PP2A inhibition sensitizes cancer stem cells to ABL tyrosine kinase inhibitors in BCR-ABL + human leukemia
Abstract
blast cells and drug-insensitive LSCs and confers a survival advantage in preclinical xenotransplant models. Thus, dual PP2A and BCR-ABL inhibition may be a valuable therapeutic strategy to synergistically target drug-insensitive LSCs that maintain minimal residual disease in patients.
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PP2A inhibition sensitizes cancer cells to kinase inhibitor treatment in hepatocellular carcinoma and BCR-ABL-positive leukemia.
“With this regard, it has been reported that PP2A inhibition sensitizes cancer cells to kinase inhibitors treatment in HCC and BCR-ABL+ leukemia (Fu et al., 2016; Lai et al., 2018).”
From PP2A holoenzymes, substrate specificity driving cellular functions and deregulation in cancer (2019) · cites this paper as Lai et al., 2018
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PP2A holoenzymes, substrate specificity driving cellular functions and deregulation in cancer
(2019) · Advances in Cancer Research · doi:10.1016/bs.acr.2019.03.009 · Cited by 93 · see citing works
- Authors
- Lai, D., Chen, M., Su, J., Liu, X., Rothe, K., Hu, K., Forrest, D. L., Eaves, C. J., Morin, G. B., & Jiang, X.
- Affiliations
- BC Cancer Agency (CA)
- University of British Columbia (CA)
- Corresponding author
- Lai, Damian
- Chen, Min
- Jiang, Xiaoyan
- Venue
- Science Translational Medicine
- Published
- 2018-02-07
- Volume
- 10
- Issue
- 427
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W2787506206
- Cited by
- 47
- References
- 67
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 11 · 2020: 9 · 2019: 8 · 2018: 4
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (award317694)
- Canadian Cancer Society (award317695)
- Topics
- Health Sciences › Medicine › Hematology › Chronic Myeloid Leukemia Treatments
- Health Sciences › Medicine › Genetics › Chronic Lymphocytic Leukemia Research
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Keywords
- PP2A inhibition, BCR-ABL, ABL tyrosine kinase inhibitors, leukemia stem cells, drug resistance, minimal residual disease, combination therapy, chronic myeloid leukemia, acute myeloid leukemia
- MeSH terms
- Animals, Cell Cycle, Drug Synergism, Enzyme Inhibitors, Humans, Tumor Cells, Cultured, Neoplastic Stem Cells, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Apoptosis, Drug Resistance, Neoplasm, Protein Kinase Inhibitors, Cell Proliferation, Mice, Protein Phosphatase 2
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