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Reprogrammed marrow adipocytes contribute to myeloma-induced bone disease
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Marrow adipocytes reprogrammed by myeloma cells induce bone lesions.
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“MM-MSCs also exhibit decreased osteogenic potential and changes in the expression of transcripts related to the pathophysiology of MM illness (IL-6).”
From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [286]
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“There is evidence that MM-MSCs have abnormal secretory profiles and senescent traits that might hinder bone production [221, 285, 286].”
From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [286]
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“According to Liu et al.‘s study, myeloma cells have the capacity to reprogram normal BM adipocytes, giving them the capacity to resorb bone in myeloma patients who are in remission [282, 283].”
From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [282]
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Metadata
- Authors
- Liu, H., He, J., Koh, S. P., Zhong, Y., Liu, Z., Wang, Z., Zhang, Y., Li, Z., Tam, B. T., Lin, P., Xiao, M., Young, K. H., Amini, B., Starbuck, M. W., Lee, H. C., Navone, N. M., Davis, R. E., Tong, Q., Bergsagel, P. L., Hou, J., Yi, Q., Orlowski, R. Z., Gagel, R. F., & Yang, J.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- The University of Texas Health Science Center at Houston (US)
- Capital Medical University (CN)
- Department of Lymphoma and Myeloma, Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- Baylor College of Medicine (US)
- Mayo Clinic (US)
- Shanghai Jiao Tong University (CN)
- Houston Methodist (US)
- Corresponding author
- Yang, Jing
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2019-05-29
- Volume
- 11
- Issue
- 494
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC6999853
- OpenAlex
- W2947821013
- Cited by
- 113
- References
- 42
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 14 · 2023: 22 · 2022: 20 · 2021: 14 · 2020: 11 · 2019: 3
- FWCI
- 8.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Cancer Society (127337-RSG-15-069-01-TBG)
- National Cancer Institute (CA190863, CA193362, P30CA016672)
- Topics
- Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- multiple myeloma, bone lesions, EZH2, polycomb repressive complex 2, adipocyte-specific knockout, therapeutic target
- MeSH terms
- Enhancer of Zeste Homolog 2 Protein, Animals, Bone Diseases, Bone Marrow, Bone Resorption, Disease Models, Animal, Histones, Humans, Methylation, Multiple Myeloma, Osteoblasts, Osteogenesis, Promoter Regions, Genetic, Remission Induction, Signal Transduction, Down-Regulation, Up-Regulation, Sp1 Transcription Factor, Adipocytes, Cell Line, Tumor, PPAR gamma, Mice, Adipokines, Polycomb Repressive Complex 2, Cellular Reprogramming
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