Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy
DeVos, Sarah L., Miller, Rebecca L., Schoch, Kathleen M., Holmes, Brandon B., Kebodeaux, Carey S., Wegener, Amy J., Chen, Guo, Shen, Tao, Tran, Hien, Nichols, Brandon, Zanardi, Tom A., Kordasiewicz, Holly B., Swayze, Eric E., Bennett, C. Frank, Diamond, Marc I., Miller, Timothy M.·2017·Science Translational Medicine
Cited by (518)
Items 101–200 of 518
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- Targeting Alzheimer's disease with gene and cell therapiesRaúl Loera‐Valencia, Antonio Piras, Muhammad-Al-Mustafa Ismail, Shaffi Manchanda, Helga Eyjolfsdottir, Takaomi C. Saido, Jan Johansson, Maria Eriksdotter, Bengt G. Winblad, Per Nilsson · 2018 · Journal of Internal Medicine
- A novel orally active HDAC6 inhibitor T-518 shows a therapeutic potential for Alzheimer’s disease and tauopathy in miceTomohiro Onishi, Ryouta Maeda, Michiko Terada, Sho Sato, Takahiro Fujii, Masahiro Ito, Kentaro Hashikami, Tomohiro Kawamoto, Maiko Tanaka · 2021 · Scientific Reports
- Expression of Tau Pathology-Related Proteins in Different Brain Regions: A Molecular Basis of Tau PathogenesisWen Hui Hu, Feng Wu, Yanchong Zhang, Cheng‐Xin Gong, Khalid Iqbal, Fei Liu · 2017 · Frontiers in Aging Neuroscience
- Subregional Density of Neurons, Neurofibrillary Tangles and Amyloid Plaques in the Hippocampus of Patients With Alzheimer’s DiseaseDiana Furcila, Marta Domínguez-Álvaro, Javier DeFelipe, Lidia Alonso‐Nanclares · 2019 · Frontiers in Neuroanatomy
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- Gene suppression approaches to neurodegenerationRhia Ghosh, Sarah J. Tabrizi · 2017 · Alzheimer s Research & Therapy
- A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human Tau but minimal levels of other key modificationsFriedel Drepper, Jacek Biernat, Senthilvelrajan Kaniyappan, Helmut E. Meyer, Eva‐Maria Mandelkow, Bettina Warscheid, Eckhard Mandelkow� · 2020 · Journal of Biological Chemistry
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- Amyloid-β and Tau in Alzheimer’s Disease: Novel Pathomechanisms and Non-Pharmacological Treatment StrategiesRebecca M. Nisbet, Jürgen Götz · 2018 · Journal of Alzheimer s Disease
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- Blood tau‐PT217 contributes to the anesthesia/surgery‐induced delirium‐like behavior in aged miceJing Lu, Feng Liang, Ping Bai, Chenghao Liu, Miao Xu, Zhengwang Sun, Wenjie Tian, Yuanlin Dong, Yiying Zhang, Qimin Quan et al. · 2023 · Alzheimer s & Dementia
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- The Role of Amyloid-Beta and Tau in the Early Pathogenesis of Alzheimer’s DiseaseYin, Xiaomin, Qiu, Yanyan, Zhao, Chenhao, Zhou, Zheng, Bao, Junze, Qian, Wei · 2021 · Medical Science Monitor
- Astrocytic 4R tau expression drives astrocyte reactivity and dysfunctionLubov A. Ezerskiy, Kathleen M. Schoch, Chihiro Sato, Mariana Beltcheva, Kanta Horie, Frank Rigo, Ryan Martynowicz, Celeste M M. Karch, Randall John Bateman, Timothy M. Miller · 2021 · JCI Insight
- Towards Personalized Allele-Specific Antisense Oligonucleotide Therapies for Toxic Gain-of-Function Neurodegenerative DiseasesJacob Helm, Ludger J. Schöls, Stefan Hauser · 2022 · Pharmaceutics
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- A silver lining for 24-hydroxycholesterol in Alzheimer's disease: The involvement of the neuroprotective enzyme sirtuin 1Testa, Gabriella, Staurenghi, Erica, Giannelli, Serena, Gargiulo, Simona, Guglielmotto, Michela, Tabaton, Massimo, Tamagno, Elena, Gamba, Paola, Leonarduzzi, Gabriella · 2018 · Redox Biology
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- Combining P301L and S320F tau variants produces a novel accelerated model of tauopathyKoller, Emily J, Gonzalez De La Cruz, Elsa, Machula, Timothy, Ibanez, Kristen R, Lin, Wen-Lang, Williams, Tosha, Riffe, Cara J, Ryu, Daniel, Strang, Kevin H, Liu, Xuefei et al. · 2019 · Human Molecular Genetics
- Novel Targets for Alzheimer's Disease: A View Beyond AmyloidWilliam J. Ray, Virginie Buggia-Prévot · 2020 · Annual Review of Medicine
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- Neuronal ApoE4 in Alzheimer’s disease and potential therapeutic targetsZhang, Lan, Xia, Yiyuan, Gui, Yuran · 2023 · Frontiers in Aging Neuroscience
- Pharmacogenetic neuronal stimulation increases human tau pathology and trans-synaptic spread of tau to distal brain regions in miceMark K. Schultz, Renee C. Gentzel, Marija Usenovic, Cheryl A. Gretzula, C. Ware, Sophie Parmentier‐Batteur, Joel B. Schachter, Hatim A. Zariwala · 2018 · Neurobiology of Disease
- Nanotechnology-enabled gene delivery for cancer and other genetic diseasesTong Jiang, Karina Marie Gonzalez, Leyla Estrella Cordova, Jianqin Lu · 2023 · Expert Opinion on Drug Delivery
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- Neuronal levels and sequence of tau modulate the power of brain rhythmsMelanie M. Das, Sumihiro Maeda, Bozhong Hu, Gui-Qiu Yu, Weikun Guo, Isabel Lopez, Xinxing Yu, Chao Tai, Xin Wang, Lennart Mucke · 2018 · Neurobiology of Disease
- Tau secretion and propagation: Perspectives for potential preventive interventions in Alzheimer's disease and other tauopathiesNarendran Annadurai, Juan Bautista De Sanctis, Marián Hajdúch, Viswanath Das · 2021 · Experimental Neurology
- Recent Development in the Understanding of Molecular and Cellular Mechanisms Underlying the Etiopathogenesis of Alzheimer’s DiseaseAtefeh Afsar, Maria del Carmen Chacon Castro, Adedamola Saidi Soladogun, Zhang Li · 2023 · International Journal of Molecular Sciences
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- Cytosolic condensates rich in polyserine define subcellular sites of tau aggregationEvan Lester, Meaghan Van Alstyne, Kathleen L. McCann, Spoorthy Reddy, Li Yi Cheng, Jeff Kuo, James Pratt, Roy Parker · 2023 · Proceedings of the National Academy of Sciences
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- Therapeutic strategies for targeting neurodegenerative protein misfolding disordersRobert H. Scannevin · 2018 · Current Opinion in Chemical Biology
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- Therapeutic antisense oligonucleotides for movement disordersEpaminondas Doxakis · 2020 · Medicinal Research Reviews
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- Current Management and Emerging Therapies in Multiple System AtrophyMatthew R. Burns, Nikolaus R. McFarland · 2020 · Neurotherapeutics
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- Antisense therapies in neurological diseasesJ.-B. Brunet de Courssou, Alexandra Dürr, David Adams, Jean‐Christophe Corvol, Louise‐Laure Mariani · 2021 · Brain