The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Food-Grade Bacteria Expressing Elafin Protect Against Inflammation and Restore Colon Homeostasis
Abstract
Lactic acid–producing bacteria engineered to produce the antiprotease Elafin restore colon homeostasis in mice with colitis and protect human tissue from inflammation.
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Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In both CD and UC patients, increased host serine protease production from colonic tissue have been reported.27,28”
From The emerging roles of bacterial proteases in intestinal diseases (2023) · cites this paper as [27]
In the citing paper
“Consistent with a role of proteolytic overactivity in disease pathogenesis, inhibitors of serine proteases have beneficial effects in mouse models of IBD.27,30”
From The emerging roles of bacterial proteases in intestinal diseases (2023) · cites this paper as [27]
In the citing paper
“Elafin, a Lactobacillus-derived inhibitor of serine proteases reduced the severity of colitis in mice exposed to dextran sulfate sodium (DSS) or trinitro benzene sulphonic acid.27,30,31”
From The emerging roles of bacterial proteases in intestinal diseases (2023) · cites this paper as [27]
Citations
Cites
Treatment of Murine Colitis by Lactococcus lactis Secreting Interleukin-10
Steidler, L., Hans, W., Schotte, L., Neirynck, S., Obermeier, F., Falk, W., Fiers, W., & Remaut, E. (2000) · Science · doi:10.1126/science.289.5483.1352 · Cited by 1,513
A Phase I Trial With Transgenic Bacteria Expressing Interleukin-10 in Crohn’s Disease
Braat, H., Rottiers, P., Hommes, D. W., Huyghebaert, N., Remaut, E., Remon, J., van Deventer, S. J. H., Neirynck, S., Peppelenbosch, M. P., & Steidler, L. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.03.028 · Cited by 786
Powrie, F., Correa-Oliveira, R., Mauze, S., & Coffman, R. L. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.2.589 · Cited by 613
Role for protease activity in visceral pain in irritable bowel syndrome
Cenac, N., Andrews, C. N., Holzhausen, M., Chapman, K., Cottrell, G., Andrade-Gordon, P., Steinhoff, M., Barbara, G., Beck, P., Bunnett, N. W., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29255 · Cited by 591 · cited 1×
“Indeed, elevated proteolytic activity has been detected in intestinal tissues from CD and UC patients (5, 6).”
BackgroundSelf-citationSteidler, L., Neirynck, S., Huyghebaert, N., Snoeck, V., Vermeire, A., Goddeeris, B. M., Cox, E., Remon, J. P., & Remaut, E. (2003) · Nature Biotechnology · doi:10.1038/nbt840 · Cited by 545
Wiedow, O., Schröder, J. M., Gregory, H., Young, J. A., & Christophers, E. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77182-2 · Cited by 433
Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2.
Cénac, N., Coelho, A., Nguyen, C., Compton, S., Andrade-Gordon, P., MacNaughton, W., Wallace, J., Hollenberg, M., Bunnett, N., Garcia-Villar, R., et al. (2002) · American Journal of Pathology · doi:10.1016/s0002-9440(10)64466-5 · Cited by 386
Self-citationRole of the microbiota in inflammatory bowel diseases
Nagalingam, N. A., & Lynch, S. V. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21866 · Cited by 315 · cited 1×
“The presence of Elafin-expressing LAB in the colon lumen might also modify the composition of the gut microbiota, which is associated with the development of colitis in the DSS mouse model (24).”
BackgroundBermúdez‐Humarán, L. G., Cortes‐Perez, N. G., Lefèvre, F., Guimarães, V., Rabot, S., Alcocer-González, J. M., Gratadoux, J., Rodrı́guez-Padilla, C., Taméz-Guerra, R. S., Corthier, G., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.11.7297 · Cited by 191
Self-citationCLINICAL RELEVANCE OF PROTEINASE ACTIVATED RECEPTORS (PARS) IN THE GUT
Vergnolle, N. (2005) · Gut · doi:10.1136/gut.2004.048876 · Cited by 166
Self-citation
Cited by
Sorted by citations
Next-generation probiotics: the spectrum from probiotics to live biotherapeutics
O’Toole, P. W., Marchesi, J. R., & Hill, C. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.57 · Cited by 971
Principles of genetic circuit design
Brophy, J. A. N., & Voigt, C. A. (2014) · Nature Methods · doi:10.1038/nmeth.2926 · Cited by 965
Cao, F., Jin, L., Gao, Y., Ding, Y., Wen, H., Qian, Z., Zhang, C., Hong, L., Huang, Y., Zhang, J., et al. (2023) · Nature Nanotechnology · doi:10.1038/s41565-023-01346-x · Cited by 491
Engineering bacteria for diagnostic and therapeutic applications
Riglar, D. T., & Silver, P. A. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.172 · Cited by 460
Yu, L. C. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0483-8 · Cited by 419
Metadata
- Authors
- Motta, J.-P., Bermúdez-Humarán, L. G., Deraison, C., Martin, L., Rolland, C., Rousset, P., Boue, J., Dietrich, G., Chapman, K., Kharrat, P., Vinel, J.-P., Alric, L., Mas, E., Sallenave, J.-M., Langella, P., & Vergnolle, N.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Institut National de la Recherche Agronomique (INRA), UMR 1319 Micalis, Commensal and Probiotics-Host Interactions Laboratory, Domaine de Vilvert, 78352 Jouy-en-Josas Cedex, France.
- INSERM, U1043, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse F-31300, France.
- University of Calgary (CA)
- Microbiologie de l’alimentation au service de la santé (FR)
- Université Toulouse III - Paul Sabatier (FR)
- Inserm (FR)
- Corresponding author
- Motta, Jean-Paul
- Langella, Philippe
- Vergnolle, Nathalie
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2012-10-31
- Volume
- 4
- Issue
- 158
- Pages
- 158ra144-158ra144
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W2128549250
- Cited by
- 257
- References
- 33
- Citations by year
- 2026: 10 · 2025: 19 · 2024: 17 · 2023: 19 · 2022: 21 · 2021: 22 · 2020: 23 · 2019: 19 · 2018: 18 · 2017: 21 · 2016: 18 · 2015: 17 · 2014: 19 · 2013: 12 · 2012: 2
- FWCI
- 24.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Bacterial Cancer Therapy
- Keywords
- elafin, lactic acid bacteria, inflammatory bowel disease, colitis, anti-inflammatory therapy, intestinal mucosa, intestinal permeability, cytokines and chemokines, oral drug delivery, food-grade bacteria, intestinal homeostasis, protease inhibitors
- MeSH terms
- Animals, Bacteria, Colon, Humans, Inflammation, Intestinal Mucosa, Inflammatory Bowel Diseases, Mice, Elafin, In Vitro Techniques
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