Quorum sensing between bacterial species on the skin protects against epidermal injury in atopic dermatitis
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Quorum sensing peptides produced by commensal skin staphylococci protect against skin injury and inflammation induced by Staphylococcus aureus toxins.
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The skin microbiome is regulated by quorum-sensing mechanisms between bacterial strains and by crosstalk between bacteria and the skin innate immune system and epidermal Langerhans cells that continuously educate the adaptive immune system.
“The skin microbiome is regulated on one hand by the quorum-sensing mechanisms between bacterial strains26 and on the other hand by the crosstalk between the bacteria and the skin innate immune system and epidermal Langerhans cells continuously educating the adaptive immune system.”
From Atopic dermatitis: an expanding therapeutic pipeline for a complex disease (2022) · cites this paper as [26]
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- Authors
- Williams, M. R., Costa, S. K., Zaramela, L. S., Khalil, S., Todd, D. A., Winter, H. L., Sanford, J. A., O’Neill, A. M., Liggins, M. C., Nakatsuji, T., Cech, N. B., Cheung, A. L., Zengler, K., Horswill, A. R., & Gallo, R. L.
- Affiliations
- University of California San Diego (US)
- Dartmouth College (US)
- University of North Carolina at Greensboro (US)
- Veterans Health Administration (US)
- Corresponding author
- Gallo, Richard L.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2019-05
- Volume
- 11
- Issue
- 490
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC7106486
- OpenAlex
- W2943169224
- Cited by
- 292
- References
- 57
- Citations by year
- 2026: 25 · 2025: 44 · 2024: 48 · 2023: 38 · 2022: 40 · 2021: 49 · 2020: 32 · 2019: 16
- FWCI
- 11.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (R01AI116576,, R01AR064781, U19 AI117673, R01AR064781-04S1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Keywords
- quorum sensing, Staphylococcus aureus toxin, epidermal damage, atopic dermatitis, skin inflammation, bacterial peptides, skin microbiome, host defense
- MeSH terms
- Animals, Bacteria, Bacterial Toxins, Coagulase, Dermatitis, Atopic, Epidermis, Homeostasis, Humans, Inflammation, Male, Mice, Inbred C57BL, Peptide Hydrolases, Peptides, Staphylococcus, Keratinocytes, Quorum Sensing
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