The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Food-Grade Bacteria Expressing Elafin Protect Against Inflammation and Restore Colon Homeostasis
Abstract
Lactic acid–producing bacteria engineered to produce the antiprotease Elafin restore colon homeostasis in mice with colitis and protect human tissue from inflammation.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In both CD and UC patients, increased host serine protease production from colonic tissue have been reported.27,28”
From The emerging roles of bacterial proteases in intestinal diseases (2023) · cites this paper as [27]
In the citing paper
“Consistent with a role of proteolytic overactivity in disease pathogenesis, inhibitors of serine proteases have beneficial effects in mouse models of IBD.27,30”
From The emerging roles of bacterial proteases in intestinal diseases (2023) · cites this paper as [27]
In the citing paper
“Elafin, a Lactobacillus-derived inhibitor of serine proteases reduced the severity of colitis in mice exposed to dextran sulfate sodium (DSS) or trinitro benzene sulphonic acid.27,30,31”
From The emerging roles of bacterial proteases in intestinal diseases (2023) · cites this paper as [27]
Citations
Cites
Treatment of Murine Colitis by Lactococcus lactis Secreting Interleukin-10
Steidler, L., Hans, W., Schotte, L., Neirynck, S., Obermeier, F., Falk, W., Fiers, W., & Remaut, E. (2000) · Science · doi:10.1126/science.289.5483.1352 · Cited by 1,513
A Phase I Trial With Transgenic Bacteria Expressing Interleukin-10 in Crohn’s Disease
Braat, H., Rottiers, P., Hommes, D. W., Huyghebaert, N., Remaut, E., Remon, J., van Deventer, S. J. H., Neirynck, S., Peppelenbosch, M. P., & Steidler, L. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.03.028 · Cited by 786
Powrie, F., Correa-Oliveira, R., Mauze, S., & Coffman, R. L. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.2.589 · Cited by 613
Role for protease activity in visceral pain in irritable bowel syndrome
Cenac, N., Andrews, C. N., Holzhausen, M., Chapman, K., Cottrell, G., Andrade-Gordon, P., Steinhoff, M., Barbara, G., Beck, P., Bunnett, N. W., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29255 · Cited by 591 · cited 1×
“Indeed, elevated proteolytic activity has been detected in intestinal tissues from CD and UC patients (5, 6).”
BackgroundSelf-citationSteidler, L., Neirynck, S., Huyghebaert, N., Snoeck, V., Vermeire, A., Goddeeris, B. M., Cox, E., Remon, J. P., & Remaut, E. (2003) · Nature Biotechnology · doi:10.1038/nbt840 · Cited by 545
Wiedow, O., Schröder, J. M., Gregory, H., Young, J. A., & Christophers, E. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77182-2 · Cited by 433
Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2.
Cénac, N., Coelho, A., Nguyen, C., Compton, S., Andrade-Gordon, P., MacNaughton, W., Wallace, J., Hollenberg, M., Bunnett, N., Garcia-Villar, R., et al. (2002) · American Journal of Pathology · doi:10.1016/s0002-9440(10)64466-5 · Cited by 386
Self-citationRole of the microbiota in inflammatory bowel diseases
Nagalingam, N. A., & Lynch, S. V. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21866 · Cited by 315 · cited 1×
“The presence of Elafin-expressing LAB in the colon lumen might also modify the composition of the gut microbiota, which is associated with the development of colitis in the DSS mouse model (24).”
BackgroundBermúdez‐Humarán, L. G., Cortes‐Perez, N. G., Lefèvre, F., Guimarães, V., Rabot, S., Alcocer-González, J. M., Gratadoux, J., Rodrı́guez-Padilla, C., Taméz-Guerra, R. S., Corthier, G., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.11.7297 · Cited by 191
Self-citationCLINICAL RELEVANCE OF PROTEINASE ACTIVATED RECEPTORS (PARS) IN THE GUT
Vergnolle, N. (2005) · Gut · doi:10.1136/gut.2004.048876 · Cited by 166
Self-citationHenriksen, P. A., Hitt, M., Xing, Z., Wang, J., Haslett, C., Riemersma, R. A., Webb, D. J., Kotelevtsev, Y. V., & Sallenave, J. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.7.4535 · Cited by 143
Self-citationSecretory Leukocyte Protease Inhibitor and Elafin/Trappin-2
Sallenave, J. (2010) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2010-0095rt · Cited by 136
Self-citationReview article: proteinase‐activated receptors — novel signals for gastrointestinal pathophysiology
Vergnolle, N. (2000) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2000.00690.x · Cited by 135
Self-citationWatterlot, L., Rochat, T., Sokol, H., Cherbuy, C., Bouloufa, I., Lefèvre, F., Gratadoux, J., Honvo‐Houeto, E., Chilmonczyk, S., Blugeon, S., et al. (2010) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2010.03.037 · Cited by 134
Self-citationBonnart, C., Deraison, C., Lacroix, M., Uchida, Y., Besson‐Fournier, C., Robin, A., Briot, A., Gonthier, M., Lamant, L., Dubus, P. R., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41440 · Cited by 133
Self-citationRochat, T., Bermúdez‐Humarán, L. G., Gratadoux, J., Fourage, C., Hoebler, C., Corthier, G., & Langella, P. (2007) · Microbial Cell Factories · doi:10.1186/1475-2859-6-22 · Cited by 132
Self-citationModifying the Protease, Antiprotease Pattern by Elafin Overexpression Protects Mice From Colitis
Motta, J., Magne, L., Descamps, D., Rolland, C., Squarzoni–Dale, C., Rousset, P., Martin, L., Cenac, N., Balloy, V., Huerre, M., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2010.12.050 · Cited by 130
Self-citationProtease-activated receptors as drug targets in inflammation and pain
Vergnolle, N. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.05.004 · Cited by 124
Self-citationSchmid, M., Fellermann, K., Fritz, P., Wiedow, O., Stange, E. F., & Wehkamp, J. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0906581 · Cited by 116
Grimoud, J., Durand, H., Souza, S. D. M. P., MONSAN, P. F., Ouarné, F., Théodorou, V., & Roques, C. G. (2010) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2010.09.007 · Cited by 114
Chin, A. C., Lee, W. Y., Nusrat, A., Vergnolle, N., & Parkos, C. A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.8.5702 · Cited by 106
Self-citationProtease-activated receptor-2 activation: a major actor in intestinal inflammation
Hyun, E., Andrade‐Gordon, P., Steinhoff, M. S., & Vergnolle, N. (2008) · Gut · doi:10.1136/gut.2008.150722 · Cited by 106
Self-citationSallenave, J., & RYLE, A. P. (1991) · Biological Chemistry Hoppe-Seyler · doi:10.1515/bchm3.1991.372.1.13 · Cited by 95
Self-citationRecombinant lactic acid bacteria as mucosal biotherapeutic agents
Daniel, C., Roussel, Y., Kleerebezem, M., & Pot, B. (2011) · Trends in biotechnology · doi:10.1016/j.tibtech.2011.05.002 · Cited by 93
Nieto, C., & Espinosa, M. (2003) · Plasmid · doi:10.1016/s0147-619x(03)00020-9 · Cited by 87
Butler, M. W., Robertson, I., Greene, C. M., O'Neill, S. J., Taggart, C. C., & McElvaney, N. G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604844200 · Cited by 83
Therapeutic potential of human elafin
Shaw, L., & Wiedow, O. (2011) · Biochemical Society Transactions · doi:10.1042/bst0391450 · Cited by 80
Guyot, N., Zani, M.-L., Maurel, M.-C., Dallet‐Choisy, S., & Moreau, T. (2005) · Biochemistry · doi:10.1021/bi051418i · Cited by 71
Therapeutic Drug Delivery by Genetically Modified Lactococcus lactis
Steidler, L., & Rottiers, P. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1326.031 · Cited by 59
Cénac, N., Cellars, L., Steinhoff, M. S., Andrade‐Gordon, P., Hollenberg, M. D., Wallace, J. L., Fiorucci, S., & Vergnolle, N. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000177506.71784.bd · Cited by 58
Self-citationSallenave, J., Xing, Z., Simpson, A. J., Graham, F., & Gauldie, J. (1998) · Gene Therapy · doi:10.1038/sj.gt.3300610 · Cited by 48
Self-citationChogle, A. S., Bu, H., Wang, X., Brown, J. B., Chou, P. M., & Tan, X. (2011) · Molecular Medicine · doi:10.2119/molmed.2010.00074 · Cited by 46
Pharmabiotic Manipulation of the Microbiota in Gastrointestinal Disorders, from Rationale to Reality
Shanahan, F., & Collins, S. M. (2010) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2010.08.006 · Cited by 41
Cited by
Sorted by citations
Next-generation probiotics: the spectrum from probiotics to live biotherapeutics
O’Toole, P. W., Marchesi, J. R., & Hill, C. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.57 · Cited by 971
Principles of genetic circuit design
Brophy, J. A. N., & Voigt, C. A. (2014) · Nature Methods · doi:10.1038/nmeth.2926 · Cited by 965
Cao, F., Jin, L., Gao, Y., Ding, Y., Wen, H., Qian, Z., Zhang, C., Hong, L., Huang, Y., Zhang, J., et al. (2023) · Nature Nanotechnology · doi:10.1038/s41565-023-01346-x · Cited by 491
Engineering bacteria for diagnostic and therapeutic applications
Riglar, D. T., & Silver, P. A. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.172 · Cited by 460
Yu, L. C. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0483-8 · Cited by 419
Metadata
- Authors
- Motta, J.-P., Bermúdez-Humarán, L. G., Deraison, C., Martin, L., Rolland, C., Rousset, P., Boue, J., Dietrich, G., Chapman, K., Kharrat, P., Vinel, J.-P., Alric, L., Mas, E., Sallenave, J.-M., Langella, P., & Vergnolle, N.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Institut National de la Recherche Agronomique (INRA), UMR 1319 Micalis, Commensal and Probiotics-Host Interactions Laboratory, Domaine de Vilvert, 78352 Jouy-en-Josas Cedex, France.
- INSERM, U1043, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse F-31300, France.
- University of Calgary (CA)
- Microbiologie de l’alimentation au service de la santé (FR)
- Université Toulouse III - Paul Sabatier (FR)
- Inserm (FR)
- Corresponding author
- Motta, Jean-Paul
- Langella, Philippe
- Vergnolle, Nathalie
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2012-10-31
- Volume
- 4
- Issue
- 158
- Pages
- 158ra144-158ra144
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W2128549250
- Cited by
- 257
- References
- 33
- Citations by year
- 2026: 10 · 2025: 19 · 2024: 17 · 2023: 19 · 2022: 21 · 2021: 22 · 2020: 23 · 2019: 19 · 2018: 18 · 2017: 21 · 2016: 18 · 2015: 17 · 2014: 19 · 2013: 12 · 2012: 2
- FWCI
- 24.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Bacterial Cancer Therapy
- Keywords
- elafin, lactic acid bacteria, inflammatory bowel disease, colitis, anti-inflammatory therapy, intestinal mucosa, intestinal permeability, cytokines and chemokines, oral drug delivery, food-grade bacteria, intestinal homeostasis, protease inhibitors
- MeSH terms
- Animals, Bacteria, Colon, Humans, Inflammation, Intestinal Mucosa, Inflammatory Bowel Diseases, Mice, Elafin, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
