cGAS-STING–mediated DNA sensing maintains CD8 + T cell stemness and promotes antitumor T cell therapy

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

Chen, Q., Sun, L., & Chen, Z. J. (2016) · Nature Immunology · doi:10.1038/ni.3558 · Cited by 2,333

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

Deng, L., Liang, H., Xu, M., Yang, X., Burnette, B., Arina, A., Li, X.-D., Mauceri, H., Beckett, M., Darga, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.019 · Cited by 2,182

Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

Miller, B. C., Sen, D. R., Al Abosy, R., Bi, K., Virkud, Y. V., LaFleur, M. W., Yates, K. B., Lako, A., Felt, K., Naik, G. S., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0312-6 · Cited by 2,087

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

Sade-Feldman, M., Yizhak, K., Bjorgaard, S. L., Ray, J. P., de Boer, C. G., Jenkins, R. W., Lieb, D. J., Chen, J. H., Frederick, D. T., Barzily-Rokni, M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.10.038 · Cited by 2,053

A human memory T cell subset with stem cell–like properties

Gattinoni, L., Lugli, E., Ji, Y., Pos, Z., Paulos, C. M., Quigley, M. F., Almeida, J. R., Gostick, E., Yu, Z., Carpenito, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2446 · Cited by 1,974

Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy

Siddiqui, I., Schaeuble, K., Chennupati, V., Fuertes Marraco, S. A., Calderon-Copete, S., Pais Ferreira, D., Carmona, S. J., Scarpellino, L., Gfeller, D., Pradervand, S., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.021 · Cited by 1,679

Mitotic progression following DNA damage enables pattern recognition within micronuclei

Harding, S. M., Benci, J. L., Irianto, J., Discher, D. E., Minn, A. J., & Greenberg, R. A. (2017) · Nature · doi:10.1038/nature23470 · Cited by 1,508

A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization

Sanmamed, M. F., & Chen, L. (2018) · Cell · doi:10.1016/j.cell.2018.09.035 · Cited by 1,414

STING: infection, inflammation and cancer.

Barber, G. N. (2015) · Nature Reviews Immunology · doi:10.1038/nri3921 · Cited by 1,313

The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

Li, T., & Chen, Z. J. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20180139 · Cited by 1,293

Biomaterial-enabled therapeutic modulation of cGAS-STING signaling for enhancing antitumor immunity

Liu, Y., Yang, F., Wang, X., Yang, B., Li, M., & Luo, Z. Y. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2023.03.026 · Cited by 24

The bidirectional roles of the cGAS-STING pathway in pain processing: Cellular and molecular mechanisms

Hu, Y., Chen, Y., Liu, T., Zhu, C., Wan, L., & Yao, W. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114869 · Cited by 25

Bridging innate and adaptive tumor immunity: cGAS–STING pathway activation to potentiate immune checkpoint blockade

Li, Z. Y., Zheng, W., Liu, Y., Cao, R., Wei, J., & Jia, H. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03555-9 · Cited by 22

Loss of Zfp335 triggers cGAS/STING-dependent apoptosis of post-β selection thymocytes

Ratiu, J. J., Barclay, W. E., Lin, E. Y.-H., Wang, Q., Wellford, S. A., Mehta, N. U., Harnois, M. J., DiPalma, D. T., Roy, S., Contreras, A. V., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33610-4 · Cited by 22

Cell-intrinsic PD-L1 ablation sustains effector CD8+ T cell responses and promotes antitumor T cell therapy

Wang, X., Lu, L., Hong, X., Wu, L., Yang, C., Wang, Y., Li, W., Yang, Y., Cao, D., Di, W. J., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113712 · Cited by 22

Unlocking the therapeutic potential of the STING signaling pathway in anti-tumor treatment

Li, J., Yang, H., Zhu, M., Zhang, P., Liu, Y., Niu, Y., Zhou, T., & Li, Y. (2025) · Clinical and Experimental Medicine · doi:10.1007/s10238-025-01838-1 · Cited by 21

Recent trends in STING modulators: Structures, mechanisms, and therapeutic potential

Zou, Y., Zhang, M., & Zhou, J. (2023) · Drug Discovery Today · doi:10.1016/j.drudis.2023.103694 · Cited by 22

Toxoplasma gondii ROP18 I inhibits host innate immunity through cGAS‐STING signaling

Chen, M., Yao, L., Zhou, L., Yang, P., Zou, W., Xu, L., Li, S., & Peng, H. (2022) · The FASEB Journal · doi:10.1096/fj.202101347r · Cited by 21

CD64+ fibroblast-targeted vilanterol and a STING agonist augment CLDN18.2 BiTEs efficacy against pancreatic cancer by reducing desmoplasia and enriching stem-like CD8+ T cells

Zhou, T., Hou, X., Yan, J., Lin, L., Xie, Y., Bai, W., Jiang, W., Zou, Y., Li, X., Liu, Z., et al. (2024) · Gut · doi:10.1136/gutjnl-2024-332371 · Cited by 20

The role of cGAS-STING in remodeling the tumor immune microenvironment induced by radiotherapy

Jiang, Q., Chen, Z., Jiang, J., Chen, Q., Lan, H., Zhu, J. Y., & Mao, W. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104658 · Cited by 21

FOSL2 promotes intertumoral infiltration of T cells and increases pathological complete response rates in locally advanced rectal cancer patients

Xu, K., Yin, X., Zhou, B., Zheng, X., Wang, H., Chen, J., Cai, X., Gao, H., Xu, X., Wang, L., et al. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216145 · Cited by 20

GAS-STING: a classical DNA recognition pathways to tumor therapy

Wang, X., Lin, M., Zhu, L., & Ye, Z. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1200245 · Cited by 22

New insights into the stemness of adoptively transferred T cells by γc family cytokines

Luo, M., Gong, W., Zhang, Y., Li, H., Ma, D., Wu, K., Gao, Q., & Fang, Y. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01354-3 · Cited by 21

Tissue factor promotes TREX1 protein stability to evade cGAS-STING innate immune response in pancreatic ductal adenocarcinoma

Xue, Y., Wang, Y., Ren, Z., & Yu, K. (2024) · Oncogene · doi:10.1038/s41388-024-03248-1 · Cited by 20

Intrinsic STING of CD8 + T cells regulates self-metabolic reprogramming and memory to exert anti-tumor effects

Xu, Q., Hua, X., Li, B., Jiang, B., Jin, J., Wu, R., Gu, Y., Xu, H., Cheng, Q., Zhu, S., et al. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02069-3 · Cited by 21

PARP inhibitor plus radiotherapy reshape the immune suppressive microenvironment and potentiate the efficacy of immune checkpoint inhibitors in tumors with IDH1 mutation

Hu, X., Zhao, M., Bai, M., Xue, Z., Wang, F., Zhu, Z., Yu, J., & Yue, J. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216676 · Cited by 21

Photosynthetic Plant-Derived Nanovesicles Precisely Amplify Photodynamic Effect by Light-Activated Oxygen Generation for Enhanced Cancer Photoimmunotherapy

Mei, J., Pan, W., Li, B., Zhong, M., Shi, X., Cheng, Y., Wu, B., Xiu, Q., Xue, Y., Situ, B., et al. (2025) · ACS Nano · doi:10.1021/acsnano.5c13350 · Cited by 18

Functional Nucleic Acid-Based Immunomodulation for T Cell-Mediated Cancer Therapy

Wu, H., Lin, J., Ling, N., Zhang, Y., He, Y., Qiu, L., & Tan, W. (2023) · ACS Nano · doi:10.1021/acsnano.3c09861 · Cited by 18

The effects of cGAS-STING inhibition in liver disease, kidney disease, and cellular senescence

Wang, L., Zhang, Z., Zhang, H., Zhou, M., Huang, C. Z., Xia, W., Li, J., & You, H. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1346446 · Cited by 18

Presetting CAR-T cells during ex vivo biomanufacturing

Wang, X., Liao, Y., Liu, D., Zheng, J., & Shi, M. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.02.031 · Cited by 19

Enhancing nano-immunotherapy of cancer through cGAS–STING pathway modulation

Fu, G., Zhao, Y., Mao, C., & Liu, Y. (2025) · Biomaterials Science · doi:10.1039/d4bm01532k · Cited by 17

Cancer Radiosensitization Nanoagent to Activate cGAS‐STING Pathway for Molecular Imaging Guided Synergistic Radio/Chemo/Immunotherapy

Wu, Z., Li, Q., Zhu, K., Zheng, S., Hu, H., Hou, M., Li, Q., Chen, S., Xu, Y., Zhao, B., et al. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202303626 · Cited by 18

Unlocking Apoptotic Pathways: Overcoming Tumor Resistance in CAR ‐T‐Cell Therapy

Zhang, Z., Su, M., Jiang, P., Wang, X., Tong, X., & Wu, G. (2024) · Cancer Medicine · doi:10.1002/cam4.70283 · Cited by 17

Immunological Impact of Intestinal T Cells on Metabolic Diseases

Zhou, H., Wang, L., & Liu, F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.639902 · Cited by 19

RELA tunes innate-like interferon I/III responses in human T cells

Jeremiah, N., Ferran, H., Antoniadou, K., de Azevedo, K., Nikolić, J., Maurin, M., Benaroch, P., & Manel, N. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20220666 · Cited by 17

GSH‐Responsive Mn 2+ Burst Nanoboxes as Mitophagy Intervention Agents Augment Ferroptosis and Chemoimmunotherapy in Triple‐Negative Breast Cancer

Zhang, G., Duan, J., Yu, F., Qi, Y., Zhao, S., Zhao, Y., Han, X., Liu, H., Sang, Y., & Yu, D. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202500491 · Cited by 16

Targeting WEE1 in tumor-associated dendritic cells potentiates antitumor immunity via the cGAS/STING pathway

Ng, I.-I., Zhang, Z., Xiao, K., Ye, M., Tian, T., Zhu, Y., He, Y.-D., Chu, L., & Tang, H. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115733 · Cited by 16

Electroacupuncture alleviates postoperative pain through inhibiting neuroinflammation via stimulator of interferon genes/type-1 interferon pathway

Ding, Y., Xu, F. L., Wang, Y., Han, L.-L., Huang, S.-Q., Zhao, S., Ma, L., Zhang, T., Zhao, W., & Chen, X. (2023) · Journal of Chinese Integrative Medicine · doi:10.1016/j.joim.2023.07.001 · Cited by 17

Conventional DNA-Damaging Cancer Therapies and Emerging cGAS-STING Activation: A Review and Perspectives Regarding Immunotherapeutic Potential

Lewicky, J. D., Martel, A. L., Gupta, M. R., Roy, R., Rodriguez, G. M., Vanderhyden, B. C., & Le, H. (2023) · Cancers · doi:10.3390/cancers15164127 · Cited by 16

Radiofrequency hyperthermia enhances the effect of OK-432 for Hepatocellular carcinoma by activating of TLR4-cGAS-STING pathway

Sun, B., Zhang, Q., Sun, T., Liu, J., Cao, Y., Liang, B., Zheng, C., & Kan, X. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111769 · Cited by 16

Impacts of combining PD-L1 inhibitor and radiotherapy on the tumour immune microenvironment in a mouse model of esophageal squamous cell carcinoma

Yin, Z., Zhang, H., Zhang, K., Yue, J., Tang, R., Wang, Y., Deng, Q., & Yu, Q. (2025) · BMC Cancer · doi:10.1186/s12885-025-13801-0 · Cited by 16

cGAS exacerbates Schistosoma japonicum infection in a STING-type I IFN-dependent and independent manner

Liang, L., Shen, Y., Hu, Y., Liu, H., & Cao, J. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010233 · Cited by 16

Tumor cell–intrinsic Piezo2 drives radioresistance by impairing CD8+ T cell stemness maintenance

Miao, N., Cao, D., Jin, J., Ma, G., Yu, H., Qu, J., Li, G., Gao, C., Dong, D., Xia, F., et al. (2024) · The Journal of Experimental Medicine · doi:10.1084/jem.20231486 · Cited by 15

RIG-I is an intracellular checkpoint that limits CD8+ T-cell antitumour immunity

Duan, X., Hu, J., Zhang, Y., Zhao, X., Yang, M., Sun, T., Liu, S., Chen, X., Feng, J., Li, W., et al. (2024) · EMBO Molecular Medicine · doi:10.1038/s44321-024-00136-9 · Cited by 15

Glabridin improves autoimmune disease in Trex1-deficient mice by reducing type I interferon production

Wen, J., Mu, W., Li, H., Yan, Y., Zhan, X., Luo, W., Wang, Z., Kan, W., Jia, Z., Hui, S., et al. (2023) · Molecular Medicine · doi:10.1186/s10020-023-00754-y · Cited by 15

Functional tumor cell-intrinsic STING, not host STING, drives local and systemic antitumor immunity and therapy efficacy following cryoablation

Alshebremi, M., Tomchuck, S. L., Myers, J. T., Kingsley, D. T., Eid, S., Abiff, M., Bonner, M., Saab, S. T., Choi, S. H., & Huang, A. Y.-C. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-006608 · Cited by 14

Metabolic reprogramming in the tumor microenvironment: unleashing T cell stemness for enhanced cancer immunotherapy

Liu, Y., Wang, T., Ma, W., Jia, Z., Wang, Q., Zhang, M., Luo, Y., & Sun, H. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1327717 · Cited by 15

STimulator of INterferon Genes Agonism Accelerates Antitumor Activity in Poorly Immunogenic Tumors

Perera, S. A., Kopinja, J. E., Ma, Y., Muise, E. S., Laskey, J., Chakravarthy, K., Chen, Y., Cui, L., Presland, J. P., Sathe, M., et al. (2021) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-21-0136 · Cited by 14

What role of the cGAS-STING pathway plays in chronic pain?

Wu, J., Li, X., Zhang, X., Wang, W., & You, X. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.963206 · Cited by 15

High mobility group A1 (HMGA1) promotes esophageal squamous cell carcinoma progression by inhibiting STING-mediated anti-tumor immunity

He, K.-Y., Zhao, A., Guo, J.-R., Wu, D., Liu, H., Gao, F., Liu, M., Yang, J.-Y., Lei, X., Li, J.-Q., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60221-6 · Cited by 13

Overcoming Immune Therapy Resistance in Cancer Through Innate Immune Reprogramming

Mandracci, G., Soliman, N., & Khawanky, N. E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199554 · Cited by 15

Dual and multi-immune activation strategies for emerging cancer immunotherapy

Zhang, Y., Liu, L., He, H., Sun, Y., & Zhong, Z. (2024) · Materials Today · doi:10.1016/j.mattod.2024.08.006 · Cited by 13

BCL2A1 and CCL18 Are Predictive Biomarkers of Cisplatin Chemotherapy and Immunotherapy in Colon Cancer Patients

Yue, T., Liu, X., Zuo, S., Zhu, J., Li, J., Liu, Y., Chen, S., & Wang, P. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.799278 · Cited by 13

Cytoplasmic DNAs: Sources, sensing, and roles in the development of lung inflammatory diseases and cancer

He, X., Sun, Y., Lu, J., Naz, F., Ma, S., & Liu, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1117760 · Cited by 14

Precursor central memory versus effector cell fate and naïve CD4+ T cell heterogeneity

Deep, D., Gudjonson, H., Brown, C. C., Rose, S. A., Sharma, R., Iza, Y. A. P., Hong, S., Hemmers, S., Schizas, M., Wang, Z.-M., et al. (2024) · The Journal of Experimental Medicine · doi:10.1084/jem.20231193 · Cited by 12

Cucurbitacin B stimulates PD-1 immunotherapy response in malignant breast cancer by covalent targeting MTCH2

Xu, Q., Jiang, Z., Pan, Y., Li, S., Cao, Z., Hua, S., Yang, R., He, Q., Wu, H., Wen, H., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157017 · Cited by 12

Limitations of CAR-T-Cell Therapy in Hematologic Malignancies: Focusing on Antigen Escape and T-Cell Dysfunction

Lin, Y., Luo, S., Wei, J., Lin, S., Wang, D., Zhao, X., Feng, Z., Shen, Y., & Chen, Q. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199669 · Cited by 12

Nanoparticle targeting cGAS-STING signaling in disease therapy

Zhou, L., Huang, Y., Wu, Y., & Tang, S. (2024) · Nano Research · doi:10.1007/s12274-024-6714-x · Cited by 11

cGAS-STING signaling pathway in lung cancer: Regulation on antitumor immunity and application in immunotherapy

Wu, J., Chen, Y., Xie, M., Yu, X., & Su, C. (2024) · Chinese Medical Journal - Pulmonary and Critical Care Medicine · doi:10.1016/j.pccm.2024.11.001 · Cited by 11

Targeting USP1 Potentiates Radiation‐Induced Type I IFN‐Dependent Antitumor Immunity by Enhancing Oligo‐Ubiquitinated SAR1A‐Mediated STING Trafficking and Activation

Zhou, W., Zhao, Y., Qin, W., Wu, W., Liao, C.-Y., Zhang, Y., Yang, X., Chen, X., Wang, Y., Kang, Y., et al. (2025) · Advanced Science · doi:10.1002/advs.202412687 · Cited by 11

Systemic Inactivation of TREX1 Induces Selective Inflammation of the Tumor Microenvironment and Invigorated T-cell–Mediated Tumor Control

Marinković, E., Chen, M., Schubert, N., Dar, E. D., Poth, T., Leung, J. Y., Lohre, J., Sahni, J. M., Tun, C., Rajeswaran, P., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-24-2262 · Cited by 11

NIR-Switched DNA Shutter Enables Reversible Intermittent cGAS-STING Activation for Enhanced Antitumor Immunity

Bi, S., Yang, R., Cong, Y., Ju, H., & Liu, Y. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.5c08583 · Cited by 11

NAD+ Metabolism-Mediated SURF4-STING Axis Enhances T-Cell Anti-Tumor Effects in the Ovarian Cancer Microenvironment

Shen, J., Xu, F., Liu, T., Ye, Y., & Xu, S. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07939-9 · Cited by 13

Nanomaterials Application for STING Pathway-Based Tumor Immunotherapy

Zhao, W., Tang, X., Qin, Y., Wang, X., Zhong, K., Gong, N., & Li, T. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s535460 · Cited by 11

Development of Small-Molecule STING Activators for Cancer Immunotherapy

Jung, H. R., Jo, S., Jeon, M. J., Lee, H., Chu, Y., Lee, J., Kim, E., Song, G., Jung, C., Kim, H., et al. (2021) · Biomedicines · doi:10.3390/biomedicines10010033 · Cited by 11

Harnessing cGAS‐STING Pathway for Cancer Immunotherapy: From Bench to Clinic

Lee, D., Huntoon, K. M., Kang, M., Lü, Y., Gallup, T. D., Jiang, W., & Kim, B. Y. S. (2022) · Advanced Therapeutics · doi:10.1002/adtp.202200040 · Cited by 10

TBK1-Zyxin signaling controls tumor-associated macrophage recruitment to mitigate antitumor immunity

Zhou, R., Wang, M., Li, X., Liu, Y., Yao, Y., Wang, A., Chen, C., Zhang, Q. Y., Wu, Q., Zhang, Q., et al. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00244-9 · Cited by 10

In situ self-reassembling nanosystem enhances PD-L1 blockade for cancer immunotherapy

Liang, C., Ding, X., Li, X., Jiang, X., Yang, H., Yang, H., Liu, K., & Hou, L. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.11.075 · Cited by 10

Discovery of a non‐nucleotide stimulator of interferon genes (STING) agonist with systemic antitumor effect

Wang, X., Zhan, Z., Wang, Z., Zhang, Y., Zhao, K., Han, L., Zhou, X., Guo, Y., Fan, F., Ding, J., et al. (2024) · MedComm · doi:10.1002/mco2.70001 · Cited by 10

DNA-PK inhibition sustains the antitumor innate immune response in small cell lung cancer

Rosa, C. D., Morgillo, F., Amato, L., Iommelli, F., Rosa, V. D., Tirino, V., Papaccio, F., Tuccillo, C., Guida, G. D., D'Angiolella, D. M., et al. (2025) · iScience · doi:10.1016/j.isci.2025.111943 · Cited by 10

Chemically Inducible Cyclic Dinucleotides as Self-Deliverable STING Agonists with Enhanced Antitumor Immunity

Hai, Y., Xun, Z., Yang, L., Cai, Z., Wu, Z., & Jiang, J. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.5c09626 · Cited by 10

STING synergizes with TOX suppressing HO-1 expression to trigger ferroptosis in tumor-infiltrating CD8+ T cell and immunotherapy resistance

Zhu, Q., Zhang, J.-S., Nie, C.-P., Liu, X.-F., Zhan, L., Li, M., Zeng, X.-L., He, J., Huang, H., Xia, X., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-69350-y · Cited by 10

The cGAS-STING pathway in senescence and aging-related diseases: mechanisms and therapeutic opportunities

Tan, S., Nepovimová, E., Valko, M., Jomová, K., Wu, Q., & Kuča, K. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-02855-7 · Cited by 10

Two chemotherapeutic agents expand stem-like CD62L+CD8+ T cells in antitumor immune responses

Ruan, X., Wu, L., Tang, Z., Li, Y., Wang, J., Jiang, H., Zhang, L., Wang, S., Chen, Z., Yuan, C., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1533857 · Cited by 10

Mitochondria-targeted strategies in tumor immunity

Cheng, X., Wang, Y., Johnson, B., & You, M. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1646138 · Cited by 10

Engineering nanomedicine for STING pathway activation: Advancing cancer immunotherapy

Li, Z., Zhang, H., Gong, Q., & Luo, K. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2026.114957 · Cited by 9

Revitalizing antitumor immunity: Leveraging nucleic acid sensors as therapeutic targets

Liu, D., He, W., & Yang, L. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216729 · Cited by 9

Paving the Way to Solid Tumors: Challenges and Strategies for Adoptively Transferred Transgenic T Cells in the Tumor Microenvironment

Füchsl, F., & Krackhardt, A. M. (2022) · Cancers · doi:10.3390/cancers14174192 · Cited by 9

Activated STING in the thymic epithelium alters T cell development and selection leading to autoimmunity

Deng, Z., Law, C. S., Kurra, S., Simchoni, N., & Shum, A. K. (2025) · Journal of Clinical Investigation · doi:10.1172/jci180252 · Cited by 9

Restoration of cGAS in cancer cells promotes antitumor immunity via transfer of cancer cell–generated cGAMP

Cryer, A. M., Dosta, P., Dion, M. Z., Soto, L. D. L. P., Amar‐Lewis, E., Carmona, G. G. D. L., Perez, A. A. E., Aguilar, D. F. R., Sanchez-Huerta, T. M., Ruiz, B. N., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2409556122 · Cited by 8

Boosting Doxil-Based Chemoimmunotherapy Via Reprogramming Tumor-Associated Macrophages

Zhang, X., Wei, Z., Ding, Z., Lv, W., Li, J., Li, X., Liu, H., Yu, P., Yang, X., & Gan, L. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.138971 · Cited by 8

Parallels Between the Antiviral State and the Irradiated State

McGee, H. M., Marciscano, A. E. E., Campbell, A. M., Monjazeb, A. M., Kaech, S. M., & Teijaro, J. R. (2020) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djaa190 · Cited by 8

Cancer-cell-derived cGAMP limits the activity of tumor-associated CD8+ T cells

Herbst, M., Köksal, H., Brunn, S., Zanetti, D., Domocos, I., Stefani, V. D., Gatti, M., Vivalda, F., Pereira, P., Nater, M., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115510 · Cited by 7

BAG2 Inhibits Cervical Cancer Progression by Modulating Type I Interferon Signaling through Stabilizing STING

Yao, S., Chen, S., Wang, A., Liang, Z., Liu, X., Gao, Y., & Cai, H. (2025) · Advanced Science · doi:10.1002/advs.202414637 · Cited by 9

A lyophilizable LNP vaccine enables STING-reinforced postoperational adjuvant immunotherapy

Yang, Y., Guo, J., Qi, J., Deng, W., Hu, J., Hasan, M. W., Deng, F., Zhou, Y. L., Song, Z., Deng, W., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03445-4 · Cited by 10

Targeting organelle function in T cells for cancer immunotherapy

Baldwin, J., Heuser-Loy, C., & Gattinoni, L. (2025) · Nature reviews. Immunology · doi:10.1038/s41577-025-01223-9 · Cited by 8

Multitarget natural compounds taming NETosis: A translational strategy for cancer and inflammatory diseases

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Unleashing the potential of bimetallic nanobomb-mediated STING pathway to enhance bispecific T-cell engager against colorectal cancer photo-immunotherapy

Mu, M., Li, H., Chen, B., Fan, R., Zhong, K., Wang, G., Feng, C., Chen, N., Guo, G., Tong, A., et al. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02596-6 · Cited by 7

Lactate binds and inhibits the innate immune sensor STING to promote tumor immune evasion

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Generation of CAR-TSCM: CAR-T with super clutch

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DNAzyme-loaded bimetallic nanoflowers for STING activation and dual metabolic regulation to enhance antitumor immunity

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Nanodelivery of arsenic trioxide induces macrophage-governed cGAS-STING signaling to remodel immune microenvironment in hepatocellular carcinoma

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cGAS-STING pathway as a promising target for digestive diseases: insights from natural plant products

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Coagulation proteases modulate nucleic acid uptake and cGAS-STING-IFN induction in the tumor microenvironment

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Leveraging innate immune signals in CD8+ T cells to boost antitumor immunity

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Redox phenotype confers T cell-exclusion microenvironment and resistance to immunotherapy by suppressing STING/MDA5 expression and interferon signaling in lung cancers harboring KEAP1/STK11 mutations

Lin, Z., Ashish, S., Huang, L., Li, S., Li, Y., Zhou, Y., & Gu, J. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1676797 · Cited by 6

Nanomedicine leverages cuproptosis-mediated cGAS-STING activation to enhance antitumor immunity

Li, C., Li, Y., Wang, Z., Wang, Y., Guan, W., & Huang, Z. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04203-w · Cited by 6

Expression and prognostic value of DNA sensors in hepatocellular carcinoma

Chen, D., Ren, H., Zhao, N., & Hao, J. (2023) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiad055 · Cited by 6

Picrasidine S Induces cGAS‐Mediated Cellular Immune Response as a Novel Vaccine Adjuvant

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Novel goose parvovirus VP1 targets IRF7 protein to block the type I interferon upstream signaling pathway

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Decoding STING’s roles in cancer: immunity, pain, dormancy, and autophagy

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Synergistic immunostimulation for tumor sensitization with a biomineralized DNA sponge

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Harnessing Genomic Stress for Antitumor Immunity

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Bcl10 phosphorylation-dependent droplet-like condensation positively regulates DNA virus-induced innate immune signaling

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Engineered bacterial extracellular vesicles mediate pyroptosis to counteract m6A methylation-based immunosuppression after insufficient radiofrequency ablation of hepatocellular carcinoma

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Low-dose radiotherapy remodels the tumor immune microenvironment via the cGAS–STING pathway: mechanisms, challenges, and combination therapy strategies

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Aging modulation of the immune system and immunotherapy efficacy in cancer

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STING-Activating Nanomedicines in Cancer Immunotherapy: Mechanisms, Design, and Therapeutic Outcomes

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Copper homeostasis and cuproptosis: molecular mechanisms and therapeutic opportunities

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Molecular map of cGAS-STING pathway-related genes in bladder cancer: the perspective toward immune microenvironment and prognosis

Dong, W., Liu, Y., Yuan, Y., Li, Y., Zhao, F., & Qin, X. (2024) · Aging · doi:10.18632/aging.205442 · Cited by 5

cGAS-STING signaling in cancer immunity and immunotherapy

Du, H., Xu, T., & Cui, M. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110972 · Cited by 106

The cGAS/STING pathway in cancer: translating innate DNA sensing into therapeutic potential

Wang, Y., Angulo-Lozano, J. C., Wang, Y., & Deng, L. (2026) · Journal of Clinical Investigation · doi:10.1172/jci204552 · Cited by 2

The cGAS–STING pathway in cancer immunotherapy: prognostic value and therapeutic potential

Alabi, F. A., Imodoye, S. O., Adedokun, K. A., Eltokhy, M. A., Curcic, M., Okoyeocha, E., Thapa, I., Tiwari, S., Ogundele, A. V., Ayo, T. E., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1760947 · Cited by 5

cGAS-STING signalings potentiate tumor progression via sustaining cancer stemness

Liu, F.-R., Jiang, M., Mei, Z., Lin, C.-J., & Tian, L. (2022) · Translational Oncology · doi:10.1016/j.tranon.2022.101404 · Cited by 24

Intuitive CD8+ T cells sense DNA

Pujanandez, L. (2020) · Science · doi:10.1126/science.368.6498.1443-t