Cited by 74Bone Metabolism and DiseasesMultiple Myeloma Research and TreatmentsBone health and treatments

Thymidine phosphorylase exerts complex effects on bone resorption and formation in myeloma

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Liu, Huan, Liu, Zhiqiang, Du, Juan, He, Jin, Lin, Pei, Amini, Behrang, Starbuck, Michael W., Novane, Nora +5 more·2016·Science Translational Medicine

Abstract

Myeloma-expressed thymidine phosphorylase enhances bone lesion formation by acting on osteoclasts and osteoblasts.

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Authors
Liu, H., Liu, Z., Du, J., He, J., Lin, P., Amini, B., Starbuck, M. W., Novane, N., Shah, J. J., Davis, R. E., Hou, J., Gagel, R. F., & Yang, J.
Affiliations
  • The University of Texas MD Anderson Cancer Center (US)
  • Second Military Medical University (CN)
Corresponding author
  • Liu, Huan
  • Liu, Zhiqiang
  • Yang, Jing
Venue
Science Translational Medicine
Published
2016-08-24
Volume
8
Issue
353
Pages
353ra113-353ra113
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W2518455045
Cited by
74
References
37
Citations by year
2026: 4 · 2025: 11 · 2024: 7 · 2023: 6 · 2022: 13 · 2021: 16 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 3
FWCI
2.08
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Cancer Institute (CA190863, CA193362)
  • National Cancer Institute UTMDACC SPORE in Multiple Myeloma Career Development Award (CDP-060315)
  • Developmental Research Program (DRP-00013585)
  • American Cancer Society Research (127337-RSG-15-069-01-TBG)
  • University of Texas MD Anderson Cancer Center Institutional Research Grants Basic Research
  • Leukemia Research Foundation
  • American Society of Hematology
  • National Natural Science Foundation of China (81470356)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
  • Health Sciences › Medicine › Oncology › Bone health and treatments
Keywords
thymidine phosphorylase, multiple myeloma, osteolytic lesions, bone resorption, bone formation, DNA methylation, Runx2, Osterix, IRF8, NFATc1, osteoblast progenitors, osteoclast precursors, 2-deoxy-D-ribose, integrin αvβ3, alpha5beta1 integrin, PI3K/Akt signaling, DNMT3A, epigenetic regulation
MeSH terms
Sp7 Transcription Factor, DNA Methyltransferase 3A, Interferon Regulatory Factor-8, Bone Neoplasms, Bone Resorption, DNA (Cytosine-5-)-Methyltransferases, Humans, Multiple Myeloma, Osteoblasts, Osteoclasts, Osteogenesis, Osteolysis, Thymidine Phosphorylase, Down-Regulation, Up-Regulation, CpG Islands, DNA Methylation, Cell Line, Tumor, Core Binding Factor Alpha 1 Subunit, Interferon Regulatory Factors, RANK Ligand

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