The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy
Open accessAbstract
Patient-specific iPSCs model endothelial dysfunction in lamin A and C–related dilated cardiomyopathy and identify lovastatin as a therapy.
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“we used a well-established model for endothelial aging57,58 by generating human induced pluripotent stem cells (hiPSCs) from fibroblasts obtained from five independent human donors59 and subsequently differentiated them into endothelial cells (hiPSC-ECs)60.”
From An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging (2021) · cites this paper as [60]
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Generation of an induced pluripotent stem cell line from a patient with Varicose veins
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Metadata
- Authors
- Sayed, N., Liu, C., Ameen, M., Himmati, F., Zhang, J. Z., Khanamiri, S., Moonen, J.-R., Wnorowski, A., Cheng, L., Rhee, J.-W., Gaddam, S., Wang, K. C., Sallam, K., Boyd, J. H., Woo, Y. J., Rabinovitch, M., & Wu, J. C.
- Affiliations
- Stanford Medicine (US)
- Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
- Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
- Corresponding author
- Sayed, Nazish
- Liu, Chun
- Wu, Joseph C.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2020-07-29
- Volume
- 12
- Issue
- 554
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC7557117
- OpenAlex
- W3045708127
- Cited by
- 111
- References
- 64
- Citations by year
- 2026: 17 · 2025: 14 · 2024: 23 · 2023: 24 · 2022: 14 · 2021: 16 · 2020: 3
- FWCI
- 4.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R01 HL130020, R01 HL113006, R01 HL123968, R01 HL141371, R01 HL141851, and R01 HL126527, K01 HL135455)
- American Heart Association (13SDG17340025, 19CDA34760019)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- LMNA cardiomyopathy, dilated cardiomyopathy, endothelial dysfunction, lovastatin, statins, induced pluripotent stem cell-derived endothelial cells, iPSC-derived cardiomyocytes, KLF2, angiogenesis, nitric oxide, chromatin accessibility, genome editing, reactive hyperemia
- MeSH terms
- Cardiomyopathy, Dilated, Humans, Lovastatin, Lamin Type A, Endothelial Cells, Induced Pluripotent Stem Cells
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