Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells
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Four different T cell populations with different functions and migration patterns protect human skin.
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Both CD8+ and CD4+ Trm have been identified in human skin, lung, intestines, salivary glands, bone marrow, brain, spleen, tonsils, and lymph nodes.
“Both CD8+ and CD4+ Trm have been identified in the human skin, lung, intestines, salivary glands, bone marrow, brain, spleen, tonsils, and lymph nodes [241, 244, 246, 253-259].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [255]
The Results section identifies both CD4+ and CD8+ resident memory T cells in human skin. The cited paper does not establish their presence in the other listed human tissues, so it supports the skin portion of the sentence but not the full list. (LLM, conf=0.86)
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- Authors
- Watanabe, R., Gehad, A., Yang, C., Scott, L. L., Teague, J. E., Schlapbach, C., Elco, C. P., Huang, V., Matos, T. R., Kupper, T. S., & Clark, R. A.
- Affiliations
- Brigham and Women's Hospital (US)
- University of Bern (CH)
- Corresponding author
- Clark, Rachael A.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2015-03-18
- Volume
- 7
- Issue
- 279
- Pages
- 279ra39-279ra39
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC4425193
- OpenAlex
- W2166321278
- Cited by
- 569
- References
- 34
- Citations by year
- 2026: 23 · 2025: 44 · 2024: 40 · 2023: 43 · 2022: 58 · 2021: 84 · 2020: 58 · 2019: 56 · 2018: 52 · 2017: 54 · 2016: 37 · 2015: 18 · 2014: 1 · 2013: 1
- FWCI
- 26.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- BORIS (University Library Bern) (submittedVersion, other-oa)
- Pure Amsterdam UMC (submittedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion)
- Open Access CRIS of the University of Bern
- Funders
- National Institute of Allergy and Infectious Diseases (R01 AI097128)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (R01 AR063962)
- NIAMS (R01 AR056720)
- Damon Runyon Clinical Investigator Award
- Leukemia and Lymphoma Society
- Swiss National Science Foundation
- NIH/National Cancer Institute (P50 CA9368305)
- Fondation Rene Touraine
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- skin-resident memory T cells, central memory T cells, alemtuzumab, CD103, CD69, CCR7, L-selectin, cutaneous T-cell lymphoma, T cell migration, T cell effector function, human skin
- MeSH terms
- Alemtuzumab, CD69 Antigens, Animals, Antigens, Differentiation, T-Lymphocyte, Flow Cytometry, Humans, Interleukin-2, Phenotype, Skin, T-Lymphocytes, CD4-Positive T-Lymphocytes, Keratinocytes, Antigens, CD, Mice, SCID, Mice, Inbred NOD, CD8-Positive T-Lymphocytes, Lectins, C-Type, Integrin alpha Chains, Mice, Antibodies, Monoclonal, Humanized
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