Sodium-glucose transporter 2 is a diagnostic and therapeutic target for early-stage lung adenocarcinoma
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Lung premalignancy and early-stage adenocarcinoma use a mechanism of glucose transport that can be targeted for early diagnosis and treatment.
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Me4FDG is taken up by SGLT and can identify AAH and low-grade adenocarcinomas of the lung.
“But an alternative tracer, methyl-4-deoxy-4-[18F]-fluoro-α-d-glucopyranoside (Me4FDG), is taken up by SGLT and can identify AAH and low-grade adenocarcinomas of the lung (24).”
From Metabolic reprogramming and cancer progression (2020) · cites this paper as [24]
In atypical adenomatous hyperplasias of the lung, premalignant lesions overexpress SGLT2.
“In atypical adenomatous hyperplasias (AAHs) of the lung, premalignant lesions overexpress sodium-dependent glucose transporter 2 (SGLT2).”
From Metabolic reprogramming and cancer progression (2020) · cites this paper as [24]
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- Authors
- Scafoglio, C. R., Villegas, B., Abdelhady, G., Bailey, S. T., Liu, J., Shirali, A. S., Wallace, W. D., Magyar, C. E., Grogan, T. R., Elashoff, D., Walser, T., Yanagawa, J., Aberle, D. R., Barrio, J. R., Dubinett, S. M., & Shackelford, D. B.
- Affiliations
- University of California, Los Angeles (US)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Scafoglio, Claudio R.
- Shackelford, David B.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2018-11-14
- Volume
- 10
- Issue
- 467
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC6428683
- OpenAlex
- W2901781577
- Cited by
- 176
- References
- 55
- Citations by year
- 2026: 22 · 2025: 21 · 2024: 35 · 2023: 17 · 2022: 22 · 2021: 29 · 2020: 15 · 2019: 14 · 2018: 1
- FWCI
- 4.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- American Cancer Society (130696-RSG-17-003-01-CCE)
- Tobacco-Related Disease Research Program (26IR-0009)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
- Keywords
- SGLT2, lung adenocarcinoma, early-stage lung cancer, SGLT2 inhibitors, tumor growth inhibition, patient-derived xenografts, autochthonous mouse model, diagnostic imaging, therapeutic target
- MeSH terms
- Adenocarcinoma of Lung, Sodium-Glucose Transporter 2 Inhibitors, Aged, Aged, 80 and over, Animals, Biological Transport, Cell Differentiation, Female, Glucose, Humans, Male, Mice, Transgenic, Middle Aged, Neoplasm Staging, Precancerous Conditions, Survival Analysis, Mice, SCID, Xenograft Model Antitumor Assays, Cell Proliferation, Positron-Emission Tomography, Glucose Transporter Type 1, Sodium-Glucose Transporter 2, Molecular Targeted Therapy
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