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Comprehensive Characterization of Molecular Differences in Cancer between Male and Female Patients

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CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells

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Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response

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Genetics and biomarkers in personalisation of lung cancer treatment

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LKB1 and AMPK and the cancer-metabolism link - ten years after

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<scp>AMP</scp> ‐activated protein kinase: a key regulator of energy balance with many roles in human disease

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Repurposing metformin: an old drug with new tricks in its binding pockets

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Repositioning metformin for cancer prevention and treatment

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Loss of the Tumor Suppressor LKB1 Promotes Metabolic Reprogramming of Cancer Cells via HIF-1α

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AMPK protects leukemia-initiating cells in myeloid leukemias from metabolic stress in the bone marrow

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Mitophagy and cancer

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AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival

Kishton, R. J., Barnes, C. E., Nichols, A., Cohen, S., Gerriets, V. A., Siska, P. J., Macintyre, A. N., Goraksha-Hicks, P., de Cubas, A. A., Liu, T., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.03.008 · Cited by 261 · see citing works

AMPK signaling and its targeting in cancer progression and treatment

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AMPK activity regulates trafficking of mitochondria to the leading edge during cell migration and matrix invasion

Cunniff, B., McKenzie, A. J., Heintz, N. H., & Howe, A. K. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-05-0286 · Cited by 249 · see citing works

Metabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment

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Vimentin Is Required for Lung Adenocarcinoma Metastasis via Heterotypic Tumor Cell–Cancer-Associated Fibroblast Interactions during Collective Invasion

Richardson, A. M., Havel, L. S., Koyen, A. E., Konen, J. M., Shupe, J. A., Wiles, W. G., Martin, W. D., Grossniklaus, H. E., Sica, G., Gilbert‐Ross, M., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-1776 · Cited by 228 · see citing works

In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer

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The OncoPPi network of cancer-focused protein–protein interactions to inform biological insights and therapeutic strategies

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Cancer Cells Don’t Live Alone: Metabolic Communication within Tumor Microenvironments

Li, F., & Simon, M. C. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.06.018 · Cited by 226 · see citing works

Molecular pathways and therapeutic targets in lung cancer

Shtivelman, E., Hensing, T., Simon, G. R., Dennis, P. A., Otterson, G. A., Bueno, R., & Salgia, R. (2014) · Oncotarget · doi:10.18632/oncotarget.1891 · Cited by 220 · see citing works

Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK

Liu, X., Chhipa, R. R., Pooya, S., Wortman, M. D., Yachyshin, S., Chow, L. M. L., Kumar, A., Zhou, X., Sun, Y. H., Quinn, B., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311121111 · Cited by 222 · see citing works

AMPK directly activates mTORC2 to promote cell survival during acute energetic stress

Kazyken, D., Magnuson, B., Bodur, Ç., Acosta-Jaquez, H. A., Zhang, D., Tong, X., Barnes, T. M., Steinl, G. K., Patterson, N., Altheim, C. H., et al. (2019) · Science Signaling · doi:10.1126/scisignal.aav3249 · Cited by 221 · see citing works

Phenformin enhances the therapeutic benefit of BRAF V600E inhibition in melanoma

Yuan, P., Ito, K., Pérez‐Lorenzo, R., Guzzo, C. D., Lee, J. H., Shen, C., Bosenberg, M., McMahon, M., Cantley, L. C., & Zheng, B. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1317577110 · Cited by 218 · see citing works

Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis

Griss, T., Vincent, E. E., Egnatchik, R. A., Chen, J., Ma, E. H., Faubert, B., Viollet, B., DeBerardinis, R. J., & Jones, R. G. (2015) · PLoS Biology · doi:10.1371/journal.pbio.1002309 · Cited by 211 · see citing works

Targeting OXPHOS and the electron transport chain in cancer; Molecular and therapeutic implications

Greene, J. P., Segaran, A., & Lord, S. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.02.002 · Cited by 212 · see citing works

Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells

Cheng, G., Zielonka, J., Ouari, O., López, M., McAllister, D. M., Boyle, K., Barrios, C. S., Weber, J. J., Johnson, B. D., Hardy, M., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2534 · Cited by 212 · see citing works

Type 2 diabetes as a redox disease

Watson, J. D. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62365-x · Cited by 203 · see citing works

Metabolic regulator LKB1 is crucial for Schwann cell–mediated axon maintenance

Beirowski, B., Babetto, E., Golden, J. P., Chen, Y., Yang, K., Gross, R. W., Patti, G. J., & Milbrandt, J. (2014) · Nature Neuroscience · doi:10.1038/nn.3809 · Cited by 197 · see citing works

Mitochondrial complex III is necessary for endothelial cell proliferation during angiogenesis

Diebold, L. P., Gil, H. J., Gao, P., Martinez, C. A., Weinberg, S. E., & Chandel, N. S. (2018) · Nature Metabolism · doi:10.1038/s42255-018-0011-x · Cited by 197 · see citing works

Phase II clinical trial of metformin as a cancer stem cell–targeting agent in ovarian cancer

Brown, J. R., Chan, D., Shank, J., Griffith, K. A., Fan, H., Szulawski, R., Yang, K., Reynolds, R. K., Johnston, C., McLean, K., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.133247 · Cited by 201 · see citing works

Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models

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Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism

Fendt, S., Bell, E. L., Keibler, M. A., Davidson, S. M., Wirth, G. J., Fiske, B. P., Mayers, J. R., Schwab, M. G., Bellinger, G., Csibi, A., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0080 · Cited by 196 · see citing works

Critical role of AMPK in redox regulation under glucose starvation

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cAMP/CREB-regulated LINC00473 marks LKB1-inactivated lung cancer and mediates tumor growth

Chen, Z., Li, J., Lin, S., Cao, C., Gimbrone, N. T., Yang, R., Fu, D., Carper, M. B., Haura, E. B., Schabath, M. B., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci85250 · Cited by 192 · see citing works

Potential applications for biguanides in oncology

Pollak, M. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67232 · Cited by 188 · see citing works

The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma

Momcilovic, M., Bailey, S. T., Lee, J. T., Fishbein, M. C., Braas, D., Go, J. L., Graeber, T. G., Parlati, F., Demo, S. D., Li, R., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.04.002 · Cited by 182 · see citing works

Metabolic Plasticity in Chemotherapy Resistance

Desbats, M. A., Giacomini, I., Prayer‐Galetti, T., & Montopoli, M. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00281 · Cited by 180 · see citing works

Sodium-glucose transporter 2 is a diagnostic and therapeutic target for early-stage lung adenocarcinoma

Scafoglio, C. R., Villegas, B., Abdelhady, G., Bailey, S. T., Liu, J., Shirali, A. S., Wallace, W. D., Magyar, C. E., Grogan, T. R., Elashoff, D., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aat5933 · Cited by 176 · see citing works

Systematic Identification of Molecular Subtype-Selective Vulnerabilities in Non-Small-Cell Lung Cancer

Kim, H. S., Mendiratta, S., Kim, J., Pecot, C. V., Larsen, J. E., Zubovych, I., Seo, B. Y., Kim, J., Eskiocak, B., Chung, H., et al. (2013) · Cell · doi:10.1016/j.cell.2013.09.041 · Cited by 172 · see citing works

LKB1 Inactivation Elicits a Redox Imbalance to Modulate Non-small Cell Lung Cancer Plasticity and Therapeutic Response

Li, F., Han, X., Li, F., Wang, R., Wang, H., Gao, Y., Wang, X., Fang, Z., Zhang, W., Yao, S., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.04.001 · Cited by 169 · see citing works

Targeted inhibition of EGFR and glutaminase induces metabolic crisis in EGFR mutant lung cancer

Momcilovic, M., Bailey, S. T., Lee, J. T., Fishbein, M. C., Magyar, C., Braas, D., Graeber, T., Jackson, N. J., Czernin, J., Emberley, E., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.061 · Cited by 157 · see citing works

The AMPK-Related Kinases SIK1 and SIK3 Mediate Key Tumor-Suppressive Effects of LKB1 in NSCLC

Hollstein, P. E., Eichner, L. J., Brun, S. N., Kamireddy, A., Svensson, R. U., Vera, L. I., Ross, D. S., Rymoff, T. J., Hutchins, A., Galvez, H. M., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-1261 · Cited by 168 · see citing works

Spatial mapping of mitochondrial networks and bioenergetics in lung cancer

Han, M., Bushong, E. A., Segawa, M., Tiard, A., Wong, A., Brady, M. R., Momcilovic, M., Wolf, D. M., Zhang, R., Petcherski, A., et al. (2023) · Nature · doi:10.1038/s41586-023-05793-3 · Cited by 168 · see citing works

Metabolic reprogramming in cancer cells: glycolysis, glutaminolysis, and Bcl-2 proteins as novel therapeutic targets for cancer

Li, C., Zhang, G., Zhao, L., Ma, Z., & Chen, H. (2015) · World Journal of Surgical Oncology · doi:10.1186/s12957-016-0769-9 · Cited by 168 · see citing works

Cardiovascular disease and cancer: Evidence for shared disease pathways and pharmacologic prevention

Masoudkabir, F., Sarrafzadegan, N., Gotay, C. C., Ignaszewski, A. P., Krahn, A. D., Davis, M. K., Franco, C. D., & Mani, A. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.06.001 · Cited by 165 · see citing works

Molecular Pathways: Is AMPK a Friend or a Foe in Cancer?

Hardie, D. G. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-3300 · Cited by 161 · see citing works

Deep learning in digital pathology image analysis: a survey

Deng, S., Zhang, X., Wen, Y., Chang, E., Fan, Y., Lai, M., & Xu, Y. L. (2020) · Frontiers of Medicine · doi:10.1007/s11684-020-0782-9 · Cited by 161 · see citing works

Targeting Metabolism in Cancer Cells and the Tumour Microenvironment for Cancer Therapy

Li, J., Eu, J. Q., Kong, L. R., Wang, L., Lim, Y. C., Goh, B. C., & Wong, A. L. (2020) · Molecules · doi:10.3390/molecules25204831 · Cited by 159 · see citing works

Differential effects of AMPK agonists on cell growth and metabolism

Vincent, E. E., Coelho, P. P., Blagih, J., Griss, T., Viollet, B., & Jones, R. G. (2014) · Oncogene · doi:10.1038/onc.2014.301 · Cited by 155 · see citing works

Mechanisms by which low glucose enhances the cytotoxicity of metformin to cancer cells both in vitro and in vivo

Zhuang, Y., Chan, D. K., Haugrud, A. B., & Miskimins, W. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108444 · Cited by 149 · see citing works

Metformin and cancer: An existing drug for cancer prevention and therapy (Review)

Zi, F., Zi, H., Li, Y., He, J., Shi, Q., & Cai, Z. (2017) · Oncology Letters · doi:10.3892/ol.2017.7412 · Cited by 152 · see citing works

The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition

Goodwin, J., Neugent, M. L., Lee, S. Y., Choe, J. H., Choi, H., Jenkins, D. M. R., Ruthenborg, R. J., Robinson, M. W., Jeong, J. Y., Wake, M., et al. (2017) · Nature Communications · doi:10.1038/ncomms15503 · Cited by 151 · see citing works

LKB1/AMPK Pathway and Drug Response in Cancer: A Therapeutic Perspective

Ciccarese, F., Zulato, E., & Indraccolo, S. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/8730816 · Cited by 147 · see citing works

The metabolic landscape of lung cancer: New insights in a disturbed glucose metabolism

Vanhove, K., Graulus, G.-J., Mesotten, L., Thomeer, M., Derveaux, E., Noben, J.-P., Guedens, W., & Adriaensens, P. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01215 · Cited by 147 · see citing works

The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer

Kim, J., Lee, H. M., Cai, F., Ko, B., Yang, C., Lieu, E. L., Muhammad, N., Rhyne, S., Li, K., Haloul, M., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00316-0 · Cited by 143 · see citing works

Collateral lethality: a new therapeutic strategy in oncology

Muller, F. L., Aquilanti, E. A., & DePinho, R. A. (2015) · Trends in Cancer · doi:10.1016/j.trecan.2015.10.002 · Cited by 132 · see citing works

Metabolic Roles of AMPK and Metformin in Cancer Cells

Choi, Y. K., & Park, K. (2013) · Molecules and Cells · doi:10.1007/s10059-013-0169-8 · Cited by 143 · see citing works

Phenformin Inhibits Myeloid-Derived Suppressor Cells and Enhances the Anti-Tumor Activity of PD-1 Blockade in Melanoma

Kim, S. H., Li, M., Trousil, S., Zhang, Y., di Magliano, M. P., Swanson, K. D., & Zheng, B. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.03.033 · Cited by 140 · see citing works

NanoString, a novel digital color-coded barcode technology: current and future applications in molecular diagnostics

Tsang, H. F., Xue, V. W., Koh, S. P., Chiu, Y.-M., Ng, L. P. W., & Wong, S. C. C. (2016) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2017.1268533 · Cited by 139 · see citing works

Serine deprivation enhances antineoplastic activity of biguanides

Gravel, S.-P., Hulea, L., Toban, N., Birman, E., Blouin, M.-J., Zakikhani, M., Zhao, Y., Topisirovic, I., St-Pierre, J., & Pollak, M. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-2643-t · Cited by 138 · see citing works

The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde?

Vara‐Ciruelos, D., Russell, F. M., & Hardie, D. G. (2019) · Open Biology · doi:10.1098/rsob.190099 · Cited by 136 · see citing works

Abstract 2449: Identifying therapy responsive and resistant LKB1 mutant non-small cell lung tumor populations

Abt, E. R., Momcilovic, M., Seki, A., McMickle, R., Stout, D., Fishbein, M. C., & Shackelford, D. B. (2014) · Cancer Research · doi:10.1158/1538-7445.am2014-2449

LKB1 Mutation Sensitizes NSCLC Cells to Phenformin

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Abstract C114: The role of LKB1 and TP53 mutation status in determining sensitivity of non-small cell lung cancer cells to the metabolic inhibitors; metformin, phenformin and 2-DG

Cahill, F. F., Bokobza, S., Devery, A., Drobnitzky, N., Jiang, Y., Lourenço, L. M., Mumin, N. H., Weber, A. M., Ashton, T. M., & Ryan, A. J. (2015) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.targ-15-c114

MA17.02 Identify Vulnerable Pathways and Improve Treatment Outcomes in LKB1-Deficient Lung Tumors

Welliver, M. X., Jin, F., Amann, J. M., Koenig, M. J., Mo, X. M., & Carbone, D. P. (2019) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2019.08.638

Heightening Energetic Stress Selectively Targets LKB1-Deficient Non–Small Cell Lung Cancers

Momcilovic, M., McMickle, R., Abt, E., Seki, A., Simko, S. A., Magyar, C., Stout, D. B., Fishbein, M. C., Walser, T. C., Dubinett, S. M., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-0797 · Cited by 46 · see citing works