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High-dose vitamin C enhances cancer immunotherapy
Open accessAbstract
Vitamin C promotes anticancer adaptive immunity and enhances efficacy of immune checkpoint therapy.
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“A potential mechanism underlying the association between diet and immunotherapy response is the gut microbiome.”
From Association of a Mediterranean Diet With Outcomes for Patients Treated With Immune Checkpoint Blockade for Advanced Melanoma (2023) · cites this paper as [14]
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Metadata
- Authors
- Magrì, A., Germano, G., Lorenzato, A., Lamba, S., Chilà, R., Montone, M., Amodio, V., Ceruti, T., Sassi, F., Arena, S., Abrignani, S., D’Incalci, M., Zucchetti, M., Di Nicolantonio, F., & Bardelli, A.
- Affiliations
- Candiolo Cancer Institute (IT)
- IFOM (IT)
- Mario Negri Institute for Pharmacological Research (IT)
- University of Milan (IT)
- Department of Oncology, University of Torino, 10060 Candiolo (TO), Italy.
- Corresponding author
- Magrì, Alessandro
- Germano, Giovanni
- Bardelli, Alberto
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2020-02-26
- Volume
- 12
- Issue
- 532
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W3008623708
- Cited by
- 285
- References
- 55
- Citations by year
- 2026: 33 · 2025: 44 · 2024: 59 · 2023: 39 · 2022: 48 · 2021: 41 · 2020: 21
- FWCI
- 23.55
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- Funders
- Cancer Research UK (22795)
- Ministero della Salute (NET-2011-02352137, 21091)
- Associazione Italiana per la Ricerca sul Cancro (IG-2018, #21407, AIRC IG 2018, 21091, 21923, 22795, ID.21091)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- vitamin C, high-dose ascorbic acid, cancer immunotherapy, immune checkpoint inhibitors, CD8+ T cells, tumor microenvironment, tumor mutational burden, breast cancer, colorectal cancer, melanoma, pancreatic cancer, combination therapy
- MeSH terms
- Animals, Antineoplastic Agents, Ascorbic Acid, Immunotherapy, Melanoma, Mice, Tumor Microenvironment
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