A Bihormonal Closed-Loop Artificial Pancreas for Type 1 Diabetes
Open accessAbstract
An algorithm continuously delivers appropriate insulin and glucagon doses to diabetic patients, maintaining their blood glucose at near-normal values, even after high-carbohydrate meals.
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In bihormonal closed-loop glucose control, glucagon has been used subcutaneously along with insulin for protection against hypoglycemia.
“More recently, in a bihormonal closed-loop glucose control, glucagon has been used subcutaneously along with insulin for protection against hypoglycemia.”
From Pharmacokinetics Modeling of Exogenous Glucagon in Type 1 Diabetes Mellitus Patients (2013) · cites this paper as [4]
In bihormonal closed-loop systems, small doses of glucagon are frequently administered.
“In this context, small doses of glucagon are frequently administered.”
From Pharmacokinetics Modeling of Exogenous Glucagon in Type 1 Diabetes Mellitus Patients (2013) · cites this paper as [4]
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- Authors
- El-Khatib, F. H., Russell, S. J., Nathan, D. M., Sutherlin, R. G., & Damiano, E. R.
- Affiliations
- Boston University (US)
- Corresponding author
- El-Khatib, Firas H.
- Russell, Steven J.
- ORCID
- Russell, Steven J.
- Venue
- Science Translational Medicine
- Published
- 2010-04-14
- Volume
- 2
- Issue
- 27
- Pages
- 27ra27-27ra27
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC4242106
- OpenAlex
- W2114529996
- Cited by
- 403
- References
- 25
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 7 · 2023: 8 · 2022: 9 · 2021: 26 · 2020: 14 · 2019: 31 · 2018: 34 · 2017: 22 · 2016: 24 · 2015: 29 · 2014: 46 · 2013: 45 · 2012: 51
- FWCI
- 34.75
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Center for Research Resources (RR 01066, UL1RR025758, M01RR001066)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- type 1 diabetes, artificial pancreas, glucagon, insulin lispro, glycemic control, hypoglycemia prevention, pharmacokinetic modeling
- MeSH terms
- Adult, Aged, Blood Glucose, Diabetes Mellitus, Type 1, Female, Glucagon, Humans, Insulin, Male, Middle Aged, Drug Delivery Systems, Pancreas, Artificial, Young Adult, Insulin Lispro
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