The DOI matches its Crossref record; 60 of the 61 references it cites were found in a registry or an index.
SLC7A11 expression is associated with seizures and predicts poor survival in patients with malignant glioma
Open accessAbstract
SLC7A11, the catalytic subunit of the cystine/glutamate antiporter, System x c − (SXC), is up-regulated in a subpopulation of patient gliomas, where it is responsible for excitotoxic glutamate release, accelerated tumor growth, and tumor-associated seizures.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The enhanced glutamatergic drive is the result of glutamate (Glu) being assiduously released from gliomas via system Xc transporter (SXC) encoded by the SLC7A11 gene that is upregulated in about 54% of glioma patients4.”
From Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy (2018) · cites this paper as [4]
In the citing paper
“The cellular and molecular changes underlying tumor-associated epilepsy collectively point to a decrease in GABAergic and increase in glutamatergic transmission as the major contributors3–6.”
From Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy (2018) · cites this paper as [4]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Benveniste, H., Drejer, J., Schousboe, A., & Diemer, N. H. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb05396.x · Cited by 2,863
Hartigan, J. A., & Hartigan, P. M. (1985) · The Annals of Statistics · doi:10.1214/aos/1176346577 · Cited by 2,088
Ben-Ari, Y. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90299-4 · Cited by 1,753
Improved Method for Accurate and Efficient Quantification of MRS Data with Use of Prior Knowledge
Vanhamme, L., van den Boogaart, A., & Huffel, S. V. (1997) · Journal of Magnetic Resonance · doi:10.1006/jmre.1997.1244 · Cited by 1,631
Sato, H., Tamba, M., Ishii, T., & Bannai, S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.17.11455 · Cited by 1,111
Excitotoxicity and stroke: Identifying novel targets for neuroprotection
Lai, T. W., Zhang, S., & Wang, Y. T. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.11.006 · Cited by 1,106
Java-based graphical user interface for the MRUI quantitation package
Naressi, A., Couturier, C., Devos, J. M., Janssen, M., Mangeat, C., de Beer, R., & Graveron‐Demilly, D. (2001) · Magnetic Resonance Materials in Physics Biology and Medicine · doi:10.1007/bf02668096 · Cited by 1,003
Glutamate release promotes growth of malignant gliomas
Takano, T., Lin, J. H.-C., Arcuino, G., Gao, Q., Yang, J., & Nedergaard, M. (2001) · Nature Medicine · doi:10.1038/nm0901-1010 · Cited by 610
Glutamate release by primary brain tumors induces epileptic activity
Buckingham, S. C., Campbell, S. L., Haas, B. R., Montana, V., Robel, S., Ogunrinu, T., & Sontheimer, H. (2011) · Nature Medicine · doi:10.1038/nm.2453 · Cited by 578
Self-citationExchange of cystine and glutamate across plasma membrane of human fibroblasts.
Bannai, S. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35926-4 · Cited by 549
Flagged first, then by citations
1 of the 61 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 201–300 of 306
Donati, V., Pietro, C. D., Persano, L., Rampazzo, E., Panarelli, M., Cambria, C., Selimi, A., Manfreda, L., do Rêgo, A. G. D. O., Sala, G. L., et al. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02370-1 · Cited by 10
Martínez‐Lozada, Z., Farmer, W. T., Schober, A. L., Krizman, E. N., Robinson, M. B., & Murai, K. K. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15908 · Cited by 8
Zhou, Y., Cao, Y., Liu, W., Wang, L., Kuang, Y., Zhou, Y., Chen, Q., Cheng, Z., Huang, H., Zhang, W., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1294459 · Cited by 8
State of the art: glioma-associated epilepsy—bridging tumor biology and epileptogenesis
Divé, I., Luger, A., Muench, D., Weber, K. J., Steinbach, J. P., Rosenow, F., Winkler, F., & Zeiner, P. S. (2025) · Neurological Research and Practice · doi:10.1186/s42466-025-00434-8 · Cited by 7
System Xc-pathway as a potential regulatory target in neurological disorders
Chen, Y., Xiao, W. L., Qian, C., Huang, L., Lv, J., Wang, Z., & Luo, Y. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1701320 · Cited by 10
xCT regulates redox homeostasis and promotes photoreceptor survival after retinal detachment
Gao, M., Liu, H., Xiao, Y., Guo, Y., Wan, X., Li, X., Li, M., Liang, J., Zhai, Y., Liu, W., et al. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.06.023 · Cited by 7
Čolović, M., Yang, H., Southcott, L., Merkens, H., Colpo, N., Bénard, F., & Schaffer, P. C. (2023) · Journal of Nuclear Medicine · doi:10.2967/jnumed.122.265254 · Cited by 6
Structural and material basis of neuron–glioma interactions
Wang, J., Shen, T.-H., Liu, J., Wen, Q., Yang, X., Deng, Y., Duan, J., & Yu, S. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217843 · Cited by 7
Single Nucleus Total RNA Sequencing of Formalin‐Fixed Paraffin‐Embedded Gliomas
Xu, Z., Chen, L., Lin, X., Lyu, Y., Zhou, M., Chen, H., Zhang, H., Zhang, T., Chen, Y., Suo, Y., et al. (2024) · Small Methods · doi:10.1002/smtd.202301801 · Cited by 6
Mao, X., Tokay, T., Zhou, H.-H., & Jin, W. (2016) · Oncotarget · doi:10.18632/oncotarget.7962 · Cited by 6
Seizures as Complications in Cancer
Benit, C. P., Kerkhof, M., Durán-Peña, A., & Vecht, C. J. (2017) · Springer eBooks · doi:10.1007/978-3-319-57901-6_9 · Cited by 6
Seol, M. Y., Choi, S. H., & Yoon, H. I. (2025) · Journal of Neuro-Oncology · doi:10.1007/s11060-025-05128-4 · Cited by 5
Park, Y., Lee, S., Park, S., Kim, J., Kim, S., Lee, Y., Choi, J., Shin, M., & Choi, J. (2025) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2025.118208 · Cited by 5
An, Y., Liu, W., Deng, Y., Huang, W., & Huang, J. (2025) · Biomedical Journal · doi:10.1016/j.bj.2025.100869 · Cited by 5
Hong, J., & Cai, X. (2022) · Disease Markers · doi:10.1155/2022/6201987 · Cited by 4
The molecular landscape of glioblastoma-associated epilepsy
Scheffel, T. B., Diz, F. M., Wieck, A., Begnini, K. R., & da Costa, J. C. (2025) · Journal of Molecular Medicine · doi:10.1007/s00109-025-02567-4 · Cited by 5
Using evolutionary constraint to define novel candidate driver genes in medulloblastoma
Roy, A., Sakthikumar, S., Kozyrev, S. V., Nordin, J., Pensch, R., Mäkeläinen, S., Pettersson, M. E., Karlsson, E. K., Lindblad‐Toh, K., Forsberg‐Nilsson, K., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2300984120 · Cited by 5
Electrochemical sensor toolkit for simultaneous glutamate detection at edge of cleft and peri-soma
Liu, J., Liu, Y., Yin, D., & Tian, Y. (2025) · Cell chemical biology · doi:10.1016/j.chembiol.2025.05.002 · Cited by 4
Feng, S., Hisada, K., Yorifuji, H., Shirakami, Y., & Kaneda‐Nakashima, K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110736 · Cited by 4
Bouwen, B. L. J., Bolleboom, A., Tang, Y., Yu, Z., van der Stap, A., van Rij, J. A., van Dis, V., Dirven, C. M. F., Zeeuw, C. I. D., van Tellingen, O., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-66226-5 · Cited by 4
Skeie, B. S., Craven, A. R., Grüner, E. R., Biermann, M., Riemer, F., Bragstad, S., Sarowar, S., Behbahani, M., Sleire, L., Schwarzlmüller, T., et al. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104241 · Cited by 6
Magloire, V., de Curtis, M., Noebels, J. L., Huberfeld, G., Suffczyński, P., Gnatkovsky, V., Tyurikova, O., Durand, D. M., Henshall, D. C., & McCafferty, C. P. (2025) · Epilepsia · doi:10.1111/epi.18548 · Cited by 5
Levetiracetam: A Potent Sword against Microglia Polarization in Gliomas
Cui, X., Wang, Q., Liu, X., & Kang, C. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-3322 · Cited by 4
Strzelczyk, A., Maschio, M. C. E., Pensel, M. C., Coppola, A., Takahashi, S., Izumoto, S., Trinka, E., Cappucci, S., Sáinz‐Fuertes, R., & Villanueva, V. (2024) · Neurology and Therapy · doi:10.1007/s40120-024-00618-5 · Cited by 4
Lange, F., Gade, R., Einsle, A., Porath, K., Reichart, G., Maletzki, C., Schneider, B., Henker, C., Dubinski, D., Linnebacher, M., et al. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1335401 · Cited by 4
Fyn, an important molecule in the brain, is a potential therapeutic target for brain tumours
Xu, C., Tang, Y. P., Lu, X., & Chen, R. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1485919 · Cited by 4
Jiang, W., Li, L., Tang, H., Gu, B., Feng, D., Zhou, F., Liu, Y., Xu, X., Chen, Y., Yao, K., et al. (2018) · Translational Cancer Research · doi:10.21037/tcr.2018.12.17 · Cited by 4
Prokudin, M. Y., Владимирович, М. Б., Yakovenko, A. I., Litvinenko, I., Lobzin, V. Y., Свистов, Д. В., Chirskiy, V. S., Чемодакова, К. А., & Клиценко, О. А. (2022) · Epilepsy and Paroxysmal Conditions · doi:10.17749/2077-8333/epi.par.con.2022.118 · Cited by 4
Ferroptosis in the pathogenesis of brain tumors
Nikolaev, A. A., & Викторович, Б. В. (2022) · Journal of clinical practice · doi:10.17816/clinpract114787 · Cited by 4
The metabolic reprogramming and vulnerability of SF3B1 mutations
Dalton, W. B. (2020) · Molecular & Cellular Oncology · doi:10.1080/23723556.2019.1697619 · Cited by 4
Reciprocal interactions between glioma and tissue-resident cells fueling tumor progression
Laurenge, A., Castro‐Vega, L. J., & Huberfeld, G. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19102-2.00007-7 · Cited by 3
Wychowski, T., Fessler, A. J., Nadler, J. W., Mohile, N. A., Brinkmann, B. H., Worrell, G. A., Walter, K. A., & Birbeck, G. L. (2020) · Interdisciplinary Neurosurgery · doi:10.1016/j.inat.2020.100772 · Cited by 3
Oxaloacetate as a Holy Grail Adjunctive Treatment in Gliomas: A Revisit to Metabolic Pathway
Samad, A., Samant, R., Rao, K., Bhargava, V., Sadique, S. I., & Yadav, R. (2023) · Cureus · doi:10.7759/cureus.48821 · Cited by 5
WNT vampirization by glioblastoma leads to tumor growth and neurodegenerationPreprint
Portela, M., Venkataramani, V., Fahey-Lozano, N., Seco, E., Losada‐Pérez, M., Winkler, F., & Casas‐Tintó, S. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/428953 · Cited by 3
Riggins, T. E., Whitsitt, Q. A., Saxena, A., Hunter, E., Hunt, B., Thompson, C. H., Moore, M. G., & Purcell, E. K. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.06.522870 · Cited by 3
Remote neuronal activity drives glioma infiltration via Sema4fPreprint
Huang-Hobbs, E., Cheng, Y.-T., Ko, Y., Luna-Figueroa, E., Lozzi, B., Taylor, K. R., McDonald, M. F., He, P., Chen, H., Yang, Y., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.15.532832 · Cited by 3
Nissi, L., Tuominen, S., Routila, J., Huusko, T., Ketonen, P., Sundvall, M., Leivo, I. V. V., Irjala, H., Minn, H. R. I., Grönroos, T. J., et al. (2024) · Cancer Medicine · doi:10.1002/cam4.70371 · Cited by 2
Wang, Z., Wang, Y., Dai, Y., Zhang, W., Luo, C., Che, S., Luo, D., Zhang, J., Deng, L., & Yu, Z. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.168827 · Cited by 2
Wei, Q., Zhao, K., Wu, Y., Wu, W., & Hao, N. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70531 · Cited by 2
Progress in research on the mechanisms and therapeutic strategies of SLC7A11 regulation in glioma
Wei, Q., Xiong, B., Yang, G., Wang, J., & Chai, E. (2025) · Discover Oncology · doi:10.1007/s12672-025-04154-y · Cited by 2
Lu, J., Yu, F., Geng, Z., & Wang, Z. (2026) · Analytical Chemistry · doi:10.1021/acs.analchem.5c05904 · Cited by 2
Disarming the “Neural Hijack”: Repurposing neuroactive drugs for cancer therapy
Jin, M.-Z., Dang, H.-R., & Jin, W.-L. (2026) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2026.109051 · Cited by 3
Kumar, K., Dubey, V., Zaidi, S. S. Z., Tripathi, M., Siraj, F., Sharma, M. C., Chandra, P. S., Doddamani, R. S., Dixit, A. B., & Banerjee, J. (2023) · Journal of Molecular Neuroscience · doi:10.1007/s12031-023-02125-y · Cited by 2
Chen, Y., Yang, X. Y., Lv, D., Tang, L., & Liu, Y.-W. (2024) · Clinical & Translational Oncology · doi:10.1007/s12094-024-03617-y · Cited by 2
Lu, C., Zhu, W., Han, X., Du, X., Zhang, H., Yao, Q., Liu, T., & Zhang, C. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1492498 · Cited by 2
Alçiçek, Ş., Ronellenfitsch, M. W., Steinbach, J., Manzhurtsev, A. V., Thomas, D. C., Weber, K. J., Prinz, V., Forster, M.-T., Hattingen, E., Pilatus, U., et al. (2025) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.29787 · Cited by 2
Highlights from the Literature
Huse, J. T., Abounader, R., Purow, B. W., Hegi, M. E., Soffietti, R., & Aldape, K. (2016) · Neuro-Oncology · doi:10.1093/neuonc/now215 · Cited by 2
Galván, I., & Sanz, J. (2020) · Journal of Avian Biology · doi:10.1111/jav.02275 · Cited by 2
Cases‐Cunillera, S., Friker, L. L., Müller, P., Becker, A. J., & Gielen, G. H. (2024) · Molecular Oncology · doi:10.1002/1878-0261.13680 · Cited by 3
Sontheimer, H. W. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821228-8.00009-3 · Cited by 3
Self-citationTargeting xCT-mediated glutamate release normalizes tumor angiogenesis in the brainPreprint
Fan, Z., Broggini, T., Yakubov, E., Sehm, T., Schürmann, S., Meyer, E. P., Stanković, N. D., Schmidt, M. H. H., Stampanoni, M., Czabanka, M., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/134924 · Cited by 3
Zhang, X., Wen, X., Si, Y., Li, D., Yang, C., Wang, L., & Song, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111342 · Cited by 1
Ferroptosis: is it both cause and effect in refractory epilepsy?
Auzmendi, J., & Lazarowski, A. (2025) · Exploration of neuroscience · doi:10.37349/en.2025.100692 · Cited by 1
Jayasekera, B. A. P., Parikh, J. D., Modebadze, T., da Silva, A. B., Stefanetti, R. J., Crossman, J. E., Holliman, D., Hussain, M. A., Jenkins, A. J., Major, O., et al. (2025) · Brain Communications · doi:10.1093/braincomms/fcaf451 · Cited by 1
Rhythmic network activity in human brain slices: variability, mechanisms, and translational insights
Yang, D., & Feldmeyer, D. (2026) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2026.1798456 · Cited by 2
Tumor-associated epilepsy and high expression of xCT shape the proteome of IDH-wildtype glioblastoma
Divé, I., Schäfer, J. A., Weber, K. J., Çakır, A. Y., Verheyden, N. A., Lorenz, N. I., Chong, S., Zeiner, P. S., Franiczek, C., Sauer, B., et al. (2026) · Cell Death Discovery · doi:10.1038/s41420-026-03029-7 · Cited by 2
WNT vampirization by glioblastoma leads to tumor growth and neurodegeneration
Portela-Esteban, M., Venkataramani, V., Fahey-Lozano, N., Seco, E., Losada‐Pérez, M., Winkler, F., & Casas‐Tintó, S. (2018) · Figshare · doi:10.26181/6004ef260c4d4 · Cited by 1
Zou, L., Zhang, T., Yang, C., Liu, W., Fahira, A., Yang, D., Zheng, B., Yao, X., Liu, Y., & Huang, Z. (2025) · Molecular Carcinogenesis · doi:10.1002/mc.23874 · Cited by 1
Robert, S. M., & Sontheimer, H. W. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.00069-9 · Cited by 1
Self-citationKeen, J. R., Swanger, S. A., Traynelis, S. F., & Olson, J. J. (2016) · Annals of Translational Medicine · doi:10.21037/atm.2016.10.23 · Cited by 1
Liu, W., Ji, Y., Ren, R., & Zhang, G. (2021) · Research Square · doi:10.21203/rs.3.rs-198130/v1 · Cited by 1
Cysteine induces mitochondrial reductive stress in glioblastoma through hydrogen peroxide productionPreprint
Noch, E., Palma, L., Yim, I., Barnett, D., Walsh, A., Bhinder, B., Benedetti, E., Krumsiek, J., Gurvitch, J., Khwaja, S., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.10.459864 · Cited by 1
Cai, X., & Hong, J. (2022) · Research Square · doi:10.21203/rs.3.rs-1142038/v2 · Cited by 1
Xu, Z., Chen, L., Lin, X., Lyu, Y., Zhou, M., Chen, H., Zhang, H., Zhang, T., Chen, Y., Suo, Y., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.16.567325 · Cited by 1
Human Neuron and Mouse Models Reveal Synaptic Imbalance in Kabuki SyndromePreprint
Wenninger, A., Knopp, J., Frye, S., Weaver, A., McAdams, N., Miller, S., Nomura, T., Whitlark, A., Swantkowski, J., Noble, A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.04.616738 · Cited by 1
Therapeutic Targets and Future Directions
Hubbard, J. A., & Binder, D. K. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802401-0.00022-3
The Neuroscience of Glioblastoma
Yu, K. (2021) · Molecular pathology library · doi:10.1007/978-3-030-69170-7_14
Hong, J., & Cai, X. (2021) · Research Square · doi:10.21203/rs.3.rs-1142038/v1
Forcato, S., Aquino, A., Camparoto, N. D. M., Lens, H. H. M., Guarnier, F. A., Kiss, A. I., & Gerardin, D. C. C. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3974357
Highlights from the Literature
Bhat, K., Pope, W., Huse, J. T., Hegi, M. E., & Aldape, K. (2015) · Neuro-Oncology · doi:10.1093/neuonc/nov252
Studying Synaptic Integration of Glioma Cells into Neural Circuits
Shamardani, K., Taylor, K. R., Barron, T., & Monje, M. (2024) · Neuromethods · doi:10.1007/978-1-0716-3742-5_16
Intact corticostriatal function in aged system xc- - deficient mice
Pauw, L. D., Villers, A., Moore, C., Lara, O., Vanonckelen, O., Verbruggen, L., Sato, H., Bentea, E., Arckens, L., Ris, L., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03686-9
Wang, M., Zhao, Y., Yu, Z.-Y., Zhang, R.-D., Li, S.-A., Zhang, P., Shan, T.-K., Liu, X., Wang, Z.-M., Zhao, P.-C., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13152962
Additional file 4 of CIC reduces xCT/SLC7A11 expression and glutamate release in glioma
Park, J., Kilic, O., Deo, M., Jimenez-Cowell, K., Demirdizen, E., Kim, H., & Turcan, Ş. (2024) · Figshare · doi:10.6084/m9.figshare.26561647
Additional file 3 of CIC reduces xCT/SLC7A11 expression and glutamate release in glioma
Park, J., Kilic, O., Deo, M., Jimenez-Cowell, K., Demirdizen, E., Kim, H., & Turcan, Ş. (2024) · Figshare · doi:10.6084/m9.figshare.26561644
Additional file 6 of CIC reduces xCT/SLC7A11 expression and glutamate release in glioma
Park, J., Kilic, O., Deo, M., Jimenez-Cowell, K., Demirdizen, E., Kim, H., & Turcan, Ş. (2024) · Figshare · doi:10.6084/m9.figshare.26561653
Additional file 2 of CIC reduces xCT/SLC7A11 expression and glutamate release in glioma
Park, J., Kilic, O., Deo, M., Jimenez-Cowell, K., Demirdizen, E., Kim, H., & Turcan, Ş. (2024) · Figshare · doi:10.6084/m9.figshare.26561641
Additional file 5 of CIC reduces xCT/SLC7A11 expression and glutamate release in glioma
Park, J., Kilic, O., Deo, M., Jimenez-Cowell, K., Demirdizen, E., Kim, H., & Turcan, Ş. (2024) · Figshare · doi:10.6084/m9.figshare.26561650
Additional file 1 of CIC reduces xCT/SLC7A11 expression and glutamate release in glioma
Park, J., Kilic, O., Deo, M., Jimenez-Cowell, K., Demirdizen, E., Kim, H., & Turcan, Ş. (2024) · Figshare · doi:10.6084/m9.figshare.26561638
Wang, M., Zhao, Y., Yu, Z.-Y., Zhang, R.-D., Li, S.-A., Zhang, P., Shan, T.-K., Liu, X., Wang, Z.-M., Zhao, P.-C., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13152965
Shandra, O. O., Winemiller, A. R., Heithoff, B. P., Muñoz‐Ballester, C., George, K. K., Benko, M. J., Zuidhoek, I. A., Besser, M. N., Curley, D. E., Edwards, G. F., et al. (2019) · Maryland Shared Open Access Repository (USMAI Consortium) · doi:10.13016/m24leb-ie2j
Self-citationPetrillo, S., Loia, F., Giustizieri, M., Torda, C., Cairoli, S., Goffredo, B. M., Trivisano, M., Palma, L. D., Vigevano, F., Specchio, N., et al. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1758230
Bedrosian, T. A., Wong, M. L., Heinzen, E. L., Deneen, B., & Christian, C. A. (2026) · Epiliepsy currents/Epilepsy currents · doi:10.1177/15357597261418332
GPR40 Attenuates Glioma TMZ-Resistance Through Ferroptosis Inhibition
Yang, J. F., Zou, Y., Xu, S., Mu, Z., Wu, S., Xu, X., Miao, Z., Zhao, X., & Zhou, Y. (2026) · Neurochemical Research · doi:10.1007/s11064-026-04726-6
Joo, J. D., Yang, W. S., & Koh, H. J. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27073307
Zhang, S., Wang, H., Wang, B., Chi, N., He, Q., Sun, Y. M., & Zhang, H. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1793961
xCT (Slc7a11) Regulation: Lessons from Cancer Research
Chirla, S., Pandit, R., & Martínez‐Lozada, Z. (2026) · Neurochemical Research · doi:10.1007/s11064-026-04776-w
What is the Relevance of Neuron-Tumor Interactions in Malignant CNS Tumors?
Benarroch, E. E. (2026) · Neurology · doi:10.1212/wnl.0000000000218291
Wu, T., Zhang, Y.-G., & Han, J.-H. (2026) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2026.07.011
Metabolic control of ferroptosis in cancer: lipid dependencies as therapeutic vulnerabilities
Dio, A. D., Smaldone, G., Napolitano, V., Bertamino, A., & Gomez-Monterrey, I. M. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1872103
Carmicheal, J., Fritson, C., Seas, A. A., Vieira, H. M., & Batra, S. K. (2026) · Cancer Medicine · doi:10.1002/cam4.72146
Cancer neuroscience: Mechanisms to medicine
Pasvolsky, L., Jones, G. H., Vu, Y., Winkler, F., & Amit, M. (2026) · Science Translational Medicine · doi:10.1126/scitranslmed.aeh1718
Fatima, T. (2026) · International Journal of Neurooncology · doi:10.4103/ijno.ijno_2_26
Neuronal regulation of cancer: Mechanisms, functional consequences and therapeutic opportunities
Liu, S., Cao, C., Zhu, C., Gui, L., & Wu, P. (2026) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2026.189693
miR ‐15a‐5p Regulates Ferroptosis in Glioblastoma by Targeting GLS2
Yu, Y., 袁荷兰, Fang, Z., Liao, J., Yang, Y., Liu, J. L., Wei, W., & Jiang, Q. (2026) · CNS Neuroscience & Therapeutics · doi:10.1002/cns.71097
Neural–metabolic crosstalk governing cell death and therapy resistance in tumors
Yan, Y., Sun, H., Liu, Z., Bhol, C. S., Sethi, G., Xue, W., & Li, L. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108442
Harnessing Neurogenic Potential of Glial Cell Types as an Emerging Strategy for Treating Epilepsy
Chesnokova, E., Kotova, I., Reznikova, A., Balaban, P. M., & Bal, N. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27209147
Metadata
- Authors
- Robert, S. M., Buckingham, S. C., Campbell, S. L., Robel, S., Holt, K. T., Ogunrinu-Babarinde, T., Warren, P. P., White, D. M., Reid, M. A., Eschbacher, J. M., Berens, M. E., Lahti, A. C., Nabors, L. B., & Sontheimer, H.
- Affiliations
- University of Alabama at Birmingham (US)
- Department of Neurobiology, Center for Glial Biology in Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
- Translational Genomics Research Institute (US)
- Division of Neuro-oncology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
- Corresponding author
- Sontheimer, Harald
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2015-05-27
- Volume
- 7
- Issue
- 289
- Pages
- 289ra86-289ra86
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC4503260
- OpenAlex
- W2099513242
- Cited by
- 301
- References
- 61
- Citations by year
- 2026: 29 · 2025: 31 · 2024: 32 · 2023: 34 · 2022: 26 · 2021: 32 · 2020: 22 · 2019: 26 · 2018: 22 · 2017: 19 · 2016: 23 · 2015: 5
- FWCI
- 12.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (5R01NS052634, 2RO1NS036692, 5RO1NS031234, 1F31NS074597, 1R01NS082851, 5TL1RR025775-04, 2T32NS048039, T32GM008361, T32GM008362)
- Ben & Catherine Ivy Foundation
- Topics
- Health Sciences › Medicine › Oncology › Glioma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- SLC7A11, system xc-, high-grade glioma, seizures, glutamate release, glutathione synthesis, tumor growth, overall survival, sulfasalazine, magnetic resonance spectroscopy, prognostic factors
- MeSH terms
- Edema, Glioma, Glutamates, Humans, Neurons, Neurotoxins, Seizures, Survival Analysis, Genomics, Amino Acid Transport System y+
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
