Reprogrammed marrow adipocytes contribute to myeloma-induced bone disease
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Marrow adipocytes reprogrammed by myeloma cells induce bone lesions.
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Multiple myeloma mesenchymal stromal cells exhibit decreased osteogenic potential and changes in the expression of transcripts related to the pathophysiology of multiple myeloma illness (IL-6).
“MM-MSCs also exhibit decreased osteogenic potential and changes in the expression of transcripts related to the pathophysiology of MM illness (IL-6).”
From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [286]
The Results section on osteoblastogenesis (page not provided) reports reduced bone-forming activity in MSCs cultured with conditioned medium from myeloma-associated adipocytes. It does not establish that MM-MSCs themselves have intrinsically decreased osteogenic potential. The reported gene-expression changes concern adipocytes, not IL-6 transcripts in MM-MSCs; a search for IL-6 found no supporting passage. (LLM, conf=0.84)
Experimental — accuracy not yet measuredMultiple myeloma mesenchymal stromal cells have abnormal secretory profiles and senescent traits that might hinder bone production.
“There is evidence that MM-MSCs have abnormal secretory profiles and senescent traits that might hinder bone production [221, 285, 286].”
From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [286]
The Introduction (page unavailable) says myeloma cells suppress MSC maturation into osteoblasts, and the Results section on osteoblastogenesis (page unavailable) shows that factors secreted by myeloma-associated adipocytes inhibit bone formation. The paper does not establish that MM-MSCs themselves have abnormal secretory profiles or senescent traits; the altered secretion studied here is from adipocytes. (LLM, conf=0.86)
Experimental — accuracy not yet measuredMyeloma cells have the capacity to reprogram normal bone marrow adipocytes, giving them the capacity to resorb bone in myeloma patients who are in remission.
“According to Liu et al.‘s study, myeloma cells have the capacity to reprogram normal BM adipocytes, giving them the capacity to resorb bone in myeloma patients who are in remission [282, 283].”
From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [282]
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- Authors
- Liu, H., He, J., Koh, S. P., Zhong, Y., Liu, Z., Wang, Z., Zhang, Y., Li, Z., Tam, B. T., Lin, P., Xiao, M., Young, K. H., Amini, B., Starbuck, M. W., Lee, H. C., Navone, N. M., Davis, R. E., Tong, Q., Bergsagel, P. L., Hou, J., Yi, Q., Orlowski, R. Z., Gagel, R. F., & Yang, J.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- The University of Texas Health Science Center at Houston (US)
- Capital Medical University (CN)
- Department of Lymphoma and Myeloma, Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- Baylor College of Medicine (US)
- Mayo Clinic (US)
- Shanghai Jiao Tong University (CN)
- Houston Methodist (US)
- Corresponding author
- Yang, Jing
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2019-05-29
- Volume
- 11
- Issue
- 494
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC6999853
- OpenAlex
- W2947821013
- Cited by
- 113
- References
- 42
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 14 · 2023: 22 · 2022: 20 · 2021: 14 · 2020: 11 · 2019: 3
- FWCI
- 8.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Cancer Society (127337-RSG-15-069-01-TBG)
- National Cancer Institute (CA190863, CA193362, P30CA016672)
- Topics
- Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- multiple myeloma, bone lesions, EZH2, polycomb repressive complex 2, adipocyte-specific knockout, therapeutic target
- MeSH terms
- Enhancer of Zeste Homolog 2 Protein, Animals, Bone Diseases, Bone Marrow, Bone Resorption, Disease Models, Animal, Histones, Humans, Methylation, Multiple Myeloma, Osteoblasts, Osteogenesis, Promoter Regions, Genetic, Remission Induction, Signal Transduction, Down-Regulation, Up-Regulation, Sp1 Transcription Factor, Adipocytes, Cell Line, Tumor, PPAR gamma, Mice, Adipokines, Polycomb Repressive Complex 2, Cellular Reprogramming
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