Cited by 94HIV Research and TreatmentCell Adhesion Molecules ResearchHIV/AIDS Research and Interventions

Integrin α 4 β 7 expression on peripheral blood CD4 + T cells predicts HIV acquisition and disease progression outcomes

Open access
Sivro, Aida, Schuetz, Alexandra, Sheward, Daniel, Joag, Vineet, Yegorov, Sergey, Liebenberg, Lenine J., Yende-Zuma, Nonhlanhla, Stalker, Andrew +23 more·2018·Science Translational Medicine

Abstract

CD4 + T cells expressing α 4 β 7 play an important role in HIV pathogenesis.

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Crossref · 10.1126/scitranslmed.aam6354

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49 of 49 references verified0 citation errors · 0 not checkable

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  • Organ-specific non-peripheral cells with tissue-homing markers can transiently appear in blood cell preparations.

    “In these blood cell preparations, organ-specific non-peripheral cells with tissue-homing markers can also transiently appear. 16-20”

    From Revealing viral and cellular dynamics of HIV-1 at the single-cell level during early treatment periods (2023) · cites this paper as [20]

    The Introduction (page unavailable) identifies α4β7 as an intestinal-homing marker, and the Results section on pre-HIV frequencies finds α4β7-expressing CD4+ T cells in blood. The paper does not establish that these are organ-resident, non-peripheral cells appearing transiently in blood preparations; it reports relatively stable frequencies across blood samples. (LLM, conf=0.84)

    Experimental — accuracy not yet measured
  • It is known that especially integrin a4b7-expressing cells are predominantly infected and depleted during the early infection phases, with a rather poor recovery during ART.

    “It is known that especially integrin a 4 b 7 -expressing cells are predominantly infected and depleted during the early infection phases, with a rather poor recovery during ART. 18,20”

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Authors
Sivro, A., Schuetz, A., Sheward, D., Joag, V., Yegorov, S., Liebenberg, L. J., Yende-Zuma, N., Stalker, A., Mwatelah, R. S., Selhorst, P., Garrett, N., Samsunder, N., Balgobin, A., Nawaz, F., Cicala, C., Arthos, J., Fauci, A. S., Anzala, A. O., Kimani, J., Bagaya, B. S., Kiwanuka, N., Williamson, C., Kaul, R., Passmore, J.-A. S., Phanuphak, N., Ananworanich, J., Ansari, A., Abdool Karim, Q., Abdool Karim, S. S., McKinnon, L. R., & groups, O. B. O. T. C. A. R. S.
Affiliations
  • Centre for the AIDS Programme of Research in South Africa (ZA)
  • Henry M. Jackson Foundation (US)
  • National Health Laboratory Service (ZA)
  • University of Toronto (CA)
  • Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban 4013, South Africa.
  • University of Manitoba (CA)
  • National Institutes of Health (US)
  • University of Nairobi (KE)
  • International AIDS Vaccine Initiative (US)
  • University Health Network (CA)
  • Thai Red Cross Society (TH)
  • Emory University (US)
Corresponding author
McKinnon, Lyle R.
Venue
Science Translational Medicine
Published
2018-01-24
Volume
10
Issue
425
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W2784736442
Cited by
94
References
49
Citations by year
2026: 6 · 2025: 9 · 2024: 3 · 2023: 5 · 2022: 6 · 2021: 11 · 2020: 23 · 2019: 18 · 2018: 13
FWCI
8.52
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • University of Nairobi Research Archive (University of Nairobi) (submittedVersion, cc-by-nc-nd)
Funders
NIH R21 (award348075, AI115978-01)
Topics
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Keywords
alpha4beta7 integrin, CD4+ T cells, HIV acquisition, HIV disease progression, biomarkers, peripheral blood, HIV pathogenesis
MeSH terms
Adult, Humans, Intestinal Mucosa, CD4-Positive T-Lymphocytes, HIV-1, HIV Infections, Multivariate Analysis, Logistic Models, Proportional Hazards Models, Integrins, Disease Progression, Antiretroviral Therapy, Highly Active, env Gene Products, Human Immunodeficiency Virus, Young Adult

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