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A randomized placebo-controlled pilot trial shows that intranasal vasopressin improves social deficits in children with autism
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Intranasal delivery of the neuropeptide vasopressin improves social abilities in children with autism spectrum disorder.
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“Peripheral levels of vasopressin appear to be an accurate predictor of ASD and was effective at ameliorating social deficits when administered intranasally in a small trial [175, 176].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [175]
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“Finally, intranasal AVP treatment considerably improved social abilities in children with ASD (169).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [169]
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Metadata
- Authors
- Parker, K. J., Oztan, O., Libove, R. A., Mohsin, N., Karhson, D. S., Sumiyoshi, R. D., Summers, J. E., Hinman, K. E., Motonaga, K. S., Phillips, J. M., Carson, D. S., Fung, L. K., Garner, J. P., & Hardan, A. Y.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Parker, Karen J.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2019-05-08
- Volume
- 11
- Issue
- 491
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC6716148
- OpenAlex
- W2943453749
- Cited by
- 185
- References
- 68
- Citations by year
- 2026: 22 · 2025: 21 · 2024: 23 · 2023: 29 · 2022: 42 · 2021: 27 · 2020: 14 · 2019: 7
- FWCI
- 13.08
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R21MH100387, T32MH019908, K08MH111750)
- Autism Speaks (7895)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R21HD083629, R01HD091972)
- Stanford’s Department of Psychiatry (N/A)
- The Teresa and Charles Michael Endowed Fund for Autism Research and Education (N/A)
- The Child Health Research Institute (N/A)
- The Yani Calmidis Memorial Fund for Autism Research (N/A)
- Mosbacher Family Fund for Autism Research (N/A)
- Bass Society (N/A)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, social dysfunction, children, anxiety symptoms, repetitive behavior, treatment tolerability, adverse events
- MeSH terms
- Autism Spectrum Disorder, Administration, Intranasal, Child, Female, Humans, Male, Pilot Projects, Placebos, Social Behavior, Vasopressins, Treatment Outcome
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