduction is cAMP dependent and regulated by adenylyl cyclase 6 and the primary cilium

Johnson, G. P., Stavenschi, E., Eichholz, K. F., Corrigan, M. A., Fair, S., & Hoey, D. A. (2018) · Journal of Cell Science · doi:10.1242/jcs.222737 · Cited by 36

Sclerostin: From Molecule to Clinical Biomarker

Omran, A. S., Atanasova, D., Landgren, F., & Magnusson, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094751 · Cited by 44

The role of calcium channels in osteoporosis and their therapeutic potential

Hao, Y., Yang, N., Sun, M., Yang, S., & Chen, X. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1450328 · Cited by 42

Mechanoactivation of NOX2-generated ROS elicits persistent TRPM8 Ca 2+ signals that are inhibited by oncogenic KRas

Pratt, S. J. P., Lee, R., Chang, K. T., Hernández‐Ochoa, E. O., Annis, D. A., Ory, E. C., Thompson, K. N., Bailey, P. C., Mathias, T. J., Ju, J. A., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2009495117 · Cited by 33

TRPV4 calcium influx controls sclerostin protein loss independent of purinergic calcium oscillations

Williams, K. M., Leser, J. M., Gould, N. R., Joca, H. C., Lyons, J. S., Khairallah, R. J., Ward, C. W., & Stains, J. P. (2020) · Bone · doi:10.1016/j.bone.2020.115356 · Cited by 32

The functions of mechanosensitive ion channels in tooth and bone tissues

Pei, F., Liu, J., Zhang, L., Pan, X., Huang, W., Cen, X. B., Huang, S., Jin, Y. H., & Zhao, Z. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109877 · Cited by 32

The mechanosensory and mechanotransductive processes mediated by ion channels and the impact on bone metabolism: A systematic review

Zhang, K., Liu, X., Wang, L., Liu, Z., Yi, Q., Geng, B., Chen, X., Yu, D., & Xia, Y. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.109020 · Cited by 34

Osteocyte-mediated mechanical response controls osteoblast differentiation and function

Buck, H., & Stains, J. P. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1364694 · Cited by 31

OCY454 Osteocytes as an in Vitro Cell Model for Bone Remodeling Under Mechanical Loading

Xu, L., Shao, H., Ma, Y. V., & You, L. (2019) · Journal of Orthopaedic Research® · doi:10.1002/jor.24302 · Cited by 34

Aging, Osteo-Sarcopenia, and Musculoskeletal Mechano-Transduction

Leser, J. M., Harriot, A. D., Buck, H., Ward, C. W., & Stains, J. P. (2021) · Frontiers in Rehabilitation Sciences · doi:10.3389/fresc.2021.782848 · Cited by 29

Fluid shear stress generates a unique signaling response by activating multiple TGFβ family type I receptors in osteocytes

Monteiro, D. A., Dole, N. S., Campos, J. L., Kaya, S., Schurman, C. A., Belair, C. D., & Alliston, T. N. (2021) · The FASEB Journal · doi:10.1096/fj.202001998r · Cited by 26

Research progress on the regulatory mechanism of integrin‐mediated mechanical stress in cells involved in bone metabolism

Yang, L., Chen, H., Yang, C., Hu, Z., Jiang, Z., Meng, S., Liu, R., Huang, L., & Yang, K. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18183 · Cited by 25

Connexin43 enhances Wnt and PGE2-dependent activation of β-catenin in osteoblasts

Gupta, A., Chatree, S., Buo, A. M., Moorer, M. C., & Stains, J. P. (2019) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-019-02295-y · Cited by 23

Dexamethasone Induced Osteocyte Apoptosis in Steroid‐Induced Femoral Head Osteonecrosis through ROS ‐Mediated Oxidative Stress

Zhang, X., Yang, Z., Xu, Q., Xu, C., Shi, W., Pang, R., Zhang, K., Liang, X., Li, H., Li, Z., et al. (2024) · Orthopaedic Surgery · doi:10.1111/os.14010 · Cited by 22

Perception and response of skeleton to mechanical stress

Ding, S., Chen, Y., Huang, C., Song, L., Liang, Z., & Wei, B. (2024) · Physics of Life Reviews · doi:10.1016/j.plrev.2024.03.011 · Cited by 23

TRPV4 differentially controls inflammatory cytokine networks during static and dynamic compression of the intervertebral disc

Easson, G. W. D., Savadipour, A., Gonzalez, C., Guilak, F., & Tang, S. Y. (2023) · JOR Spine · doi:10.1002/jsp2.1282 · Cited by 20

The Impact of Plasma Membrane Ion Channels on Bone Remodeling in Response to Mechanical Stress, Oxidative Imbalance, and Acidosis

Perin, M., Chinigò, G., Genova, T., Mussano, F. D., & Munaron, L. (2023) · Antioxidants · doi:10.3390/antiox12030689 · Cited by 19

Osteoblast-lineage calcium/calmodulin-dependent kinase 2 delta and gamma regulates bone mass and quality

Leser, J. M., Torre, O. M., Gould, N. R., Guo, Q., Buck, H., Kodama, J., Otsuru, S., & Stains, J. P. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2304492120 · Cited by 20

Mechanical Counterbalance of Kinesin and Dynein Motors in a Microtubular Network Regulates Cell Mechanics, 3D Architecture, and Mechanosensing

Zhovmer, A. S., Manning, A., Smith, C., Hayes, J. B., Burnette, D. T., Wang, J., Cartagena‐Rivera, A. X., Dokholyan, N. V., Singh, R. K., & Tabdanov, E. D. (2021) · ACS Nano · doi:10.1021/acsnano.1c04435 · Cited by 19

Primary cilia in skeletal development and disease

Quadri, N., & Upadhyai, P. (2023) · Experimental Cell Research · doi:10.1016/j.yexcr.2023.113751 · Cited by 19

High-fat and high-carbohydrate diets increase bone fragility through TGF-β–dependent control of osteocyte function

Dole, N. S., Betancourt-Torres, A., Kaya, S., Obata, Y., Schurman, C. A., Yoon, J., Yee, C. S., Khanal, V., Luna, C. A., Carroll, M. D., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.175103 · Cited by 16

Adenylyl cyclases and TRPV4 mediate Ca2+/cAMP dynamics to enhance fluid flow-induced osteogenesis in osteocytes.

Moore, E. R., Ryu, H.-S., Zhu, Y. X., & Jacobs, C. R. (2018) · PubMed · Cited by 15

Activation of transient receptor potential vanilloid 4 exacerbates myocardial ischemia-reperfusion injury via JNK-CaMKII phosphorylation pathway in isolated mice hearts

Zhang, S., Lu, K., Yang, S., Wu, Y., Liao, J., Lu, Y., Wu, Q., Zhao, N., Dong, Q., Chen, L., et al. (2021) · Cell Calcium · doi:10.1016/j.ceca.2021.102483 · Cited by 15

Plasma membrane disruption (PMD) formation and repair in mechanosensitive tissues

Hagan, M. L., Balayan, V., & McGee‐Lawrence, M. E. (2021) · Bone · doi:10.1016/j.bone.2021.115970 · Cited by 13

Transient receptor potential vanilloid 4 activation inhibits the delayed rectifier potassium channels in hippocampal pyramidal neurons: An implication in pathological changes following pilocarpine‐induced status epilepticus

Zhou, L., Xu, W., An, D., Sha, S., Men, C., Li, Y., Wang, X., Du, Y., & Chen, L. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24749 · Cited by 13

The Skeletal Cellular and Molecular Underpinning of the Murine Hindlimb Unloading Model

Garg, P., Strigini, M., Peurière, L., Vico, L., & Iandolo, D. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.749464 · Cited by 19

The regulation and functions of the matricellular CCN proteins induced by shear stress

Wang, Y.-K., Weng, H.-K., & Mo, F. (2023) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-023-00760-z · Cited by 12

New and Old Osteocytic Cell Lines and 3D Models

Pajevic, P. D. (2020) · Current Osteoporosis Reports · doi:10.1007/s11914-020-00613-3 · Cited by 11

The Diminishing Returns of Mechanical Loading and Potential Mechanisms that Desensitize Osteocytes

Gardinier, J. D. (2021) · Current Osteoporosis Reports · doi:10.1007/s11914-021-00693-9 · Cited by 12

Mechanical effects in aging of the musculoskeletal system: Molecular signaling and spatial scale alterations

Zhang, Z., Cao, F., Liang, D., Pan, M., Lu, W. W., Lyu, H., Xie, Y., Zhang, L., & Tang, P. (2025) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2025.04.018 · Cited by 10

NAD+/Nrf2 signaling promotes osteogenesis by regulating oxidative level of BMSCs under mechanical stress

Ren, H., Wang, J., Liu, J., Zhang, Z., Wang, L., & Wei, F. (2025) · Progress in Orthodontics · doi:10.1186/s40510-025-00566-2 · Cited by 9

Connexin43 regulates osteoprotegerin expression via ERK1/2 -dependent recruitment of Sp1

Gupta, A., Leser, J. M., Gould, N. R., Buo, A. M., Moorer, M. C., & Stains, J. P. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.12.173 · Cited by 9

Osteocyte Dendrites: How Do They Grow, Mature, and Degenerate in Mineralized Bone?

Guerra, R. M., Fowler, V. M., & Wang, L. (2024) · Cytoskeleton · doi:10.1002/cm.21964 · Cited by 10

Mechanotransduction and musculoskeletal regeneration: Molecular mechanisms and interdisciplinary applications

Huang, X., Hao, W., Mo, Y., Liang, X., Wu, X., Zeng, D., Mo, Y. J., Lu, W. W., Chen, D., & Chen, Y. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101731 · Cited by 9

Hydrogen Peroxide Induces α-Tubulin Detyrosination and Acetylation and Impacts Breast Cancer Metastatic Phenotypes

Stemberger, M. B., Ju, J. A., Thompson, K. N., Mathias, T. J., Jerrett, A. E., Chang, K. T., Ory, E. C., Annis, D. A., Mull, M. L., Gilchrist, D. E., et al. (2023) · Cells · doi:10.3390/cells12091266 · Cited by 8

Small molecule compound M12 reduces vascular permeability in obese mice via blocking endothelial TRPV4–Nox2 interaction

Gao, M., Zhang, P., Han, J. D. J., Tang, C., Zhu, Y., Kan, H., Li, H., Han, X., & Ma, X. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00780-8 · Cited by 7

The intraflagellar transport protein IFT52 associated with short-rib thoracic dysplasia is essential for ciliary function in osteogenic differentiation in vitro and for sensory perception in Drosophila

Guleria, V. S., Parit, R., Quadri, N., Das, R., & Upadhyai, P. (2022) · Experimental Cell Research · doi:10.1016/j.yexcr.2022.113273 · Cited by 7

Osteocyte Sptbn1 Deficiency Alters Cell Survival and Mechanotransduction Following Formation of Plasma Membrane Disruptions (PMD) from Mechanical Loading

Hagan, M. L., Tuladhar, A., Yu, K., Alhamad, D. W., Bensreti, H., Dorn, J., Piedra, V. M., Cantu, N., Stokes, E., Blumenthal, D., et al. (2024) · Calcified Tissue International · doi:10.1007/s00223-024-01285-2 · Cited by 6

Current status and future direction of mechanotransduction mechanisms: Perspectives from cell membrane to nucleus

Shi, Y., Yue, J., Wang, Z., He, S., & Sa, G. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152524 · Cited by 6

Mechanobiology and Primary Cilium in the Pathophysiology of Bone Marrow Myeloproliferative Diseases

Tiberio, F., Coda, A. R. D., Tosi, D. D., Luzi, D., Polito, L., Liso, A., & Lattanzi, W. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168860 · Cited by 6

The roles of focal adhesion and cytoskeleton systems in fluid shear stress-induced endothelial cell response

Shahzad, K. A., Qin, Z., Li, Y., & Xia, D. (2020) · Biocell · doi:10.32604/biocell.2020.08500 · Cited by 7

Nitric oxide contributes to rapid sclerostin protein loss following mechanical load

Buck, H., Torre, O. M., Leser, J. M., Gould, N. R., Ward, C. W., & Stains, J. P. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150315 · Cited by 5

Cells Involved in Mechanotransduction Including Mesenchymal Stem Cells

Zuckerman, P. C., Liu, C., & Castillo, A. B. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11209-7 · Cited by 5

Inhibition of transient receptor potential vanilloid 4: A promising novel strategy for myocardial ischemia/reperfusion injury treatment

Dong, Q., Wang, Z., Wu, Q., & Du, Y. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118765 · Cited by 4

High throughput cell mechanotyping of cell response to cytoskeletal modulations using a microfluidic cell deformation system

Smith, I. M., Ursitti, J. A., Venkata, S. P. M., Givpoor, N., Stemberger, M. B., Hengen, A. C., Banerjee, S., Hached, K., van der Laan, S., Stains, J. P., et al. (2024) · Microfluidics and Nanofluidics · doi:10.1007/s10404-024-02774-4 · Cited by 3

P2Y2 Inhibition Modifies the Anabolic Response to Exercise in Adult Mice

Chougule, A., Zhang, C., Denbow, J., Vinokurov, N., Mendez, D., Vojtisek, E., & Gardinier, J. D. (2024) · Aging Cell · doi:10.1111/acel.14464 · Cited by 3

Differential distribution of microtubules in immature osteocytes in vivo

Murshid, S. A., Takano‐Yamamoto, T., & Kamioka, H. (2018) · Journal of Oral Biosciences · doi:10.1016/j.job.2018.08.001 · Cited by 3

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Mechanobiological crosstalk among bone cells and between bone and other organs

Zhao, F., Zhang, Y., Pei, S., Wang, S., Hu, L., Wang, L., Qian, A., Yang, T., & Guo, Y. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-96123-3.00015-4 · Cited by 2

Mechanobiology of osteocytes

Pei, S., Wasi, M., Wang, S., Chu, T., Guerra, R. M., & Wang, L. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-96123-3.00010-5 · Cited by 3

Biophysical forces rewire cell metabolism to guide microtubule-dependent cell mechanicsPreprint

Torrino, S., Audebert, S., Belhadj, I., Lacoux, C., Pisano, S., Abélanet, S., Brau, F., Chan, S. Y., Mari, B. P., Oldham, W. M., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.10.985036 · Cited by 2

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Waldeck‐Weiermair, M., Covington, T. A., Pandey, A. K., & Michel, T. M. (2026) · Redox Biochemistry and Chemistry · doi:10.1016/j.rbc.2026.100080 · Cited by 1

Tension force causes cell cycle arrest at G2/M phase in osteocyte-like cell line MLO-Y4

Shimizu, N., Fujiwara, K., Mayahara, K., Motoyoshi, M., & Takahashi, T. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e13236 · Cited by 1

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Donahue, H. J., Friendman, M. J., & Genetos, D. C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-817931-4.00001-7 · Cited by 1

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OSTEOCYTE SIGNALING AND ITS EFFECTS ON THE ACTIVITES OF OSTEOBLASTS AND BREAST CANCER CELLS

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Effect of transient receptor potential vanilloid 4 activation on the delayed rectifier potassium current in the hippocampal pyramidal neurons and Kv subunit expression in the hippocampi of micePreprint

Zhou, L., Xu, W., An, D., Men, C., Li, Y., Du, Y., & Chen, L. (2020) · doi:10.21203/rs.3.rs-24895/v1

Microtubule Mechanotransduction through Nox2-ROS Initiates TRPV4 Calcium Influx and Purinergic Calcium Oscillations that Regulate Osteocyte Mechano-Sensing

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Williams, K. M., Leser, J. M., Gould, N. R., Joca, H. C., Lyons, J. S., Khairallah, R. J., Ward, C. W., & Stains, J. P. (2020) · Bone · doi:10.1016/j.bone.2020.115356 · Cited by 32

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Kindlin-2 mediates mechanotransduction in bone by regulating expression of Sclerostin in osteocytes

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Mechanical stimulation in vivo reduces osteocyte expression of sclerostin.

Robling, A. G., Bellido, T., & Turner, C. H. (2006) · PubMed · Cited by 141