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A randomized placebo-controlled pilot trial shows that intranasal vasopressin improves social deficits in children with autism
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Intranasal delivery of the neuropeptide vasopressin improves social abilities in children with autism spectrum disorder.
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“Peripheral levels of vasopressin appear to be an accurate predictor of ASD and was effective at ameliorating social deficits when administered intranasally in a small trial [175, 176].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [175]
In the citing paper
“Finally, intranasal AVP treatment considerably improved social abilities in children with ASD (169).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [169]
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“Anxiety was selected as an outcome measure due to its frequent comorbidity with ASD (67) and the existence of literature linking AVP to anxiety (42).”
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Metadata
- Authors
- Parker, K. J., Oztan, O., Libove, R. A., Mohsin, N., Karhson, D. S., Sumiyoshi, R. D., Summers, J. E., Hinman, K. E., Motonaga, K. S., Phillips, J. M., Carson, D. S., Fung, L. K., Garner, J. P., & Hardan, A. Y.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Parker, Karen J.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2019-05-08
- Volume
- 11
- Issue
- 491
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC6716148
- OpenAlex
- W2943453749
- Cited by
- 185
- References
- 68
- Citations by year
- 2026: 22 · 2025: 21 · 2024: 23 · 2023: 29 · 2022: 42 · 2021: 27 · 2020: 14 · 2019: 7
- FWCI
- 13.08
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R21MH100387, T32MH019908, K08MH111750)
- Autism Speaks (7895)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R21HD083629, R01HD091972)
- Stanford’s Department of Psychiatry (N/A)
- The Teresa and Charles Michael Endowed Fund for Autism Research and Education (N/A)
- The Child Health Research Institute (N/A)
- The Yani Calmidis Memorial Fund for Autism Research (N/A)
- Mosbacher Family Fund for Autism Research (N/A)
- Bass Society (N/A)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, social dysfunction, children, anxiety symptoms, repetitive behavior, treatment tolerability, adverse events
- MeSH terms
- Autism Spectrum Disorder, Administration, Intranasal, Child, Female, Humans, Male, Pilot Projects, Placebos, Social Behavior, Vasopressins, Treatment Outcome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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