Cited by 24HER2/EGFR in Cancer ResearchCell death mechanisms and regulationBreast Cancer Treatment Studies

ELP-dependent expression of MCL1 promotes resistance to EGFR inhibition in triple-negative breast cancer cells

Open access
Cruz-Gordillo, Peter, Honeywell, Megan E., Harper, Nicholas W., Leete, Thomas, Lee, Michael J.·2020·Science Signaling

Published version of a preprint

Abstract

Blocking the antiapoptotic protein Mcl-1 sensitizes TNBC cells to erlotinib.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1126/scisignal.abb9820

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Cruz-Gordillo, P., Honeywell, M. E., Harper, N. W., Leete, T., & Lee, M. J.
Affiliations
  • Program in Systems Biology, University of Massachusetts Medical School, Worcester MA 01605, USA.
  • University of Massachusetts Chan Medical School (US)
Corresponding author
  • Honeywell, Megan E.
  • Lee, Michael J.
Venue
Science Signaling
Published
2020-11-17
Volume
13
Issue
658
ISSN
  • 1937-9145 (ISSN-L)
  • 1945-0877
OpenAlex
W3098776690
Cited by
24
References
54
Citations by year
2026: 5 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 4 · 2021: 5
FWCI
1.35
Type
journal article
Language
en
Open access
Locations
  • Science Signaling (publishedVersion)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • American Cancer Society (RSG-17-011-01)
  • National Cancer Institute (T32-CA130807)
  • National Institute of General Medical Sciences (R01GM127559)
Topics
  • Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
Keywords
Elongator complex, Mcl-1, EGFR inhibition, erlotinib, triple-negative breast cancer, drug resistance, oncogene addiction, apoptosis, CRISPR-Cas9 screen, combination therapy, non-small cell lung cancer
MeSH terms
Female, Humans, Signal Transduction, Cell Line, Tumor, Histone Acetyltransferases, Myeloid Cell Leukemia Sequence 1 Protein, Triple Negative Breast Neoplasms, ErbB Receptors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review