Cited by 159Gold and Silver Nanoparticles Synthesis and ApplicationsNanoparticle-Based Drug DeliverySpectroscopy Techniques in Biomedical and Chemical Research

The DOI matches its Crossref record; 34 of the 35 references it cites were found in a registry or an index.

The Fate and Toxicity of Raman-Active Silica-Gold Nanoparticles in Mice

Open access

Thakor, Avnesh S., Luong, Richard, Paulmurugan, Ramasamy, Lin, Frank I., Kempen, Paul, Zavaleta, Cristina, Chu, Pauline, Massoud, Tarik F., Sinclair, Robert, Gambhir, Sanjiv S.·2011·Science Translational Medicine

DOI 10.1126/scitranslmed.3001963PMC PMC3873137

Open this paper in CoChat — free account

Abstract

Gold-core nanoparticles designed for imaging by Raman spectroscopy in patients are generally nontoxic in mice, causing only temporary liver inflammation when given intravenously.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1126/scitranslmed.3001963

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A new mathematical model for relative quantification in real-time RT-PCR
Pfaffl, M. W. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.9.e45 · Cited by 34,610
Molecular imaging in living subjects: seeing fundamental biological processes in a new lightPreprint
Massoud, T. F., & Gambhir, S. S. (2003) · Genes & Development · doi:10.1101/gad.1047403 · Cited by 2,205
Self-citation
Luminescent quantum dots for multiplexed biological detection and imaging
Chan, W. C. W., Maxwell, D. J., Gao, X., Bailey, R. E., Han, M., & Nie, S. (2002) · Current Opinion in Biotechnology · doi:10.1016/s0958-1669(02)00282-3 · Cited by 2,068
Size‐Dependent Cytotoxicity of Gold Nanoparticles
Pan, Y., Neuß, S., Leifert, A., Fischler, M., Wen, F., Simon, U., Schmid, G., Brandau, W., & Jahnen‐Dechent, W. (2007) · Small · doi:10.1002/smll.200700378 · Cited by 1,881
Molecular imaging of cancer with positron emission tomography
Gambhir, S. S. (2002) · Nature reviews. Cancer · doi:10.1038/nrc882 · Cited by 1,658
Self-citation
PEGylated nanoparticles for biological and pharmaceutical applications
Otsuka, H., Nagasaki, Y., & Kataoka, K. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00226-0 · Cited by 1,619
Toxicity of Gold Nanoparticles Functionalized with Cationic and Anionic Side Chains
Goodman, C. M., McCusker, C. E., Yilmaz, T., & Rotello, V. M. (2004) · Bioconjugate Chemistry · doi:10.1021/bc049951i · Cited by 1,602
Prospects forin vivoRaman spectroscopy
Hanlon, E. B., Manoharan, R., Koo, T.-W., Shafer‐Peltier, K., Motz, J. T., Fitzmaurice, M., Kramer, J. R., Itzkan, I., Dasari, R. R., & Feld, M. S. (2000) · Physics in Medicine and Biology · doi:10.1088/0031-9155/45/2/201 · Cited by 906
Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death.
Korsmeyer, S. J., Shutter, J. R., Novack, D. V., Merry, D. E., & Oltvai, Z. N. (1993) · PubMed · Cited by 865
Rationally designed nanostructures for surface-enhanced Raman spectroscopy
Banholzer, M. J., Millstone, J. E., Qin, L., & Mirkin, C. A. (2008) · Chemical Society Reviews · doi:10.1039/b710915f · Cited by 795

Show all 35 references

Sorted by citations

Nanomaterials for In Vivo Imaging
Smith, B. R., & Gambhir, S. S. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00073 · Cited by 1,084
Self-citation
A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle
Kircher, M. F., de la Zerda, A., Jokerst, J. V., Zavaleta, C. L., Kempen, P. J., Mittra, E., Pitter, K. L., Huang, R., Campos, C., Habte, F. G., et al. (2012) · Nature Medicine · doi:10.1038/nm.2721 · Cited by 1,074
Self-citation
SERS Nanoparticles in Medicine: From Label-Free Detection to Spectroscopic Tagging
Lane, L. A., Qian, X., & Nie, S. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00265 · Cited by 881
Nanooncology: The future of cancer diagnosis and therapy
Thakor, A. S., & Gambhir, S. S. (2013) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21199 · Cited by 602
Self-citation
Hybrid Nanoparticles for Detection and Treatment of Cancer
Sailor, M. J., & Park, J. (2012) · Advanced Materials · doi:10.1002/adma.201200653 · Cited by 495
Nonporous silica nanoparticles for nanomedicine application
Tang, L., & Cheng, J. (2013) · Nano Today · doi:10.1016/j.nantod.2013.04.007 · Cited by 499
Gold Nanoparticles: A Revival in Precious Metal Administration to Patients
Thakor, A. S., Jokerst, J. V., Zavaleta, C. L., Massoud, T. F., & Gambhir, S. S. (2011) · Nano Letters · doi:10.1021/nl202559p · Cited by 465
Self-citation
Surface-enhanced Raman spectroscopy for in vivo biosensing
Laing, S., Jamieson, L. E., Faulds, K., & Graham, D. (2017) · Nature Reviews Chemistry · doi:10.1038/s41570-017-0060 · Cited by 444
Gold Nanorods for Ovarian Cancer Detection with Photoacoustic Imaging and Resection GuidanceviaRaman Imaging in Living Mice
Jokerst, J. V., Cole, A. J., Sompel, D. V. D., & Gambhir, S. S. (2012) · ACS Nano · doi:10.1021/nn304347g · Cited by 403
Self-citation
Recent advances in metal nanoparticles in cancer therapy
Sharma, A., Goyal, A. K., & Rath, G. (2017) · Journal of drug targeting · doi:10.1080/1061186x.2017.1400553 · Cited by 345
Towards clinically translatable in vivo nanodiagnostics
Park, S.-M., Aalipour, A., Vermesh, O., Yu, J. H., & Gambhir, S. S. (2017) · Nature Reviews Materials · doi:10.1038/natrevmats.2017.14 · Cited by 330
Self-citation
Carbon-based SERS biosensor: from substrate design to sensing and bioapplication
Liang, X. H., Li, N., Zhang, R., Yin, P., Zhang, C., Yang, N., Liang, K., & Kong, B. (2021) · NPG Asia Materials · doi:10.1038/s41427-020-00278-5 · Cited by 307
Surface-enhanced resonance Raman scattering nanostars for high-precision cancer imaging
Harmsen, S., Huang, R., Wall, M. A., Karabeber, H., Samii, J. M., Spaliviero, M., White, J. R., Monette, S., O’Connor, R., Pitter, K. L., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.3010633 · Cited by 296
Pharmacokinetics of metallic nanoparticles
Lin, Z., Monteiro-Riviere, N. A., & Riviere, J. E. (2014) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1304 · Cited by 260
A Raman-based endoscopic strategy for multiplexed molecular imaging
Zavaleta, C. L., Garai, E., Liu, J. T. C., Sensarn, S., Mandella, M. J., Van de Sompel, D., Friedland, S., Van Dam, J., Contag, C. H., & Gambhir, S. S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1211309110 · Cited by 238
Self-citation
Surface-Enhanced Raman Spectroscopy Biosensing:In VivoDiagnostics and Multimodal Imaging
Henry, A.-I., Sharma, B., Cardinal, M. F., Kurouski, D., & Duyne, R. P. V. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b01597 · Cited by 224
Guiding Brain Tumor Resection Using Surface-Enhanced Raman Scattering Nanoparticles and a Hand-Held Raman Scanner
Karabeber, H., Huang, R., Iacono, P., Samii, J. M., Pitter, K. L., Holland, E. C., & Kircher, M. F. (2014) · ACS Nano · doi:10.1021/nn503948b · Cited by 212
Stability and biocompatibility of a library of polyester dendrimers in comparison to polyamidoamine dendrimers
Feliu, N., Walter, M. V., Montañez, M. I., Kunzmann, A., Hult, A., Nyström, A. M., Malkoch, M., & Fadeel, B. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.11.054 · Cited by 174
Construction and Validation of Nano Gold Tripods for Molecular Imaging of Living Subjects
Cheng, K., Kothapalli, S., Liu, H., Koh, A. L., Jokerst, J. V., Jiang, H., Yang, M., Li, J., Levi, J., Wu, J. C., et al. (2014) · Journal of the American Chemical Society · doi:10.1021/ja412001e · Cited by 173
Self-citation
Surface Chemistry of Gold Nanoparticles Mediates Their Exocytosis in Macrophages
Oh, N., & Park, J. (2014) · ACS Nano · doi:10.1021/nn501668a · Cited by 172
Imaging of Liver Tumors Using Surface-Enhanced Raman Scattering Nanoparticles
Andreou, C., Neuschmelting, V., Tschaharganeh, D. F., Huang, C., Oseledchyk, A., Iacono, P., Karabeber, H., Colen, R. R., Mannelli, L., Lowe, S. W., et al. (2016) · ACS Nano · doi:10.1021/acsnano.5b07200 · Cited by 170
In vivo magnetic resonance imaging of hyperpolarized silicon particles
Cassidy, M. C., Chan, H. R., Ross, B. D., Bhattacharya, P. K., & Marcus, C. M. (2013) · Nature Nanotechnology · doi:10.1038/nnano.2013.65 · Cited by 163
Differential cytotoxic effects of gold nanoparticles in different mammalian cell lines
Chueh, P. J., Liang, R., Lee, Y.-H., Zeng, Z.-M., & Chuang, S. (2013) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2013.11.031 · Cited by 162
Gold nanoparticles as computerized tomography (CT) contrast agents
Xi, D., Dong, S., Meng, X., Lu, Q., Meng, L., & Ye, J. (2012) · RSC Advances · doi:10.1039/c2ra21263c · Cited by 163
Role of Nanoparticle Surface Functionality in the Disruption of Model Cell Membranes
Moghadam, B. Y., Hou, W.-C., Corredor, C., Westerhoff, P. K., & Posner, J. D. (2012) · Langmuir · doi:10.1021/la302654s · Cited by 154
Nanoparticle Mediated Tumor Vascular Disruption: A Novel Strategy in Radiation Therapy
Kunjachan, S., Detappe, A., Kumar, R., Ireland, T. J., Cameron, L., Biancur, D. E., Motto‐Ros, V., Sancey, L., Sridhar, S., Makrigiorgos, G. M., et al. (2015) · Nano Letters · doi:10.1021/acs.nanolett.5b03073 · Cited by 153
Retracted
Cancer imaging using surface-enhanced resonance Raman scattering nanoparticles
Harmsen, S., Wall, M. A., Huang, R., & Kircher, M. F. (2017) · Nature Protocols · doi:10.1038/nprot.2017.031 · Cited by 144
Folate-Targeted Surface-Enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detection of Microscopic Ovarian Cancer
Oseledchyk, A., Andreou, C., Wall, M. A., & Kircher, M. F. (2016) · ACS Nano · doi:10.1021/acsnano.6b06796 · Cited by 144
Rational design of a chalcogenopyrylium-based surface-enhanced resonance Raman scattering nanoprobe with attomolar sensitivity
Harmsen, S., Bedics, M. A., Wall, M. A., Huang, R., Detty, M. R., & Kircher, M. F. (2015) · Nature Communications · doi:10.1038/ncomms7570 · Cited by 137
Synergistically Enhancing the Therapeutic Effect of Radiation Therapy with Radiation Activatable and Reactive Oxygen Species-Releasing Nanostructures
Cheng, K., Sano, M. B., Jenkins, C. H., Zhang, G., Vernekohl, D., Zhao, W., Wei, C., Zhang, Y., Zhang, Z., Liu, Y., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b02038 · Cited by 137
A small animal Raman instrument for rapid, wide-area, spectroscopic imaging
Bohndiek, S. E., Wagadarikar, A., Zavaleta, C. L., Van de Sompel, D., Garai, E., Jokerst, J. V., Yazdanfar, S., & Gambhir, S. S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301379110 · Cited by 133
Self-citation
Multiplexed imaging in oncology
Andreou, C., Weissleder, R., & Kircher, M. F. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-022-00891-5 · Cited by 132
A Novel Clinically Translatable Fluorescent Nanoparticle for Targeted Molecular Imaging of Tumors in Living Subjects
Gao, J., Chen, K., Luong, R. H., Bouley, D. M., Mao, H., Qiao, T., Gambhir, S. S., & Cheng, Z. (2011) · Nano Letters · doi:10.1021/nl203526f · Cited by 125
Self-citation
Silica Nanoparticles as Substrates for Chelator-free Labeling of Oxophilic Radioisotopes
Shaffer, T. M., Wall, M. A., Harmsen, S., Longo, V. A., Drain, C. M., Kircher, M. F., & Grimm, J. (2015) · Nano Letters · doi:10.1021/nl503522y · Cited by 121
Surface-Enhanced Raman Scattering Nanoparticles for Multiplexed Imaging of Bladder Cancer Tissue Permeability and Molecular Phenotype
Davis, R. M., Kiss, B. M., Trivedi, D. R., Metzner, T. J., Liao, J. C., & Gambhir, S. S. (2018) · ACS Nano · doi:10.1021/acsnano.8b03217 · Cited by 119
Self-citation
Overcoming the stability, toxicity, and biodegradation challenges of tumor stimuli-responsive inorganic nanoparticles for delivery of cancer therapeutics
Paris, J. L., Baeza, A., & Vallet‐Regí, M. (2019) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2019.1662786 · Cited by 121
Effect of silica and gold nanoparticles on macrophage proliferation, activation markers, cytokine production, and phagocytosis in vitro
Tyner, K. M., Bancos, S., & Stevens, D. L. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s72580 · Cited by 114
MUC1 Aptamer Targeted SERS Nanoprobes
Pal, S., Harmsen, S., Oseledchyk, A., Hsu, H., & Kircher, M. F. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201606632 · Cited by 113
DNA-enabled rational design of fluorescence-Raman bimodal nanoprobes for cancer imaging and therapy
Pal, S., Ray, A., Andreou, C., Zhou, Y., Rakshit, T., Wlodarczyk, M., Maeda, M., Toledo‐Crow, R., Berisha, N., Jiang, Y., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09173-2 · Cited by 112
High Precision Imaging of Microscopic Spread of Glioblastoma with a Targeted Ultrasensitive SERRS Molecular Imaging Probe
Huang, R., Harmsen, S., Samii, J. M., Karabeber, H., Pitter, K. L., Holland, E. C., & Kircher, M. F. (2016) · Theranostics · doi:10.7150/thno.13842 · Cited by 111
In vivo multiplexed molecular imaging of esophageal cancer via spectral endoscopy of topically applied SERS nanoparticles
Wang, Y. W., Kang, S., Khan, A., Bao, P. Q., & Liu, J. T. C. (2015) · Biomedical Optics Express · doi:10.1364/boe.6.003714 · Cited by 110
Dual‐Modality Surface‐Enhanced Resonance Raman Scattering and Multispectral Optoacoustic Tomography Nanoparticle Approach for Brain Tumor Delineation
Neuschmelting, V., Harmsen, S., Bézière, N., Lockau, H., Hsu, H., Huang, R., Razansky, D., Ntziachristos, V., & Kircher, M. F. (2018) · Small · doi:10.1002/smll.201800740 · Cited by 103
Molecular imaging of inflammation - Current and emerging technologies for diagnosis and treatment
MacRitchie, N. A., Frleta‐Gilchrist, M., Sugiyama, A., Lawton, T., McInnes, I. B., & Maffia, P. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107550 · Cited by 106
Surface-Enhanced Raman Spectroscopy: A New Modality for Cancer Imaging
Andreou, C., Kishore, S. A., & Kircher, M. F. (2015) · Journal of Nuclear Medicine · doi:10.2967/jnumed.115.158196 · Cited by 96
Nanomaterials in complex biological systems: insights from Raman spectroscopy
Drescher, D., & Kneipp, J. (2012) · Chemical Society Reviews · doi:10.1039/c2cs35127g · Cited by 93
Gold-core silica shell nanoparticles application in imaging and therapy: A review
Moreira, A. F., Rodrigues, C. F., Reis, C. A., Costa, E. C., & Correia, I. J. (2018) · Microporous and Mesoporous Materials · doi:10.1016/j.micromeso.2018.05.022 · Cited by 91
Gold Nanoparticles for Brain Tumor Imaging: A Systematic Review
Meola, A., Rao, J., Chaudhary, N., Sharma, M., & Chang, S. D. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00328 · Cited by 89
Emerging Intraoperative Imaging Modalities to Improve Surgical Precision
Alam, I. S., Steinberg, I., Vermesh, O., van den Berg, N. S., Rosenthal, E. L., van Dam, G. M., Ntziachristos, V., Gambhir, S. S., Hernot, S., & Rogalla, S. (2018) · Molecular Imaging and Biology · doi:10.1007/s11307-018-1227-6 · Cited by 97
Self-citation
Raman's “Effect” on Molecular Imaging
Zavaleta, C. L., Kircher, M. F., & Gambhir, S. S. (2011) · Journal of Nuclear Medicine · doi:10.2967/jnumed.111.087775 · Cited by 88
Self-citation
Expanding the Multiplexing Capabilities of Raman Imaging to Reveal Highly Specific Molecular Expression and Enable Spatial Profiling
Eremina, O. E., Czaja, A. T., Fernando, A., Aron, A., Eremin, D. B., & Zavaleta, C. (2022) · ACS Nano · doi:10.1021/acsnano.2c00353 · Cited by 88
Self-citation
Multiplexed Optical Imaging of Tumor-Directed Nanoparticles: A Review of Imaging Systems and Approaches
Wang, Y., Reder, N. P., Kang, S., Glaser, A. K., & Liu, J. T. C. (2017) · Nanotheranostics · doi:10.7150/ntno.21136 · Cited by 93
Emergence of two near-infrared windows for in vivo and intraoperative SERS
Lane, L. A., Xue, R., & Nie, S. (2018) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2018.03.015 · Cited by 88
Biomedical applications of gold nanomaterials: opportunities and challenges
Sasidharan, A., & Monteiro-Riviere, N. A. (2015) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1341 · Cited by 83
Luminescent Silica Nanoparticles for Cancer Diagnosis
Arap, W., Pasqualini, R., Montalti, M., Petrizza, L., Prodi, L., Rampazzo, E., Zaccheroni, N., & Marchiò, S. (2013) · Current Medicinal Chemistry · doi:10.2174/0929867311320170005 · Cited by 77
Gold nanoparticles for cleaning contaminated water
Qian, H., Pretzer, L. A., Velázquez, J. C., Zhao, Z., & Wong, M. S. (2013) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.4030 · Cited by 76
Effects of Naked Gold Nanoparticles on Proinflammatory Cytokines mRNA Expression in Rat Liver and Kidney
Khan, H. A., Abdelhalim, M. A. K., Alhomida, A. S., & Al-Ayed, M. S. (2013) · BioMed Research International · doi:10.1155/2013/590730 · Cited by 76
Rapid ratiometric biomarker detection with topically applied SERS nanoparticles
Wang, Y. "., Khan, A., Som, M., Wang, D., Chen, Y., Leigh, S. Y., Meza, D., McVeigh, P. Z., Wilson, B. C., & Liu, J. T. C. (2014) · TECHNOLOGY · doi:10.1142/s2339547814500125 · Cited by 74
Image‐guided tumor surgery: The emerging role of nanotechnology
Wojtynek, N. E., & Mohs, A. M. (2020) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1624 · Cited by 76
High-sensitivity, real-time, ratiometric imaging of surface-enhanced Raman scattering nanoparticles with a clinically translatable Raman endoscope device
Garai, E., Sensarn, S., Zavaleta, C. L., Sompel, D. V. D., Loewke, N. O., Mandella, M. J., Gambhir, S. S., & Contag, C. H. (2013) · Journal of Biomedical Optics · doi:10.1117/1.jbo.18.9.096008 · Cited by 68
Self-citation
Porphyrin–Lipid Stabilized Gold Nanoparticles for Surface Enhanced Raman Scattering Based Imaging
Tam, N. C. M., McVeigh, P. Z., MacDonald, T. D., Farhadi, A., Wilson, B. C., & Zheng, G. (2012) · Bioconjugate Chemistry · doi:10.1021/bc300214z · Cited by 69
Noninvasive and Highly Multiplexed Five-Color Tumor Imaging of Multicore Near-Infrared Resonant Surface-Enhanced Raman Nanoparticles In Vivo
Yu, J. H., Steinberg, I., Davis, R. M., Malkovskiy, A. V., Zlitni, A., Radzyminski, R. K., Jung, K. O., Chung, D. T., Curet, L. D., D’Souza, A. L., et al. (2021) · ACS Nano · doi:10.1021/acsnano.1c07470 · Cited by 67
Self-citation
From Past to Present: Gold Nanoparticles (AuNPs) in Daily Life─Synthesis Mechanisms, Influencing Factors, Characterization, Toxicity, and Emerging Applications in Biomedicine, Nanoelectronics, and Materials Science
Sati, A., Mali, S. N., Samdani, N., Annadurai, S., Dongre, R., Satpute, N. N., Ranade, T. N., & Pratap, A. P. (2025) · ACS Omega · doi:10.1021/acsomega.5c03162 · Cited by 70
Probing the biological obstacles of nanomedicine with gold nanoparticles
Li, B., & Lane, L. A. (2018) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1542 · Cited by 68
Superparamagnetic iron oxide polyacrylic acid coated γ-Fe2O3 nanoparticles do not affect kidney function but cause acute effect on the cardiovascular function in healthy mice
Iversen, N., Frische, S., Thomsen, K. L., Laustsen, C., Pedersen, M., Hansen, P., Bie, P., Fresnais, J., Berret, J., Baatrup, E., et al. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.10.014 · Cited by 64
Surface-enhanced Raman spectroscopy (SERS) nanoprobes for ratiometric detection of cancer cells
Li, L., Liao, M., Chen, Y., Shan, B., & Li, M. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb02828a · Cited by 62
A Multifunctional Nanoplatform for Imaging, Radiotherapy, and the Prediction of Therapeutic Response
McQuade, C. N., Zaki, A. A., Desai, Y. B., Vido, M. J., Sakhuja, T., Cheng, Z., Hickey, R. J., Joh, D. Y., Park, S., Kao, G. D., et al. (2014) · Small · doi:10.1002/smll.201401927 · Cited by 65
Widefield quantitative multiplex surface enhanced Raman scattering imaging in vivo
McVeigh, P. Z., Mallia, R. J., Veilleux, I., & Wilson, B. C. (2013) · Journal of Biomedical Optics · doi:10.1117/1.jbo.18.4.046011 · Cited by 55
Advances in Surface Enhanced Raman Spectroscopy for in Vivo Imaging in Oncology
Kenry, K., Nicolson, F., Clark, L. M., Panikkanvalappil, S. R., Andreiuk, B., & Andreou, C. (2021) · Nanotheranostics · doi:10.7150/ntno.62970 · Cited by 54
Nanotechnology for water treatment: A green approach
Patanjali, P., Singh, R. K., Kumar, A., & Chaudhary, P. (2019) · Elsevier eBooks · doi:10.1016/b978-0-08-102579-6.00021-6 · Cited by 58
Raman Spectroscopy in Prostate Cancer: Techniques, Applications and Advancements
Gaba, F., Tipping, W. J., Salji, M. J., Faulds, K., Graham, D., & Leung, H. Y. (2022) · Cancers · doi:10.3390/cancers14061535 · Cited by 56
Tissue factor-specific ultra-bright SERRS nanostars for Raman detection of pulmonary micrometastases
Nayak, T. R., Andreou, C., Oseledchyk, A., Marcus, W. D., Wong, H. C., Massagué, J., & Kircher, M. F. (2016) · Nanoscale · doi:10.1039/c6nr08217c · Cited by 49
Hybrid anisotropic nanostructures for dual-modal cancer imaging and image-guided chemo-thermo therapies
Zhang, R., Cheng, K., Antaris, A. L., Ma, X., Yang, M., Ramakrishnan, S., Liu, G., Lu, A., Dai, H., Tian, M., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.06.063 · Cited by 48
Comprehensive spectral endoscopy of topically applied SERS nanoparticles in the rat esophagus
Wang, Y., Khan, A., Leigh, S. Y., Wang, D., Chen, Y., Meza, D., & Liu, J. T. C. (2014) · Biomedical Optics Express · doi:10.1364/boe.5.002883 · Cited by 46
Artificial Scaffold PolypeptidesAs an Efficient Tool for the Targeted Delivery of Nanostructures In Vitro and In Vivo
Shipunova, V. O., & Deyev, S. M. (2022) · Acta Naturae · doi:10.32607/actanaturae.11545 · Cited by 46
Highly Excretable Gold Supraclusters for Translatable In Vivo Raman Imaging of Tumors
Yu, J. H., Jeong, M. S., Cruz, E. O., Alam, I. S., Tumbale, S. K., Zlitni, A., Lee, S. Y., Park, Y. I., Ferrara, K. W., Kwon, S., et al. (2023) · ACS Nano · doi:10.1021/acsnano.2c10378 · Cited by 46
Self-citation
Ultrahigh affinity Raman probe for targeted live cell imaging of prostate cancer
Li, M., Banerjee, S. R., Zheng, C., Pomper, M. G., & Barman, I. (2016) · Chemical Science · doi:10.1039/c6sc01739h · Cited by 46
Surgical Guidance via Multiplexed Molecular Imaging of Fresh Tissues Labeled With SERS-Coded Nanoparticles
Wang, Y., Kang, S., Doerksen, J. D., Glaser, A. K., & Liu, J. T. C. (2015) · IEEE Journal of Selected Topics in Quantum Electronics · doi:10.1109/jstqe.2015.2507358 · Cited by 41
Simultaneous Detection of EGFR and VEGF in Colorectal Cancer using Fluorescence-Raman Endoscopy
Kim, Y.-I., Jeong, S., Jung, K. O., Song, M. G., Lee, C., Chung, S., Park, J. Y., Cha, M. G., Lee, S. G., Jun, B., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-01020-y · Cited by 42
Multimodal assessment of SERS nanoparticle biodistribution post ingestion reveals new potential for clinical translation of Raman imaging
Campbell, J. L., SoRelle, E. D., Ilovich, O., Liba, O., James, M. L., Qiu, Z., Perez, V., Chan, C. T., de la Zerda, A., & Zavaleta, C. L. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.04.045 · Cited by 42
Self-citation
Lipid vesicles containing transferrin receptor binding peptide TfR-T12 and octa-arginine conjugate stearyl-R8 efficiently treat brain glioma along with glioma stem cells
Mu, L.-M., Bu, Y.-Z., Liu, L., Xie, H., Ju, R.-J., Wu, J.-S., Zeng, F., Zhao, Y. L., Zhang, J., & Lü, W.-L. (2017) · Scientific Reports · doi:10.1038/s41598-017-03805-7 · Cited by 41
Colorectal distribution and retention of polymeric nanoparticles following incorporation into a thermosensitive enema
Melo, M., Nunes, R., Sarmento, B. F. C. C., & das Neves, J. (2019) · Biomaterials Science · doi:10.1039/c9bm00759h · Cited by 40
Achieving ultrasensitive in vivo detection of bone crack with polydopamine-capsulated surface-enhanced Raman nanoparticle
Jiang, C., Wang, Y., Wang, J., Song, W., & Lu, L. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.11.007 · Cited by 40
Development of poly-2-ethyl-2-oxazoline Coated gold-core Silica Shell Nanorods for Cancer chemo-photothermal Therapy
Moreira, A. F., Rodrigues, C. F., Reis, C. A., Costa, E. C., Ferreira, P. C. N., & Correia, I. J. (2018) · Nanomedicine · doi:10.2217/nnm-2018-0179 · Cited by 39
Detection of Lymph Node Metastases with SERRS Nanoparticles
Spaliviero, M., Harmsen, S., Huang, R., Wall, M. A., Andreou, C., Eastham, J. A., Touijer, K. A., Scardino, P. T., & Kircher, M. F. (2016) · Molecular Imaging and Biology · doi:10.1007/s11307-016-0932-2 · Cited by 38
Rectal administration of nanosystems: from drug delivery to diagnostics
Melo, M., Nunes, R., Sarmento, B. F. C. C., & das Neves, J. (2018) · Materials Today Chemistry · doi:10.1016/j.mtchem.2018.09.001 · Cited by 38
Targeted SERS Imaging and Intraoperative Real‐Time Elimination of Microscopic Tumors for Improved Breast‐Conserving Surgery
Wen, Y., Liu, R., Xie, Y., & Li, M. (2024) · Advanced Materials · doi:10.1002/adma.202405253 · Cited by 36
Raman Nanotags‐Guided Intraoperative Sentinel Lymph Nodes Precise Location with Minimal Invasion
Deng, B., Wang, Y., Wu, Y., Yin, W., Lu, J., & Ye, J. (2021) · Advanced Science · doi:10.1002/advs.202102405 · Cited by 32
A correlative optical microscopy and scanning electron microscopy approach to locating nanoparticles in brain tumors
Kempen, P. J., Kircher, M. F., de la Zerda, A., Zavaleta, C. L., Jokerst, J. V., Mellinghoff, I. K., Gambhir, S. S., & Sinclair, R. (2014) · Micron · doi:10.1016/j.micron.2014.09.004 · Cited by 32
Self-citation
Synthesis and characterization of graphite-encapsulated iron nanoparticles from ball milling-assisted low-pressure chemical vapor deposition
Ağaoğulları, D., Madsen, S. J., Ögüt, B., Koh, A. L., & Sinclair, R. (2017) · Carbon · doi:10.1016/j.carbon.2017.08.043 · Cited by 31
Self-citation
A Scanning Transmission Electron Microscopy Approach to Analyzing Large Volumes of Tissue to Detect Nanoparticles
Kempen, P. J., Thakor, A. S., Zavaleta, C. L., Gambhir, S. S., & Sinclair, R. (2013) · Microscopy and Microanalysis · doi:10.1017/s143192761300192x · Cited by 29
Self-citation
Delineating the tumor margin with intraoperative surface-enhanced Raman spectroscopy
Jiang, C., Wang, Y., Song, W., & Lu, L. (2019) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-019-01577-9 · Cited by 29
Theranostic Nanoparticles Carrying Doxorubicin Attenuate Targeting Ligand Specific Antibody Responses Following Systemic Delivery
Yang, E., Qian, W., Cao, Z., Wang, L., Bozeman, E. N., Ward, C., Yang, B., Selvaraj, P., Lipowska, M., Wang, Y. A., et al. (2014) · Theranostics · doi:10.7150/thno.10350 · Cited by 29
Gold nanoparticles for cancer theranostics — A brief update
Zhao, N., Pan, Y., Cheng, Z., & Liu, H. (2016) · Journal of Innovative Optical Health Sciences · doi:10.1142/s1793545816300044 · Cited by 28
Applications of Green Synthesized Nanomaterials in Water Remediation
Singh, N. B., Susan, M. A. B. H., & Guin, M. (2020) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201021666201027160029 · Cited by 24
Boosting the Brightness of Thiolated Surface-Enhanced Raman Scattering Nanoprobes by Maximal Utilization of the Three-Dimensional Volume of Electromagnetic Fields
Li, J., Liu, F., & Ye, J. (2022) · The Journal of Physical Chemistry Letters · doi:10.1021/acs.jpclett.2c01741 · Cited by 24
Differentiation of MCF-7 tumor cells from leukocytes and fibroblast cells using epithelial cell adhesion molecule targeted multicore surface-enhanced Raman spectroscopy labels
Freitag, I., Matthäus, C., Csáki, A., Clement, J. H., Cialla‐May, D., Weber, K., Krafft, C., & Popp, J. (2015) · Journal of Biomedical Optics · doi:10.1117/1.jbo.20.5.055002 · Cited by 23
RETRACTED ARTICLE: Selective Priming of Tumor Blood Vessels by Radiation Therapy Enhances Nanodrug Delivery
Kunjachan, S., Kotb, S., Pola, R., Pechar, M., Kumar, R., Singh, B., Gremse, F., Taleeli, R., Trichard, F., Motto‐Ros, V., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-50538-w · Cited by 23
Retracted
Role of Nanodiagnostics in Personalized Cancer Therapy
Jain, K. K. (2011) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2011.10.001 · Cited by 21
Biomimetic gold nanocomplexes for gene knockdown: Will gold deliver dividends for small interfering RNA nanomedicines?
Guo, J., Rahme, K., Fitzgerald, K. A., Holmes, J. D., & O’Driscoll, C. M. (2015) · Nano Research · doi:10.1007/s12274-015-0829-4 · Cited by 21
One-step, low-temperature fabrication of CdS quantum dots by watermelon rind: a green approach
Pasha, S. K. K., Lakshmipathy, R., Sarada, N. C., & Chidambaram, K. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s79988 · Cited by 20

Authors: Thakor, A. S., Luong, R., Paulmurugan, R., Lin, F. I., Kempen, P., Zavaleta, C., Chu, P., Massoud, T. F., Sinclair, R., & Gambhir, S. S.
Affiliations: University of Cambridge (GB)
Stanford University (US)
Stanford Medicine (US)
Corresponding author: Gambhir, Sanjiv S.
ORCID: Thakor, Avnesh S.
Paulmurugan, Ramasamy
Lin, Frank I.
Kempen, Paul
Zavaleta, Cristina
Chu, Pauline
Massoud, Tarik F.
Sinclair, Robert
Gambhir, Sanjiv S.
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2011-04-20
Volume: 3
Issue: 79
Pages: 79ra33-79ra33
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.3001963
PMC: PMC3873137
OpenAlex: W2099459454
Semantic Scholar: 8fd9649353de84ba2ee80b82b8ae3b10c09fc076
Cited by: 159
References: 35
Citations by year: 2026: 3 · 2025: 7 · 2024: 5 · 2023: 2 · 2022: 11 · 2021: 12 · 2020: 8 · 2019: 11 · 2018: 14 · 2017: 13 · 2016: 10 · 2015: 15 · 2014: 13 · 2013: 15 · 2012: 13
FWCI: 6.13
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science Translational Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (U54CA119367, P50CA114747, U54CA151459)
Topics: Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
Keywords: surface-enhanced Raman scattering, PEGylated nanoparticles, acute toxicity, tissue distribution, reticuloendothelial system, macrophage clearance, oxidative stress, liver inflammation, rectal administration, colorectal cancer detection, affibody
MeSH terms: Animals, Female, Gold, Male, Polyethylene Glycols, Silicon Dioxide, Spectrum Analysis, Raman, Mice, Metal Nanoparticles

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Fate and Toxicity of Raman-Active Silica-Gold Nanoparticles in Mice

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks