ELP-dependent expression of MCL1 promotes resistance to EGFR inhibition in triple-negative breast cancer cells
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Abstract
Blocking the antiapoptotic protein Mcl-1 sensitizes TNBC cells to erlotinib.
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Mutant KRAS is a well-known regulator of glycolysis.
“Mutant KRAS is a well known regulator of glycolysis (72)”
From Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy (2023) · cites this paper as [72]
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- Authors
- Cruz-Gordillo, P., Honeywell, M. E., Harper, N. W., Leete, T., & Lee, M. J.
- Affiliations
- Program in Systems Biology, University of Massachusetts Medical School, Worcester MA 01605, USA.
- University of Massachusetts Chan Medical School (US)
- Corresponding author
- Honeywell, Megan E.
- Lee, Michael J.
- Venue
- Science Signaling
- Published
- 2020-11-17
- Volume
- 13
- Issue
- 658
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC7685180
- OpenAlex
- W3098776690
- Cited by
- 24
- References
- 54
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 4 · 2021: 5
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Signaling (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Cancer Society (RSG-17-011-01)
- National Cancer Institute (T32-CA130807)
- National Institute of General Medical Sciences (R01GM127559)
- Topics
- Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Keywords
- Elongator complex, Mcl-1, EGFR inhibition, erlotinib, triple-negative breast cancer, drug resistance, oncogene addiction, apoptosis, CRISPR-Cas9 screen, combination therapy, non-small cell lung cancer
- MeSH terms
- Female, Humans, Signal Transduction, Cell Line, Tumor, Histone Acetyltransferases, Myeloid Cell Leukemia Sequence 1 Protein, Triple Negative Breast Neoplasms, ErbB Receptors
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