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A silver lining for 24-hydroxycholesterol in Alzheimer's disease: The involvement of the neuroprotective enzyme sirtuin 1

Testa, Gabriella, Staurenghi, Erica, Giannelli, Serena, Gargiulo, Simona, Guglielmotto, Michela, Tabaton, Massimo, Tamagno, Elena, Gamba, Paola, Leonarduzzi, Gabriella·2018·Redox Biology
DOI 10.1016/j.redox.2018.05.009
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Research works printed but not linked: 43

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  11. Gamba, 2014, Up-regulation of β-amyloidogenesis in neuron-like human cells by both 24- and 27-hydroxycholesterol: protective effect of N-acetyl-cysteine, Aging Cell, 13, 561, 10.1111/acel.12206 · DOI
  12. Marwarha, 2013, Gadd153 and NF-κB crosstalk regulates 27-hydroxycholesterol-induced increase in BACE1 and β-amyloid production in human neuroblastoma SH-SY5Y cells, PLoS One, 8, e70773, 10.1371/journal.pone.0070773 · DOI
  13. Urano, 2013, Suppression of amyloid-β production by 24S-hydroxycholesterol via inhibition of intracellular amyloid precursor protein trafficking, FASEB J., 27, 4305, 10.1096/fj.13-231456 · DOI
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  15. Prasanthi, 2011, Silencing GADD153/CHOP gene expression protects against Alzheimer's disease-like pathology induced by 27-hydroxycholesterol in rabbit hippocampus, PLoS One, 6, e26420, 10.1371/journal.pone.0026420 · DOI
  16. Burlot, 2015, Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology, Hum. Mol. Genet., 24, 5965, 10.1093/hmg/ddv268 · DOI · Paper page
  17. Herskovits, 2013, Sirtuin deacetylases in neurodegenerative diseases of aging, Cell Res., 23, 746, 10.1038/cr.2013.70 · DOI
  18. Julien, 2009, Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease, J. Neuropathol. Exp. Neurol., 68, 48, 10.1097/NEN.0b013e3181922348 · DOI
  19. Bonda, 2011, The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations, Lancet Neurol., 10, 2752, 10.1016/S1474-4422(11)70013-8 · DOI
  20. Andorfer, 2003, Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms, J. Neurochem., 86, 582, 10.1046/j.1471-4159.2003.01879.x · DOI · Paper page
  21. Manassero, 2016, Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein, Aging Cell, 15, 914, 10.1111/acel.12500 · DOI
  22. Livak, 2001, Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)), Method Methods, 25, 402, 10.1006/meth.2001.1262 · DOI · Paper page
  23. Biasi, 2009, Pro-oxidant and proapoptotic effects of cholesterol oxidation products on human colonic epithelial cells: a potential mechanism of inflammatory bowel disease progression, Free Radic. Biol. Med., 47, 1731, 10.1016/j.freeradbiomed.2009.09.020 · DOI
  24. Gargiulo, 2011, Plaque oxysterols induce unbalanced up-regulation of matrix metalloproteinase-9 in macrophagic cells through redox-sensitive signaling pathways: implications regarding the vulnerability of atherosclerotic lesions, Free Radic. Biol. Med., 51, 844, 10.1016/j.freeradbiomed.2011.05.030 · DOI
  25. Vurusaner, 2014, Survival signaling elicited by 27-hydroxycholesterol through the combined modulation of cellular redox state and ERK/Akt phosphorylation, Free Radic. Biol. Med., 77, 376, 10.1016/j.freeradbiomed.2014.07.026 · DOI
  26. Vurusaner, 2016, Oxysterols and mechanisms of survival signaling, Mol. Asp. Med., 49, 8, 10.1016/j.mam.2016.02.004 · DOI
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  30. Yamanaka, 2011, 24(S)-hydroxycholesterol induces neuronal cell death through necroptosis, a form of programmed necrosis, J. Biol. Chem., 286, 24666, 10.1074/jbc.M111.236273 · DOI
  31. Okabe, 2013, Adaptive responses induced by 24S-hydroxycholesterol through liver X receptor pathway reduce 7-ketocholesterol-caused neuronal cell death, Redox Biol., 2, 28, 10.1016/j.redox.2013.11.007 · DOI
  32. Testa, 2012, Potentiation of amyloid-β peptide neurotoxicity in human dental-pulp neuron-like cells by the membrane lipid peroxidation product 4-hydroxynonenal, Free Radic. Biol. Med., 53, 10.1016/j.freeradbiomed.2012.08.581 · DOI
  33. Famer, 2007, Regulation of alpha- and beta-secretase activity by oxysterols: cerebrosterol stimulates processing of APP via the alpha-secretase pathway, Biochem. Biophys. Res. Commun., 359, 46, 10.1016/j.bbrc.2007.05.033 · DOI
  34. Prasanthi, 2009, Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells, Mol. Neurodegener., 4, 1, 10.1186/1750-1326-4-1 · DOI
  35. Paul, 2013, The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors, J. Neurosci., 33, 17290, 10.1523/JNEUROSCI.2619-13.2013 · DOI
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  37. Jang, 2011, 7-ketocholesterol induces apoptosis in differentiated PC12 cells via reactive oxygen species-dependent activation of NF-κB and Akt pathways, Neurochem. Int., 58, 52, 10.1016/j.neuint.2010.10.012 · DOI
  38. Donmez, 2012, The neurobiology of sirtuins and their role in neurodegeneration, Trends Pharmacol. Sci., 33, 494, 10.1016/j.tips.2012.05.007 · DOI
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Cited by

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Metadata

Authors
Testa, G., Staurenghi, E., Giannelli, S., Gargiulo, S., Guglielmotto, M., Tabaton, M., Tamagno, E., Gamba, P., & Leonarduzzi, G.
Venue
Redox Biology
Publisher
Elsevier BV
Published
2018-07
Volume
17
Pages
423-431
ISSN
2213-2317
DOI
10.1016/j.redox.2018.05.009
Cited by
46
References
6
Language
en
Licence
Funders
  • Compagnia di San Paolo (CSTO167048)
  • Università degli Studi di Torino (RILO2016)

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