Integrin α 4 β 7 expression on peripheral blood CD4 + T cells predicts HIV acquisition and disease progression outcomes
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CD4 + T cells expressing α 4 β 7 play an important role in HIV pathogenesis.
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Organ-specific non-peripheral cells with tissue-homing markers can transiently appear in blood cell preparations.
“In these blood cell preparations, organ-specific non-peripheral cells with tissue-homing markers can also transiently appear. 16-20”
From Revealing viral and cellular dynamics of HIV-1 at the single-cell level during early treatment periods (2023) · cites this paper as [20]
The Introduction (page unavailable) identifies α4β7 as an intestinal-homing marker, and the Results section on pre-HIV frequencies finds α4β7-expressing CD4+ T cells in blood. The paper does not establish that these are organ-resident, non-peripheral cells appearing transiently in blood preparations; it reports relatively stable frequencies across blood samples. (LLM, conf=0.84)
Experimental — accuracy not yet measuredIt is known that especially integrin a4b7-expressing cells are predominantly infected and depleted during the early infection phases, with a rather poor recovery during ART.
“It is known that especially integrin a 4 b 7 -expressing cells are predominantly infected and depleted during the early infection phases, with a rather poor recovery during ART. 18,20”
From Revealing viral and cellular dynamics of HIV-1 at the single-cell level during early treatment periods (2023) · cites this paper as [20]
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Self-citation
- Authors
- Sivro, A., Schuetz, A., Sheward, D., Joag, V., Yegorov, S., Liebenberg, L. J., Yende-Zuma, N., Stalker, A., Mwatelah, R. S., Selhorst, P., Garrett, N., Samsunder, N., Balgobin, A., Nawaz, F., Cicala, C., Arthos, J., Fauci, A. S., Anzala, A. O., Kimani, J., Bagaya, B. S., Kiwanuka, N., Williamson, C., Kaul, R., Passmore, J.-A. S., Phanuphak, N., Ananworanich, J., Ansari, A., Abdool Karim, Q., Abdool Karim, S. S., McKinnon, L. R., & groups, O. B. O. T. C. A. R. S.
- Affiliations
- Centre for the AIDS Programme of Research in South Africa (ZA)
- Henry M. Jackson Foundation (US)
- National Health Laboratory Service (ZA)
- University of Toronto (CA)
- Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban 4013, South Africa.
- University of Manitoba (CA)
- National Institutes of Health (US)
- University of Nairobi (KE)
- International AIDS Vaccine Initiative (US)
- University Health Network (CA)
- Thai Red Cross Society (TH)
- Emory University (US)
- Corresponding author
- McKinnon, Lyle R.
- ORCID
- Sivro, Aida
- Schuetz, Alexandra
- Sheward, Daniel
- Joag, Vineet
- Yegorov, Sergey
- Liebenberg, Lenine J.
- Stalker, Andrew
- Mwatelah, Ruth S.
- Garrett, Nigel
- Samsunder, Natasha
- Cicala, Claudia
- Arthos, James
- Fauci, Anthony S.
- Kimani, Joshua
- Bagaya, Bernard S.
- Kiwanuka, Noah
- Williamson, Carolyn
- Kaul, Rupert
- Passmore, Jo-Ann S.
- Phanuphak, Nittaya
- Ananworanich, Jintanat
- Ansari, Aftab
- Abdool Karim, Quarraisha
- Abdool Karim, Salim S.
- McKinnon, Lyle R.
- Venue
- Science Translational Medicine
- Published
- 2018-01-24
- Volume
- 10
- Issue
- 425
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC6820005
- OpenAlex
- W2784736442
- Cited by
- 94
- References
- 49
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 3 · 2023: 5 · 2022: 6 · 2021: 11 · 2020: 23 · 2019: 18 · 2018: 13
- FWCI
- 8.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- University of Nairobi Research Archive (University of Nairobi) (submittedVersion, cc-by-nc-nd)
- Funders
- NIH R21 (award348075, AI115978-01)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Keywords
- alpha4beta7 integrin, CD4+ T cells, HIV acquisition, HIV disease progression, biomarkers, peripheral blood, HIV pathogenesis
- MeSH terms
- Adult, Humans, Intestinal Mucosa, CD4-Positive T-Lymphocytes, HIV-1, HIV Infections, Multivariate Analysis, Logistic Models, Proportional Hazards Models, Integrins, Disease Progression, Antiretroviral Therapy, Highly Active, env Gene Products, Human Immunodeficiency Virus, Young Adult
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