Schwabe, Robert F.

TLR4 enhances TGF-β signaling and hepatic fibrosis

Seki, E., De Minicis, S., Österreicher, C. H., Kluwe, J., Osawa, Y., Brenner, D. A., & Schwabe, R. F. (2007) · Nature Medicine

Liver physiology and pathologyImmune Response and Inflammation

Cited by 1,942

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

Fischer, K. R., Durrans, A., Lee, S., Sheng, J., Li, F., Wong, S. T. C., Choi, H., El Rayes, T., Ryu, S., Troeger, J., et al. (2015) · Nature

Cancer Cells and MetastasisTGF-β signaling in diseases

Cited by 1,791

The microbiome and cancer

Schwabe, R. F., & Jobin, C. (2013) · Nature Reviews Cancer

Gut microbiota and healthOral microbiology and periodontitis research

Cited by 1,689

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology

Mederacke, I., Hsu, C. C., Troeger, J. S., Huebener, P., Mu, X., Dapito, D. H., Pradere, J.-P., & Schwabe, R. F. (2013) · Nature Communications

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 1,443

Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4

Dapito, D. H., Mencin, A., Gwak, G.-Y., Pradere, J.-P., Jang, M.-K., Mederacke, I., Caviglia, J. M., Khiabanian, H., Adeyemi, A., Bataller, R., et al. (2012) · Cancer Cell

Hepatocellular Carcinoma Treatment and PrognosisLiver physiology and pathology

Cited by 1,346

NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma

Luedde, T., & Schwabe, R. F. (2011) · Nature Reviews Gastroenterology & Hepatology

Liver physiology and pathologyNF-κB Signaling Pathways

Cited by 1,345

Hepatic inflammation and fibrosis: Functional links and key pathways

Seki, E., & Schwabe, R. F. (2015) · Hepatology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 972

The Role of Cancer-Associated Fibroblasts and Fibrosis in Liver Cancer

Affo, S., Yu, L.-X., & Schwabe, R. F. (2017) · Annual Review of Pathology: Mechanisms of Disease

Liver physiology and pathologyHepatocellular Carcinoma Treatment and Prognosis

Cited by 757

Mechanisms of Fibrosis Development in Nonalcoholic Steatohepatitis

Schwabe, R. F., Tabas, I., & Pajvani, U. B. (2020) · Gastroenterology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 671

Toll-Like Receptor 4 Mediates Inflammatory Signaling by Bacterial Lipopolysaccharide in Human Hepatic Stellate Cells

Paik, Y.-H., Schwabe, R. F., Bataller, R., Russo, M. P., Jobin, C., & Brenner, D. A. (2003) · Hepatology

Immune Response and InflammationLiver physiology and pathology

Cited by 651

The gut microbiome and liver cancer: mechanisms and clinical translation

Yu, L.-X., & Schwabe, R. F. (2017) · Nature Reviews Gastroenterology & Hepatology

Gut microbiota and healthHepatocellular Carcinoma Treatment and Prognosis

Cited by 634

Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice

Pradere, J.-P., Kluwe, J., De Minicis, S., Jiao, J.-J., Gwak, G.-Y., Dapito, D. H., Jang, M.-K., Guenther, N. D., Mederacke, I., Friedman, R., et al. (2013) · Hepatology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 613

Apoptosis and necroptosis in the liver: a matter of life and death

Schwabe, R. F., & Luedde, T. (2018) · Nature Reviews Gastroenterology & Hepatology

Cell death mechanisms and regulationLiver physiology and pathology

Cited by 582

Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease – novel insights into cellular communication circuits

Peiseler, M., Schwabe, R., Hampe, J., Kubes, P., Heikenwälder, M., & Tacke, F. (2022) · Journal of Hepatology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 564

Deactivation of Hepatic Stellate Cells During Liver Fibrosis Resolution in Mice

Troeger, J. S., Mederacke, I., Gwak, G., Dapito, D. H., Mu, X., Hsu, C. C., Pradere, J., Friedman, R. A., & Schwabe, R. F. (2012) · Gastroenterology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 515

Hepatic stellate cell lipid droplets: A specialized lipid droplet for retinoid storage

Blaner, W. S., O'Byrne, S. M., Wongsiriroj, N., Kluwe, J., D'Ambrosio, D. M., Jiang, H., Schwabe, R. F., Hillman, E. M. C., Piantedosi, R., & Libien, J. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Lipid metabolism and biosynthesisLiver physiology and pathology

Cited by 444

CCR1 and CCR5 promote hepatic fibrosis in mice

Seki, E., De Minicis, S., Gwak, G.-Y., Kluwe, J., Inokuchi, S., Bursill, C. A., Llovet, J. M., Brenner, D. A., & Schwabe, R. F. (2009) · Journal of Clinical Investigation

Liver physiology and pathologyChemokine receptors and signaling

Cited by 431

Free Cholesterol-loaded Macrophages Are an Abundant Source of Tumor Necrosis Factor-α and Interleukin-6

Li, Y., Schwabe, R. F., DeVries-Seimon, T., Yao, P. M., Gerbod-Giannone, M.-C., Tall, A. R., Davis, R. J., Flavell, R., Brenner, D. A., & Tabas, I. (2005) · Journal of Biological Chemistry

Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid Metabolism

Cited by 421

Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations

Affo, S., Nair, A., Brundu, F., Ravichandra, A., Bhattacharjee, S., Matsuda, M., Chin, L., Filliol, A., Wen, W., Song, X., et al. (2021) · Cancer Cell

Cholangiocarcinoma and Gallbladder Cancer StudiesLiver physiology and pathology

Cited by 416

Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis

Wang, X., Zheng, Z., Caviglia, J. M., Corey, K. E., Herfel, T. M., Cai, B., Masia, R., Chung, R. T., Lefkowitch, J. H., Schwabe, R. F., et al. (2016) · Cell Metabolism

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 413

Tumor restriction by type I collagen opposes tumor-promoting effects of cancer-associated fibroblasts

Bhattacharjee, S., Hamberger, F., Ravichandra, A., Miller, M., Nair, A., Affo, S., Filliol, A., Chin, L., Savage, T. M., Yin, D., et al. (2021) · Journal of Clinical Investigation

Cancer Cells and MetastasisCellular Mechanics and Interactions

Cited by 367

Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis

Filliol, A., Saito, Y., Nair, A., Dapito, D. H., Yu, L.-X., Ravichandra, A., Bhattacharjee, S., Affo, S., Fujiwara, N., Su, H., et al. (2022) · Nature

Liver physiology and pathologyHepatocellular Carcinoma Treatment and Prognosis

Cited by 349

Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis

Cai, B., Dongiovanni, P., Corey, K. E., Wang, X., Shmarakov, I. O., Zheng, Z., Kasikara, C., Davra, V., Meroni, M., Chung, R. T., et al. (2020) · Cell Metabolism

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 266

Human Hepatic Stellate Cells Express CCR5 and RANTES to Induce Proliferation and Migration

Schwabe, R. F., Bataller, R., & Brenner, D. A. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology

Liver physiology and pathologyChemokine receptors and signaling

Cited by 252