Cited by 271Osteoarthritis Treatment and MechanismsFOXO transcription factor regulationProteoglycans and glycosaminoglycans research

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FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis

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Matsuzaki, Tokio, Alvarez-Garcia, Oscar, Mokuda, Sho, Nagira, Keita, Olmer, Merissa, Gamini, Ramya, Miyata, Kohei, Akasaki, Yukio, Su, Andrew I., Asahara, Hiroshi, Lotz, Martin K.·2018·Science Translational Medicine

DOI 10.1126/scitranslmed.aan0746PMC PMC6204214

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Abstract

and synergized with transforming growth factor-β stimulation. In OA chondrocytes, overexpression of FoxO1 reduced inflammatory mediators and cartilage-degrading enzymes, increased protective genes, and antagonized interleukin-1β effects. Our observations suggest that FoxO play a key role in postnatal cartilage development, maturation, and homeostasis and protect against OA-associated cartilage damage.

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Authors: Matsuzaki, T., Alvarez-Garcia, O., Mokuda, S., Nagira, K., Olmer, M., Gamini, R., Miyata, K., Akasaki, Y., Su, A. I., Asahara, H., & Lotz, M. K.
Affiliations: Scripps Research Institute (US)
Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Corresponding author: Lotz, Martin K.
ORCID: Matsuzaki, Tokio
Alvarez-Garcia, Oscar
Mokuda, Sho
Nagira, Keita
Olmer, Merissa
Gamini, Ramya
Miyata, Kohei
Akasaki, Yukio
Su, Andrew I.
Asahara, Hiroshi
Lotz, Martin K.
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2018-02-14
Volume: 10
Issue: 428
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.aan0746
PMC: PMC6204214
OpenAlex: W2786308277
Cited by: 271
References: 65
Citations by year: 2026: 15 · 2025: 24 · 2024: 38 · 2023: 47 · 2022: 46 · 2021: 47 · 2020: 23 · 2019: 19 · 2018: 12
FWCI: 21.50
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science Translational Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (award315935, AG007996, award315936, AG049617)
Topics: Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › FOXO transcription factor regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Keywords: FOXO transcription factors, FOXO1, autophagy, proteoglycan 4, cartilage homeostasis, osteoarthritis, chondrocytes, chondrogenesis, IL-1β, TGF-beta, cartilage degeneration, inflammation
MeSH terms: Proteoglycan 4, Animals, Animals, Newborn, Autophagy, Bone and Bones, Cartilage, Articular, Cell Survival, Gene Expression Regulation, Growth Plate, Homeostasis, Humans, Osteoarthritis, Proteoglycans, Transforming Growth Factor beta, Gene Deletion, Mice, Knockout, Chondrocytes, Cell Proliferation, Body Size, Forkhead Transcription Factors, Interleukin-1beta

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FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis

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