Thymidine phosphorylase exerts complex effects on bone resorption and formation in myeloma
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Myeloma-expressed thymidine phosphorylase enhances bone lesion formation by acting on osteoclasts and osteoblasts.
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Myeloma cells prevent mesenchymal stromal cells from differentiating into mature osteoblasts.
“According to reports, myeloma cells prevent MSCs from differentiating into mature osteoblasts [42, 276, 277].”
From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [277]
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- Authors
- Liu, H., Liu, Z., Du, J., He, J., Lin, P., Amini, B., Starbuck, M. W., Novane, N., Shah, J. J., Davis, R. E., Hou, J., Gagel, R. F., & Yang, J.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Second Military Medical University (CN)
- Corresponding author
- Liu, Huan
- Liu, Zhiqiang
- Yang, Jing
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2016-08-24
- Volume
- 8
- Issue
- 353
- Pages
- 353ra113-353ra113
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC5109917
- OpenAlex
- W2518455045
- Cited by
- 74
- References
- 37
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 7 · 2023: 6 · 2022: 13 · 2021: 16 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 3
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (CA190863, CA193362)
- National Cancer Institute UTMDACC SPORE in Multiple Myeloma Career Development Award (CDP-060315)
- Developmental Research Program (DRP-00013585)
- American Cancer Society Research (127337-RSG-15-069-01-TBG)
- University of Texas MD Anderson Cancer Center Institutional Research Grants Basic Research
- Leukemia Research Foundation
- American Society of Hematology
- National Natural Science Foundation of China (81470356)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
- Health Sciences › Medicine › Oncology › Bone health and treatments
- Keywords
- thymidine phosphorylase, multiple myeloma, osteolytic lesions, bone resorption, bone formation, DNA methylation, Runx2, Osterix, IRF8, NFATc1, osteoblast progenitors, osteoclast precursors, 2-deoxy-D-ribose, integrin αvβ3, alpha5beta1 integrin, PI3K/Akt signaling, DNMT3A, epigenetic regulation
- MeSH terms
- Sp7 Transcription Factor, DNA Methyltransferase 3A, Interferon Regulatory Factor-8, Bone Neoplasms, Bone Resorption, DNA (Cytosine-5-)-Methyltransferases, Humans, Multiple Myeloma, Osteoblasts, Osteoclasts, Osteogenesis, Osteolysis, Thymidine Phosphorylase, Down-Regulation, Up-Regulation, CpG Islands, DNA Methylation, Cell Line, Tumor, Core Binding Factor Alpha 1 Subunit, Interferon Regulatory Factors, RANK Ligand
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