The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Reprogrammed marrow adipocytes contribute to myeloma-induced bone disease
Open accessAbstract
Marrow adipocytes reprogrammed by myeloma cells induce bone lesions.
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“MM-MSCs also exhibit decreased osteogenic potential and changes in the expression of transcripts related to the pathophysiology of MM illness (IL-6).”
From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [286]
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“There is evidence that MM-MSCs have abnormal secretory profiles and senescent traits that might hinder bone production [221, 285, 286].”
From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [286]
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“According to Liu et al.‘s study, myeloma cells have the capacity to reprogram normal BM adipocytes, giving them the capacity to resorb bone in myeloma patients who are in remission [282, 283].”
From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [282]
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A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907
Cold-Activated Brown Adipose Tissue in Healthy Men
van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M. A. F. L., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808718 · Cited by 3,452
Palumbo, A. P., & Anderson, K. C. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1011442 · Cited by 2,382
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
Nieman, K. M., Kenny, H. A., Penicka, C. V., Ladanyi, A., Buell-Gutbrod, R., Zillhardt, M. R., Romero, I. L., Carey, M. S., Mills, G. B., Hotamisligil, G. S., et al. (2011) · Nature Medicine · doi:10.1038/nm.2492 · Cited by 2,279
Histone methylation: a dynamic mark in health, disease and inheritance
Greer, E. L., & Shi, Y. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3173 · Cited by 2,241
Raje, N. S., & Anderson, K. C. (2000) · Current Treatment Options in Oncology · doi:10.1007/s11864-000-0017-x · Cited by 2,164
Fat and Beyond: The Diverse Biology of PPARγ
Tontonoz, P., & Spiegelman, B. M. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061307.091829 · Cited by 2,085
Yoshida, H., Hayashi, S.-I., Kunisada, T., Ogawa, M., Nishikawa, S., Okamura, H., Sudo, T., Shultz, L. D., & Nishikawa, S.-I. (1990) · Nature · doi:10.1038/345442a0 · Cited by 1,789
Tian, E., Zhan, F., Walker, R. C., Rasmussen, E., Ma, Y., Barlogie, B., & Shaughnessy, J. D. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030847 · Cited by 1,505
Genome Regulation by Polycomb and Trithorax Proteins
Schuettengruber, B., Chourrout, D., Vervoort, M., Leblanc, B., & Cavalli, G. (2007) · Cell · doi:10.1016/j.cell.2007.02.009 · Cited by 1,418
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Invasion and metastasis in cancer: molecular insights and therapeutic targets
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Monocyte-derived macrophages promote breast cancer bone metastasis outgrowth
Ma, R., Zhang, H., Li, X., Zhang, C., Selli, Ç., Tagliavini, G., Lam, A. D., Prost, S., Sims, A. H., Hu, H., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20191820 · Cited by 166
Self-citationInduction of m6A methylation in adipocyte exosomal LncRNAs mediates myeloma drug resistance
Wang, Z., He, J., Bach, D., Huang, Y.-H., Li, Z., Liu, H., Lin, P., & Yang, J. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02209-w · Cited by 124
Self-citationPanaroni, C., Fulzele, K. S., Mori, T., Siu, K. T., Onyewadume, C., Maebius, A., & Raje, N. S. (2021) · Blood · doi:10.1182/blood.2021013832 · Cited by 118
Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma
Li, Z., Liu, H., He, J., Wang, Z., Yin, Z., You, G., Wang, Z., Davis, R. E., Lin, P., Bergsagel, P. L., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2020.12.011 · Cited by 110
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Metadata
- Authors
- Liu, H., He, J., Koh, S. P., Zhong, Y., Liu, Z., Wang, Z., Zhang, Y., Li, Z., Tam, B. T., Lin, P., Xiao, M., Young, K. H., Amini, B., Starbuck, M. W., Lee, H. C., Navone, N. M., Davis, R. E., Tong, Q., Bergsagel, P. L., Hou, J., Yi, Q., Orlowski, R. Z., Gagel, R. F., & Yang, J.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- The University of Texas Health Science Center at Houston (US)
- Capital Medical University (CN)
- Department of Lymphoma and Myeloma, Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- Baylor College of Medicine (US)
- Mayo Clinic (US)
- Shanghai Jiao Tong University (CN)
- Houston Methodist (US)
- Corresponding author
- Yang, Jing
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2019-05-29
- Volume
- 11
- Issue
- 494
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC6999853
- OpenAlex
- W2947821013
- Cited by
- 113
- References
- 42
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 14 · 2023: 22 · 2022: 20 · 2021: 14 · 2020: 11 · 2019: 3
- FWCI
- 8.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Cancer Society (127337-RSG-15-069-01-TBG)
- National Cancer Institute (CA190863, CA193362, P30CA016672)
- Topics
- Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- multiple myeloma, bone lesions, EZH2, polycomb repressive complex 2, adipocyte-specific knockout, therapeutic target
- MeSH terms
- Enhancer of Zeste Homolog 2 Protein, Animals, Bone Diseases, Bone Marrow, Bone Resorption, Disease Models, Animal, Histones, Humans, Methylation, Multiple Myeloma, Osteoblasts, Osteogenesis, Promoter Regions, Genetic, Remission Induction, Signal Transduction, Down-Regulation, Up-Regulation, Sp1 Transcription Factor, Adipocytes, Cell Line, Tumor, PPAR gamma, Mice, Adipokines, Polycomb Repressive Complex 2, Cellular Reprogramming
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