The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Reprogrammed marrow adipocytes contribute to myeloma-induced bone disease
Open accessAbstract
Marrow adipocytes reprogrammed by myeloma cells induce bone lesions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“MM-MSCs also exhibit decreased osteogenic potential and changes in the expression of transcripts related to the pathophysiology of MM illness (IL-6).”
From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [286]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“There is evidence that MM-MSCs have abnormal secretory profiles and senescent traits that might hinder bone production [221, 285, 286].”
From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [286]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“According to Liu et al.‘s study, myeloma cells have the capacity to reprogram normal BM adipocytes, giving them the capacity to resorb bone in myeloma patients who are in remission [282, 283].”
From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [282]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907
Cold-Activated Brown Adipose Tissue in Healthy Men
van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M. A. F. L., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808718 · Cited by 3,452
Palumbo, A. P., & Anderson, K. C. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1011442 · Cited by 2,382
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
Nieman, K. M., Kenny, H. A., Penicka, C. V., Ladanyi, A., Buell-Gutbrod, R., Zillhardt, M. R., Romero, I. L., Carey, M. S., Mills, G. B., Hotamisligil, G. S., et al. (2011) · Nature Medicine · doi:10.1038/nm.2492 · Cited by 2,279
Histone methylation: a dynamic mark in health, disease and inheritance
Greer, E. L., & Shi, Y. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3173 · Cited by 2,241
Raje, N. S., & Anderson, K. C. (2000) · Current Treatment Options in Oncology · doi:10.1007/s11864-000-0017-x · Cited by 2,164
Fat and Beyond: The Diverse Biology of PPARγ
Tontonoz, P., & Spiegelman, B. M. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061307.091829 · Cited by 2,085
Yoshida, H., Hayashi, S.-I., Kunisada, T., Ogawa, M., Nishikawa, S., Okamura, H., Sudo, T., Shultz, L. D., & Nishikawa, S.-I. (1990) · Nature · doi:10.1038/345442a0 · Cited by 1,789
Tian, E., Zhan, F., Walker, R. C., Rasmussen, E., Ma, Y., Barlogie, B., & Shaughnessy, J. D. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030847 · Cited by 1,505
Genome Regulation by Polycomb and Trithorax Proteins
Schuettengruber, B., Chourrout, D., Vervoort, M., Leblanc, B., & Cavalli, G. (2007) · Cell · doi:10.1016/j.cell.2007.02.009 · Cited by 1,418
Mechanisms of Disease: is osteoporosis the obesity of bone?
Rosen, C. J., & Bouxsein, M. (2006) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0070 · Cited by 974
Molecular mechanisms of cancer development in obesity
Khandekar, M. J., Cohen, P., & Spiegelman, B. M. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3174 · Cited by 921
Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis
Justesen, J., Stenderup, K., Ebbesen, E., Mosekilde, L., Steiniche, T., & Kassem, M. (2004) · Biogerontology (Dordrecht) · doi:10.1023/a:1011513223894 · Cited by 847
Vidal‐Puig, A., Considine, R. V., Jimenez‐Liñan, M., Werman, A., Pories, W. J., Caro, J. F., & Flier, J. S. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119424 · Cited by 785
Adipose tissue and adipocytes support tumorigenesis and metastasis
Nieman, K. M., Romero, I. L., Houten, B. V., & Lengyel, E. R. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.02.010 · Cited by 773
Evaluation of bone regeneration using the rat critical size calvarial defect
Spicer, P. P., Kretlow, J. D., Young, S. W., Jansen, J. A., Kasper, F. K., & Mikos, A. G. (2012) · Nature Protocols · doi:10.1038/nprot.2012.113 · Cited by 666
Inflammasomes in carcinogenesis and anticancer immune responses
Zitvogel, L., Kepp, O., Galluzzi, L., & Kroemer, G. (2012) · Nature Immunology · doi:10.1038/ni.2224 · Cited by 593
Lee, J.-E., Wang, C., Xu, S., Cho, Y.-W., Wang, L., Feng, X., Baldridge, A., Sartorelli, V., Zhuang, L., Peng, W., et al. (2013) · eLife · doi:10.7554/elife.01503 · Cited by 522
The function of adipocytes in the bone marrow stroma: an update
Gimble, J. M., Robinson, C. E., Wu, X., & Kelly, K. A. (1996) · Bone · doi:10.1016/s8756-3282(96)00258-x · Cited by 446
DNA methylation and the regulation of gene transcription
Attwood, J. T., Yung, R. L., & Richardson, B. C. (2002) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-002-8420-z · Cited by 440
A new world of Polycombs: unexpected partnerships and emerging functions
Schwartz, Y. B., & Pirrotta, V. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3603 · Cited by 299
Breast cancer metastasis to the bone: mechanisms of bone loss
Chen, Y., Sosnoski, D. M., & Mastro, A. M. (2010) · Breast Cancer Research · doi:10.1186/bcr2781 · Cited by 283
PPARγ activation in adipocytes is sufficient for systemic insulin sensitization
Sugii, S., Olson, P., Sears, D. D., Saberi, M., Atkins, A. R., Barish, G. D., Hong, S.-H., Castro, G. L., Yin, Y.-Q., Nelson, M. C., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912487106 · Cited by 255
Weighing in on Adipocyte Precursors
Berry, R., Jeffery, E. C., & Rodeheffer, M. S. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.10.003 · Cited by 246
Chesi, M., Matthews, G. M., Garbitt, V. M., Palmer, S. E., Shortt, J., Lefebure, M., Stewart, A. K., Johnstone, R. W., & Bergsagel, P. L. (2012) · Blood · doi:10.1182/blood-2012-02-412783 · Cited by 215
Self-citationHistone H3K9 methyltransferase G9a represses PPARγ expression and adipogenesis
Wang, L., Xu, S., Lee, J., Baldridge, A., Grullon, S., Peng, W., & Ge, K. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.306 · Cited by 182
Molecular regulation of osteoclast activity
Bruzzaniti, A., & Baron, R. (2006) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-006-9009-x · Cited by 181
Liu, Z., Xu, J., He, J., Liu, H., Lin, P., Wan, X., Navone, N. M., Tong, Q., Kwak, L. W., Orlowski, R. Z., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6020 · Cited by 165
Self-citationNeighboring adipocytes participate in the bone marrow microenvironment of multiple myeloma cells
Caers, J., Deleu, S., Belaid, Z., Raeve, H. D., Valckenborgh, E. V., Bruyne, E. D., Mp, D., Riet, I. V., Camp, B. V., & Vanderkerken, K. (2007) · Leukemia · doi:10.1038/sj.leu.2404658 · Cited by 155
Immunosurveillance and therapy of multiple myeloma are CD226 dependent
Guillerey, C., de Andrade, L. F., Vučković, S., Miles, K. M., Ngiow, S. F., Yong, M. C. R., Teng, M. W. L., Colonna, M., Ritchie, D. S., Chesi, M., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci77181 · Cited by 151
Self-citationFowler, J. A., Lwin, S. T., Drake, M. T., Edwards, J., Kyle, R. A., Mundy, G. R., & Edwards, C. M. (2011) · Blood · doi:10.1182/blood-2011-01-330407 · Cited by 136
Chen, Y., Jacamo, R. O., Shi, Y.-X., Wang, R., Battula, V. L., Konoplev, S. N., Strunk, D., Hofmann, N., Reinisch, A., Konopleva, M. Y., et al. (2012) · Blood · doi:10.1182/blood-2011-11-389957 · Cited by 135
Breast Cancer Cell Colonization of the Human Bone Marrow Adipose Tissue Niche
Templeton, Z. S., Lie, W., Wang, W., Rosenberg‐Hasson, Y., Alluri, R. V., Tamaresis, J. S., Bachmann, M. H., Lee, K., Maloney, W. J., Contag, C. H., et al. (2015) · Neoplasia · doi:10.1016/j.neo.2015.11.005 · Cited by 126
Lipton, A., Uzzo, R. G., Amato, R. J., Ellis, G. K., Hakimian, B., Roodman, G. D., & Smith, M. R. (2009) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2009.0080 · Cited by 120
The impact of bone marrow adipocytes on osteoblast and osteoclast differentiation
Muruganandan, S., & Sinal, C. J. (2014) · IUBMB Life · doi:10.1002/iub.1254 · Cited by 100
Li, X., Ling, W., Pennisi, A., Wang, Y., Khan, S., Heidaran, M. A., Pal, A., Zhang, X., He, S., Zeitlin, A., et al. (2010) · Stem Cells · doi:10.1002/stem.572 · Cited by 83
Thymidine phosphorylase exerts complex effects on bone resorption and formation in myeloma
Liu, H., Liu, Z., Du, J., He, J., Lin, P., Amini, B., Starbuck, M. W., Novane, N., Shah, J. J., Davis, R. E., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad8949 · Cited by 74
Self-citationBone Marrow Adipose Tissue: A New Player in Cancer Metastasis to Bone
Morris, E. V., & Edwards, C. M. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00090 · Cited by 68
Effect of Long-term Storage in TRIzol on Microarray-Based Gene Expression Profiling
Ma, W., Wang, M. L., Wang, Z., Sun, L., Graber, D., Matthews, J. A., Champlin, R., Yi, Q., Orlowski, R. Z., Kwak, L. W., et al. (2010) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-10-0565 · Cited by 56
Self-citationThe effects of proteasome inhibitors on bone remodeling in multiple myeloma
Zangari, M., & Suva, L. J. (2016) · Bone · doi:10.1016/j.bone.2016.02.019 · Cited by 50
Immunosurveillance and therapy of multiple myeloma are CD226 dependent
Guillerey, C., de Andrade, L. F., Vučković, S., Miles, K. M., Ngiow, S. F., Yong, M. C. R., Teng, M. W. L., Colonna, M., Ritchie, D. S., Chesi, M., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci82646 · Cited by 42
Self-citationRavazzolo, R., Cappato, S., & Bocciardi, R. (2017) · Bone · doi:10.1016/j.bone.2017.10.028 · Cited by 2
Cited by
Sorted by citations
Invasion and metastasis in cancer: molecular insights and therapeutic targets
Li, Y., Liu, F., Cai, Q., Deng, L., Ouyang, Q., Zhang, X. H.-F., & Zheng, J. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02148-4 · Cited by 314
Monocyte-derived macrophages promote breast cancer bone metastasis outgrowth
Ma, R., Zhang, H., Li, X., Zhang, C., Selli, Ç., Tagliavini, G., Lam, A. D., Prost, S., Sims, A. H., Hu, H., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20191820 · Cited by 166
Self-citationInduction of m6A methylation in adipocyte exosomal LncRNAs mediates myeloma drug resistance
Wang, Z., He, J., Bach, D., Huang, Y.-H., Li, Z., Liu, H., Lin, P., & Yang, J. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02209-w · Cited by 124
Self-citationPanaroni, C., Fulzele, K. S., Mori, T., Siu, K. T., Onyewadume, C., Maebius, A., & Raje, N. S. (2021) · Blood · doi:10.1182/blood.2021013832 · Cited by 118
Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma
Li, Z., Liu, H., He, J., Wang, Z., Yin, Z., You, G., Wang, Z., Davis, R. E., Lin, P., Bergsagel, P. L., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2020.12.011 · Cited by 110
Self-citation
Metadata
- Authors
- Liu, H., He, J., Koh, S. P., Zhong, Y., Liu, Z., Wang, Z., Zhang, Y., Li, Z., Tam, B. T., Lin, P., Xiao, M., Young, K. H., Amini, B., Starbuck, M. W., Lee, H. C., Navone, N. M., Davis, R. E., Tong, Q., Bergsagel, P. L., Hou, J., Yi, Q., Orlowski, R. Z., Gagel, R. F., & Yang, J.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- The University of Texas Health Science Center at Houston (US)
- Capital Medical University (CN)
- Department of Lymphoma and Myeloma, Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- Baylor College of Medicine (US)
- Mayo Clinic (US)
- Shanghai Jiao Tong University (CN)
- Houston Methodist (US)
- Corresponding author
- Yang, Jing
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2019-05-29
- Volume
- 11
- Issue
- 494
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC6999853
- OpenAlex
- W2947821013
- Cited by
- 113
- References
- 42
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 14 · 2023: 22 · 2022: 20 · 2021: 14 · 2020: 11 · 2019: 3
- FWCI
- 8.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Cancer Society (127337-RSG-15-069-01-TBG)
- National Cancer Institute (CA190863, CA193362, P30CA016672)
- Topics
- Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- multiple myeloma, bone lesions, EZH2, polycomb repressive complex 2, adipocyte-specific knockout, therapeutic target
- MeSH terms
- Enhancer of Zeste Homolog 2 Protein, Animals, Bone Diseases, Bone Marrow, Bone Resorption, Disease Models, Animal, Histones, Humans, Methylation, Multiple Myeloma, Osteoblasts, Osteogenesis, Promoter Regions, Genetic, Remission Induction, Signal Transduction, Down-Regulation, Up-Regulation, Sp1 Transcription Factor, Adipocytes, Cell Line, Tumor, PPAR gamma, Mice, Adipokines, Polycomb Repressive Complex 2, Cellular Reprogramming
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
