Cited by 251Liver physiology and pathologyLiver Disease Diagnosis and TreatmentDrug-Induced Hepatotoxicity and Protection

The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.

Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis

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Abstract

Aberrant hepatocyte Notch activation is required for development of NASH-associated fibrosis, and Notch inhibition ameliorates obesity-induced liver disease.

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Metadata

Authors
Zhu, C., Kim, K., Wang, X., Bartolome, A., Salomao, M., Dongiovanni, P., Meroni, M., Graham, M. J., Yates, K. P., Diehl, A. M., Schwabe, R. F., Tabas, I., Valenti, L., Lavine, J. E., & Pajvani, U. B.
Affiliations
  • Columbia University (US)
  • Department of Medicine, Columbia University, New York, NY 10032, USA.
  • Mayo Clinic (US)
  • University of Milan (IT)
  • Ionis Pharmaceuticals (United States) (US)
  • Johns Hopkins University (US)
  • Duke Medical Center (US)
Corresponding author
Pajvani, Utpal B.
Venue
Science Translational Medicine
Published
2018-11-21
Volume
10
Issue
468
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W2901663946
Cited by
250
References
78
Citations by year
2026: 19 · 2025: 40 · 2024: 41 · 2023: 40 · 2022: 31 · 2021: 43 · 2020: 29 · 2019: 7
FWCI
12.37
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (acceptedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (DK103818, DK105303)
Topics
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Keywords
Notch signaling, hepatocytes, liver fibrosis, nonalcoholic steatohepatitis, antifibrotic therapy, diet-induced liver disease
MeSH terms
Animals, Choline, Diet, Female, Humans, Liver Cirrhosis, Male, Methionine, Mice, Inbred C57BL, Hepatocytes, Receptors, Notch, Osteopontin, Hepatic Stellate Cells, SOX9 Transcription Factor, Non-alcoholic Fatty Liver Disease

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