The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis
Open accessAbstract
and synergized with transforming growth factor-β stimulation. In OA chondrocytes, overexpression of FoxO1 reduced inflammatory mediators and cartilage-degrading enzymes, increased protective genes, and antagonized interleukin-1β effects. Our observations suggest that FoxO play a key role in postnatal cartilage development, maturation, and homeostasis and protect against OA-associated cartilage damage.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Activating FoxO transcription factors protect against OA-associated cartilage damage [26].”
From Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy (2019) · cites this paper as [26]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Sandri, M., Sandri, C., Gilbert, A., Skurk, C., Calabria, E., Picard, A., Walsh, K., Schiaffino, S., Lecker, S. H., & Goldberg, A. L. (2004) · Cell · doi:10.1016/s0092-8674(04)00400-3 · Cited by 3,012
Osteoarthritis cartilage histopathology: grading and staging
Pritzker, K. P. H., Gay, S., Jiménez, S. A., Østergaard, K., Pelletier, J., Revell, P. A., Salter, D. M., & van den Berg, W. B. (2005) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2005.07.014 · Cited by 2,355
Epidemiology of Osteoarthritis
Zhang, Y., & Jordan, J. M. (2010) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2010.03.001 · Cited by 2,320
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
Kops, G. J. P. L., Dansen, T. B., Polderman, P. E., Saarloos, I., Wirtz, K. W. A., Coffer, P. J., Huang, T.-T., Bos, J. L., Medema, R. H., & Burgering, B. M. T. (2002) · Nature · doi:10.1038/nature01036 · Cited by 1,580
Glasson, S. S., Blanchet, T., & Morris, E. A. (2007) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2007.03.006 · Cited by 1,524
FOXOs: signalling integrators for homeostasis maintenance
Eijkelenboom, A., & Burgering, B. M. T. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3507 · Cited by 1,110
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis
Paik, J.-H., Kollipara, R., Chu, G., Ji, H., Xiao, Y., Ding, Z., Miao, L., Tothova, Z., Horner, J. W., Carrasco, D. R., et al. (2007) · Cell · doi:10.1016/j.cell.2006.12.029 · Cited by 1,032
FOXO3A genotype is strongly associated with human longevity
Willcox, B. J., Donlon, T. A., He, Q., Chen, R., Grove, J. S., Yano, K., Masaki, K. H., Willcox, D. C., Rodriguez, B., & Curb, J. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801030105 · Cited by 983
Primary culture and phenotyping of murine chondrocytes
Gosset, M., Berenbaum, F., Thirion, S., & Jacques, C. (2008) · Nature Protocols · doi:10.1038/nprot.2008.95 · Cited by 735
The Role of Cytokines in Cartilage Matrix Degeneration in Osteoarthritis
Goldring, S. R., & Goldring, M. B. (2004) · Clinical Orthopaedics and Related Research · doi:10.1097/01.blo.0000144854.66565.8f · Cited by 655
FOXO transcription factors: key regulators of cellular quality control
Webb, A. E., & Brunet, A. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.02.003 · Cited by 649
Epidemiology of Osteoarthritis
Zhang, Y., & Jordan, J. M. (2008) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2008.05.007 · Cited by 633
Caramés, B., Taniguchi, N., Otsuki, S., Blanco, F. J., & Lotz, M. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27305 · Cited by 632
Self-citationThe secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth
Rhee, D. K., Marcelino, J. R., Baker, M., Gong, Y., Smits, P. J., Lefebvre, V., Jay, G. D., Stewart, M. C., Wang, H., Warman, M. L., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200522263 · Cited by 630
The bone–cartilage unit in osteoarthritis
Lories, R. J. U., & Luyten, F. P. (2010) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2010.197 · Cited by 610
FoxO transcription factors in the maintenance of cellular homeostasis during aging
Salih, D. A., & Brunet, A. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.02.005 · Cited by 604
Epidemiology of Osteoarthritis
Neogi, T., & Zhang, Y. (2012) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2012.10.004 · Cited by 603
The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth
Rhee, D. K., Marcelino, J. R., Baker, M., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22263 · Cited by 501
Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells
Ouyang, W., Beckett, O. R., Ma, Q., Paik, J.-H., DePinho, R. A., & Li, M. O. (2010) · Nature Immunology · doi:10.1038/ni.1884 · Cited by 467
Autophagy activation by rapamycin reduces severity of experimental osteoarthritis
Caramés, B., Hasegawa, A., Taniguchi, N., Miyaki, S., Blanco, F. J., & Lotz, M. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2011-200557 · Cited by 466
Self-citationNovel Foxo1-dependent transcriptional programs control Treg cell function
Ouyang, W., Liao, W., Luo, C. T., Yin, N., Huse, M., Kim, M. V., Peng, M., Chan, P., Ma, Q., Mo, Y., et al. (2012) · Nature · doi:10.1038/nature11581 · Cited by 430
Effects of aging on articular cartilage homeostasis
Lotz, M., & Loeser, R. F. (2012) · Bone · doi:10.1016/j.bone.2012.03.023 · Cited by 393
Self-citationRached, M.-T., Kode, A., Xu, L., Yoshikawa, Y., Paik, J.-H., DePinho, R. A., & Kousteni, S. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.01.001 · Cited by 334
Krenn, V., Morawietz, L., Häupl, T., Neidel, J., Petersen, I., & König, A. (2002) · Pathology - Research and Practice · doi:10.1078/0344-0338-5710261 · Cited by 334
Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA
Lotz, M. K., & Caramés, B. (2011) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2011.109 · Cited by 314
Self-citationLotz, M. (2010) · Arthritis Research & Therapy · doi:10.1186/ar3046 · Cited by 294
Self-citationRole of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis
Waller, K. A., Zhang, L. X., Elsaid, K. A., Fleming, B. C., Warman, M. L., & Jay, G. D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219289110 · Cited by 266
Hunziker, E. B., Kapfinger, E., & Geiss, J. (2006) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2006.09.010 · Cited by 259
Association between friction and wear in diarthrodial joints lacking lubricin
Jay, G. D., Torres, J. R., Rhee, D. K., Helminen, H. J., Hyttinen, M. M., Cha, C., Elsaid, K. A., Kim, K., Cui, Y., & Warman, M. L. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22974 · Cited by 252
FOXOs attenuate bone formation by suppressing Wnt signaling
Iyer, S. V., Ambrogini, E., Bartell, S. M., Li, H., Roberson, P. K., de Cabo, R., Jilka, R. L., Weinstein, R. S., O’Brien, C. A., Manolagas, S. C., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci68049 · Cited by 233
Swann, D. A., Slayter, H. S., & Silver, F. H. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)69297-5 · Cited by 232
FoxO Transcription Factors Support Oxidative Stress Resistance in Human Chondrocytes
Akasaki, Y., Álvarez-García, Ó., Saito, M., Caramés, B., Iwamoto, Y., & Lotz, M. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38868 · Cited by 228
Self-citationJay, G. D., Britt, D. E., & J, C. (2000) · PubMed · Cited by 206
Schumacher, B. L., Hughes, C., Kuettner, K. E., Caterson, B., & Aydelotte, M. B. (1999) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100170117 · Cited by 202
Generation of aggrecan‐CreERT2 knockin mice for inducible Cre activity in adult cartilage
Henry, S. P., Jang, C., Deng, J. M., Zhang, Z., Behringer, R. R., & Crombrugghe, B. D. (2009) · genesis · doi:10.1002/dvg.20564 · Cited by 186
Isolation, characterization and mapping of the mouse and human PRG4 (proteoglycan 4) genes
Ikegawa, S., Sano, M., Koshizuka, Y., & Nakamura, Y. (2000) · Cytogenetic and Genome Research · doi:10.1159/000056791 · Cited by 185
Hepatic Suppression of Foxo1 and Foxo3 Causes Hypoglycemia and Hyperlipidemia in Mice
Zhang, K., Li, L., Qi, Y., Zhu, X., Gan, B., DePinho, R. A., Averitt, T., & Guo, S. (2011) · Endocrinology · doi:10.1210/en.2011-1527 · Cited by 179
Matsuzaki, T., Matsushita, T., Takayama, K., Matsumoto, T., Nishida, K., Kuroda, R., & Kurosaka, M. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-202620 · Cited by 178
Self-citationTerkeltaub, R. A., Yang, B., Lotz, M., & Liu‐Bryan, R. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30333 · Cited by 168
Self-citationIyer, S. V., Han, L., Bartell, S. M., Kim, H., Gubrij, I. B., de Cabo, R., O’Brien, C. A., Manolagas, S. C., & Almeida, M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.561803 · Cited by 151
Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis
Akasaki, Y., Hasegawa, A., Saito, M., Asahara, H., Iwamoto, Y., & Lotz, M. (2013) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2013.11.004 · Cited by 141
Self-citationAge- and site-associated biomechanical weakening of human articular cartilage of the femoral condyle
Temple, M. M., Bae, W. C., Chen, M. Q., Lotz, M., Amiel, D., Coutts, R. D., & Sah, R. L. (2007) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2007.03.005 · Cited by 131
Self-citationGenome‐wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling
Eijkelenboom, A., Mokrý, M., de Wit, E., Smits, L. M. M., Polderman, P. E., van Triest, M. H., van Boxtel, R., Schulze, A., de Laat, W. L., Cuppen, E. P. J. G., et al. (2013) · Molecular Systems Biology · doi:10.1038/msb.2012.74 · Cited by 125
Bortolotti, F., Ukovich, L., Razban, V., Martinelli, V. C., Ruozi, G., Pelos, B., Dore, F., Giacca, M., & Zacchigna, S. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.01.001 · Cited by 123
Proteoglycan 4 (PRG4) synthesis and immunolocalization in bovine meniscus
Schumacher, B. L., Schmidt, T. A., Voegtline, M. S., Chen, A. C., & Sah, R. L. (2005) · Journal of Orthopaedic Research® · doi:10.1016/j.orthres.2004.11.011 · Cited by 108
Stage-and tissue-specific expression of a Col2a1-Cre fusion gene in transgenic mice
Sakai, K., Hiripi, L., Glumoff, V., Brandau, O., Eerola, R., VUORIO, E. I., Bösze, Z., Fässler, R., & Aszódi, A. (2001) · Matrix Biology · doi:10.1016/s0945-053x(00)00122-0 · Cited by 102
Differential regulation of proteoglycan 4 metabolism in cartilage by IL-1α, IGF-I, and TGF-β1
Schmidt, T. A., Gastelum, N. S., Han, E., Nugent, G. E., Schumacher, B. L., & Sah, R. L. (2007) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2007.05.009 · Cited by 91
Elsaid, K. A., Zhang, L., Waller, K. A., Tofte, J. N., Teeple, E. A., Fleming, B. C., & Jay, G. D. (2012) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2012.04.021 · Cited by 90
FOXO1 modulates osteoblast differentiation
Siqueira, M. F., Flowers, S. J., Bhattacharya, R., Faibish, D., Behl, Y., Kotton, D. N., Gerstenfeld, L. C., Morán, E., & Graves, D. T. (2011) · Bone · doi:10.1016/j.bone.2011.01.019 · Cited by 88
Unraveling the role of FoxOs in bone—Insights from mouse models
Almeida, M. (2011) · Bone · doi:10.1016/j.bone.2011.05.023 · Cited by 85
Grabiec, A. M., Angiolilli, C., Hartkamp, L. M., van Baarsen, L. G. M., Tak, P. P., & Reedquist, K. A. (2014) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-203610 · Cited by 84
Highly Specialized Role of Forkhead Box O Transcription Factors in the Immune System
Dejean, A. S., Hedrick, S. Μ., & Kerdiles, Y. M. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3414 · Cited by 78
Álvarez-García, Ó., Olmer, M., Akagi, R., Akasaki, Y., Fisch, K. M., Shen, T., Su, A. I., & Lotz, M. (2016) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2016.04.015 · Cited by 60
Self-citationStaal, B., Williams, B. O., Beier, F., Woude, G. F. V., & Zhang, Y.-W. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400744111 · Cited by 56
van der Kraan, P. M. (2014) · Bio-Medical Materials and Engineering · doi:10.3233/bme-140976 · Cited by 55
Shen, T., Álvarez-García, Ó., Li, Y.-K., Olmer, M., & Lotz, M. K. (2016) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2016.09.017 · Cited by 52
Self-citationFOXO3 and Related Transcription Factors in Development, Aging, and Exceptional Longevity
Kahn, A. J. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu044 · Cited by 43
Col2-Cre and tamoxifen-inducible Col2-CreER target different cell populations in the knee joint
Nagao, M., Cheong, C. W., & Olsen, B. R. (2015) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2015.07.025 · Cited by 41
Xiong, Y., Zhang, Y., Xin, N., Yuan, Y., Zhang, Q., Gong, P., & Wu, Y. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.796367 · Cited by 38
Transthyretin deposition promotes progression of osteoarthritis
Matsuzaki, T., Akasaki, Y., Olmer, M., Álvarez-García, Ó., Reixach, N., Buxbaum, J. N., & Lotz, M. (2017) · Aging Cell · doi:10.1111/acel.12665 · Cited by 33
Self-citationJay, G. D., & Hong, B. (1992) · Connective Tissue Research · doi:10.3109/03008209209014229 · Cited by 32
Superficial zone cellularity is deficient in mice lacking lubricin: a stereoscopic analysis
Karamchedu, N. P., Tofte, J. N., Waller, K. A., Zhang, L. X., Patel, T. K., & Jay, G. D. (2016) · Arthritis Research & Therapy · doi:10.1186/s13075-016-0967-4 · Cited by 26
Forkhead box O transcription factors in chondrocytes regulate endochondral bone formation
Eelen, G., Verlinden, L., Maes, C., Beullens, I., Gysemans, C. A., Paik, J.-H., DePinho, R. A., Bouillon, R., Carmeliet, G., & Verstuyf, A. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.07.015 · Cited by 25
Cuellar, A., & Reddi, A. H. (2014) · Tissue Engineering Part A · doi:10.1089/ten.tea.2014.0381 · Cited by 23
Ubiquitous postnatal LoxP recombination using a doxycycline auto-inducible Cre transgene (DAI-Cre)
Holzenberger, M., Zaoui, R., Leneuve, P., Hamard, G., & Bouc, Y. L. (2000) · genesis · doi:10.1002/(sici)1526-968x(200002)26:2 · Cited by 23
Lu, Y., Ding, M. L., Li, N., Wang, Q., Li, J., Li, X., Gu, J., Im, H., Lei, G., & Zheng, Q. (2014) · Europe PMC (PubMed Central) · Cited by 17
Cited by
Sorted by citations
The role of autophagy in bone metabolism and clinical significance
Wang, J., Zhang, Y., Cao, J., Wang, Y., Anwar, N., Zhang, Z., Zhang, D., Ma, Y., Xiao, Y., Xiao, L., et al. (2023) · Autophagy · doi:10.1080/15548627.2023.2186112 · Cited by 337
The FoxO–Autophagy Axis in Health and Disease
Cheng, Z. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.07.009 · Cited by 257
Transcriptional Regulation of Autophagy: Mechanisms and Diseases
Di Malta, C., Cinque, L., & Settembre, C. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00114 · Cited by 255
Qiao, Z., Lian, M., Yu, H., Sun, B., Zhang, X. Y., Jiang, W., Li, H., Hao, Y., & Dai, K. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120385 · Cited by 231
FOXO transcription factors as mediators of stress adaptation
Colman, M. J. R., Dansen, T. B., & Burgering, B. M. T. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00649-0 · Cited by 228
Metadata
- Authors
- Matsuzaki, T., Alvarez-Garcia, O., Mokuda, S., Nagira, K., Olmer, M., Gamini, R., Miyata, K., Akasaki, Y., Su, A. I., Asahara, H., & Lotz, M. K.
- Affiliations
- Scripps Research Institute (US)
- Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
- Corresponding author
- Lotz, Martin K.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2018-02-14
- Volume
- 10
- Issue
- 428
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC6204214
- OpenAlex
- W2786308277
- Cited by
- 271
- References
- 65
- Citations by year
- 2026: 15 · 2025: 24 · 2024: 38 · 2023: 47 · 2022: 46 · 2021: 47 · 2020: 23 · 2019: 19 · 2018: 12
- FWCI
- 21.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (award315935, AG007996, award315936, AG049617)
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › FOXO transcription factor regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Keywords
- FOXO transcription factors, FOXO1, autophagy, proteoglycan 4, cartilage homeostasis, osteoarthritis, chondrocytes, chondrogenesis, IL-1β, TGF-beta, cartilage degeneration, inflammation
- MeSH terms
- Proteoglycan 4, Animals, Animals, Newborn, Autophagy, Bone and Bones, Cartilage, Articular, Cell Survival, Gene Expression Regulation, Growth Plate, Homeostasis, Humans, Osteoarthritis, Proteoglycans, Transforming Growth Factor beta, Gene Deletion, Mice, Knockout, Chondrocytes, Cell Proliferation, Body Size, Forkhead Transcription Factors, Interleukin-1beta
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review