The DOI matches its Crossref record; 60 of the 61 references it cites were found in a registry or an index.
SLC7A11 expression is associated with seizures and predicts poor survival in patients with malignant glioma
Open accessAbstract
SLC7A11, the catalytic subunit of the cystine/glutamate antiporter, System x c − (SXC), is up-regulated in a subpopulation of patient gliomas, where it is responsible for excitotoxic glutamate release, accelerated tumor growth, and tumor-associated seizures.
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“The enhanced glutamatergic drive is the result of glutamate (Glu) being assiduously released from gliomas via system Xc transporter (SXC) encoded by the SLC7A11 gene that is upregulated in about 54% of glioma patients4.”
From Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy (2018) · cites this paper as [4]
In the citing paper
“The cellular and molecular changes underlying tumor-associated epilepsy collectively point to a decrease in GABAergic and increase in glutamatergic transmission as the major contributors3–6.”
From Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy (2018) · cites this paper as [4]
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Cites
Benveniste, H., Drejer, J., Schousboe, A., & Diemer, N. H. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb05396.x · Cited by 2,863
Hartigan, J. A., & Hartigan, P. M. (1985) · The Annals of Statistics · doi:10.1214/aos/1176346577 · Cited by 2,088
Ben-Ari, Y. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90299-4 · Cited by 1,753
Improved Method for Accurate and Efficient Quantification of MRS Data with Use of Prior Knowledge
Vanhamme, L., van den Boogaart, A., & Huffel, S. V. (1997) · Journal of Magnetic Resonance · doi:10.1006/jmre.1997.1244 · Cited by 1,631
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Excitotoxicity and stroke: Identifying novel targets for neuroprotection
Lai, T. W., Zhang, S., & Wang, Y. T. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.11.006 · Cited by 1,106
Java-based graphical user interface for the MRUI quantitation package
Naressi, A., Couturier, C., Devos, J. M., Janssen, M., Mangeat, C., de Beer, R., & Graveron‐Demilly, D. (2001) · Magnetic Resonance Materials in Physics Biology and Medicine · doi:10.1007/bf02668096 · Cited by 1,003
Glutamate release promotes growth of malignant gliomas
Takano, T., Lin, J. H.-C., Arcuino, G., Gao, Q., Yang, J., & Nedergaard, M. (2001) · Nature Medicine · doi:10.1038/nm0901-1010 · Cited by 610
Glutamate release by primary brain tumors induces epileptic activity
Buckingham, S. C., Campbell, S. L., Haas, B. R., Montana, V., Robel, S., Ogunrinu, T., & Sontheimer, H. (2011) · Nature Medicine · doi:10.1038/nm.2453 · Cited by 578
Self-citationExchange of cystine and glutamate across plasma membrane of human fibroblasts.
Bannai, S. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35926-4 · Cited by 549
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Items 301–306 of 306
The parasitic synapse: How gliomas hijack the connectome for malignant gain
Mansour, M. A., Wahid, M., Molla, M. A. S. E., Helmy, M. H., Adel, T. M., Elsanafiry, M. S., & Mostafa, H. N. (2026) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2026.101438
Qu, Z., Guo, K., Xiang, X., An, Y., Lei, T., Liu, A., Wang, Y., Chen, D., Chen, H., Zhang, Z., et al. (2026) · Biomedicines · doi:10.3390/biomedicines14092067
Bai, L., Gu, J., Wang, F., Wang, Z., Lv, R., Wang, S., Liu, Y., Yao, S., Zhang, C., Zhang, K., et al. (2026) · Bio-Design and Manufacturing · doi:10.1631/bdm.2500581
Emerging role of targeted therapy in drug-resistant epilepsy in patients with glioma
Bruno, F., Pellerino, A., & Rudà, R. (2026) · Current Opinion in Oncology · doi:10.1097/cco.0000000000001279
[18F]FET uptake in diffuse lower-grade IDH-mutant glioma correlates with glioma-related epilepsy
Oezdemir, Z., Roll, W., Stummer, W., Kovac, S., & Müther, M. (2026) · Journal of Neuro-Oncology · doi:10.1007/s11060-026-05815-w
Glioma regulates GABAergic signaling to drive hyperactivity and tumor progression
McDonald, M. F., Ko, Y., Curry, R. N., Woo, J., Ho, R., He, P., Puentes, A., Yang, Y., Latha, K., Goethe, E. A., et al. (2026) · Neuron · doi:10.1016/j.neuron.2026.10.001
Metadata
- Authors
- Robert, S. M., Buckingham, S. C., Campbell, S. L., Robel, S., Holt, K. T., Ogunrinu-Babarinde, T., Warren, P. P., White, D. M., Reid, M. A., Eschbacher, J. M., Berens, M. E., Lahti, A. C., Nabors, L. B., & Sontheimer, H.
- Affiliations
- University of Alabama at Birmingham (US)
- Department of Neurobiology, Center for Glial Biology in Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
- Translational Genomics Research Institute (US)
- Division of Neuro-oncology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
- Corresponding author
- Sontheimer, Harald
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2015-05-27
- Volume
- 7
- Issue
- 289
- Pages
- 289ra86-289ra86
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC4503260
- OpenAlex
- W2099513242
- Cited by
- 301
- References
- 61
- Citations by year
- 2026: 29 · 2025: 31 · 2024: 32 · 2023: 34 · 2022: 26 · 2021: 32 · 2020: 22 · 2019: 26 · 2018: 22 · 2017: 19 · 2016: 23 · 2015: 5
- FWCI
- 12.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (5R01NS052634, 2RO1NS036692, 5RO1NS031234, 1F31NS074597, 1R01NS082851, 5TL1RR025775-04, 2T32NS048039, T32GM008361, T32GM008362)
- Ben & Catherine Ivy Foundation
- Topics
- Health Sciences › Medicine › Oncology › Glioma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- SLC7A11, system xc-, high-grade glioma, seizures, glutamate release, glutathione synthesis, tumor growth, overall survival, sulfasalazine, magnetic resonance spectroscopy, prognostic factors
- MeSH terms
- Edema, Glioma, Glutamates, Humans, Neurons, Neurotoxins, Seizures, Survival Analysis, Genomics, Amino Acid Transport System y+
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