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Cited by 49Multiple Myeloma Research and TreatmentsBone Metabolism and DiseasesMesenchymal stem cell research

Myeloma cells shift osteoblastogenesis to adipogenesis by inhibiting the ubiquitin ligase MURF1 in mesenchymal stem cells

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Liu, Zhiqiang, Liu, Huan, He, Jin, Lin, Pei, Tong, Qiang, Yang, Jing·2020·Science Signaling
DOI 10.1126/scisignal.aay8203PMC PMC7376968
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Abstract

Myeloma cells repress osteoblastogenesis by inhibiting the degradation of PPARγ2 in mesenchymal stem cells.

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Crossref · 10.1126/scisignal.aay8203

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  • Myeloma cells prevent mesenchymal stromal cells from developing into adipocytes.

    “MSCs can develop into adipocytes, but myeloma cells prevent them from doing so [279].”

    From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [279]

    The Results section, “Myeloma cells enhance adipogenesis and reduce osteoblastogenesis from MSCs” (page not provided), says myeloma cells directed MSC differentiation preferentially toward adipocytes. The claim reverses that finding: the paper reports that myeloma cells promote, rather than prevent, adipocyte development. (LLM, conf=0.95)

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Research works printed but not linked: 43

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Cited by

Sorted by citations

Authors
Liu, Z., Liu, H., He, J., Lin, P., Tong, Q., & Yang, J.
Affiliations
  • The University of Texas MD Anderson Cancer Center (US)
  • Houston Methodist (US)
  • Baylor College of Medicine (US)
Corresponding author
  • Liu, Zhiqiang
  • Liu, Huan
  • Yang, Jing
ORCID
Venue
Science Signaling
Publisher
American Association for the Advancement of Science (AAAS)
Published
2020-05-26
Volume
13
Issue
633
ISSN
  • 1937-9145 (ISSN-L)
  • 1945-0877
DOI
10.1126/scisignal.aay8203
PMC
PMC7376968
OpenAlex
W3031701227
Cited by
49
References
3
Citations by year
2026: 5 · 2025: 8 · 2024: 6 · 2023: 11 · 2022: 4 · 2021: 12 · 2020: 3
FWCI
4.74
Type
journal article
Language
en
Open access
Locations
  • Science Signaling (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Digital Commons-TMC (Texas Medical Center) (submittedVersion)
Funders
  • American Cancer Society (127337-RSG-15-069-01-TBG)
  • National Cancer Institute (CA190863, CA193362)
Topics
  • Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
Keywords
multiple myeloma, mesenchymal stem cells, osteoblastogenesis, adipogenesis, MuRF1, ubiquitin ligase, PPARγ2, VCAM-1, integrins, bone resorption, bone formation, tumor microenvironment
MeSH terms
Tripartite Motif Proteins, Animals, Cell Communication, Cell Differentiation, Humans, Multiple Myeloma, Muscle Proteins, Osteoblasts, Mice, SCID, Ubiquitin-Protein Ligases, Cell Line, Tumor, Adipogenesis, Mice, Mesenchymal Stem Cells

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