Microhemorrhage-associated tissue iron enhances the risk for Aspergillus fumigatus invasion in a mouse model of airway transplantation
Open accessAbstract
Increased ferric iron in allografts triggers a switch in the growth of the mold Aspergillus fumigatus from a colonizing to an invasive phenotype.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Iron availability and fungal iron uptake determine the virulence of many fungal pathogens.
“A. fumigatus grows substantially better in the presence of NTBI in the plasma or in an iron-rich microenvironment in the lung, supporting the concept that iron availability and fungal iron uptake determines the virulence of many fungal pathogens (Haas, 2012;Hsu et al., 2018;Petzer et al., 2019).”
From Iron in infection and immunity (2020) · cites this paper as Hsu et al., 2018
The Discussion (page unavailable) reports that increased iron uptake was associated with increased virulence in A. fumigatus, and the Results link tissue iron to invasion in a mouse airway-transplant model. The paper also mentions an association between excess iron and virulence in Rhizopus oryzae, but it does not establish that iron availability and fungal iron uptake determine virulence across many fungal pathogens. (LLM, conf=0.86)
Experimental — accuracy not yet measuredA. fumigatus grows substantially better in the presence of NTBI in plasma or in an iron-rich microenvironment in the lung.
“A. fumigatus grows substantially better in the presence of NTBI in the plasma or in an iron-rich microenvironment in the lung, supporting the concept that iron availability and fungal iron uptake determines the virulence of many fungal pathogens (Haas, 2012;Hsu et al., 2018;Petzer et al., 2019).”
From Iron in infection and immunity (2020) · cites this paper as Hsu et al., 2018
The Results section on tissue iron and the Discussion report that iron-rich airway grafts promoted A. fumigatus invasion in mice. But the paper does not establish better growth in plasma containing NTBI; its culture experiments used iron dextran or hemoglobin, and the Results state that iron supplementation did not alter wild-type growth rate. The lung finding is therefore supported as increased invasion in a transplant model, not as a general increase in growth. (LLM, conf=0.89)
Experimental — accuracy not yet measuredThe predominant role of iron deregulation in the development of IA has been demonstrated recently in a nonneutropenic model of lung transplantation and in the Aspergillus keratitis model.
“The predominant role of iron deregulation in the development of IA has been demonstrated recently in a nonneutropenic model of lung transplantation (596) and in the Aspergillus keratitis model (279).”
From Aspergillus fumigatus and Aspergillosis in 2019 (2019) · cites this paper as [596]
Nutritional immunity, an ancient host defense strategy of iron limitation to pathogens, becomes essential once other immune effector mechanisms are compromised.
“intracellular and extracellular pathways of nutritional immunity, an ancient host defense strategy of iron limitation to pathogens, becomes essential once other immune effector mechanisms are compromised (239, 279, 596).”
From Aspergillus fumigatus and Aspergillosis in 2019 (2019) · cites this paper as [596]
The predominant role of iron deregulation in the development of IA has been demonstrated in a nonneutropenic model of lung transplantation and in the Aspergillus keratitis model.
“The predominant role of iron deregulation in the development of IA has been demonstrated recently in a nonneutropenic model of lung transplantation (596) and in the Aspergillus keratitis model (279).”
From Aspergillus fumigatus and Aspergillosis in 2019 (2019) · cites this paper as [596]
Intracellular and extracellular pathways of nutritional immunity become essential once other immune effector mechanisms are compromised.
“intracellular and extracellular pathways of nutritional immunity, an ancient host defense strategy of iron limitation to pathogens, becomes essential once other immune effector mechanisms are compromised (239, 279, 596).”
From Aspergillus fumigatus and Aspergillosis in 2019 (2019) · cites this paper as [596]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Sindrilaru, A., Peters, T., Wieschalka, S., Baican, C., Baican, A., Peter, H., Hainzl, A., Schatz, S., Qi, Y., Schlecht, A., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44490 · Cited by 1,100 · see citing works
Histopathologic Diagnosis of Fungal Infections in the 21st Century
Guarner, J., & Brandt, M. E. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00053-10 · Cited by 1,007 · see citing works
Pathogenesis of <i>Aspergillus fumigatus</i> in Invasive Aspergillosis
Dagenais, T. R. T., & Keller, N. P. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00055-08 · Cited by 993 · see citing works
The clinical spectrum of pulmonary aspergillosis
Kosmidis, C., & Denning, D. W. (2015) · Thorax · doi:10.1136/thoraxjnl-2014-206291 · Cited by 850 · see citing works
Hepcidin and the iron-infection axis
Drakesmith, H., & Prentice, A. M. (2012) · Science · doi:10.1126/science.1224577 · Cited by 686 · see citing works
Andrews, N. C., & Schmidt, P. J. (2006) · Annual Review of Physiology · doi:10.1146/annurev.physiol.69.031905.164337 · Cited by 640 · see citing works
The Clinical Spectrum of Pulmonary Aspergillosis
Soubani, A. O., & Chandrasekar, P. H. (2002) · CHEST Journal · doi:10.1378/chest.121.6.1988 · Cited by 595 · see citing works
Yusen, R. D., Edwards, L. B., Kucheryavaya, A. Y., Benden, C., Dipchand, A. I., Goldfarb, S., Levvey, B. J., Lund, L. H., Meiser, B., Rossano, J. W., et al. (2015) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2015.08.014 · Cited by 595 · see citing works
Aspergillus Infections in Transplant Recipients
Singh, N., & Paterson, D. L. (2005) · Clinical Microbiology Reviews · doi:10.1128/cmr.18.1.44-69.2005 · Cited by 579 · see citing works
Schrettl, M., Bignell, E., Kragl, C., Joechl, C., Rogers, T., Arst, H. N., Haynes, K., & Haas, H. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041242 · Cited by 493 · see citing works
Self-citationIron Homeostasis and the Inflammatory Response
Wessling-Resnick, M. (2010) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104804 · Cited by 480 · see citing works
Siderophores in Fungal Physiology and Virulence
Haas, H., Eisendle, M., & Turgeon, B. G. (2008) · Annual Review of Phytopathology · doi:10.1146/annurev.phyto.45.062806.094338 · Cited by 451 · see citing works
Self-citationThe struggle for iron - a metal at the host-pathogen interface: Iron at the host-pathogen interface
Nairz, M., Schroll, A., Sonnweber, T., & Weiss, G. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2010.01529.x · Cited by 398 · see citing works
Invasive Aspergillosis in Transplant Recipients
Paterson, D. L., & Singh, N. (1999) · Medicine · doi:10.1097/00005792-199903000-00003 · Cited by 359 · see citing works
Boelaert, J. R., de Locht, M., Van Cutsem, J., Kerrels, V, Cantinieaux, B., Verdonck, A., Van Landuyt, H. W., & Schneider, Y. J. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116419 · Cited by 340 · see citing works
The iron chelator deferasirox protects mice from mucormycosis through iron starvation
Ibrahim, A. S., Gebermariam, T., Fu, Y., Lin, Husseiny, M. I., French, S. W., Schwartz, J., Skory, C. D., Edwards, J. E., & Spellberg, B. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32338 · Cited by 308 · see citing works
Spellberg, B., Ibrahim, A. S., Chin-Hong, P. V., Kontoyiannis, D. P., Morris, M. I., Perfect, J. R., Fredricks, D., & Brass, E. P. (2012) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkr375 · Cited by 308 · see citing works
HapX-Mediated Adaption to Iron Starvation Is Crucial for Virulence of Aspergillus fumigatus
Schrettl, M., Beckmann, N., Varga, J., Heinekamp, T., Jacobsen, I. D., Jöchl, C., Moussa, T. A., Wang, S., Gsaller, F., Blatzer, M., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001124 · Cited by 284 · see citing works
Self-citationSreA‐mediated iron regulation in Aspergillus fumigatus
Schrettl, M., Kim, H. S., Eisendle, M., Kragl, C., Nierman, W. C., Heinekamp, T., Werner, E. R., Jacobsen, I. D., Illmer, P., Yi, H., et al. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06376.x · Cited by 264 · see citing works
Self-citationIron metabolism and the innate immune response to infection
Johnson, E. E., & Wessling-Resnick, M. (2012) · Microbes and Infection · doi:10.1016/j.micinf.2011.10.001 · Cited by 253 · cited 2× · see citing works
“To evaluate the potential contribution of host pathways involved in iron sequestration from pathogens, we used reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) to measure the expression of hepcidin, natural resistance–associated macrophage protein 1 (nRAMP1), ferroportin (FPN), transferrin recept…”
BackgroundMethodEisendle, M., Oberegger, H., Zadra, I., & Haas, H. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03586.x · Cited by 233 · see citing works
Self-citationAn update on iron chelation therapy.
(2012) · Europe PMC (PubMed Central) · doi:10.2450/2012.0008-12 · Cited by 233 · see citing works
Iron - a key nexus in the virulence of Aspergillus fumigatus
Haas, H. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00028 · Cited by 217 · see citing works
Self-citationAssociation of hemochromatosis with infectious diseases: expanding spectrum
Khan, F. A., Fisher, M. A., & Khakoo, R. A. (2007) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2007.04.007 · Cited by 216 · see citing works
Aspergillus Airway Colonization and Invasive Disease After Lung Transplantation
Cahill, B. C., Hibbs, J. R., Savik, K., Juni, B. A., Dosland, B. M., Stibbe, C., & Hertz, M. I. (1997) · CHEST Journal · doi:10.1378/chest.112.5.1160 · Cited by 213 · see citing works
Fungal infections in the recipients of solid organ transplantation
Singh, N. (2003) · Infectious Disease Clinics of North America · doi:10.1016/s0891-5520(02)00067-3 · Cited by 202 · see citing works
Aspergillus infections in lung transplant recipients: risk factors and outcome
Solé, A., Morant, P., Salavert, M., Pemán, J., & Morales, P. (2005) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2005.01128.x · Cited by 183 · see citing works
Nramp1 promotes efficient macrophage recycling of iron following erythrophagocytosis in vivo
Soe-Lin, S., Apte, S. S., Andriopoulos, B., Andrews, M. C., Schranzhofer, M., Kahawita, T., Garcia-Santos, D., & Ponka, P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900808106 · Cited by 167 · see citing works
Aspergillus infection in lung transplant patients: incidence and prognosis
Iversen, M., Burton, C. M., Vand, S., Skovfoged, L., Carlsen, J., Milman, N. T., Andersen, C. B., Rasmussen, M., & Tvede, M. (2007) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-007-0376-3 · Cited by 148 · see citing works
Hepcidin expression and iron transport in alveolar macrophages
Nguyen, N.-B., Callaghan, K. D., Ghio, A. J., Haile, D. J., & Yang, F. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00484.2005 · Cited by 143 · see citing works
Iron homeostasis—Achilles’ heel of Aspergillus fumigatus?
Schrettl, M., & Haas, H. (2011) · Current Opinion in Microbiology · doi:10.1016/j.mib.2011.06.002 · Cited by 139 · see citing works
Self-citationAltés, A., Remacha, A. F., Sardà, P., Sancho, F. J., Sureda, A. M., Martino, R., Briones, J., Brunet, S., Canals, C., & Sierra, J. (2004) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1704628 · Cited by 129 · see citing works
Microvascular destruction identifies murine allografts that cannot be rescued from airway fibrosis
Babu, A. N., Murakawa, T., Thurman, J. M., Miller, E. J., Henson, P. M., Zamora, M. R., Voelkel, N. F., & Nicolls, M. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32311 · Cited by 124 · see citing works
Self-citationEpidemiology of fungal infections in solid organ transplant patients
PATTERSON, J. E. (1999) · Transplant Infectious Disease · doi:10.1034/j.1399-3062.1999.010402.x · Cited by 123 · see citing works
Nunley, D. R., Gal, A. A., Vega, J. D., Perlino, C. A., Smith, P., & Lawrence, E. C. (2002) · CHEST Journal · doi:10.1378/chest.122.4.1185 · Cited by 121 · see citing works
Weigt, S. S., Copeland, C., Derhovanessian, A., Shino, M. Y., Davis, W. A., Snyder, L. D., Gregson, A. L., Saggar, R., Lynch, J. P., Ross, D. J., et al. (2013) · American Journal of Transplantation · doi:10.1111/ajt.12131 · Cited by 113 · see citing works
Jiang, X., Khan, M. A., Tian, W., Beilke, J. N., Natarajan, R., Kosek, J. C., Yöder, M. C., Semenza, G. L., & Nicolls, M. R. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46192 · Cited by 104 · see citing works
Self-citationIn vitro and in vivo evaluation of selected 68Ga-siderophores for infection imaging
Petřík, M., Haas, H., Schrettl, M., Helbok, A., Blatzer, M., & Decristoforo, C. (2011) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2011.09.012 · Cited by 92 · see citing works
Self-citationAssociation of hepatic iron overload with invasive fungal infection in liver transplant recipients
Alexander, J., Limaye, A. P., Ko, C. W., Bronner, M. P., & Kowdley, K. V. (2006) · Liver Transplantation · doi:10.1002/lt.20827 · Cited by 85 · see citing works
Lama, V. N., Belperio, J. A., Christie, J. D., El‐Chemaly, S., Fishbein, M. C., Gelman, A. E., Hancock, W. W., Keshavjee, S. H., Kreisel, D., Laubach, V. E., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.93121 · Cited by 81 · see citing works
Self-citationZarember, K. A., Cruz, A. R., Huang, C.-Y., & Gallin, J. I. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01547-08 · Cited by 78 · see citing works
Targeting complement component 5a promotes vascular integrity and limits airway remodeling
Khan, M. A., Maasch, C., Vater, A., Klußmann, S., Morser, J., Leung, L. L. K., Atkinson, C., Tomlinson, S., Heeger, P. S., & Nicolls, M. R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217991110 · Cited by 69 · see citing works
Self-citationIbrahim, A. S., Gebremariam, T., French, S. W., Edwards, J. E., & Spellberg, B. (2010) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkp426 · Cited by 68 · see citing works
Diagnosing invasive fungal disease in critically ill patients
Hsu, J. L., Ruoss, S. J., Bower, N. D., Lin, M., Holodniy, M., & Stevens, D. A. (2011) · Critical Reviews in Microbiology · doi:10.3109/1040841x.2011.581223 · Cited by 67 · see citing works
Self-citationRizzo, M., SivaSai, K. S. R., Smith, M. A., Trulock, E. P., Lynch, J. P., Patterson, G. A., & Mohanakumar, T. (2000) · The Journal of Heart and Lung Transplantation · doi:10.1016/s1053-2498(00)00165-0 · Cited by 66 · see citing works
The interplay between vacuolar and siderophore-mediated iron storage in Aspergillus fumigatus
Gsaller, F., Eisendle, M., Lechner, B. E., Schrettl, M., Lindner, H. H., Müller, D., Geley, S., & Haas, H. (2012) · Metallomics · doi:10.1039/c2mt20179h · Cited by 66 · see citing works
Self-citationChronic Allograft Rejection: Epidemiology, Diagnosis, Pathogenesis, and Treatment
WEIGT, S. S., Wallace, W. D., Derhovanessian, A., Saggar, R., Saggar, R., Lynch, J. P., & Belperio, J. A. (2010) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0030-1249116 · Cited by 61 · see citing works
Jiang, X., Malkovskiy, A. V., Tian, W., Sung, Y. K., Sun, W., Hsu, J. L., Manickam, S., Wagh, D. A., Joubert, L., Semenza, G. L., et al. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.09.092 · Cited by 55 · see citing works
Self-citationKhan, M. A., Jiang, X., Dhillon, G. S., Beilke, J. N., Holers, V. M., Atkinson, C., Tomlinson, S., & Nicolls, M. R. (2011) · Circulation Research · doi:10.1161/circresaha.111.250167 · Cited by 53 · see citing works
Self-citationGałkowska, H., Wojewódzka, U., & Olszewski, W. L. (2005) · Wound Repair and Regeneration · doi:10.1111/j.1067-1927.2005.130306.x · Cited by 51 · see citing works
Efficacy of micafungin alone or in combination against experimental pulmonary aspergillosis
Clemons, K. V., & Stevens, D. A. (2005) · Medical Mycology · doi:10.1080/13693780500148350 · Cited by 51 · see citing works
Self-citationGhio, A. J., Turi, J. L., Yang, F., Garrick, L. M., & Garrick, M. D. (2006) · Biological Research · doi:10.4067/s0716-97602006000100008 · Cited by 51 · see citing works
Effects of Iron Chelators on the Formation and Development of Aspergillus fumigatus Biofilm
Nazik, H., Penner, J. C., Ferreira, J. A. G., Haagensen, J. A. J., Cohen, K., Spormann, A. M., Martinez, M., Chen, V., Hsu, J. L., Clemons, K. V., et al. (2015) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01684-15 · Cited by 46 · see citing works
Self-citationAspergillus fumigatus Invasion Increases with Progressive Airway Ischemia
Hsu, J. L., Khan, M. A., Sobel, R. A., Jiang, X., Clemons, K. V., Nguyen, T. T., Stevens, D. A., Martinez, M., & Nicolls, M. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077136 · Cited by 45 · see citing works
Self-citationWoo, P. C. Y., Ngan, A. H. Y., Chui, H.-K., Lau, S. K. P., & Yuen, K. (2010) · Journal of Clinical Microbiology · doi:10.1128/jcm.00917-10 · Cited by 43 · see citing works
Iron Accumulation in Lung Allografts After Transplantation*
Baz, M. A., Ghio, A. J., Roggli, V. L., Tapson, V. F., & Piantadosi, C. A. (1997) · CHEST Journal · doi:10.1378/chest.112.2.435 · Cited by 37 · see citing works
Madill, J., Aghdassi, E., Arendt, B. M., Hartman‐Craven, B., Gutierrez, C., Chow, C., & Allard, J. P. (2009) · Transplantation Reviews · doi:10.1016/j.trre.2009.01.003 · Cited by 30 · see citing works
Iron overload and nitric oxide-derived oxidative stress following lung transplantation
Reid, D. W., Snell, G. I., Ward, C., Krishnaswamy, R., Ward, R. J., Zheng, L., Williams, T. J., & Walters, E. H. (2001) · The Journal of Heart and Lung Transplantation · doi:10.1016/s1053-2498(01)00282-0 · Cited by 30 · see citing works
Pulmonary infection defense after lung transplantation: does airway ischemia play a role?
Verleden, G. M., Vos, R., Raemdonck, D. E. V., & Vanaudenaerde, B. M. (2010) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0b013e32833debd0 · Cited by 28 · see citing works
Jiang, X., Hsu, J. L., Tian, W., Yuan, K., Olcholski, M., Pérez, V. D. J., Semenza, G. L., & Nicolls, M. R. (2013) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1063-8 · Cited by 27 · see citing works
Self-citationKhan, M. A., Dhillon, G. S., Jiang, X., Lin, Y.-C., & Nicolls, M. R. (2012) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00162.2012 · Cited by 23 · see citing works
Self-citationInvasive Mold Infections in Solid Organ Transplant Recipients
Crabol, Y., & Lortholary, O. (2014) · Scientifica · doi:10.1155/2014/821969 · Cited by 20 · see citing works
Meyer‐Luehmann, M., Mora, J. R., Mielke, M. L., Spires‐Jones, T. L., de Calignon, A., von Andrian, U. H., & Hyman, B. T. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-22 · Cited by 17 · see citing works
Iron Accumulation in Lung Allografts Is Associated With Acute Rejection But Not With Adverse Outcome
Sandmeier, P., Speich, R., Grebski, E., VOGT, P. R., Russi, E. W., Weder, W., & Boehler, A. (2005) · CHEST Journal · doi:10.1378/chest.128.3.1379 · Cited by 15 · see citing works
Franken, A. C. W., Lokman, B. C., Ram, A. F. J., van den Hondel, C. A. M. J. J., de Weert, S., & Punt, P. J. (2012) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2012.02655.x · Cited by 10 · see citing works
Selection for hematocrit percent in the house mouse
Schlager, G., & Weibust, R. S. (1976) · Journal of Heredity · doi:10.1093/oxfordjournals.jhered.a108734 · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Aspergillus fumigatus and Aspergillosis in 2019
Latgé, J.-P., & Chamilos, G. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00140-18 · Cited by 1,400 · see citing works
Iron in infection and immunity
Nairz, M., & Weiss, G. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100864 · Cited by 359 · see citing works
Fungal iron homeostasis with a focus on Aspergillus fumigatus
Misslinger, M., Hortschansky, P., Brakhage, A. A., & Haas, H. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2020.118885 · Cited by 134 · see citing works
Self-citationIron Homeostasis in the Lungs—A Balance between Health and Disease
Neves, J., Haider, T., Gassmann, M., & Muckenthaler, M. U. (2019) · Pharmaceuticals · doi:10.3390/ph12010005 · Cited by 94 · see citing works
Multifaceted Roles of Ferroptosis in Lung Diseases
Li, Y., Yang, Y., & Yang, Y. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.919187 · Cited by 72 · see citing works
Sass, G., Ansari, S. R., Dietl, A., Déziel, É., Haas, H., & Stevens, D. A. (2019) · PLoS ONE · doi:10.1371/journal.pone.0216085 · Cited by 65 · see citing works
Self-citationMenacing Mold: Recent Advances in Aspergillus Pathogenesis and Host Defense
Tischler, B. Y., & Hohl, T. M. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.03.027 · Cited by 55 · see citing works
Aspergillus fumigatus biology, immunopathogenicity and drug resistance
van de Veerdonk, F. L., Carvalho, A., Wauters, J., Chamilos, G., & Verweij, P. E. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-025-01180-z · Cited by 58 · see citing works
Nazik, H., Sass, G., Ansari, S. R., Ertekin, R., Haas, H., Déziel, É., & Stevens, D. A. (2019) · Microbiology · doi:10.1099/mic.0.000858 · Cited by 42 · see citing works
Self-citationIron: an essential nutrient for Aspergillus fumigatus and a fulcrum for pathogenesis
Matthaiou, E. I., Sass, G., Stevens, D. A., & Hsu, J. L. (2018) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000487 · Cited by 40 · see citing works
Self-citationHappacher, I., Aguiar, M. M., Yap, A., Decristoforo, C., & Haas, H. (2023) · Essays in Biochemistry · doi:10.1042/ebc20220252 · Cited by 31 · see citing works
Self-citationNitrogen, Iron, and Zinc Acquisition: Key Nutrients to Aspergillus fumigatus Virulence
Perez‐Cuesta, U., Guruceaga, X., Cendon‐Sanchez, S., Pelegri‐Martinez, E., Hernando, F. L., Ramirez‐Garcia, A., Abad, A., & Rementerı́a, A. (2021) · Journal of Fungi · doi:10.3390/jof7070518 · Cited by 31 · see citing works
Dong, Y., Geng, J., Liu, J., Pang, M., Awan, F., Lu, C., & Liu, Y. (2019) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-09757-4 · Cited by 28 · see citing works
Invasive aspergillosis in liver transplant recipients
Melenotte, C., Aimanianda, V., Slavin, M. A., Aguado, J. M., Armstrong-James, D. P. H., Chen, Y., Husain, S., van Delden, C., Saliba, F., Lefort, A., et al. (2023) · Transplant Infectious Disease · doi:10.1111/tid.14049 · Cited by 30 · see citing works
Petzer, V., Wermke, M., Tymoszuk, P., Wolf, D., Seifert, M., Ovaçin, R., Berger, S., Orth-Höller, D., Loacker, L., Weiss, G., et al. (2019) · Blood Advances · doi:10.1182/bloodadvances.2019000043 · Cited by 22 · see citing works
Self-citationAirway hypoxia in lung transplantation
Pasupneti, S., & Nicolls, M. R. (2018) · Current Opinion in Physiology · doi:10.1016/j.cophys.2018.12.002 · Cited by 21 · see citing works
Self-citationMichels, K. R., Solomon, A. L., Scindia, Y. M., Vieira, L. S., Goddard, Y., Whitten, S., Vaulont, S., Burdick, M. D., Atkinson, C., Laubenbacher, R., et al. (2022) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiac079 · Cited by 18 · see citing works
Pagani, N., Armstrong-James, D. P. H., & Reed, A. K. (2020) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2020.09.015 · Cited by 19 · see citing works
Zhao, L., Jin, X., Xiong, Z., Tang, H., Guo, H., Ye, G., Chen, D., Yang, S., Yin, Z., Fu, H., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911119 · Cited by 18 · see citing works
How metals fuel fungal virulence, yet promote anti-fungal immunity
Alselami, A., & Drummond, R. A. (2023) · Disease Models & Mechanisms · doi:10.1242/dmm.050393 · Cited by 17 · see citing works
Quo vadis? Central Rules of Pathogen and Disease Tropism
McCall, L. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.640987 · Cited by 16 · see citing works
Host defense mechanisms against Aspergillus fumigatus lung colonization and invasion
Mackel, J. J., & Steele, C. H. (2019) · Current Opinion in Microbiology · doi:10.1016/j.mib.2019.04.003 · Cited by 17 · see citing works
Jiang, C., Cheng, Y., Cao, H., Zhang, B., Li, J., Zhu, L., Li, Z., Zeng, W., Li, C., & He, Q. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00019 · Cited by 14 · see citing works
Preservation of Microvascular Integrity in Murine Orthotopic Tracheal Allografts by Clopidogrel
Heim, C., Khan, M. A., von Silva-Tarouca, B., Kuckhahn, A. V., Stamminger, T., Ramsperger-Gleixner, M., Nicolls, M. R., Weyand, M., & Ensminger, S. M. (2019) · Transplantation · doi:10.1097/tp.0000000000002571 · Cited by 12 · see citing works
Self-citationBaliga, S., Yadav, S., Sagdeo, P., & Balakrishnan, C. (2023) · Clinical Rheumatology · doi:10.1007/s10067-023-06785-4 · Cited by 11 · see citing works
Ribeiro, H. A., Scindia, Y. M., Mehrad, B., & Laubenbacher, R. (2023) · Journal of Mathematical Biology · doi:10.1007/s00285-023-01940-6 · Cited by 6 · see citing works
Matthaiou, E. I., Chiu, W., Conrad, C., & Hsu, J. L. (2022) · Journal of Fungi · doi:10.3390/jof8070751 · Cited by 3 · see citing works
Self-citationLamberink, H., Heijmans, J., Wagemakers, A., & van Dijk, K. (2025) · Mycopathologia · doi:10.1007/s11046-025-00934-w · Cited by 2 · see citing works
Iron induces Aspergillus proteases in cystic fibrosis allergic bronchopulmonary aspergillosis
Chatterjee, P., Ahmad, A., Dhillon, E., Matthaiou, E. I., El‐Hafeez, A. A. A., Chiu, W., Illek, B., Stevens, D. A., Milla, C. E., & Hsu, J. L. (2025) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2025-0077oc · Cited by 2 · see citing works
Self-citationLiu, H., Wang, C., Huang, W., Hu, S., & Huang, C. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1788786 · Cited by 2 · see citing works
Iron in respiratory immunity and infection
Martinelli, A. W., Jordan, R., Wugk, S., Nathan, J. A., & Cloonan, S. M. (2026) · QJM · doi:10.1093/qjmed/hcag090 · Cited by 2 · see citing works
Wong, S. S. W., Dellière, S., Lafont, E., & Aimanianda, V. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818731-9.00045-8 · Cited by 2 · see citing works
Ferreira, J. A. G., & Stevens, D. A. (2025) · Springer series on biofilms · doi:10.1007/978-3-031-93315-8_13 · Cited by 1 · see citing works
Self-citationGrau, M. S., Jackson, B. P., Ringelberg, C. S., Kolling, F., Deepe, G. S., Cramer, R. A., & Obar, J. J. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.22.720189 · Cited by 1 · see citing works
Aspergilosis invasiva secundaria a corticoterapia
Álvarez, S. M., González, M. C., Somarriba, J. P., & Pérez, V. E. (2025) · Enfermedades Infecciosas y Microbiología Clínica · doi:10.1016/j.eimc.2024.12.015
Invasive aspergillosis secondary to corticosteroid therapy
Álvarez, S. M., González, M. C., Somarriba, J. P., & Pérez, V. E. (2025) · Enfermedades infecciosas y microbiologia clinica (English ed ) · doi:10.1016/j.eimce.2025.02.010
Macrophage ferroptosis inhibits Aspergillus conidial killing in lung transplantationPreprint
Matthaiou, E. I., El‐Hafeez, A. A. A., Sharifi, H., Chatterjee, P., Zinter, M. S., Johansson, P. K., Dhillon, E., Chiu, W., Qian, J., Shaller, B. D., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.13.643092
Self-citationNutritional Support Strategies in Lung Transplant Recipients: A Narrative Review
Vasistha, P., & Venegas, C. (2025) · Current Surgery Reports · doi:10.1007/s40137-025-00453-z
- Authors
- Hsu, J. L., Manouvakhova, O. V., Clemons, K. V., Inayathullah, M., Tu, A. B., Sobel, R. A., Tian, A., Nazik, H., Pothineni, V. R., Pasupneti, S., Jiang, X., Dhillon, G. S., Bedi, H., Rajadas, J., Haas, H., Aurelian, L., Stevens, D. A., & Nicolls, M. R.
- Affiliations
- VA Palo Alto Health Care System (US)
- California Institute for Medical Research (US)
- Stanford Cardiovascular Institute (US)
- Veterans Affairs Palo Alto Health Care System, Medical Service, Palo Alto, CA 94304, USA.
- Stanford Medicine (US)
- Innsbruck Medical University (AT)
- University of Maryland, Baltimore (US)
- Corresponding author
- Nicolls, Mark R.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2018-02-21
- Volume
- 10
- Issue
- 429
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC5841257
- OpenAlex
- W2788429536
- Cited by
- 38
- References
- 66
- Citations by year
- 2026: 3 · 2025: 8 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 9 · 2018: 2
- FWCI
- 3.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1K08HL122528-01A1, R01 HL095686, P01HL108797, 1T32HL12997001)
- The Parker Foundation
- Austrian Science Foundation (FWF I-1346)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- Aspergillus fumigatus, tissue iron, microhemorrhages, invasive aspergillosis, fungal colonization, mouse model
- MeSH terms
- Animals, Aspergillosis, Aspergillus fumigatus, Disease Models, Animal, Iron, Lung, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Lung Transplantation, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
