Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer
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Detection of circulating tumor DNA in patients with resected stage II colon cancer provides evidence of residual disease.
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A growing body of evidence shows many clinical uses for ctDNA in adults with solid tumors, from prognostication and minimal residual disease evaluation to detection of targetable alterations.
“There is a growing body of data demonstrating numerous clinical applications for ctDNA in adults with solid tumors, ranging from prognostication and evaluation of minimal residual disease (MRD) to detection of targetable alterations.7–12”
From Clinical Liquid Biopsy Testing for Detection of Actionable Genomic Alterations in Children and Young Adults With Advanced Solid Tumors on the GAIN Study (2026) · cites this paper as [10]
A well-established relationship exists between ctDNA burden and disease status in adult solid tumors, as shown by ctDNA use for minimal residual disease detection and recurrence monitoring in colorectal cancers.
“A salient example of the well-established relationship between ctDNA burden and disease status in adult solid tumors is the use of ctDNA for MRD detection and monitoring for recurrence in colorectal cancers.10–12”
From Clinical Liquid Biopsy Testing for Detection of Actionable Genomic Alterations in Children and Young Adults With Advanced Solid Tumors on the GAIN Study (2026) · cites this paper as [10]
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- Authors
- Tie, J., Wang, Y., Tomasetti, C., Li, L., Springer, S., Kinde, I., Silliman, N., Tacey, M., Wong, H.-L., Christie, M., Kosmider, S., Skinner, I., Wong, R., Steel, M., Tran, B., Desai, J., Jones, I., Haydon, A., Hayes, T., Price, T. J., Strausberg, R. L., Diaz, L. A., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., & Gibbs, P.
- Affiliations
- The University of Melbourne (AU)
- Howard Hughes Medical Institute (US)
- Johns Hopkins University (US)
- PapGene (United States) (US)
- The Royal Melbourne Hospital (AU)
- Western Health (AU)
- Walter and Eliza Hall Institute of Medical Research (AU)
- Eastern Health (AU)
- The Alfred Hospital (AU)
- Department of Medical Oncology, Warrnambool Hospital, Warrnambool, Victoria 3280, Australia.
- Department of Medical Oncology, Queen Elizabeth Hospital and University of Adelaide, Adelaide, South Australia 3174, Australia.
- Ludwig Cancer Research (US)
- Corresponding author
- Tie, Jeanne
- Wang, Yuxuan
- Vogelstein, Bert
- Gibbs, Peter
- ORCID
- Tie, Jeanne
- Wang, Yuxuan
- Tomasetti, Cristian
- Li, Lu
- Springer, Simeon
- Silliman, Natalie
- Tacey, Mark
- Wong, Hui-Li
- Christie, Michael
- Kosmider, Suzanne
- Skinner, Iain
- Wong, Rachel
- Steel, Malcolm
- Tran, Ben
- Desai, Jayesh
- Jones, Ian
- Haydon, Andrew
- Hayes, Theresa
- Diaz, Luis A.
- Papadopoulos, Nickolas
- Kinzler, Kenneth W.
- Vogelstein, Bert
- Gibbs, Peter
- Venue
- Science Translational Medicine
- Published
- 2016-07-06
- Volume
- 8
- Issue
- 346
- Pages
- 346ra92-346ra92
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC5346159
- OpenAlex
- W2460179076
- Cited by
- 1,492
- References
- 43
- Citations by year
- 2026: 119 · 2025: 131 · 2024: 130 · 2023: 181 · 2022: 173 · 2021: 197 · 2020: 173 · 2019: 146 · 2018: 134 · 2017: 90 · 2016: 14 · 2015: 1
- FWCI
- 53.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Funders
- Virginia and D.K. Ludwig Fund for Cancer Research
- Conrad N. Hilton Foundation
- Sol Goldman Sequencing Facility at Johns Hopkins
- NIH (CA57345, R37-CA43460, U01-CA152753, P30-CA006973)
- Victorian Cancer Agency
- Victorian Cancer Agency Clinical Research Fellowship
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- circulating tumor DNA, stage II colon cancer, minimal residual disease, tumor recurrence prediction, adjuvant chemotherapy, liquid biopsy, recurrence-free survival, plasma biomarkers, resected colon cancer
- MeSH terms
- Circulating Tumor DNA, Colonic Neoplasms, Humans, Neoplasm Recurrence, Local, Neoplasm Staging, Prospective Studies, Proportional Hazards Models, Neoplasm, Residual, Disease-Free Survival
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