p38 MAPK in Myeloma Cells Regulates Osteoclast and Osteoblast Activity and Induces Bone Destruction

The Role of the Wnt-Signaling Antagonist DKK1 in the Development of Osteolytic Lesions in Multiple Myeloma

Tian, E., Zhan, F., Walker, R. C., Rasmussen, E., Ma, Y., Barlogie, B., & Shaughnessy, J. D. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030847 · Cited by 1,499 · see citing works

Pathogenesis of myeloma bone disease

Roodman, G. D. (2009) · Leukemia · doi:10.1038/leu.2008.336 · Cited by 398 · see citing works

A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket

Tong, L., Pav, S., White, D. M., Rogers, S., Crane, K. M., Cywin, C. L., Brown, M. L., & Pargellis, C. A. (1997) · Nature Structural Biology · doi:10.1038/nsb0497-311 · Cited by 386 · see citing works

Signal transduction by receptor activator of nuclear factor kappa B in osteoclasts

Lee, Z. H., & Kim, H. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00695-8 · Cited by 381 · see citing works

Pathogenesis of myeloma bone disease

Roodman, G. D. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22403 · Cited by 296 · see citing works

MCP-1 Is Induced by Receptor Activator of Nuclear Factor-κB Ligand, Promotes Human Osteoclast Fusion, and Rescues Granulocyte Macrophage Colony-stimulating Factor Suppression of Osteoclast Formation

Kim, M. S., Day, C. J., & Morrison, N. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412713200 · Cited by 252 · see citing works

Inhibiting Dickkopf-1 (Dkk1) Removes Suppression of Bone Formation and Prevents the Development of Osteolytic Bone Disease in Multiple Myeloma

Heath, D. J., Chantry, A., Buckle, C., Coulton, L., Shaughnessy, J. D., Evans, H., Snowden, J. A., Stover, D. R., Vanderkerken, K., & Croucher, P. I. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.081104 · Cited by 251 · see citing works

Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma

Qiang, Y., Chen, Y., Stephens, O., Brown, N., Chen, B., Epstein, J., Barlogie, B., & Shaughnessy, J. D. (2008) · Blood · doi:10.1182/blood-2008-01-132134 · Cited by 249 · see citing works

Estrogen-dependent and C-C chemokine receptor-2–dependent pathways determine osteoclast behavior in osteoporosis

Binder, N. B., Niederreiter, B., Hoffmann, O., Stange, R., Pap, T., Stulnig, T. M., Mack, M., Erben, R. G., Smolen, J. S., & Redlich, K. (2009) · Nature Medicine · doi:10.1038/nm.1945 · Cited by 207 · see citing works

RANK ligand signaling modulates the matrix metalloproteinase-9 gene expression during osteoclast differentiation

Sundaram, K., Nishimura, R., Senn, J. J., Youssef, R. F., London, S. D., & Reddy, S. V. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.10.001 · Cited by 206 · see citing works

Inhibiting Dickkopf-1 (Dkk1) Removes Suppression of Bone Formation and Prevents the Development of Osteolytic Bone Disease in Multiple Myeloma

Clarke, B. L. (2009) · Yearbook of Endocrinology · doi:10.1016/s0084-3741(09)79307-2 · Cited by 200 · see citing works

Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma

Qiang, Y., Barlogie, B., Rudikoff, S., & Shaughnessy, J. D. (2007) · Bone · doi:10.1016/j.bone.2007.12.006 · Cited by 168 · see citing works

Monocyte Chemotactic Protein-1 Mediates Prostate Cancer–Induced Bone Resorption

Lü, Y., Cai, Z. Y., Xiao, G., Keller, E. T., Mizokami, A., Yao, Z., Roodman, G. D., & Zhang, J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-1210 · Cited by 162 · see citing works

Osteoclast differentiation requires TAK1 and MKK6 for NFATc1 induction and NF-κB transactivation by RANKL

Huang, H., Ryu, J., Ha, J., Chang, E., Kim, H., Kim, H.-M., Kitamura, T., Lee, Z., & Kim, H. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401882 · Cited by 159 · see citing works

Activation of p38 MAPK is a key step in tumor necrosis factor–mediated inflammatory bone destruction

Zwerina, J., Hayer, S., Redlich, K., Bobacz, K., Kollias, G., Smolen, J. S., & Schett, G. A. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21626 · Cited by 132 · see citing works

Role of the Bone Marrow Microenvironment in Multiple Myeloma

Roodman, G. D. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.11.1921 · Cited by 130 · see citing works

Targeting p38 MAPK inhibits multiple myeloma cell growth in the bone marrow milieu

Hideshima, T., Akiyama, M., Hayashi, T., Richardson, P. G. G., Schlossman, R. L., Chauhan, D., & Anderson, K. C. (2002) · Blood · doi:10.1182/blood-2002-06-1874 · Cited by 116 · see citing works

Tumor evasion of the immune system: inhibiting p38 MAPK signaling restores the function of dendritic cells in multiple myeloma

Wang, S., Yang, J., Qian, J., Wezeman, M. J., Kwak, L. W., & Yi, Q. (2005) · Blood · doi:10.1182/blood-2005-06-2486 · Cited by 106 · see citing works

Critical roles of Raf/MEK/ERK and PI3K/AKT signaling and inactivation of p38 MAP kinase in the differentiation and survival of monocyte-derived immature dendritic cells

Xie, J., Qian, J., Yang, J., Wang, S., Freeman, M. E., & Yi, Q. (2005) · Experimental Hematology · doi:10.1016/j.exphem.2005.03.001 · Cited by 98 · see citing works

Optimizing immunotherapy in multiple myeloma: restoring the function of patients' monocyte-derived dendritic cells by inhibiting p38 or activating MEK/ERK MAPK and neutralizing interleukin-6 in progenitor cells

Wang, S., Hong, S., Yang, J., Qian, J., Zhang, X., Shpall, E. J., Kwak, L. W., & Yi, Q. (2006) · Blood · doi:10.1182/blood-2006-04-016980 · Cited by 95 · see citing works

MKK3/6-p38 MAPK Signaling Is Required for IL-1 β and TNF- α -Induced RANKL Expression in Bone Marrow Stromal Cells

Rossa, C., Ehmann, K., Liu, M., Patil, C. S., & Kirkwood, K. L. (2006) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2006.26.719 · Cited by 71 · see citing works

Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation

Nguyen, A. N., Stebbins, E. G., Henson, M., O’Young, G., Choi, S. J., Quon, D. H., Damm, D., Reddy, M., Ma, J. Y., Haghnazari, E., et al. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.02.026 · Cited by 67 · see citing works

Characterization of Wnt/β‐catenin signalling in osteoclasts in multiple myeloma

Qiang, Y., Chen, Y., Brown, N., Hu, B., Epstein, J., Barlogie, B., & Shaughnessy, J. D. (2009) · British Journal of Haematology · doi:10.1111/j.1365-2141.2009.08009.x · Cited by 58 · see citing works

Anti–β2-microglobulin monoclonal antibodies induce apoptosis in myeloma cells by recruiting MHC class I to and excluding growth and survival cytokine receptors from lipid rafts

Yang, J., Zhang, X., Wang, J., Qian, J., Zhang, L., Wang, M. L., Kwak, L. W., & Yi, Q. (2007) · Blood · doi:10.1182/blood-2007-06-094417 · Cited by 52 · see citing works

Treatment strategies for bone disease

Roodman, G. D. (2007) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1705802 · Cited by 42 · see citing works

MCP-1 Derived from Stromal Keratocyte Induces Corneal Infiltration of CD4+ T Cells in Herpetic Stromal Keratitis

Lee, S., Choi, B. K., Kang, W. J., Kim, Y. H., Park, H. Y., Kim, K. H., & Kwon, B. S. (2008) · Molecules and Cells · doi:10.1016/s1016-8478(23)13965-3 · Cited by 38 · see citing works

Novel targets for myeloma bone disease

Roodman, G. D. (2008) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.12.11.1377 · Cited by 37 · see citing works

Inhibition of p38α MAPK disrupts the pathological loop of proinflammatory factor production in the myelodysplastic syndrome bone marrow microenvironment

Navas, T. A., Zhou, L., Estes, M. L., Haghnazari, E., Nguyen, A. N., Mo, Y., Pahanish, P., Mohindru, M., Cao, T. C., Higgins, L. S., et al. (2008) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190802322919 · Cited by 33 · see citing works

Constitutive activation of p38 MAPK in tumor cells contributes to osteolytic bone lesions in multiple myeloma

Yang, J., He, J., Wang, J. R., Cao, Y., Ling, J., Qian, J., Lu, Y., Li, H., Zheng, Y., Lan, Y., et al. (2012) · Leukemia · doi:10.1038/leu.2012.71 · Cited by 31 · see citing works

Bone-breaking cancer treatment

Roodman, G. D. (2007) · Nature Medicine · doi:10.1038/nm0107-25 · Cited by 15 · see citing works

Mechanisms of bone resorption in myeloma.

Roodman, G. D. (2003) · PubMed · Cited by 6 · see citing works

CircRNA circ_0000190 inhibits the progression of multiple myeloma through modulating miR-767-5p/MAPK4 pathway

Feng, Y., Zhang, L., Wu, J., Khadka, B., Fang, Z., Gu, J., Tang, B., Xiao, R., Pan, G., & Liu, J. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1071-9 · Cited by 134 · see citing works

Induction of m6A methylation in adipocyte exosomal LncRNAs mediates myeloma drug resistance

Wang, Z., He, J., Bach, D., Huang, Y.-H., Li, Z., Liu, H., Lin, P., & Yang, J. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02209-w · Cited by 122 · see citing works

Characterization of LY2228820 Dimesylate, a Potent and Selective Inhibitor of p38 MAPK with Antitumor Activity

Campbell, R. M., Anderson, B. D., Brooks, N. A., Brooks, H. B., Chan, E. M., de Dios, A., Gilmour, R., Graff, J. R., Jambrina, E., Mader, M. M., et al. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0513 · Cited by 118 · see citing works

Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma

Li, Z., Liu, H., He, J., Wang, Z., Yin, Z., You, G., Wang, Z., Davis, R. E., Lin, P., Bergsagel, P. L., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2020.12.011 · Cited by 108 · see citing works

Enhanced CAR-T activity against established tumors by polarizing human T cells to secrete interleukin-9

Liu, L., Bi, E., Ma, X., Xiong, W., Qian, J., Ye, L., Pan, S., Wang, Q., Xiao, L., Yang, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19672-2 · Cited by 104 · see citing works

A critical role of autocrine sonic hedgehog signaling in human CD138+ myeloma cell survival and drug resistance

Liu, Z., Xu, J., He, J., Zheng, Y., Li, H., Lu, Y., Qian, J., Lin, P., Weber, D. M., Yang, J., et al. (2014) · Blood · doi:10.1182/blood-2014-03-557298 · Cited by 99 · see citing works

Targeting the Pim kinases in multiple myeloma

Keane, N. A., Reidy, M., Natoni, A., Raab, M. S., & O'Dwyer, M. E. (2015) · Blood Cancer Journal · doi:10.1038/bcj.2015.46 · Cited by 99 · see citing works

p38α MAPK regulates proliferation and differentiation of osteoclast progenitors and bone remodeling in an aging-dependent manner

Cong, Q., Jia, H., Li, P., Qiu, S., Yeh, J., Wang, Y., Zhang, Z., Ao, J., Li, B., & Liu, H. (2017) · Scientific Reports · doi:10.1038/srep45964 · Cited by 85 · see citing works

Thymidine phosphorylase exerts complex effects on bone resorption and formation in myeloma

Liu, H., Liu, Z., Du, J., He, J., Lin, P., Amini, B., Starbuck, M. W., Novane, N., Shah, J. J., Davis, R. E., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad8949 · Cited by 74 · see citing works

Mechanisms of Drug Resistance in Relapse and Refractory Multiple Myeloma

Yang, W., & Lin, S.-F. (2015) · BioMed Research International · doi:10.1155/2015/341430 · Cited by 66 · see citing works

Increased Dickkopf-1 in Recent-onset Rheumatoid Arthritis is a New Biomarker of Structural Severity. Data from the ESPOIR Cohort

Séror, R., Boudaoud, S., Pavy, S., Nocturne, G., Schaeverbeke, T., Saraux, A., Chanson, P., Gottenberg, J., Devauchelle‐Pensec, V., Tobón, G. J., et al. (2016) · Scientific Reports · doi:10.1038/srep18421 · Cited by 62 · see citing works

FFAs-ROS-ERK/P38 pathway plays a key role in adipocyte lipotoxicity on osteoblasts in co-culture

Dong, X., Bi, L., He, S., Meng, G., Wei, B.-Y., Jia, S., & Liu, J. (2014) · Biochimie · doi:10.1016/j.biochi.2014.01.002 · Cited by 60 · see citing works

p38 MAPK inhibits breast cancer metastasis through regulation of stromal expansion

Hong, B., Li, H., Zhang, M., Xu, J., Lu, Y., Zheng, Y., Qian, J., Chang, J. T., Yang, J., & Yi, Q. (2014) · International Journal of Cancer · doi:10.1002/ijc.28958 · Cited by 59 · see citing works

MIF as a biomarker and therapeutic target for overcoming resistance to proteasome inhibitors in human myeloma

Wang, Q., Zhao, D., Xian, M., Wang, Z., Bi, E., Su, P., Qian, J., Ma, X., Yang, M., Liu, L., et al. (2020) · Blood · doi:10.1182/blood.2020005795 · Cited by 57 · see citing works

p38 MAPK-inhibited dendritic cells induce superior antitumour immune responses and overcome regulatory T-cell-mediated immunosuppression

Lu, Y., Zhang, M., Wang, S., Hong, B., Wang, Z., Li, H., Zheng, Y., Yang, J., Davis, R. E., Qian, J., et al. (2014) · Nature Communications · doi:10.1038/ncomms5229 · Cited by 58 · see citing works

p38 MAPK regulates the Wnt inhibitor Dickkopf-1 in osteotropic prostate cancer cells

Browne, A. J., Göbel, A., Thiele, S., Hofbauer, L. C., Rauner, M., & Rachner, T. D. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.32 · Cited by 58 · see citing works

Molecularly Targeted Therapies in Multiple Myeloma

de la Puente, P., Muz, B., Azab, F., Luderer, M. J., & Azab, A. K. (2014) · Leukemia Research and Treatment · doi:10.1155/2014/976567 · Cited by 57 · see citing works

Multiple Myeloma and Bone: The Fatal InteractionPreprint

Marino, S., & Roodman, G. D. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a031286 · Cited by 56 · see citing works

miR-17-92/p38α Dysregulation Enhances Wnt Signaling and Selects Lgr6+ Cancer Stem-like Cells during Lung Adenocarcinoma Progression

Guinot, A., Oeztuerk-Winder, F., & Ventura, J. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-3302 · Cited by 53 · see citing works

Myeloma cells shift osteoblastogenesis to adipogenesis by inhibiting the ubiquitin ligase MURF1 in mesenchymal stem cells

Liu, Z., Liu, H., He, J., Lin, P., Tong, Q., & Yang, J. (2020) · Science Signaling · doi:10.1126/scisignal.aay8203 · Cited by 49 · see citing works

C-reactive protein promotes bone destruction in human myeloma through the CD32–p38 MAPK–Twist axis

Yang, J., Liu, H., Liu, H., He, J., Yang, J., Lin, P., Wang, Q., Du, J., Ma, W., Yin, Z., et al. (2017) · Science Signaling · doi:10.1126/scisignal.aan6282 · Cited by 41 · see citing works

CD13 Induces Autophagy to Promote Hepatocellular Carcinoma Cell Chemoresistance Through the P38/Hsp27/CREB/ATG7 Pathway

Zhao, Y., Wu, H., Xing, X., Ma, Y., Ji, S., Xu, X., Zhao, X., Wang, S., Jiang, W., Fang, C., et al. (2020) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.120.265637 · Cited by 39 · see citing works

Intercellular Adhesion Molecule-1 Inhibits Osteogenic Differentiation of Mesenchymal Stem Cells and Impairs Bio-Scaffold-Mediated Bone Regeneration In Vivo

Xu, F.-F., Zhu, H., Li, X., Yang, F., Chen, J.-D., Tang, B., Sun, H., Chu, Y., Zheng, R., Liu, Y., et al. (2014) · Tissue Engineering Part A · doi:10.1089/ten.tea.2014.0007 · Cited by 38 · see citing works

Induction of Malignant Plasma Cell Proliferation by Eosinophils

Wong, T. W., Kita, H., Hanson, C. A., Walters, D. K., Arendt, B. K., & Jelinek, D. F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070554 · Cited by 36 · see citing works

m6A reader hnRNPA2B1 drives multiple myeloma osteolytic bone disease

Liu, R., Zhong, Y., Chen, R., Chu, C., Liu, G., Zhou, Y., Huang, Y., Fang, Z., & Liu, H. (2022) · Theranostics · doi:10.7150/thno.76852 · Cited by 35 · see citing works

Bidirectional Differentiation of Human-Derived Stem Cells Induced by Biomimetic Calcium Silicate-Reinforced Gelatin Methacrylate Bioink for Odontogenic Regeneration

Lin, Y., Hsu, T.-T., Liu, Y., Kao, C., & Huang, T. (2021) · Biomedicines · doi:10.3390/biomedicines9080929 · Cited by 34 · see citing works

RARγ activation sensitizes human myeloma cells to carfilzomib treatment through the OAS-RNase L innate immune pathway

Wang, Q., Lin, Z., Wang, Z., Ye, L., Xian, M., Xiao, L., Pan, S., Bi, E., Huang, Y.-H., Qian, J., et al. (2021) · Blood · doi:10.1182/blood.2020009856 · Cited by 32 · see citing works

MAPK11 in breast cancer cells enhances osteoclastogenesis and bone resorption

He, Z., He, J., Liu, Z., Xu, J., Yi, S., Liu, H., & Yang, J. (2014) · Biochimie · doi:10.1016/j.biochi.2014.07.017 · Cited by 32 · see citing works

Immunomodulatory drugs thalidomide and lenalidomide affect osteoblast differentiation of human bone marrow stromal cells in vitro

Bolomsky, A., Schreder, M., Meißner, T., Hose, D., Ludwig, H., Pfeifer, S., & Zojer, N. (2014) · Experimental Hematology · doi:10.1016/j.exphem.2014.03.005 · Cited by 32 · see citing works

Gamabufotalin triggers c-Myc degradation via induction of WWP2 in multiple myeloma cells

Yu, Z., Li, T., Wang, C., Deng, S., Zhang, B., Huo, X., Zhang, B., Wang, X., Zhong, Y., & Ma, X. (2016) · Oncotarget · doi:10.18632/oncotarget.7398 · Cited by 30 · see citing works

A crosstalk triggered by hypoxia and maintained by MCP-1/miR-98/IL-6/p38 regulatory loop between human aortic smooth muscle cells and macrophages leads to aortic smooth muscle cells apoptosis via Stat1 activation.

Wang, Q., Shu, C., Su, J., & Li, X. (2015) · PubMed Central · Cited by 30 · see citing works

Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword

Kamrani, S., Naseramini, R., Khani, P., Razavi, Z. S., Afkhami, H., Atashzar, M. R., Nasri, F., Alavimanesh, S., Saeidi, F., & Ronaghi, H. (2025) · Cancer Cell International · doi:10.1186/s12935-025-03741-x · Cited by 27 · see citing works

Bone-targeting engineered small extracellular vesicles carrying anti-miR-6359-CGGGAGC prevent valproic acid-induced bone loss

Xie, X., Peng, C. M., Hu, L., Zhou, W., Zhang, D., Knoedler, S. A., Liu, G., Xiong, Y., Xue, H., Hu, Y., et al. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01726-8 · Cited by 27 · see citing works

Hypoxia-induced CREB cooperates MMSET to modify chromatin and promote DKK1 expression in multiple myeloma

Xu, Y., Guo, J. R., Liu, J., Xie, Y., Li, X., Jiang, H., Wang, J., Peng, Z., Wang, J., Wang, S., et al. (2021) · Oncogene · doi:10.1038/s41388-020-01590-8 · Cited by 27 · see citing works

LncRNA‐mRNA expression profiles and functional networks in osteoclast differentiation

Liu, W., Li, Z., Cai, Z., Xie, Z., Li, J., Li, M., Cen, S., Tang, S., Guan, Z., Ye, G., et al. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15560 · Cited by 25 · see citing works

Emerging protein kinase inhibitors for the treatment of multiple myeloma

Lind, J., Czernilofsky, F., Vallet, S., & Podar, K. (2019) · Expert Opinion on Emerging Drugs · doi:10.1080/14728214.2019.1647165 · Cited by 24 · see citing works

Integrative analysis of signaling pathways and diseases associated with the miR-106b/25 cluster and their function study in berberine-induced multiple myeloma cells

Gu, C., Li, T., Yin, Z., Chen, S., Jia, F., Shen, J., & Zhang, Y. (2016) · Functional & Integrative Genomics · doi:10.1007/s10142-016-0519-7 · Cited by 24 · see citing works

Kinase inhibitors as potential agents in the treatment of multiple myeloma

Abramson, H. N. (2016) · Oncotarget · doi:10.18632/oncotarget.10745 · Cited by 23 · see citing works

p38β - MAPK11 and its role in female cancers

Katopodis, P., Kerslake, R., Zikopoulos, A., Beri, N. E., & Anikin, V. (2021) · Journal of Ovarian Research · doi:10.1186/s13048-021-00834-9 · Cited by 23 · see citing works

Molecular mechanisms, current management and next generation therapy in myeloma bone disease

Heusschen, R., Muller, J., Duray, E., Withofs, N., Bolomsky, A., Baron, F., Beguin, Y. P., Menu, E., Ludwig, H., & Caers, J. (2017) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2017.1323272 · Cited by 22 · see citing works

From precision synthesis to cross-industry applications: The future of emerging peptide technologies

Wang, M., Xia, H., Wang, Y., Zhang, T., Zhang, M., Li, X., Peng, C., Jing, T., Wang, Y., Peng, L., et al. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107839 · Cited by 18 · see citing works

In vitro anti-osteoclastogenic activity of p38 inhibitor doramapimod via inhibiting migration of pre-osteoclasts and NFATc1 activity

Moon, S., Choi, S., & Kim, S. H. (2015) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2015.06.008 · Cited by 18 · see citing works

Tumor cell p38 MAPK: A trigger of cancer bone osteolysis

Liu, H., He, J., & Yang, J. (2015) · Cancer Cell & Microenvironment · doi:10.14800/ccm.464 · Cited by 17 · see citing works

RNA interference for multiple myeloma therapy: targeting signal transduction pathways

Guo, J., McKenna, S. L., O'Dwyer, M. E., Cahill, M. R., & O’Driscoll, C. M. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2015.1071355 · Cited by 17 · see citing works

MK2 is a therapeutic target for high-risk multiple myeloma

Gu, C., Cheng, H., Yang, H., Bian, Y., Wang, Y., Zhang, Y., Pisano, M. D., Hu, G., & Yang, Y. (2018) · Haematologica · doi:10.3324/haematol.2017.182121 · Cited by 17 · see citing works

Targeting p38 MAPK: A potential bridge between ER stress and age-related bone loss

Yin, M., Zheng, X., & Shi, L. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111549 · Cited by 16 · see citing works

P38 regulates the Wnt inhibitor Dickkopf-1 in breast cancer

Rachner, T. D., Göbel, A., Browne, A. J., Hötzel, J., Rauner, M., & Hofbauer, L. C. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.09.101 · Cited by 14 · see citing works

Interleukin‐29 induces receptor activator of NF‐κB ligand expression in fibroblast‐like synoviocytes via MAPK signaling pathways

Xu, L., Feng, X., Shi, Y., Wang, X., Kong, X., Zhang, M., Liu, M., Tan, W., & Wang, F. (2015) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.12747 · Cited by 14 · see citing works

Bone Marrow Stromal Cells Derived MCP-1 Reverses the Inhibitory Effects of Multiple Myeloma Cells on Osteoclastogenesis by Upregulating the RANK Expression

Liu, Z., Xu, J., Li, H., Zheng, Y., He, J., Liu, H., Zhong, Y., Lu, Y., Hong, B., Zhang, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082453 · Cited by 14 · see citing works

The relationship between pro-resorptive inflammatory cytokines and the effect of high dose vitamin D supplementation on their circulating concentrations

Karim, M. Y., Turner, C., Dalton, N. R., Roplekar, R., Sankaralingam, A., Ewang, M., Fogelman, I., & Hampson, G. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2013.08.010 · Cited by 13 · see citing works

High expression of uPA related to p38MAPK in esophageal cancer indicates poor prognosis

Liu, Q., Li, W., Yang, S., & Liu, Z. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s181701 · Cited by 13 · see citing works

Fumitremorgin C Attenuates Osteoclast Formation and Function via Suppressing RANKL-Induced Signaling Pathways

Yuan, Y. J., Chen, K., Chen, X., Wang, C., Qiu, H., Cao, Z., Song, D., Sun, Y., Guo, J., Tickner, J. C., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00238 · Cited by 13 · see citing works

Inferring Drug-Protein–Side Effect Relationships from Biomedical Text

Song, M., Baek, S. H., Heo, G. E., & Lee, J. (2019) · Genes · doi:10.3390/genes10020159 · Cited by 12 · see citing works

Methyl 3,4-dihydroxybenzoate inhibits RANKL-induced osteoclastogenesis via Nrf2 signaling in vitro and suppresses LPS-induced osteolysis and ovariectomy-induced osteoporosis in vivo

Huang, Z., Jiang, Z., Zheng, Z., Zhang, X., Wei, X., Chen, J., & Zhao, F. (2022) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2022087 · Cited by 11 · see citing works

Oncolytic adenovirus ORCA-010 increases the type 1 T cell stimulatory capacity of melanoma-conditioned dendritic cells

González, M. L., van de Ven, R., de Haan, H. G., van der Sluijs, J. V. E., Dong, W., van Beusechem, V. W., & de Gruijl, T. D. (2020) · Clinical & Experimental Immunology · doi:10.1111/cei.13442 · Cited by 10 · see citing works

Mitogen-activated protein kinase kinase 3 induces cell cycle arrest via p38 activation mediated Bmi-1 downregulation in hepatocellular carcinoma

WANG, L., CHEN, C., Feng, S., Lei, P., & Tian, J. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4564 · Cited by 10 · see citing works

Melatonin regulates mitochondrial function to alleviate ferroptosis through the MT2/Akt signaling pathway in swine testicular cells

Zhao, Y., Qin, G., Jiang, B., Huang, J., He, S., & Peng, H. (2024) · Scientific Reports · doi:10.1038/s41598-024-65666-1 · Cited by 9 · see citing works

EZH2 serves as a viable therapeutic target for myeloma-induced osteolytic bone destruction

Liu, R., Li, Z., Chen, R., Fang, Z., Liu, Z., & Liu, H. (2025) · Nature Communications · doi:10.1038/s41467-025-56506-5 · Cited by 10 · see citing works

Black tea rich in polygonatum sibiricum polysaccharides inhibits osteoporosis in ovariectomized mice through immune regulation and gut microbiota suppression

Gao, S., Yu, Y., shu, J., Yang, B., Zhang, B., Xu, J., & Wang, Z. (2025) · Scientific Reports · doi:10.1038/s41598-025-08827-0 · Cited by 9 · see citing works

Bacterial infections exacerbate myeloma bone disease

Liu, R., Zhong, Y., Chen, R., Chen, S., Huang, Y., & Liu, H. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-021-03187-5 · Cited by 8 · see citing works

Angiotensin II inhibits osteogenic differentiation of isolated synoviocytes by increasing DKK-1 expression

Zhang, Y., Ding, H., Song, Q., Wang, Z., Yuan, W., Ren, Y., Zhao, Z., & Wang, C. (2020) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2020.105703 · Cited by 8 · see citing works

Involvement of MAPK signaling pathway in the osteogenic gene expressions of Cervi Pantotrichum Cornu in MG-63 human osteoblast-like cells

Kim, J. H., Jung, T. Y., Seo, J.-C., Lee, S., Kim, M., Leem, K., & Lim, S. C. (2013) · Life Sciences · doi:10.1016/j.lfs.2013.11.002 · Cited by 7 · see citing works

Stigmasterol mitigates estrogen-deficiency-induced osteoporosis through inhibition of phosphorylated p65 and MAPK signaling pathways

Zhao, Q., Chen, X., Mai, B., Che, F., Zhang, Z., Kang, P., Hou, C., Lu, L., & Xu, L. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1527494 · Cited by 6 · see citing works

lncRNA H19 plays a role in multiple myeloma via interacting with hnRNPA2B1 to stabilize BET proteins by targeting osteoclasts and osteoblasts

Song, Y., Guo, N., Zi, F., Zheng, J., & Cheng, J. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113080 · Cited by 6 · see citing works

P38 mitogen-activated protein kinase promotes Wnt/β-catenin signaling by impeding Dickkofp-1 expression during Haemophilus parasuis infection

Hua, K., Gong, H., Xu, Q., Li, T., Ma, B., Li, Y., He, R., Bi, D., Zhou, R., Luo, R., et al. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155287 · Cited by 6 · see citing works

LAMP5 may promote MM progression by activating p38

Chen, Y., & Ma, T. (2023) · Pathology & Oncology Research · doi:10.3389/pore.2023.1611083 · Cited by 6 · see citing works

p38 Molecular Targeting for Next-Generation Multiple Myeloma Therapy

Morales-Martínez, M., & Vega, M. I. (2024) · Cancers · doi:10.3390/cancers16020256 · Cited by 8 · see citing works

Combination of AZD3463 and DZNep Prevents Bone Metastasis of Breast Cancer by Suppressing Akt Signaling

He, W., Cao, X., Rong, K., Chen, X., Han, S., & Qin, A. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.652071 · Cited by 6 · see citing works

Shear Stress Regulates Osteogenic Differentiation of Human Dental Pulp Stem Cells via the p38 Pathway

Lwin, H. Y., Tiskratok, W., Kyawsoewin, M., Manokawinchoke, J., Termkwanchareon, C., Limjeerajarus, N., Limjeerajarus, C. N., Egusa, H., Osathanon, T., & Limraksasin, P. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125667 · Cited by 4 · see citing works

A ligand-receptor interactome of the bone tumor microenvironment in multiple myeloma bone pain

Barakat, A., Doncheva, N. T., Prado, J., Moll, L., Jensen, J. L., Diaz‐delCastillo, M., Novak, I., Eijkelkamp, N., Jensen, L. J., & Heegaard, A. (2025) · Pain · doi:10.1097/j.pain.0000000000003746 · Cited by 3 · see citing works

TRPM8 knockdown relieved inflammatory response and cell apoptosis in pneumonia model induced by Streptococcus pneumoniae in vitro

Sheng, K., Sang, L., & Ge, H. (2023) · Cellular and Molecular Biology · doi:10.14715/cmb/2023.69.15.34 · Cited by 3 · see citing works

Effect of Enterococcus faecalis on osteoclastogenesis under cobalt-mimicked hypoxia in vitro

Zhou, F., Li, X., Chang, X., Geng, Z., Hao, W., Deng, J., Wong, H. M., & Wang, S. (2022) · Microbial Pathogenesis · doi:10.1016/j.micpath.2022.105964 · Cited by 3 · see citing works

The close association between IL‑12Rβ2 and p38MAPK, and higher expression in the early stages of NSCLC, indicates a good prognosis for survival

Liu, Z., Yang, W., Yang, S., & Cai, K. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9206 · Cited by 3 · see citing works

Mechanical Stimulation Drives Multicellular Synergy and Signaling Pathways in Developing Skeletal Tissues

Guan, Q., Du, Y., Zou, J., & Zhang, L. E. (2026) · Sports Medicine · doi:10.1007/s40279-026-02393-9 · Cited by 2 · see citing works

Mycobacterium w - a promising immunotherapeutic intervention for diseases

Stefan, K., Gordon, R., Rolig, A. S., Honkala, A. T., Tailor, D., Davis, L. E., Modi, R. I., Joshipura, M., Khamar, B. M., & Malhotra, S. V. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1450118 · Cited by 2 · see citing works

Lifting the Veil on Myeloma Bone Disease

Chen, R., Liu, R., & Liu, H. (2025) · Health and Metabolism · doi:10.53941/hm.2025.100005 · Cited by 1 · see citing works

Lgr6+ cells in the biological system during homeostasis and injury

Li, H., Guan, X., Wang, Y., & Guo, H.-D. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101863 · Cited by 1 · see citing works

SGLT ‐2 Inhibitors are Associated With a Lower Risk of Multiple Myeloma

Liu, E., Sun, A., Yang, Y., Xu, J., Suvannasankha, A., Walker, B. A., & Zhang, P. (2026) · European Journal Of Haematology · doi:10.1111/ejh.70274 · Cited by 1 · see citing works

Network Pharmacology-Based Investigation For Predicting Active Ingredients And Potential Targets Of Strychnos Nux-Vomica L. In Treating Multiple MyelomaPreprint

Zhou, Y., Shen, J., Jin, K., Lin, C., Hong, Z., & Deng, S. (2020) · doi:10.21203/rs.3.rs-97494/v1 · Cited by 1 · see citing works

Oncodynamic Changes in Skeleton

Seidlitz, E. P., Popović, S., Clemons, M. J., & Singh, G. (2016) · Springer eBooks · doi:10.1007/978-3-319-28558-0_9

TAS-102 has a tumoricidal activity in multiple myeloma.

Li, G., Liu, H., He, J., Li, Z., Wang, Z., Zhou, S., Zheng, G., He, Z., & Yang, J. (2020) · PubMed Central

p38β - MAPK11 and its role in female cancersPreprint

Katopodis, P., Kerslake, R., Zikopoulos, A., Beri, N. E., & Anikin, V. (2020) · doi:10.21203/rs.3.rs-107231/v1

Osteocyte-derived exosomes confer multiple myeloma resistance to chemotherapy through acquisition of cancer stem cell-like featuresPreprint

Cheng, F., Wang, Z., You, G., Liu, Y., He, J., & Yang, J. (2023) · Research Square · doi:10.21203/rs.3.rs-2535332/v1

Additional file 5 of p38β - MAPK11 and its role in female cancers

Katopodis, P., Kerslake, R., Zikopoulos, A., Beri, N., & Anikin, V. (2021) · Figshare · doi:10.6084/m9.figshare.14853357

Additional file 2 of p38β - MAPK11 and its role in female cancers

Katopodis, P., Kerslake, R., Zikopoulos, A., Beri, N., & Anikin, V. (2021) · Figshare · doi:10.6084/m9.figshare.14853348

Additional file 6 of p38β - MAPK11 and its role in female cancers

Katopodis, P., Kerslake, R., Zikopoulos, A., Beri, N., & Anikin, V. (2021) · Figshare · doi:10.6084/m9.figshare.14853360

Additional file 1 of p38β - MAPK11 and its role in female cancers

Katopodis, P., Kerslake, R., Zikopoulos, A., Beri, N., & Anikin, V. (2021) · Figshare · doi:10.6084/m9.figshare.14853339

Additional file 3 of p38β - MAPK11 and its role in female cancers

Katopodis, P., Kerslake, R., Zikopoulos, A., Beri, N., & Anikin, V. (2021) · Figshare · doi:10.6084/m9.figshare.14853351

Additional file 1 of Bacterial infections exacerbate myeloma bone disease

Liu, R., Zhong, Y., Chen, R., Chen, S., Huang, Y., & Liu, H. (2022) · Figshare · doi:10.6084/m9.figshare.17981960

Additional file 4 of p38β - MAPK11 and its role in female cancers

Katopodis, P., Kerslake, R., Zikopoulos, A., Beri, N., & Anikin, V. (2021) · Figshare · doi:10.6084/m9.figshare.14853354

Models of myeloma bone disease: In vivo and in vitro approaches.

Wang, J., Zweegman, S., & Groen, R. (2026) · Bone · doi:10.1016/j.bone.2026.117789 · Cited by 1 · see citing works

P38 MAPK Activity in Myeloma Cells Regulates Osteoclast and Osteoblast Activity and Induces Bone Destruction in Vivo

He, J., Liu, Z., Zheng, Y., Qian, J., Li, H., Lu, Y., Xu, J., Hong, B., Zhang, M., Lin, P., et al. (2012) · Blood · doi:10.1182/blood.v120.21.566.566

Abstract LB-320: Regulation of osteoblastogenesis and osteoclastogenesis by p38 MAPK constitutive activity in myeloma cells.

Yang, J., He, J., & Yi, Q. (2011) · Cancer Research · doi:10.1158/1538-7445.am2011-lb-320

Constitutive activation of p38 MAPK in tumor cells contributes to osteolytic bone lesions in multiple myeloma

Yang, J., He, J., Wang, J. R., Cao, Y., Ling, J., Qian, J., Lu, Y., Li, H., Zheng, Y., Lan, Y., et al. (2012) · Leukemia · doi:10.1038/leu.2012.71 · Cited by 31 · see citing works

Constitutive Activation of p38 MAPK in Myeloma Cells Contributes to Myeloma-Induced Osteolytic Bone Lesions.

Yang, J., Cao, Y., Zheng, Y., Hong, S., Li, H., Qian, J., Matthews, J. A., Wang, M. L., Kwak, L. W., & Yi, Q. (2009) · Blood · doi:10.1182/blood.v114.22.740.740

Regulation Of DKK-1 Expression By p38 MAPK Signaling Via CREB Myeloma Cells

Yang, J., Zhong, Y., He, J., Liu, Z., Liu, H., Lin, P., Orlowski, R. Z., & Kwak, L. W. (2013) · Blood · doi:10.1182/blood.v122.21.1917.1917