High-dose vitamin C enhances cancer immunotherapy

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

Le, D. T., Uram, J. N., Wang, H., Bartlett, B. R., Kemberling, H., Eyring, A. D., Skora, A. D., Luber, B. S., Azad, N. S., Laheru, D., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1500596 · Cited by 9,377

Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer

Rizvi, N. A., Hellmann, M. D., Snyder, A., Kvistborg, P., Makarov, V., Havel, J. J., Lee, W., Yuan, J., Wong, P., Ho, T. S., et al. (2015) · Science · doi:10.1126/science.aaa1348 · Cited by 7,802

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

Le, D. T., Durham, J. N., Smith, K. N., Wang, H., Bartlett, B. R., Aulakh, L. K., Lu, S., Kemberling, H., Wilt, C., Luber, B. S., et al. (2017) · Science · doi:10.1126/science.aan6733 · Cited by 6,645

Pembrolizumab as Second-Line Therapy for Advanced Urothelial Carcinoma

Bellmunt, J., de Wit, R., Vaughn, D. J., Fradet, Y., Lee, J.-L., Fong, L., Vogelzang, N. J., Climent, M. A., Petrylak, D. P., Choueiri, T. K., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1613683 · Cited by 3,395

Fundamental Mechanisms of Immune Checkpoint Blockade Therapy

Wei, S. C., Duffy, C. R., & Allison, J. P. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0367 · Cited by 3,088

Nivolumab plus ipilimumab in lung cancer with a high tumor mutational burden

Hellmann, M. D., Ciuleanu, T.-E., Pluzanski, A., Lee, J. S., Otterson, G. A., Audigier-Valette, C., Minenza, E., Linardou, H., Burgers, S., Salman, P., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1801946 · Cited by 3,063

Nivolumab in Patients with Metastatic DNA Mismatch Repair-Deficient or Microsatellite Instability-High Colorectal Cancer (CheckMate 142): An Open-Label, Multicentre, Phase 2 Study

Overman, M. J., McDermott, R., Leach, J. L., Lonardi, S., Lenz, H.-J., Morse, M. A., Desai, J., Hill, A., Axelson, M., Moss, R. A., et al. (2017) · The Lancet Oncology · doi:10.1016/s1470-2045(17)30422-9 · Cited by 2,836

Durable Clinical Benefit with Nivolumab Plus Ipilimumab in DNA Mismatch Repair-Deficient/Microsatellite Instability-High Metastatic Colorectal Cancer

Overman, M. J., Lonardi, S., Wong, K. Y. M., Lenz, H.-J., Gelsomino, F., Aglietta, M., Morse, M. A., Van Cutsem, E., McDermott, R., Hill, A., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2017.76.9901 · Cited by 2,079

Immune checkpoint inhibitors: recent progress and potential biomarkers

Darvin, P., Toor, S. M., Sasidharan Nair, V., & Elkord, E. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0191-1 · Cited by 2,035

Vitamin C and Immune Function

Carr, A., & Maggini, S. (2017) · Nutrients · doi:10.3390/nu9111211 · Cited by 2,035

Oxidative stress enhances the therapeutic action of a respiratory inhibitor in MYC‐driven lymphoma

Donati, G., Nicoli, P., Verrecchia, A., Vallelonga, V., Croci, O., Rodighiero, S., Audano, M., Cassina, L., Ghsein, A., Binelli, G., et al. (2023) · EMBO Molecular Medicine · doi:10.15252/emmm.202216910 · Cited by 21

High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial

Paller, C. J., ZAHURAK, M. L., Mandl, A., Metri, N. A., Lalji, A., Heath, E. I., Kelly, W. K., Hoimes, C. J., Barata, P. C., Taksey, J. D., et al. (2024) · Cancer Research Communications · doi:10.1158/2767-9764.crc-24-0225 · Cited by 21

SVCT2–mediated ascorbic acid uptake buffers stress responses via DNA hydroxymethylation reprogramming of S100 calcium-binding protein A4 gene

Han, Q.-Q., Wu, P., Li, Y., Cao, Y., Chen, J., & Wang, F. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102543 · Cited by 22

Balanced Duality: H2O2-Based Therapy in Cancer and Its Protective Effects on Non-Malignant Tissues

Zaher, A., Petronek, M. S., Allen, B. G., & Mapuskar, K. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168885 · Cited by 23

Pharmacological vitamin C inhibits mTOR signaling and tumor growth by degrading Rictor and inducing HMOX1 expression

Qin, S., Wang, G., Chen, L., Geng, H., Zheng, Y., Xia, C., Wu, S., Yao, J., & Deng, L. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010629 · Cited by 21

Oral Immunotherapy Reshapes Intestinal Immunosuppression via Metabolic Reprogramming to Enhance Systemic Anti‐Tumor Immunity

Cao, X., Xu, Y., Zhou, C., Huo, J., Su, S., Liu, L., Zhu, Z., Li, L., Jia, W., Wang, C., et al. (2023) · Advanced Science · doi:10.1002/advs.202302910 · Cited by 18

Impact of Diets on Response to Immune Checkpoint Inhibitors (ICIs) Therapy against Tumors

Zhang, X., Li, H., Lv, X., Hu, L., Li, W., Zi, M., & He, Y. (2022) · Life · doi:10.3390/life12030409 · Cited by 18

Oxidized mC modulates synthetic lethality to PARP inhibitors for the treatment of leukemia

Brabson, J. P., Leesang, T. E., Yap, Y. S., Wang, J., Lam, M. Q., Fang, B., Dolgalev, I., Barbieri, D. A., Strippoli, V., Bañuelos, C. P., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112027 · Cited by 18

Ascorbic acid induces ferroptosis via STAT3/GPX4 signaling in oropharyngeal cancer

Wu, K., Liu, L., Wu, Z., Huang, Q., Zhou, L., Xie, R., & Wang, M. (2024) · Free Radical Research · doi:10.1080/10715762.2024.2320396 · Cited by 18

Vitamin C encapsulated biomimetic nanogels with macrophage membrane decoration for chronic wound healing

Yang, X., Lin, X., Li, J., Viitala, T., Zhao, Y., Zhang, H., & Shang, L. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.159080 · Cited by 18

Maternal pre-pregnancy weight and early life lower respiratory tract infections in a low-income urban minority birth cohort

Gutierrez, M. J., Niño, G., Hong, X., & Wang, X. (2021) · Scientific Reports · doi:10.1038/s41598-021-88360-y · Cited by 18

Blue light promotes vitamin C-mediated ferroptosis of melanoma through specifically upregulating transporter SVCT2 and generating Fe2+

Yang, R., Deng, F., Yang, Y., Tian, Q. C., Huangfu, S., Yang, L., Hou, J., Yang, G., Pang, W., Lu, J., et al. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122186 · Cited by 17

Role of Vitamin C in Targeting Cancer Stem Cells and Cellular Plasticity

Lee, Y. (2023) · Cancers · doi:10.3390/cancers15235657 · Cited by 18

Metabolic heterogeneity in tumor microenvironment – A novel landmark for immunotherapy

Chen, C., Han, P., & Qing, Y. (2024) · Autoimmunity Reviews · doi:10.1016/j.autrev.2024.103579 · Cited by 17

TET2 promotes tumor antigen presentation and T cell IFN-γ, which is enhanced by vitamin C

Cheng, M., Chu, A. K. Y., Li, Z., Yang, S., Smith, M. D., Zhang, Q., Brown, N. G., Marzluff, W. F., Bardeesy, N. M., Milner, J. J., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.175098 · Cited by 18

Death-ision: the link between cellular resilience and cancer resistance to treatments

Baldassarre, G., de la Serna, I. L., & Vallette, F. M. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02339-1 · Cited by 17

Synthetic lethality and synergetic effect: the effective strategies for therapy of IDH-mutated cancers

Yao, K., Liu, H., Yin, J., Yuan, J., & Tao, H. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02054-x · Cited by 16

Clinically feasible and prospective immunotherapeutic interventions in multidirectional comprehensive treatment of cancer

Seledtsov, V. I., & von Delwig, A. A. (2020) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2021.1828338 · Cited by 15

Embracing cancer immunotherapy with vital micronutrients

Yuen, R. C.-F., & Tsao, S. Y. (2021) · World Journal of Clinical Oncology · doi:10.5306/wjco.v12.i9.712 · Cited by 17

High-Dose Ascorbate in Combination with Anti-PD1 Checkpoint Inhibition as Treatment Option for Malignant Melanoma

Burkard, M., Niessner, H., Leischner, C., Piotrowsky, A., Renner, O., Marongiu, L., Lauer, U. M., Busch, C., Sinnberg, T. W., & Venturelli, S. (2023) · Cells · doi:10.3390/cells12020254 · Cited by 17

Targeting DTX2/UFD1-mediated FTO degradation to regulate antitumor immunity

Cui, Y., Wei, J., Fan, H., Li, W., Zhao, L., Wilkinson, E., Peterson, J., Xie, L., Zou, Z., Yang, S., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2407910121 · Cited by 15

Leveraging Vitamin C to Augment Nanoenabled Photothermal Immunotherapy

Deng, W., Wang, Y., Wang, J., Su, Y., Li, M., Qu, K., Wang, Y., & Li, M. (2025) · ACS Nano · doi:10.1021/acsnano.4c17080 · Cited by 15

Non-pharmaceutical interventions to optimize cancer immunotherapy

Boesch, M., Baty, F., Rassouli, F., Kowatsch, T., Joerger, M., Früh, M., & Brutsche, M. H. (2023) · OncoImmunology · doi:10.1080/2162402x.2023.2255459 · Cited by 15

A Portable Microelectrochemical Sensor Based on Potentiostatic Polarization-Treated and Laser-Induced Graphene for the Simultaneous Determination of Ascorbic Acid, Dopamine, and Uric Acid

Yuan, X., Wu, X.-W., Li, S., Liu, R., & Ling, Y. (2024) · Langmuir · doi:10.1021/acs.langmuir.4c03269 · Cited by 15

Vitamin C

Levine, M. N., Ebenuwa, I., & Violet, P.-C. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-805378-2.00018-8 · Cited by 17

Micro but mighty—Micronutrients in the epigenetic regulation of adaptive immune responses*

Chen, H., Hsu, M., & Lio, C. J. (2021) · Immunological Reviews · doi:10.1111/imr.13045 · Cited by 17

High-dose vitamin C: A promising anti-tumor agent, insight from mechanisms, clinical research, and challenges

Zhao, H., Fu, W., Yang, X., Zhang, W., Wu, S., Ma, J., Zhang, T., Yao, H., & Zhang, Z. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101742 · Cited by 15

High-dose ascorbic acid selectively induces pyroptosis in LKB1-deficient lung cancer and sensitizes immunotherapy

Sun, X., Cai, X.-T., Li, S., Pi, R., Guo, Z.-Q., Jiang, J., Wang, P., Xiong, J., Liu, Z., Rong, Z., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102291 · Cited by 14

Pharmacological ascorbate potentiates combination nanomedicines and reduces cancer cell stemness to prevent post-surgery recurrence and systemic metastasis

Jiang, X., Liu, J., Mao, J., Han, W., Fan, Y., Luo, T., Xia, J., Lee, M. J., & Lin, W. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122037 · Cited by 14

Angiostatic effects of ascorbic acid: current status and future perspectives

Islam, M. T. (2020) · Angiogenesis · doi:10.1007/s10456-020-09719-9 · Cited by 14

The dual role of vitamin C in cancer: from antioxidant prevention to prooxidant therapeutic applications

Cao, X., Yi, Y., Ji, M., Liu, Y., Wang, D., & Zhu, H. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1633447 · Cited by 13

Molecular evolution of GDP-L-galactose phosphorylase, a key regulatory gene in plant ascorbate biosynthesis

Tao, J., Hao, Z., & Huang, C. (2020) · AoB Plants · doi:10.1093/aobpla/plaa055 · Cited by 13

Physiological activation of Aryl hydrocarbon receptor by food-derived ligands is essential for the efficacy of anti-PD1 therapy

de Juan, A., Coillard, A., Cros, A., Rigamonti, A., Alaoui, L., Sampaio, J. L., Monot, N., Balvay, A., Foussier, A., Rieux-Laucat, M., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-66854-x · Cited by 15

Ascorbic acid modulates immune responses through Jumonji‐C domain containing histone demethylases and Ten eleven translocation (TET) methylcytosine dioxygenase

Maity, J., Majumder, S., Pal, R., Saha, B., & Mukhopadhyay, P. K. (2023) · BioEssays · doi:10.1002/bies.202300035 · Cited by 15

Vitamin C intake and colorectal cancer survival according to KRAS and BRAF mutation: a prospective study in two US cohorts

Shi, S., Wang, K., Ugai, T., Giannakis, M., Cazaubiel, J., Chan, A. T., Giovannucci, E. L., Nowak, J. A., Meyerhardt, J. A., Ogino, S., et al. (2023) · British Journal of Cancer · doi:10.1038/s41416-023-02452-2 · Cited by 12

Empowering γδ T‐cell functionality with vitamin C

Kabelitz, D., Cierna, L., Juraske, C., Zarobkiewicz, M. K., Schamel, W. W. A., & Peters, C. (2024) · European Journal of Immunology · doi:10.1002/eji.202451028 · Cited by 12

Degradation-resistant implanted biomaterials establish an immunosuppressive microenvironment that induces T cell exhaustion by recruiting myeloid cells

Fan, Q., Dai, H., Bai, J., Xu, J., Ma, Q., Fei, Z., Zhou, X., Leong, K. W., & Wang, C. (2021) · Fundamental Research · doi:10.1016/j.fmre.2021.10.007 · Cited by 12

Oxidative stress in pituitary neuroendocrine tumors: Affecting the tumor microenvironment and becoming a new target for pituitary neuroendocrine tumor therapy

Zhou, Y., Zhang, A., Fang, C., Yuan, L., Shao, A., Xu, Y., & Zhou, D. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14315 · Cited by 12

High-fat diet accelerate hepatic fatty acids synthesis in offspring male rats induced by perinatal exposure to nonylphenol

Zhang, H., Song, C., Yan, R., Cai, H., Zhou, Y., & Ke, X. (2021) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-021-00492-z · Cited by 12

Vitamin C as a Cardioprotective Agent Against Doxorubicin‐Induced Cardiotoxicity

Nsairat, H., Lafi, Z., Abualsoud, B. M., Al-Najjar, B. O., Al-Samydai, A. M., Oriquat, G. A., Alshaer, W., Ibrahim, A. A., & Dellinger, A. L. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.125.042534 · Cited by 12

Oxidative Stress and the Intersection of Oncogenic Signaling and Metabolism in Squamous Cell Carcinomas

Choe, J. H., Mazambani, S., Kim, T. H., & Kim, J. (2021) · Cells · doi:10.3390/cells10030606 · Cited by 14

Association between vitamin C in serum and trouble sleeping based on NHANES 2017–2018

Wang, S., Lai, F., Le, Z., Zhou, J., Kong, D., Yu, H., & Ding, Y. (2024) · Scientific Reports · doi:10.1038/s41598-024-56703-0 · Cited by 11

Microbial metabolites for cancer immunotherapy: Current evidence and future directions

Wang, X., Liang, J.-J., Duan, X., & Chen, G. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.10.005 · Cited by 12

Effects of the Mediterranean Diet on metabolic indices and quality of life in cancer patients: A systematic review and meta-analysis of randomized controlled trials

Lu, S., Sun, X., Zhang, W., Li, X., Zhou, Z., Xiao, R., Lv, Q., Tang, H., Wang, B., Qu, J., et al. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106074 · Cited by 10

Ultrasensitive detection of 5-hydroxymethylcytosine in genomic DNA using a graphene-based sensor modified with biotin and gold nanoparticles

Imran, H., Lee, H., Alam, A., An, J., Ko, M., & Lim, S. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101123 · Cited by 10

Ascorbic Acid-Derived Supramolecular Gels Induce Immunogenic Ferroptosis in Cancer Cells to Potentiate Tumor Immunotherapy

Cai, W., Sun, Y., Xu, W., Kuang, X., Zhang, Z., Cao, X. M., Xu, J., Li, Y., Huang, Y., & Shen, S. (2025) · ACS Nano · doi:10.1021/acsnano.5c08353 · Cited by 11

From Foods to Chemotherapeutics: The Antioxidant Potential of Dietary Phytochemicals

Briggs, M. A. (2022) · Processes · doi:10.3390/pr10061222 · Cited by 10

Molecular interaction studies on the binding ability of hydrated zinc sulphate with aqueous solution of ascorbic acid at different temperatures

Bharti, V., Kaushal, D., Kumar, S., Thakur, A., Rana, D. S., Kumar, M., & Kant, S. (2022) · Zeitschrift für Physikalische Chemie · doi:10.1515/zpch-2021-3054 · Cited by 10

Using NMR to Monitor TET-Dependent Methylcytosine Dioxygenase Activity and Regulation

Treadway, C. J., Boyer, J. A., Yang, S., Yang, H., Liu, M., Li, Z., Cheng, M., Marzluff, W. F., Ye, D., Xiong, Y., et al. (2024) · ACS Chemical Biology · doi:10.1021/acschembio.3c00619 · Cited by 10

The therapeutic role of γδT cells in TNBC

Li, W., Zhao, X., Ren, C., Gao, S., Han, Q., Lu, M. M., & Li, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1420107 · Cited by 9

Targeting the Interplay of Independent Cellular Pathways and Immunity: A Challenge in Cancer Immunotherapy

Lauriola, A., Davalli, P., Marverti, G., Santi, S., Caporali, A., & D’Arca, D. (2023) · Cancers · doi:10.3390/cancers15113009 · Cited by 9

Clinical Implications of Isocitrate Dehydrogenase Mutations and Targeted Treatment of Acute Myeloid Leukemia with Mutant Isocitrate Dehydrogenase Inhibitors—Recent Advances, Challenges and Future Prospects

Kowalczyk, A., Zarychta, J., Lejman, M., Latoch, E., & Zawitkowska, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147916 · Cited by 9

Computational modelling to reduce outcome variability in tissue-engineered heart valves

Visser, V. L., Zaytseva, P., Motta, S. E., Loerakker, S., Hoerstrup, S. P., & Emmert, M. Y. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab034 · Cited by 9

Polymeric Iron Chelators Enhancing Pro-Oxidant Antitumor Efficacy of Vitamin C by Inhibiting the Extracellular Fenton Reaction

Guo, H., Nomoto, T., Muttaqien, S. E., Sun, X., Komoto, K., Matsui, M., Miura, Y., & Nishiyama, N. (2021) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.1c00673 · Cited by 9

Prediction of homologous recombination deficiency identifies colorectal tumors sensitive to PARP inhibition

Corti, G., Buzo, K., Berrino, E., Miotto, M., Aquilano, M. C., Lentini, M., Bellomo, S. E., Lorenzato, A., Bartolini, A., Mauri, G., et al. (2024) · npj Precision Oncology · doi:10.1038/s41698-024-00706-7 · Cited by 8

Antioxidant Food Supplementation in Cancer: Lessons from Clinical Trials and Insights from Preclinical Studies

Pulliero, A., Marengo, B., Ferrante, O., Khalid, Z., Vernazza, S., Ruzzarin, N., Domenicotti, C., & Izzotti, A. (2025) · Antioxidants · doi:10.3390/antiox14101261 · Cited by 8

Redox Signaling Modulates Activity of Immune Checkpoint Inhibitors in Cancer Patients

Allegra, A., Murdaca, G., Mirabile, G., & Gangemi, S. (2023) · Biomedicines · doi:10.3390/biomedicines11051325 · Cited by 8

New promising developments for potential therapeutic applications of high-dose ascorbate as an anticancer drug

Testa, U., Pelosi, E., & Castelli, G. (2020) · Hematology/Oncology and Stem Cell Therapy · doi:10.1016/j.hemonc.2020.11.002 · Cited by 8

The nanostructure of rod-like ascorbyl dipalmitate nanoparticles stabilized by a small amount of DSPE-PEG

Chen, Z., Higashi, K., Shidara, R., Ueda, K., Morita, T., Limwikrant, W., Yamamoto, K., & Moribe, K. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120599 · Cited by 8

Multifaceted role of the vitamin B6 pathway in cancer: metabolism, immune interaction, and temporal and spatial regulationPreprint

Mishra, S. K., Li, B., Costa, A. S. H., Aelst, L. V., & Zhang, L. (2025) · Genes & Development · doi:10.1101/gad.352770.125 · Cited by 10

High-dose vitamin C attenuates radiation-induced pulmonary fibrosis by targeting S100A8 and S100A9

Ma, L., Jin, Y., Aili, A., Xu, L., Wang, X., Xiao, L., Zhao, W., Yin, S., Liu, B., & Yuan, X. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167358 · Cited by 8

Nutritional intervention alleviates T cell exhaustion and empowers anti-tumor immunity

Xu, Y., Yuan, W., Li, K., & Li, P. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1689317 · Cited by 8

Can Natural Products be Used to Overcome the Limitations of Colorectal Cancer Immunotherapy?

Dong, J., Qian, Y., Zhang, G., Lu, L., Zhang, S., Ji, G., Zhao, A., & Xu, H. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.884423 · Cited by 7

The effect of diet and nutrition on T cell function in cancer

Zhou, X., Wang, Z., & Yuan, K. (2023) · International Journal of Cancer · doi:10.1002/ijc.34668 · Cited by 8

Preclinical efficacy of carfilzomib in BRAF ‐mutant colorectal cancer models

Maione, F., Oddo, D., Galvagno, F., Falcomatà, C., Pandini, M., Macagno, M., Pessei, V., Barault, L., Gigliotti, C., Mira, A., et al. (2024) · Molecular Oncology · doi:10.1002/1878-0261.13595 · Cited by 7

Role of Nutrients Regulating Myeloid Derived Suppressor Cells in Cancer: A Scoping Review

Pérez-Peláez, B., Jiménez‐Cortegana, C., de la Cruz‐Merino, L., & Sánchez‐Margalet, V. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46090549 · Cited by 7

High-dose ascorbic acid synergizes with anti-PD1 therapy in non-small cell lung cancer in vitro and in vivo models

Kim, H. S., Kwon, S., Choi, O. K., & Lim, T. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1512605 · Cited by 9

Enhancing an Oxidative “Trojan Horse” Action of Vitamin C with Arsenic Trioxide for Effective Suppression of KRAS-Mutant Cancers: A Promising Path at the Bedside

Burska, A. N., Ilyassova, B., Dildabek, A., Khamijan, M., Бегимбетова, Д., Molnár, F., & Sarbassov, D. D. (2022) · Cells · doi:10.3390/cells11213454 · Cited by 7

Diet as a Potential Moderator for Genome Stability and Immune Response in Pediatric Leukemia

Wang, S., Maxwell, C. A., & Akella, N. M. (2021) · Cancers · doi:10.3390/cancers13030413 · Cited by 7

Deciphering the Genomic Characterization of the GGP Gene Family and Expression Verification of CmGGP1 Modulating Ascorbic Acid Biosynthesis in Melon Plants

Yang, T., Amanullah, S., Li, S., Gao, P., Bai, J., Li, C., Ma, J., Luan, F., & Wang, X. (2024) · Antioxidants · doi:10.3390/antiox13040397 · Cited by 6

Single‐Cell Analysis Reveals that Vitamin C Inhibits Bone Metastasis of Renal Cancer via Cell Cycle Arrest and Microenvironment Remodeling

Zhang, J., Zhang, Q., Lin, G., Wang, Y., Li, J., Wang, P., Qi, J., Liang, Y., He, S., Gong, Y., et al. (2025) · Advanced Science · doi:10.1002/advs.202501011 · Cited by 6

Oxidative Stress and Inflammation in Colorectal Cancer–Redox–Immune Crosstalk, Biomarkers, and Translational Implications: A Qualitative Systematic Review

Marinescu, R. A., Marinescu, D., Preda, D., Ciurea, A.-M., Popa, P., Boldeanu, L., Bică, M., Boldeanu, M. V., Pătraşcu, Ş., & Șurlin, M. V. (2026) · Life · doi:10.3390/life16030424 · Cited by 6

Comparison of the effectiveness of integrative immunomodulatory treatments and conventional therapies on the survival of selected gastrointestinal cancer patients

Kleef, R., Dank, M., Herold, M., Ágoston, E. I., Lohinszky, J., Martinek, E., Herold, Z., & Szász, A. M. (2023) · Scientific Reports · doi:10.1038/s41598-023-47802-5 · Cited by 6

Personalized Immunotherapy Achieves Complete Response in Metastatic Adenoid Cystic Carcinoma Despite Lack of Conventional Biomarkers

Tokat, Ü. M., Adibi, A., Aydın, E., Özgü, E., Bilgiç, Ş. N., Tutar, O., Doğançay, M. Ö., Demiray, İ., & Demiray, M. (2024) · Current Oncology · doi:10.3390/curroncol31100434 · Cited by 6

Understanding the rod-to-tube transformation of self-assembled ascorbyl dipalmitate lipid nanoparticles stabilized with PEGylated lipids

Chen, Z., Higashi, K., Shigehisa, Y., Ueda, K., Yamamoto, K., & Moribe, K. (2022) · Nanoscale · doi:10.1039/d2nr04987b · Cited by 6

Are Aspects of Integrative Concepts Helpful to Improve Pancreatic Cancer Therapy?

Oei, S. L., & Schad, F. (2023) · Cancers · doi:10.3390/cancers15041116 · Cited by 6

Molecular Studies for the Early Detection of Philadelphia-Negative Myeloproliferative Neoplasms

Stuckey, R., Bilbao, C., Segura-Díaz, A., & Gómez‐Casares, M. T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612700 · Cited by 6

Nanodrug constructed using dietary antioxidants for immunotherapy of metastatic tumors

Wu, X., Tan, Y., Zhang, J., Cui, R., Liao, C., & Zhang, S. (2023) · Journal of Materials Chemistry B · doi:10.1039/d2tb02773a · Cited by 6

Effects of vitamin C combined with rbFGF on inflammatory factors and oxygen environment in patients with high‐voltage electrical burns

Zhang, H., Qin, B., Zhao, Y., Zhang, R., & Zhang, G. (2023) · International Wound Journal · doi:10.1111/iwj.14138 · Cited by 6

Engineered liposomal nanoplatforms for precise cancer immunotherapy: advancing biomedical innovations

Liu, Y., Wu, Z., Wang, Z., Khan, M. K., & Wu, F. (2025) · Science China Materials · doi:10.1007/s40843-025-3621-y · Cited by 6

Extrinsic and Cell-Intrinsic Stress in the Immune Tumor Micro-Environment

Ummarino, A., Calà, N., & Allavena, P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212403 · Cited by 6

PD-1 blockade synergizes with ascorbic acid to restore the activation and anti-viral immune functions of CD8+ T cells in a mouse model of BVDV infection

Li, Y., Zhao, Z., He, L., Liang, Y., Liu, M., Dong, M., Li, Z., Xu, B., Zhang, Z., Zhou, Y., et al. (2024) · Veterinary Microbiology · doi:10.1016/j.vetmic.2024.110316 · Cited by 5

Vitamin B6 Fuels Acute Myeloid Leukemia Growth

Jiang, S. (2020) · Trends in cancer · doi:10.1016/j.trecan.2020.03.005 · Cited by 5

Natural Bioactive Compounds from Foods Inhibited Pigmentation Especially Potential Application of Fucoxanthin to Chloasma: a Mini-Review

Wang, Y., & Qi, H. (2022) · Food Reviews International · doi:10.1080/87559129.2022.2148690 · Cited by 5

Unconventional Treatments for Pancreatic Cancer: A Systematic Review

Vella, R., Giardino, A., Pizzocaro, E., Frigerio, I. M., Bannone, E., Vieni, S., & Butturini, G. (2025) · Cancers · doi:10.3390/cancers17091437 · Cited by 4

Combination immunotherapy for colorectal cancer: Clinical applications, rationale, challenges, and future perspectives

Fei, J., Cai, C., Wu, W., Shen, H., Han, Y., & Zeng, S. (2026) · Cell Reports Medicine · doi:10.1016/j.xcrm.2026.102728 · Cited by 5

[Vitamins and Immune System Health].

Kong, W.-L., Lu, X., Hou, L., Sun, X., Sun, G.-Q., & Chen, L. (2023) · PubMed Central · doi:10.12182/20230160107 · Cited by 4

Disulfidptosis-Related Classification Patterns and Tumor Microenvironment Characterization in Skin Cutaneous Melanoma

Li, Y., Cao, Z.-J., Zhang, Y., Zhou, J.-K., & Tian, J. (2023) · Melanoma Management · doi:10.2217/mmt-2023-0006 · Cited by 4

High-dose vitamin C as a metabolic treatment of cancer: a new dimension in the era of adjuvant and intensive therapy

Wang, X., He, J. W., Sun, M., Wang, S., Qu, J., Shi, H., & Rao, B. (2024) · Clinical & Translational Oncology · doi:10.1007/s12094-024-03553-x · Cited by 5

Unveiling vitamin C: A new hope in the treatment of diffuse large B‑cell lymphoma (Review)

Ren, C., Li, Y., Li, M., & Wang, Y. (2025) · International Journal of Oncology · doi:10.3892/ijo.2025.5746 · Cited by 4

Genetically predicted vitamin C levels significantly affect patient survival and immunotypes in multiple cancer types

Yuan, J., Zhang, Y., Hua, X., Hong, H., Shi, W., Liu, K., Liu, Z., & Huang, P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1177580 · Cited by 4

Treatment of severe radiation proctitis with high dosage of vitamin C in combination with cyclooxygenase-2 inhibitor

Wu, H., Liu, M., Jiang, H., Xu, H., Peng, J., Dai, J., & Zhou, F. (2024) · Radiation Medicine and Protection · doi:10.1016/j.radmp.2024.05.002 · Cited by 3

The therapeutic potential of vitamins A, C, and D in pancreatic cancer

Piotrowsky, A., Burkard, M., Schmieder, H., Venturelli, S., Renner, O., & Marongiu, L. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e41598 · Cited by 3

Vitamin‐Engineered Nanoplatforms in Precision Oncology: Integrating Immunotherapy, Delivery Systems, and Theranostics

Xu, R., Gao, Y., Zhang, H., & Luo, Z. (2025) · MedComm – Biomaterials and Applications · doi:10.1002/mba2.70028 · Cited by 3

The physiological functions of ascorbate in the development of cancer

Agathocleous, M. (2025) · Disease Models & Mechanisms · doi:10.1242/dmm.052201 · Cited by 4

Therapeutic Potential of High Dose Vitamin C in Cancer: Mechanisms, Clinical Evidence and Future Directions

Singh, R., Parchwani, D. N., Sharma, G., & Sharma, P. (2025) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-025-01341-0 · Cited by 3

Vitamin C and cancer risk and treatment

Dębska-Szmich, S., & Potemski, P. (2021) · Postępy Higieny i Medycyny Doświadczalnej · doi:10.2478/ahem-2021-0031 · Cited by 3

An ascorbic acid-decorated nanostructured surface on titanium inhibits breast cancer development and promotes osteogenesis

Li, R., Liu, H., Shi, Q., Zhang, G., Pang, G., Xu, Y., Song, J., & Lu, Y. (2023) · Biomedical Materials · doi:10.1088/1748-605x/ad0fa2 · Cited by 3

Identification of a novel prognostic signature based on vitamin metabolism clustering-related genes in lung adenocarcinoma

Chen, Y., Jiang, Y., Li, X., Huang, H., Zhou, Y., Zhang, C., Wang, S., Bohnenberger, H., & Gao, Y. (2024) · Translational Lung Cancer Research · doi:10.21037/tlcr-24-245 · Cited by 4

Pembrolizumab plus Pharmacologic Ascorbate in the Treatment of Leiomyosarcoma

Rieth, J. M., Belzer, A. C., Walhof, M. L., & Milhem, M. M. (2024) · Case Reports in Oncology · doi:10.1159/000539979 · Cited by 3

Vitamin C, From Supplement to Treatment: A Re-Emerging Adjunct for Cancer Immunotherapy?

Kouakanou, L., Peters, C., Brown, C. E., Kabelitz, D., & Wang, L. D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.765906 · Cited by 31

Vitamin C Enhances Anticancer Immunity

Editorial Office ROS (2023) · doi:10.20455/ros.2023.n811

The molecular bases of the anticancer efficacy of high-dose Vitamin C

Cavaliere, A. (n.d.) · Institutional Research Information System University of Turin (University of Turin)

Abstract 6169: Immunogenic cell death mediates the anticancer efficacy of high dose vitamin C

Cavaliere, A., Macagno, M., Maione, F., Amodio, V., Escobosa, M., Chilà, R., Lamba, S., Vitiello, P. P., Pessei, V., Grases, D., et al. (2025) · Cancer Research · doi:10.1158/1538-7445.am2025-6169 · Cited by 1

The potential role of vitamin C in empowering cancer immunotherapy

Bedhiafi, T., Inchakalody, V. P., Fernandes, Q., Mestiri, S., Billa, N., Shahab Uddin, M. S., Merhi, M., & Dermime, S. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112553 · Cited by 77