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The Fate and Toxicity of Raman-Active Silica-Gold Nanoparticles in Mice
Open accessAbstract
Gold-core nanoparticles designed for imaging by Raman spectroscopy in patients are generally nontoxic in mice, causing only temporary liver inflammation when given intravenously.
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Metadata
- Authors
- Thakor, A. S., Luong, R., Paulmurugan, R., Lin, F. I., Kempen, P., Zavaleta, C., Chu, P., Massoud, T. F., Sinclair, R., & Gambhir, S. S.
- Affiliations
- University of Cambridge (GB)
- Stanford University (US)
- Stanford Medicine (US)
- Corresponding author
- Gambhir, Sanjiv S.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2011-04-20
- Volume
- 3
- Issue
- 79
- Pages
- 79ra33-79ra33
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC3873137
- OpenAlex
- W2099459454
- Semantic Scholar
- 8fd9649353de84ba2ee80b82b8ae3b10c09fc076
- Cited by
- 159
- References
- 35
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 5 · 2023: 2 · 2022: 11 · 2021: 12 · 2020: 8 · 2019: 11 · 2018: 14 · 2017: 13 · 2016: 10 · 2015: 15 · 2014: 13 · 2013: 15 · 2012: 13
- FWCI
- 6.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (U54CA119367, P50CA114747, U54CA151459)
- Topics
- Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
- Keywords
- surface-enhanced Raman scattering, PEGylated nanoparticles, acute toxicity, tissue distribution, reticuloendothelial system, macrophage clearance, oxidative stress, liver inflammation, rectal administration, colorectal cancer detection, affibody
- MeSH terms
- Animals, Female, Gold, Male, Polyethylene Glycols, Silicon Dioxide, Spectrum Analysis, Raman, Mice, Metal Nanoparticles
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