The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis
Open accessAbstract
and synergized with transforming growth factor-β stimulation. In OA chondrocytes, overexpression of FoxO1 reduced inflammatory mediators and cartilage-degrading enzymes, increased protective genes, and antagonized interleukin-1β effects. Our observations suggest that FoxO play a key role in postnatal cartilage development, maturation, and homeostasis and protect against OA-associated cartilage damage.
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“Activating FoxO transcription factors protect against OA-associated cartilage damage [26].”
From Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy (2019) · cites this paper as [26]
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Sandri, M., Sandri, C., Gilbert, A., Skurk, C., Calabria, E., Picard, A., Walsh, K., Schiaffino, S., Lecker, S. H., & Goldberg, A. L. (2004) · Cell · doi:10.1016/s0092-8674(04)00400-3 · Cited by 3,012
Osteoarthritis cartilage histopathology: grading and staging
Pritzker, K. P. H., Gay, S., Jiménez, S. A., Østergaard, K., Pelletier, J., Revell, P. A., Salter, D. M., & van den Berg, W. B. (2005) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2005.07.014 · Cited by 2,355
Epidemiology of Osteoarthritis
Zhang, Y., & Jordan, J. M. (2010) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2010.03.001 · Cited by 2,320
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
Kops, G. J. P. L., Dansen, T. B., Polderman, P. E., Saarloos, I., Wirtz, K. W. A., Coffer, P. J., Huang, T.-T., Bos, J. L., Medema, R. H., & Burgering, B. M. T. (2002) · Nature · doi:10.1038/nature01036 · Cited by 1,580
Glasson, S. S., Blanchet, T., & Morris, E. A. (2007) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2007.03.006 · Cited by 1,524
FOXOs: signalling integrators for homeostasis maintenance
Eijkelenboom, A., & Burgering, B. M. T. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3507 · Cited by 1,110
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis
Paik, J.-H., Kollipara, R., Chu, G., Ji, H., Xiao, Y., Ding, Z., Miao, L., Tothova, Z., Horner, J. W., Carrasco, D. R., et al. (2007) · Cell · doi:10.1016/j.cell.2006.12.029 · Cited by 1,032
FOXO3A genotype is strongly associated with human longevity
Willcox, B. J., Donlon, T. A., He, Q., Chen, R., Grove, J. S., Yano, K., Masaki, K. H., Willcox, D. C., Rodriguez, B., & Curb, J. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801030105 · Cited by 983
Primary culture and phenotyping of murine chondrocytes
Gosset, M., Berenbaum, F., Thirion, S., & Jacques, C. (2008) · Nature Protocols · doi:10.1038/nprot.2008.95 · Cited by 735
The Role of Cytokines in Cartilage Matrix Degeneration in Osteoarthritis
Goldring, S. R., & Goldring, M. B. (2004) · Clinical Orthopaedics and Related Research · doi:10.1097/01.blo.0000144854.66565.8f · Cited by 655
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The role of autophagy in bone metabolism and clinical significance
Wang, J., Zhang, Y., Cao, J., Wang, Y., Anwar, N., Zhang, Z., Zhang, D., Ma, Y., Xiao, Y., Xiao, L., et al. (2023) · Autophagy · doi:10.1080/15548627.2023.2186112 · Cited by 337
The FoxO–Autophagy Axis in Health and Disease
Cheng, Z. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.07.009 · Cited by 257
Transcriptional Regulation of Autophagy: Mechanisms and Diseases
Di Malta, C., Cinque, L., & Settembre, C. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00114 · Cited by 255
Qiao, Z., Lian, M., Yu, H., Sun, B., Zhang, X. Y., Jiang, W., Li, H., Hao, Y., & Dai, K. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120385 · Cited by 231
FOXO transcription factors as mediators of stress adaptation
Colman, M. J. R., Dansen, T. B., & Burgering, B. M. T. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00649-0 · Cited by 228
Metadata
- Authors
- Matsuzaki, T., Alvarez-Garcia, O., Mokuda, S., Nagira, K., Olmer, M., Gamini, R., Miyata, K., Akasaki, Y., Su, A. I., Asahara, H., & Lotz, M. K.
- Affiliations
- Scripps Research Institute (US)
- Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
- Corresponding author
- Lotz, Martin K.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2018-02-14
- Volume
- 10
- Issue
- 428
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC6204214
- OpenAlex
- W2786308277
- Cited by
- 271
- References
- 65
- Citations by year
- 2026: 15 · 2025: 24 · 2024: 38 · 2023: 47 · 2022: 46 · 2021: 47 · 2020: 23 · 2019: 19 · 2018: 12
- FWCI
- 21.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (award315935, AG007996, award315936, AG049617)
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › FOXO transcription factor regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Keywords
- FOXO transcription factors, FOXO1, autophagy, proteoglycan 4, cartilage homeostasis, osteoarthritis, chondrocytes, chondrogenesis, IL-1β, TGF-beta, cartilage degeneration, inflammation
- MeSH terms
- Proteoglycan 4, Animals, Animals, Newborn, Autophagy, Bone and Bones, Cartilage, Articular, Cell Survival, Gene Expression Regulation, Growth Plate, Homeostasis, Humans, Osteoarthritis, Proteoglycans, Transforming Growth Factor beta, Gene Deletion, Mice, Knockout, Chondrocytes, Cell Proliferation, Body Size, Forkhead Transcription Factors, Interleukin-1beta
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