Mechanistic modeling of hemoglobin glycation and red blood cell kinetics enables personalized diabetes monitoring
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On the basis of first principles, a model of hemoglobin glycation yields a personalized, more accurate estimate of average glucose for diabetics.
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One study has suggested that differences in mean red cell half-life may explain some of the interindividual variability in the relationship between measured average glucose and HbA1c levels.
“One study has suggested that differences in mean red cell half-life, which may range from approximately 48 to 68 days (mean 58 days and 1 SD of 4.5 to 6.5 days), may explain some of the interindividual variability in the relationship between measured average glucose and HbA 1c levels (343).”
From Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus (2023) · cites this paper as [343]
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- Authors
- Malka, R., Nathan, D. M., & Higgins, J. M.
- Affiliations
- Harvard University (US)
- Corresponding author
- Higgins, John M.
- Venue
- Science Translational Medicine
- Published
- 2016-10-05
- Volume
- 8
- Issue
- 359
- Pages
- 359ra130-359ra130
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC5714656
- OpenAlex
- W2529155476
- Cited by
- 134
- References
- 49
- Citations by year
- 2026: 13 · 2025: 14 · 2024: 24 · 2023: 10 · 2022: 11 · 2021: 10 · 2020: 19 · 2019: 12 · 2018: 9 · 2017: 11
- FWCI
- 10.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH Director’s New Innovator Award (DP2DK098087)
- Abbott Diagnostics
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Keywords
- HbA1c, hemoglobin glycation, diabetes monitoring, mechanistic mathematical model, personalized medicine
- MeSH terms
- Blood Glucose, Diabetes Mellitus, Erythrocytes, Glycated Hemoglobin, Humans, Kinetics, Models, Biological, Blood Glucose Self-Monitoring, Precision Medicine
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