The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Food-Grade Bacteria Expressing Elafin Protect Against Inflammation and Restore Colon Homeostasis
Abstract
Lactic acid–producing bacteria engineered to produce the antiprotease Elafin restore colon homeostasis in mice with colitis and protect human tissue from inflammation.
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In the citing paper
“In both CD and UC patients, increased host serine protease production from colonic tissue have been reported.27,28”
From The emerging roles of bacterial proteases in intestinal diseases (2023) · cites this paper as [27]
In the citing paper
“Consistent with a role of proteolytic overactivity in disease pathogenesis, inhibitors of serine proteases have beneficial effects in mouse models of IBD.27,30”
From The emerging roles of bacterial proteases in intestinal diseases (2023) · cites this paper as [27]
In the citing paper
“Elafin, a Lactobacillus-derived inhibitor of serine proteases reduced the severity of colitis in mice exposed to dextran sulfate sodium (DSS) or trinitro benzene sulphonic acid.27,30,31”
From The emerging roles of bacterial proteases in intestinal diseases (2023) · cites this paper as [27]
Citations
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“Indeed, elevated proteolytic activity has been detected in intestinal tissues from CD and UC patients (5, 6).”
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“The presence of Elafin-expressing LAB in the colon lumen might also modify the composition of the gut microbiota, which is associated with the development of colitis in the DSS mouse model (24).”
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Metadata
- Authors
- Motta, J.-P., Bermúdez-Humarán, L. G., Deraison, C., Martin, L., Rolland, C., Rousset, P., Boue, J., Dietrich, G., Chapman, K., Kharrat, P., Vinel, J.-P., Alric, L., Mas, E., Sallenave, J.-M., Langella, P., & Vergnolle, N.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Institut National de la Recherche Agronomique (INRA), UMR 1319 Micalis, Commensal and Probiotics-Host Interactions Laboratory, Domaine de Vilvert, 78352 Jouy-en-Josas Cedex, France.
- INSERM, U1043, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse F-31300, France.
- University of Calgary (CA)
- Microbiologie de l’alimentation au service de la santé (FR)
- Université Toulouse III - Paul Sabatier (FR)
- Inserm (FR)
- Corresponding author
- Motta, Jean-Paul
- Langella, Philippe
- Vergnolle, Nathalie
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2012-10-31
- Volume
- 4
- Issue
- 158
- Pages
- 158ra144-158ra144
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W2128549250
- Cited by
- 257
- References
- 33
- Citations by year
- 2026: 10 · 2025: 19 · 2024: 17 · 2023: 19 · 2022: 21 · 2021: 22 · 2020: 23 · 2019: 19 · 2018: 18 · 2017: 21 · 2016: 18 · 2015: 17 · 2014: 19 · 2013: 12 · 2012: 2
- FWCI
- 24.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Bacterial Cancer Therapy
- Keywords
- elafin, lactic acid bacteria, inflammatory bowel disease, colitis, anti-inflammatory therapy, intestinal mucosa, intestinal permeability, cytokines and chemokines, oral drug delivery, food-grade bacteria, intestinal homeostasis, protease inhibitors
- MeSH terms
- Animals, Bacteria, Colon, Humans, Inflammation, Intestinal Mucosa, Inflammatory Bowel Diseases, Mice, Elafin, In Vitro Techniques
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