High-dose vitamin C enhances cancer immunotherapy

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

Le, D. T., Uram, J. N., Wang, H., Bartlett, B. R., Kemberling, H., Eyring, A. D., Skora, A. D., Luber, B. S., Azad, N. S., Laheru, D., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1500596 · Cited by 9,377

Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer

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Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

Le, D. T., Durham, J. N., Smith, K. N., Wang, H., Bartlett, B. R., Aulakh, L. K., Lu, S., Kemberling, H., Wilt, C., Luber, B. S., et al. (2017) · Science · doi:10.1126/science.aan6733 · Cited by 6,645

Pembrolizumab as Second-Line Therapy for Advanced Urothelial Carcinoma

Bellmunt, J., de Wit, R., Vaughn, D. J., Fradet, Y., Lee, J.-L., Fong, L., Vogelzang, N. J., Climent, M. A., Petrylak, D. P., Choueiri, T. K., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1613683 · Cited by 3,395

Fundamental Mechanisms of Immune Checkpoint Blockade Therapy

Wei, S. C., Duffy, C. R., & Allison, J. P. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0367 · Cited by 3,088

Nivolumab plus ipilimumab in lung cancer with a high tumor mutational burden

Hellmann, M. D., Ciuleanu, T.-E., Pluzanski, A., Lee, J. S., Otterson, G. A., Audigier-Valette, C., Minenza, E., Linardou, H., Burgers, S., Salman, P., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1801946 · Cited by 3,063

Nivolumab in Patients with Metastatic DNA Mismatch Repair-Deficient or Microsatellite Instability-High Colorectal Cancer (CheckMate 142): An Open-Label, Multicentre, Phase 2 Study

Overman, M. J., McDermott, R., Leach, J. L., Lonardi, S., Lenz, H.-J., Morse, M. A., Desai, J., Hill, A., Axelson, M., Moss, R. A., et al. (2017) · The Lancet Oncology · doi:10.1016/s1470-2045(17)30422-9 · Cited by 2,836

Durable Clinical Benefit with Nivolumab Plus Ipilimumab in DNA Mismatch Repair-Deficient/Microsatellite Instability-High Metastatic Colorectal Cancer

Overman, M. J., Lonardi, S., Wong, K. Y. M., Lenz, H.-J., Gelsomino, F., Aglietta, M., Morse, M. A., Van Cutsem, E., McDermott, R., Hill, A., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2017.76.9901 · Cited by 2,079

Immune checkpoint inhibitors: recent progress and potential biomarkers

Darvin, P., Toor, S. M., Sasidharan Nair, V., & Elkord, E. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0191-1 · Cited by 2,035

Vitamin C and Immune Function

Carr, A., & Maggini, S. (2017) · Nutrients · doi:10.3390/nu9111211 · Cited by 2,035

Oxidative Stress in Cancer

Hayes, J. D., Dinkova-Kostova, A. T., & Tew, K. D. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.06.001 · Cited by 2,654

Recent advances in wet adhesives: Adhesion mechanism, design principle and applications

Cui, C., & Liu, W. (2021) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2021.101388 · Cited by 557

Oxidative cell death in cancer: mechanisms and therapeutic opportunities

An, X., Yu, W., Liu, J., Tang, D., Li, Y., & Chen, X. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06939-5 · Cited by 617

Improvement of the anticancer efficacy of PD-1/PD-L1 blockade via combination therapy and PD-L1 regulation

Wu, M., Huang, Q., Xie, Y., Wu, X., Ma, H., Zhang, Y., & Xia, Y. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01242-2 · Cited by 484

Nutritional Components in Western Diet Versus Mediterranean Diet at the Gut Microbiota–Immune System Interplay. Implications for Health and Disease

Montero, C. G., Fraile‐Μartinez, O., Gomez-Lahoz, A. M., Pekarek, L., Castellanos, A. J., Noguerales-Fraguas, F., Coca, S., Guijarro, L. G., García‐Honduvilla, N., Asúnsolo, Á., et al. (2021) · Nutrients · doi:10.3390/nu13020699 · Cited by 487

Cancer immunotherapy with γδ T cells: many paths ahead of us

Kabelitz, D., Serrano, R., Kouakanou, L., Peters, C., & Kalyan, S. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-0504-x · Cited by 306

Oxidative Stress in the Tumor Microenvironment and Its Relevance to Cancer Immunotherapy

Aboelella, N. S., Brandle, C., Kim, T., Ding, Z., & Zhou, G. (2021) · Cancers · doi:10.3390/cancers13050986 · Cited by 303

Targeting EMT in Cancer with Repurposed Metabolic Inhibitors

Ramesh, V., Brabletz, T., & Ceppi, P. (2020) · Trends in cancer · doi:10.1016/j.trecan.2020.06.005 · Cited by 245

High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer

Böttger, F., Vallés‐Martí, A., Cahn, L., & Jiménez, C. R. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02134-y · Cited by 223

Immune cell - produced ROS and their impact on tumor growth and metastasis

Kennel, K. B., & Greten, F. R. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101891 · Cited by 213

Metabolism and Colorectal Cancer

Sedlak, J. C., Yilmaz, Ö. H., & Roper, J. (2022) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-031521-041113 · Cited by 208

Intravenous vitamin C for reduction of cytokines storm in acute respiratory distress syndrome

Boretti, A. A., & Banik, B. K. (2020) · PharmaNutrition · doi:10.1016/j.phanu.2020.100190 · Cited by 170

Vitamin C: A Comprehensive Review of Its Role in Health, Disease Prevention, and Therapeutic Potential

Alberts, A., Moldoveanu, E.-T., Niculescu, A.-G., & Grumezescu, A. M. (2025) · Molecules · doi:10.3390/molecules30030748 · Cited by 161

Reactive Oxygen Species Bridge the Gap between Chronic Inflammation and Tumor Development

Yu, W., Tu, Y., Long, Z., Liu, J., Kong, D., Peng, J., Wu, H., Zheng, G., Zhao, J., Chen, Y., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2606928 · Cited by 168

PD-1/PD-L1 immune checkpoint blockade in breast cancer: research insights and sensitization strategies

Jin, M., Fang, J., Peng, J., Wang, X., Xing, P., Jia, K., Hu, J., Wang, D., Ding, Y., Wang, X., et al. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02176-8 · Cited by 162

Methylation across the central dogma in health and diseases: new therapeutic strategies

Liu, R., Zhao, E., Yu, H., Yuan, C., Abbas, M. N., & Cui, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01528-y · Cited by 155

The Influence of Nutritional Factors on Immunological Outcomes

Tourkochristou, E., Triantos, C. K., & Mouzaki, Α. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.665968 · Cited by 156

Smartphone light-driven zinc porphyrinic MOF nanosheets-based enzyme-free wearable photoelectrochemical sensor for continuous sweat vitamin C detection

Yan, T., Zhang, G., Yu, K., Chai, H., Tian, M., Qu, L., Dong, H., & Zhang, X. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.140779 · Cited by 120

Medicinal Prospects of Antioxidants From Algal Sources in Cancer Therapy

Ferdous, U. T., & Yusof, Z. N. B. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.593116 · Cited by 121

The role of ROS in tumor infiltrating immune cells and cancer immunotherapy

Shah, R., Ibis, B., Kashyap, M., & Boussiotis, V. A. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155747 · Cited by 119

TET2-mediated tumor cGAS triggers endothelial STING activation to regulate vasculature remodeling and anti-tumor immunity in liver cancer

Lv, H., Zong, Q., Chen, C., Lv, G., Xiang, W., Xing, F., Jiang, G., Yan, B., Sun, X., Ma, Y., et al. (2024) · Nature Communications · doi:10.1038/s41467-023-43743-9 · Cited by 117

Integrated approaches for precision oncology in colorectal cancer: The more you know, the better

Andrei, P., Battuello, P., Grasso, G., Rovera, E., Tesio, N., & Bardelli, A. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.04.007 · Cited by 116

Association of a Mediterranean Diet With Outcomes for Patients Treated With Immune Checkpoint Blockade for Advanced Melanoma

Bolte, L. A., Lee, K. A., Björk, J. R., Leeming, E. R., Campmans-Kuijpers, M. J. E., de Haan, J. J., Vila, A. V., Maltez-Thomas, A., Segata, N., Board, R., et al. (2023) · JAMA Oncology · doi:10.1001/jamaoncol.2022.7753 · Cited by 106

TET family dioxygenases and the TET activator vitamin C in immune responses and cancer

Yue, X., & Rao, A. (2020) · Blood · doi:10.1182/blood.2019004158 · Cited by 106

Epigenetic Regulation of Genomic Stability by Vitamin C

Brabson, J. P., Leesang, T. E., Mohammad, S., & Cimmino, L. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.675780 · Cited by 111

Antioxidants for the Treatment of Breast Cancer: Are We There Yet?

Griñán‐Lisón, C., Blaya-Cánovas, J. L., López-Tejada, A., Ávalos-Moreno, M., Navarro-Ocón, A., Cara, F. E., González-González, A., Lorente, J. A., Marchal, J. A., & Granados-Principal, S. M. (2021) · Antioxidants · doi:10.3390/antiox10020205 · Cited by 108

High-Dose Vitamin C for Cancer Therapy

Mussa, A., Idris, R. A. M., Ahmed, N., Ahmad, S., Murtadha, A. H., Din, T. A. D. A. T., Yean, C. Y., Rahman, W. F. W. A., Lazim, N. M., Uskoković, V., et al. (2022) · Pharmaceuticals · doi:10.3390/ph15060711 · Cited by 85

The potential role of vitamin C in empowering cancer immunotherapy

Bedhiafi, T., Inchakalody, V. P., Fernandes, Q., Mestiri, S., Billa, N., Shahab Uddin, M. S., Merhi, M., & Dermime, S. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112553 · Cited by 77

The Evolutionary Landscape of Treatment for BRAFV600E Mutant Metastatic Colorectal Cancer

Mauri, G., Bonazzina, E., Amatu, A., Tosi, F., Bencardino, K., Gori, V., Massihnia, D., Cipani, T., Spina, F., Ghezzi, S., et al. (2021) · Cancers · doi:10.3390/cancers13010137 · Cited by 73

TET2 as a tumor suppressor and therapeutic target in T-cell acute lymphoblastic leukemia

Bensberg, M., Rundquist, O., Selimović-Pašić, A., Lagerwall, C., Benson, M., Gustafsson, M., Vogt, H., Lentini, A., & Nestor, C. E. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2110758118 · Cited by 70

Polarization of Tumor-Associated Macrophages Promoted by Vitamin C-Loaded Liposomes for Cancer Immunotherapy

Ma, Z., Yang, M., Foda, M. F., Zhang, K., Li, S., Liang, H., Zhao, Y., & Han, H. (2022) · ACS Nano · doi:10.1021/acsnano.2c08446 · Cited by 70

Mechanisms of Immune Escape and Resistance to Checkpoint Inhibitor Therapies in Mismatch Repair Deficient Metastatic Colorectal Cancers

Amodio, V., Mauri, G., Reilly, N. M., Bianchi, A. S., Siena, S., Bardelli, A., & Germano, G. (2021) · Cancers · doi:10.3390/cancers13112638 · Cited by 67

Immunoinflammatory, Thrombohaemostatic, and Cardiovascular Mechanisms in COVID-19

Gencer, S., Lacy, M., Atzler, D., van der Vorst, E. P. C., Döring, Y., & Weber, C. (2020) · Thrombosis and Haemostasis · doi:10.1055/s-0040-1718735 · Cited by 66

Vitamin C Sensitizes Pancreatic Cancer Cells to Erastin‐Induced Ferroptosis by Activating the AMPK/Nrf2/HMOX1 Pathway

Liu, Y., Huang, P., Li, Z., Xu, C., Wang, H., Jia, B., Gong, A., & Xu, M. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/5361241 · Cited by 66

Dietary pro-oxidant therapy by a vitamin K precursor targets PI 3-kinase VPS34 function

Swamynathan, M. M., Kuang, S., Watrud, K. E., Doherty, M. R., Gineste, C., Mathew, G., Gong, G. Q., Cox, H., Cheng, E., Reiss, D. J., et al. (2024) · Science · doi:10.1126/science.adk9167 · Cited by 66

A Narrative Review of the Role of Diet and Lifestyle Factors in the Development and Prevention of Endometrial Cancer

Yasin, H. K., Taylor, A. H., & Ayakannu, T. (2021) · Cancers · doi:10.3390/cancers13092149 · Cited by 65

A Randomized, Open-Label, Multicenter, Phase 3 Study of High-Dose Vitamin C Plus FOLFOX ± Bevacizumab versus FOLFOX ± Bevacizumab in Unresectable Untreated Metastatic Colorectal Cancer (VITALITY Study)

Wang, F., He, M.-M., Xiao, J., Zhang, Y., Yuan, X., Fang, W. J., Zhang, Y., Wang, W., Hu, X.-H., Ma, Z., et al. (2022) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-0655 · Cited by 67

Cross‐Talk between Oxidative Stress and m6A RNA Methylation in Cancer

Yang, B., & Chen, Q. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6545728 · Cited by 61

Vitamin C enhances NF-κB-driven epigenomic reprogramming and boosts the immunogenic properties of dendritic cells

Morante-Palacios, O., Godoy‐Tena, G., Calafell-Segura, J., Ciudad, L., Martínez-Cáceres, E. M., Sardina, J. L., & Ballestar, E. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac941 · Cited by 57

Role of vitamins A, C, D, E in cancer prevention and therapy: therapeutic potentials and mechanisms of action

Talib, W. H., Jum'Ah, D., Attallah, Z. S., Jallad, M. S., Kury, L. T. A., Hadi, R. W., & Mahmod, A. I. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1281879 · Cited by 64

A Novel Restorative Pulmonary Valve Conduit: Early Outcomes of Two Clinical Trials

Morales, D. L. S., Herrington, C. S., BACHA, E. A., Morell, V. O., Prodàn, Z., Mroczek, T., Sivalingam, S., Cox, M. A. J., Bennink, G. B. W. E., & Asch, F. M. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.583360 · Cited by 57

Metabolic engineering in food crops to enhance ascorbic acid production: crop biofortification perspectives for human health

Chaturvedi, S., Khan, S., Bhunia, R. K., Kaur, K., & Tiwari, S. (2022) · Physiology and Molecular Biology of Plants · doi:10.1007/s12298-022-01172-w · Cited by 56

The Immune Landscape of Breast Cancer: Strategies for Overcoming Immunotherapy Resistance

Retecki, K., Seweryn, M., Graczyk‐Jarzynka, A., & Bajor, M. (2021) · Cancers · doi:10.3390/cancers13236012 · Cited by 56

Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response

He, X., Wang, Q., Cheng, X., Wang, W., Li, Y., Nan, Y., Wu, J., Xiu, B., Jiang, T., Bergholz, J. S., et al. (2025) · Cell · doi:10.1016/j.cell.2025.01.043 · Cited by 57

Ascorbic acid induced TET2 enzyme activation enhances cancer immunotherapy efficacy in renal cell carcinoma

Ding, P., He, A., He, S., Ge, G., Wang, S., Ci, W., Li, X., Xia, D., & Zhou, L. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.67329 · Cited by 54

Pharmacological ascorbate improves the response to platinum-based chemotherapy in advanced stage non-small cell lung cancer

Furqan, M., Hejleh, T. A., Stephens, L. M., Hartwig, S. M., Mott, S. L., Pulliam, C. F., Petronek, M. S., Henrich, J. B., Fath, M. A., Houtman, J. C. D., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102318 · Cited by 55

Vitamin C supramolecular hydrogel for enhanced cancer immunotherapy

Zhang, H., Liu, K., Gong, Y., Zhu, W., Zhu, J., Pan, F., Chao, Y., Xiao, Z., Liu, Y., Wang, X., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121673 · Cited by 52

Cyclic fasting-mimicking diet in cancer treatment: Preclinical and clinical evidence

Vernieri, C., Ligorio, F., Tripathy, D., & Longo, V. D. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.06.014 · Cited by 57

Immunometabolism in the Tumor Microenvironment

Roy, D. G., Kaymak, I., Williams, K. S., Ma, E. H., & Jones, R. G. (2020) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030518-055817 · Cited by 49

USP15 suppresses tumor immunity via deubiquitylation and inactivation of TET2

Chen, L., Smith, M. D., Lv, L., Nakagawa, T., Li, Z., Sun, S., Brown, N. G., Xiong, Y., & Xu, Y. (2020) · Science Advances · doi:10.1126/sciadv.abc9730 · Cited by 50

Tetrasulfide bond boosts the anti-tumor efficacy of dimeric prodrug nanoassemblies

Zuo, S., Liu, T., Li, L., Xu, H., Guo, J., Wang, Q., Yang, Y., He, Z., Sun, J., & Sun, B. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101432 · Cited by 47

Metabolite regulation of epigenetics in cancer

Wang, P., Chen, L., Xiong, Y., & Ye, D. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114815 · Cited by 50

Low-dose ipilimumab plus nivolumab combined with IL-2 and hyperthermia in cancer patients with advanced disease: exploratory findings of a case series of 131 stage IV cancers – a retrospective study of a single institution

Kleef, R., Nagy, R., Baierl, A., Bacher, V., Bojar, H., McKee, D. L., Moss, R. W., Thoennissen, N. H., Szász, A. M., & Bakács, T. (2020) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-020-02751-0 · Cited by 46

Gastrointestinal Cancer Patient Nutritional Management: From Specific Needs to Novel Epigenetic Dietary Approaches

Cencioni, C., Trestini, I., Piro, G., Bria, E., Tortora, G., Carbone, C., & Spallotta, F. (2022) · Nutrients · doi:10.3390/nu14081542 · Cited by 51

Hybrid Membrane-Camouflaged Biomimetic Immunomodulatory Nanoturrets with Sequential Multidrug Release for Potentiating T Cell-Mediated Anticancer Immunity

Yao, W., Liu, W., Su, F., Wang, J., Li, H., Sun, M., Ma, Y., Xu, Y., Li, D., Wang, Y., et al. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.4c04840 · Cited by 43

Therapeutic effect of targeted antioxidant natural products

Mukherjee, S., Chopra, H., Goyal, R., Jin, S., Dong, Z., Das, T., & Bhattacharya, T. (2024) · Discover Nano · doi:10.1186/s11671-024-04100-x · Cited by 57

The pharmacology of vitamin C

Lykkesfeldt, J., Carr, A. C., & Tveden‐Nyborg, P. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100043 · Cited by 50

Harnessing GLUT1‐Targeted Pro‐oxidant Ascorbate for Synergistic Phototherapeutics

Koo, S., Lee, M., Sharma, A. K., Li, M., Zhang, X., Pu, K., Chi, S., & Kim, J. S. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202110832 · Cited by 42

Wound Healing versus Metastasis: Role of Oxidative Stress

Lopez, T. E., Wendremaire, M., Lagarde, J., Duquet, O., Alibert, L., Paquette, B., Garrido, C., & Lirussi, F. (2022) · Biomedicines · doi:10.3390/biomedicines10112784 · Cited by 44

Advances in Ascorbic Acid (Vitamin C) Manufacturing: Green Extraction Techniques from Natural Sources

Susa, F., & Pisano, R. (2023) · Processes · doi:10.3390/pr11113167 · Cited by 41

The Role of Microbiota-Derived Vitamins in Immune Homeostasis and Enhancing Cancer Immunotherapy

Gholami, H., Chmiel, J. A., Burton, J. P., & Vareki, S. M. (2023) · Cancers · doi:10.3390/cancers15041300 · Cited by 40

Immune evasion in renal cell carcinoma: biology, clinical translation, future directions

Wang, X., Lopez, R., Luchtel, R. A., Hafizi, S., Gartrell, B. A., & Shenoy, N. K. (2020) · Kidney International · doi:10.1016/j.kint.2020.08.028 · Cited by 39

Science-Driven Nutritional Interventions for the Prevention and Treatment of Cancer

Montégut, L., de Cabo, R., Zitvogel, L., & Kroemer, G. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-0504 · Cited by 38

Strategies to enhance the therapeutic efficacy of anti-PD-1 antibody, anti-PD-L1 antibody and anti-CTLA-4 antibody in cancer therapy

Su, X., Li, J., Xu, X., Ye, Y., Wang, C., Pang, G., Liu, W., Liu, A., Zhao, C., & Hao, X. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05552-6 · Cited by 45

Atrazine Toxicity: The Possible Role of Natural Products for Effective Treatment

Das, S., Sakr, H. F., Al‐Huseini, I., Jetti, R., Al-Qasmi, S., Sugavasi, R., & Sirasanagandla, S. R. (2023) · Plants · doi:10.3390/plants12122278 · Cited by 37

Multitarget Pharmacology of Sulfur–Nitrogen Heterocycles: Anticancer and Antioxidant Perspectives

Drakontaeidi, A., Papanotas, I., & Pontiki, E. A. (2024) · Antioxidants · doi:10.3390/antiox13080898 · Cited by 36

Clinical implications of differential procoagulant toxicity of the palearctic viperid genus Macrovipera, and the relative neutralization efficacy of antivenoms and enzyme inhibitors

Chowdhury, A., Zdenek, C. N., Dobson, J. S., Bourke, L. A., Soria, R., & Fry, B. G. (2021) · Toxicology Letters · doi:10.1016/j.toxlet.2020.12.019 · Cited by 36

Vitamin C intake and multiple health outcomes: an umbrella review of systematic reviews and meta-analyses

Xu, K., Peng, R., Zou, Y., Jiang, X., Sun, Q., & Song, C. (2022) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2022.2048359 · Cited by 37

Epigenetic remodeling by vitamin C potentiates plasma cell differentiation

Chen, H.-Y., Almonte-Loya, A., Lay, F.-Y., Hsu, M., Johnson, E. C., González‐Avalos, E., Yin, J., Bruno, R. S., Ma, Q., Ghoneim, H. E., et al. (2022) · eLife · doi:10.7554/elife.73754 · Cited by 37

A nanoplatform to boost multi-phases of cancer-immunity-cycle for enhancing immunotherapy

Zheng, C., Song, Q., Zhao, H., Kong, Y., Sun, L., Liu, X., Feng, Q., & Wang, L. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.10.011 · Cited by 34

High dose Vitamin C inhibits PD-L1 by ROS-pSTAT3 signal pathway and enhances T cell function in TNBC

Zhao, X., Liu, M., Li, C., Liu, X., Zhao, J., Ma, H., Zhang, S., & Qu, J. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111321 · Cited by 33

The Involvement of Ascorbic Acid in Cancer Treatment

Guo, D., Liao, Y., Na, J., Wu, L., Yin, Y., Mi, Z., Fang, S., Liu, X., & Huang, Y. (2024) · Molecules · doi:10.3390/molecules29102295 · Cited by 31

T Cell Metabolism in Cancer Immunotherapy

Aksoylar, H., Tijaro-Ovalle, N. M., Boussiotis, V. A., & Patsoukis, N. (2020) · Immunometabolism · doi:10.20900/immunometab20200020 · Cited by 31

Association of vitamin C intake with breast cancer risk and mortality: a meta-analysis of observational studies

Zhang, D., Xu, P., Li, Y., Wei, B., Yang, S., Zheng, Y., Lyu, L., Deng, Y., Zhai, Z., Li, N., et al. (2020) · Aging · doi:10.18632/aging.103769 · Cited by 31

Cell signaling pathways based on vitamin C and their application in cancer therapy

Fan, D., Liu, X., Shen, Z., Wu, P., Zhong, L., & Lin, F. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114695 · Cited by 31

Metabolites in the Tumor Microenvironment Reprogram Functions of Immune Effector Cells Through Epigenetic Modifications

Li, Y., Wu, Y., & Hu, Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.641883 · Cited by 31

Rapid and Label‐Free Detection of 5‐Hydroxymethylcytosine in Genomic DNA Using an Au/ZnO Nanorods Hybrid Nanostructure‐Based Electrochemical Sensor

Bhat, K. S., Kim, H., Alam, A., Ko, M., An, J., & Lim, S. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202101193 · Cited by 30

Epigenetics of Dendritic Cells in Tumor Immunology

Godoy‐Tena, G., & Ballestar, E. (2022) · Cancers · doi:10.3390/cancers14051179 · Cited by 30

Co-targeting BET bromodomain BRD4 and RAC1 suppresses growth, stemness and tumorigenesis by disrupting the c-MYC-G9a-FTH1axis and downregulation of HDAC1 in molecular subtypes of breast cancer

Ali, A., Shafarin, J., Unnikannan, H., Al-Jabi, N., Jabal, R. A., Bajbouj, K., Muhammad, J. S., & Hamad, M. A. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.62236 · Cited by 29

Vitamin C, From Supplement to Treatment: A Re-Emerging Adjunct for Cancer Immunotherapy?

Kouakanou, L., Peters, C., Brown, C. E., Kabelitz, D., & Wang, L. D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.765906 · Cited by 31

Harnessing Antioxidants in Cancer Therapy: Opportunities, Challenges, and Future Directions

Liu, Y., Wu, G., Feng, L., Li, J., Xia, Y., Guo, W., & Zhao, K. (2025) · Antioxidants · doi:10.3390/antiox14060674 · Cited by 32

High-dose VitC plus oncolytic adenoviruses enhance immunogenic tumor cell death and reprogram tumor immune microenvironment

Ma, J., Zhang, C., Shi, G., Yue, D., Shu, Y., Hu, S., Qi, Z., Chen, Y., Zhang, B., Zhang, Y., et al. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.09.015 · Cited by 28

The role of cuproptosis-related gene in the classification and prognosis of melanoma

Liu, J.-Y., Liu, L.-P., Li, Z., Luo, Y., & Liang, F. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.986214 · Cited by 28

Vitamin C Supplementation in the Treatment of Autoimmune and Onco-Hematological Diseases: From Prophylaxis to Adjuvant Therapy

Isola, S., Gammeri, L., Furci, F., Gangemi, S., Pioggia, G., & Allegra, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137284 · Cited by 30

Role of Vitamin C in Selected Malignant Neoplasms in Women

Markowska, A., Antoszczak, M., Markowska, J., & Huczyński, A. (2022) · Nutrients · doi:10.3390/nu14040882 · Cited by 30

Ascorbate as a Bioactive Compound in Cancer Therapy: The Old Classic Strikes Back

González‐Montero, J., Chichiarelli, S., Eufemi, M., Fabio Altieri, F., Saso, L., & Rodrigo, R. (2022) · Molecules · doi:10.3390/molecules27123818 · Cited by 28

One-Step Biosynthesis of Vitamin C in Saccharomyces cerevisiae

Zhou, M., Bi, Y., Ding, M., & Yuan, Y. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.643472 · Cited by 25

Repurposing Vitamin C for Cancer Treatment: Focus on Targeting the Tumor Microenvironment

Li, W.-N., Zhang, S.-J., Feng, J.-Q., & Jin, W. (2022) · Cancers · doi:10.3390/cancers14112608 · Cited by 30

Enhanced Therapeutic Applications of Vitamin C via Nanotechnology-Based Pro-Oxidant Properties: A Review

Pal, S., & Jana, N. R. (2022) · ACS Applied Nano Materials · doi:10.1021/acsanm.1c03000 · Cited by 25

Creatine supplementation enhances immunological function of neutrophils by increasing cellular adenosine triphosphate

Saito, S., Cao, D., Okuno, A., Xiaomo, L. I., Peng, Z., Kelel, M., & Tsuji, N. M. (2022) · Bioscience of Microbiota Food and Health · doi:10.12938/bmfh.2022-018 · Cited by 26

Meaning and Significance of “Alkalization Therapy for Cancer”

Wada, H., Hamaguchi, R., Narui, R., & Morikawa, H. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.920843 · Cited by 25

The interplay between vitamin C and thyroid

Farasati Far, B., Behnoush, A. H., Ghondaghsaz, E., Habibi, M. A., & Khalaji, A. (2023) · Endocrinology, Diabetes & Metabolism · doi:10.1002/edm2.432 · Cited by 23

Interactions between Dietary Micronutrients, Composition of the Microbiome and Efficacy of Immunotherapy in Cancer Patients

Frąk, M., Grenda, A., Krawczyk, P. A., Milanowski, J., & Kalinka‐Warzocha, E. (2022) · Cancers · doi:10.3390/cancers14225577 · Cited by 25

Nutrient vitamins enabled metabolic regulation of ferroptosis via reactive oxygen species biology

Wu, J., Shi, Y., Zhou, M., Chen, M., Ji, S., Liu, X., Zhou, M., Xia, R., Zheng, X., & Wang, W. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1434088 · Cited by 22

Toward personalized cancer management: Role of precision nutrition–diet interventions

Guo, H., Liu, Y., Wan, T., Da, S., Palanisamy, C. P., Geng, J., Pei, J., Özmen, S., & El‐Aty, A. M. A. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106584 · Cited by 31

Recent research progress and clinical status of immunotherapy for colorectal cancer

Huo, Z., Liu, G., & Li, J. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.06.089 · Cited by 27

Effects of antioxidants on cancer progression

Schmidt, S., Qiao, X., & Bergö, M. O. (2025) · EMBO Molecular Medicine · doi:10.1038/s44321-025-00269-5 · Cited by 25

Rewiring cancer metabolism: oncogenic signaling pathways and targeted therapeutics

Lyu, S., Gildor, N., Zhang, Q. H., & Liao, C. (2025) · Science China Life Sciences · doi:10.1007/s11427-025-2979-3 · Cited by 27

Pharmacological ascorbate as a novel therapeutic strategy to enhance cancer immunotherapy

Zaher, A., Stephens, L. M., Miller, A. M., Hartwig, S. M., Stolwijk, J. M., Petronek, M. S., Zacharias, Z. R., Wadas, T. J., Monga, V., Cullen, J. J., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.989000 · Cited by 25

Epigenetic Regulators of DNA Cytosine Modification: Promising Targets for Cancer Therapy

Jung, I., An, J., & Ko, M. (2023) · Biomedicines · doi:10.3390/biomedicines11030654 · Cited by 22

Vitamin C, From Supplement to Treatment: A Re-Emerging Adjunct for Cancer Immunotherapy?

Kouakanou, L., Peters, C., Brown, C. E., Kabelitz, D., & Wang, L. D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.765906 · Cited by 31

Vitamin C Enhances Anticancer Immunity

Editorial Office ROS (2023) · doi:10.20455/ros.2023.n811

The molecular bases of the anticancer efficacy of high-dose Vitamin C

Cavaliere, A. (n.d.) · Institutional Research Information System University of Turin (University of Turin)

Abstract 6169: Immunogenic cell death mediates the anticancer efficacy of high dose vitamin C

Cavaliere, A., Macagno, M., Maione, F., Amodio, V., Escobosa, M., Chilà, R., Lamba, S., Vitiello, P. P., Pessei, V., Grases, D., et al. (2025) · Cancer Research · doi:10.1158/1538-7445.am2025-6169 · Cited by 1

The potential role of vitamin C in empowering cancer immunotherapy

Bedhiafi, T., Inchakalody, V. P., Fernandes, Q., Mestiri, S., Billa, N., Shahab Uddin, M. S., Merhi, M., & Dermime, S. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112553 · Cited by 77