cGAS-STING–mediated DNA sensing maintains CD8 + T cell stemness and promotes antitumor T cell therapy

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

Chen, Q., Sun, L., & Chen, Z. J. (2016) · Nature Immunology · doi:10.1038/ni.3558 · Cited by 2,333

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

Deng, L., Liang, H., Xu, M., Yang, X., Burnette, B., Arina, A., Li, X.-D., Mauceri, H., Beckett, M., Darga, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.019 · Cited by 2,182

Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

Miller, B. C., Sen, D. R., Al Abosy, R., Bi, K., Virkud, Y. V., LaFleur, M. W., Yates, K. B., Lako, A., Felt, K., Naik, G. S., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0312-6 · Cited by 2,087

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

Sade-Feldman, M., Yizhak, K., Bjorgaard, S. L., Ray, J. P., de Boer, C. G., Jenkins, R. W., Lieb, D. J., Chen, J. H., Frederick, D. T., Barzily-Rokni, M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.10.038 · Cited by 2,053

A human memory T cell subset with stem cell–like properties

Gattinoni, L., Lugli, E., Ji, Y., Pos, Z., Paulos, C. M., Quigley, M. F., Almeida, J. R., Gostick, E., Yu, Z., Carpenito, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2446 · Cited by 1,974

Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy

Siddiqui, I., Schaeuble, K., Chennupati, V., Fuertes Marraco, S. A., Calderon-Copete, S., Pais Ferreira, D., Carmona, S. J., Scarpellino, L., Gfeller, D., Pradervand, S., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.021 · Cited by 1,679

Mitotic progression following DNA damage enables pattern recognition within micronuclei

Harding, S. M., Benci, J. L., Irianto, J., Discher, D. E., Minn, A. J., & Greenberg, R. A. (2017) · Nature · doi:10.1038/nature23470 · Cited by 1,508

A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization

Sanmamed, M. F., & Chen, L. (2018) · Cell · doi:10.1016/j.cell.2018.09.035 · Cited by 1,414

STING: infection, inflammation and cancer.

Barber, G. N. (2015) · Nature Reviews Immunology · doi:10.1038/nri3921 · Cited by 1,313

The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

Li, T., & Chen, Z. J. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20180139 · Cited by 1,293

Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer

Yu, L., Wei, J., & Liu, P. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.06.019 · Cited by 818

Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer

Jia, D., Wang, Q., Qi, Y., Jiang, Y., He, J., Lin, Y., Sun, Y., Xu, J., Chen, W., Fan, L., et al. (2024) · Cell · doi:10.1016/j.cell.2024.02.022 · Cited by 479

Chemical and Biomolecular Strategies for STING Pathway Activation in Cancer Immunotherapy

Garland, K. M., Sheehy, T. L., & Wilson, J. T. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00750 · Cited by 372

STING-induced regulatory B cells compromise NK function in cancer immunity

Li, S., Mirlekar, B., Johnson, B. M., Brickey, W. J., Wrobel, J. A., Yang, N., Song, D., Entwistle, S., Tan, X. M., Deng, M., et al. (2022) · Nature · doi:10.1038/s41586-022-05254-3 · Cited by 359

Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy

Zheng, J., Mo, J., Zhu, T., Zhuo, W., Yi, Y., Hu, S., Yin, J., Zhang, W., Zhou, H., & Liu, Z. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01250-1 · Cited by 344

Harnessing innate immune pathways for therapeutic advancement in cancer

Hu, A.-K., Sun, L., Lin, H., Liao, Y., Yang, H., & Mao, Y. Q. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01765-9 · Cited by 286

Radiation-induced tumor immune microenvironments and potential targets for combination therapy

Guo, S., Yao, Y., Tang, Y., Xin, Z., Wu, D., Ni, C., Huang, J., Wei, Q., & Zhang, T. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01462-z · Cited by 290

Targeting innate immune pathways for cancer immunotherapy

Cao, L. L., & Kagan, J. C. (2023) · Immunity · doi:10.1016/j.immuni.2023.07.018 · Cited by 234

Multifaceted functions of STING in human health and disease: from molecular mechanism to targeted strategy

Zhang, Z., Zhou, H., Ouyang, X., Dong, Y., Sarapultsev, A., Luo, S., & Hu, D. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01252-z · Cited by 222

Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity

Yang, C., Jin, J., Yang, Y., Sun, H., Wu, L., Shen, M., Hong, X., Li, W., Lu, L., Cao, D., et al. (2022) · Immunity · doi:10.1016/j.immuni.2022.05.012 · Cited by 195

The immunostimulatory RNA RN7SL1 enables CAR-T cells to enhance autonomous and endogenous immune function

Johnson, L. R., Lee, D. Y., Eacret, J. S., Ye, D., June, C. H., & Minn, A. J. (2021) · Cell · doi:10.1016/j.cell.2021.08.004 · Cited by 190

The cGAS/STING Pathway: A Novel Target for Cancer Therapy

Gan, Y., Li, X., Han, S., Liang, Q., Ma, X., Rong, P., Wang, W., & Li, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.795401 · Cited by 194

ZBP1-MLKL necroptotic signaling potentiates radiation-induced antitumor immunity via intratumoral STING pathway activation

Yang, Y., Wu, M., Cao, D., Yang, C., Jin, J., Wu, L., Hong, X., Li, W., Lu, L., Li, J., et al. (2021) · Science Advances · doi:10.1126/sciadv.abf6290 · Cited by 187

The cGAS‒STING pathway in cancer immunity: mechanisms, challenges, and therapeutic implications

Shen, M., Jiang, X., Qiu, P., Oyang, L., Ren, Z., Wang, J., Peng, M., Zhou, Y., Deng, X., & Liao, Q. (2025) · Journal of Hematology & Oncology · doi:10.1186/s13045-025-01691-5 · Cited by 210

Radiotherapy remodels the tumor microenvironment for enhancing immunotherapeutic sensitivity

Liu, S., Wang, W., Hu, S., Jia, B., Tuo, B., Sun, H., Wang, Q., Liu, Y., & Sun, Z. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06211-2 · Cited by 194

Demystifying the cGAS-STING pathway: precision regulation in the tumor immune microenvironment

Wang, Q., Yu, Y., Zhuang, J., Liu, R., & Sun, C. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02380-0 · Cited by 152

The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING–p53 signaling

Concepcion, A. R., Wagner, L. E., Zhu, J., Tao, A. Y., Yang, J. J. J., Khodadadi‐Jamayran, A., Wang, Y., Liu, M., Rose, R. E., Jones, R., et al. (2022) · Nature Immunology · doi:10.1038/s41590-021-01105-x · Cited by 120

Inflammation in cancer: therapeutic opportunities from new insights

Xie, Y., Liu, F., Wu, Y., Zhu, Y., Jiang, Y., Wu, Q., Dong, Z., & Liu, K. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02243-8 · Cited by 148

The Role of Oxidative Stress in Tumorigenesis and Progression

Li, K., Deng, Z., Lei, C., Ding, X., Li, J., & Wang, C. (2024) · Cells · doi:10.3390/cells13050441 · Cited by 142

The role of cGAS-STING signalling in liver diseases

Chen, R., Du, J., Zhu, H., & Ling, Q. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100324 · Cited by 131

Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production

Weinreb, J. T., Ghazale, N., Pradhan, K., Gupta, V., Potts, K. S., Tricomi, B. J., Daniels, N. J., Padgett, R. A., de Oliveira, S., Verma, A. K., et al. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.02.006 · Cited by 120

Blockade of STING Activation Alleviates Microglial Dysfunction and a Broad Spectrum of Alzheimer's Disease Pathologies

Chung, S., Jeong, J.-H., Park, J.-C., Han, J. W., Lee, Y., Kim, J.-I., & Mook-Jung, I. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01295-y · Cited by 103

AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1+ CD8 T cells

Li, H., Liu, Z., Liu, L., Zhang, H., Han, C., Girard, L., Park, H., Zhang, A., Dong, C., Ye, J., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100554 · Cited by 102

LL-37 transports immunoreactive cGAMP to activate STING signaling and enhance interferon-mediated host antiviral immunity

Wei, X., Zhang, L., Yang, Y., Hou, Y., Xu, Y., Wang, Z., Su, H., Han, F., Han, J., Liu, P., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110880 · Cited by 103

Targeting the DNA damage response enhances CD70 CAR-T cell therapy for renal carcinoma by activating the cGAS-STING pathway

Ji, F., Zhang, F., Zhang, M., Long, K., Xia, M., Lu, F., Li, E., Chen, J., Li, J., Chen, Z., et al. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01168-1 · Cited by 99

Epigenetic state determines the in vivo efficacy of STING agonist therapy

Falahat, R., Berglund, A., Perez-Villarroel, P., Putney, R. M., Hamaidi, I., Kim, S., Pilon-Thomas, S., Barber, G. N., & Mulé, J. J. (2023) · Nature Communications · doi:10.1038/s41467-023-37217-1 · Cited by 94

Universal STING mimic boosts antitumour immunity via preferential activation of tumour control signalling pathways

Wang, Y., Li, S., Hu, M., Yang, Y., McCabe, E., Zhang, L., Withrow, A. M., Ting, J. P. ‐., & Liu, R. (2024) · Nature Nanotechnology · doi:10.1038/s41565-024-01624-2 · Cited by 99

CD4 T cell-intrinsic STING signaling controls the differentiation and effector functions of T H 1 and T H 9 cells

Benoit-Lizon, I., Jacquin, E., Rivera Vargas, T., Richard, C., Roussey, A., Dal Zuffo, L., Martin, T., Melis, A., Vinokurova, D., Shahoei, S. H., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-003459 · Cited by 85

cGAS-STING signaling in the tumor microenvironment

Liu, Z., Wang, D., Zhang, J., Xiang, P., Zeng, Z., Xiong, W., & Shi, L. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216409 · Cited by 87

Nanomaterial-encapsulated STING agonists for immune modulation in cancer therapy

Chen, X., Xu, Z., Li, T., Thakur, A., Wen, Y., Zhang, K., Liu, Y., Liang, Q., Liu, W., Qin, J., et al. (2024) · Biomarker Research · doi:10.1186/s40364-023-00551-z · Cited by 92

Sensitizing Tumors to Immune Checkpoint Blockage via STING Agonists Delivered by Tumor-Penetrating Neutrophil Cytopharmaceuticals

Hao, M., Zhu, L., Hou, S., Chen, S., Li, X., Li, K., Zhu, N., Chen, S., Xue, L., Ju, C., et al. (2023) · ACS Nano · doi:10.1021/acsnano.2c11764 · Cited by 81

Responsive Multivesicular Polymeric Nanovaccines that Codeliver STING Agonists and Neoantigens for Combination Tumor Immunotherapy

Su, T., Cheng, F., Qi, J., Zhang, Y. X., Zhou, S., Mei, L., Fu, S., Zhang, F., Lin, S., & Zhu, G. (2022) · Advanced Science · doi:10.1002/advs.202201895 · Cited by 78

DNA Damage-Induced Inflammatory Microenvironment and Adult Stem Cell Response

Cinat, D., Coppes, R. P., & Barazzuol, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.729136 · Cited by 79

DNA Damage and Activation of cGAS/STING Pathway Induce Tumor Microenvironment Remodeling

Shen, R., Liu, D., Wang, X., Guo, Z., Sun, H., Song, Y., & Wang, D. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.828657 · Cited by 77

cGAS/STING cross-talks with cell cycle and potentiates cancer immunotherapy

Long, Z., Wang, J., Xu, J., Lei, X., & Liu, Q. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.01.044 · Cited by 76

STING agonism turns human T cells into interferon‐producing cells but impedes their functionality

Kühl, N., Linder, A., Philipp, N., Nixdorf, D., Fischer, H., Veth, S., Kuut, G., Xu, T. T., Theurich, S., Carell, T., et al. (2023) · EMBO Reports · doi:10.15252/embr.202255536 · Cited by 72

STING signaling promotes NK cell antitumor immunity and maintains a reservoir of TCF-1+ NK cells

Lu, L., Yang, C., Zhou, X., Wu, L., Hong, X., Li, W., Wang, X., Yang, Y., Cao, D., Zhang, A., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113108 · Cited by 81

Clonally expanded CD38 hi cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor–associated arthritis

Wang, R., Singaraju, A., Marks, K. E., Shakib, L., Dunlap, G. S., Adejoorin, I., Greisen, S. R., Chen, L., Tirpack, A., Aude, C. A., et al. (2023) · Science Immunology · doi:10.1126/sciimmunol.add1591 · Cited by 77

Enhancing radiotherapy-induced anti-tumor immunity via nanoparticle-mediated STING agonist synergy

Zeng, Q., Liu, M., Wang, Z., Zhou, R., & Ai, K. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02366-y · Cited by 90

The cGAS-STING pathway drives neuroinflammation and neurodegeneration via cellular and molecular mechanisms in neurodegenerative diseases

Zhang, Y., Zou, M., Wu, H., Zhu, J., & Jin, T. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106710 · Cited by 75

Zinc‐Organometallic Framework Vaccine Controlled‐Release Zn 2+ Regulates Tumor Extracellular Matrix Degradation Potentiate Efficacy of Immunotherapy

Ding, L., Liang, M., Li, Y., Zeng, M., Liu, M., Ma, W., Chen, F., Li, C., Reis, R. L., Li, F., et al. (2023) · Advanced Science · doi:10.1002/advs.202302967 · Cited by 68

A STING pathway-activatable contrast agent for MRI-guided tumor immunoferroptosis synergistic therapy

Guo, S., Xiong, W., Zhu, J., Feng, J., Zhou, R., Fan, Q., Zhang, Q., Li, Z., Yang, H. J., Zhou, H., et al. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122300 · Cited by 68

CD4+ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors

Lei, X., de Groot, D., Welters, M. J. P., de Wit, T., Schrama, E., van Eenennaam, H., Santegoets, S. J. A. M., Oosenbrug, T., van der Veen, A. G., Vos, J. L., et al. (2024) · Cellular and Molecular Immunology · doi:10.1038/s41423-024-01133-1 · Cited by 71

Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics

Gao, J., Wu, Z., Zhao, M., Zhang, R., Li, M., Sun, D., Cheng, H., Qi, X., Shen, Y., Xu, Q., et al. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.08.006 · Cited by 64

Targeting STING for cancer immunotherapy: From mechanisms to translation

Huang, R., Ning, Q., Zhao, J., Zhao, X., Zeng, L., Yi, Y., & Tang, S. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109304 · Cited by 64

Opportunities and challenges of targeting cGAS–STING in cancer

Lu, C., Wang, W., & Fu, Y. (2026) · Nature reviews. Cancer · doi:10.1038/s41568-025-00894-9 · Cited by 73

When DNA-damage responses meet innate and adaptive immunity

Tong, J., Song, J., Zhang, W., Zhai, J., Guan, Q., Wang, H., Liu, G., & Zheng, C. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05214-2 · Cited by 66

Epitope spreading driven by the joint action of CART cells and pharmacological STING stimulation counteracts tumor escape via antigen-loss variants

Conde, E., Vercher, E., Soria-Castellano, M., Suárez-Olmos, J., Mancheño, U., Elizalde, E., Rodriguez, M. L., Glez‐Vaz, J., Casares, N., Rodríguez‐García, E., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-003351 · Cited by 65

T-cell exhaustion and stemness in antitumor immunity: Characteristics, mechanisms, and implications

Chi, X., Luo, S., Ye, P., Hwang, W., Cha, J., Yan, X., & Yang, W. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1104771 · Cited by 62

The STING agonist IMSA101 enhances chimeric antigen receptor T cell function by inducing IL-18 secretion

Uslu, U., Sun, L., Castelli, S., Finck, A., Assenmacher, C., Young, R. M., Chen, Z. J., & June, C. H. (2024) · Nature Communications · doi:10.1038/s41467-024-47692-9 · Cited by 62

Inhibition of CD38 enzymatic activity enhances CAR-T cell immune-therapeutic efficacy by repressing glycolytic metabolism

Huang, Y., Shao, M., Teng, X., Si, X., Wu, L., Jiang, P., Liu, L., Cai, B., Wang, X., Han, Y., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101400 · Cited by 63

STING agonist-based hydrogel enhances immune activation in synergy with radiofrequency ablation for hepatocellular carcinoma treatment

Ao, F., Li, X., Tan, Y. Z., Jiang, Z., Yang, F., Guo, J., Zhu, Q., Chen, Z., Zhou, B., Zhang, K., et al. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.01.048 · Cited by 58

Mitochondria during T cell aging

Escrig-Larena, J. I., Delgado-Pulido, S., & Mittelbrunn, M. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101808 · Cited by 60

Immunotherapy resistance in non-small cell lung cancer: from mechanisms to therapeutic opportunities

Wang, H., Niu, X., Jin, Z., Zhang, S., Fan, R., Xiao, H., & Hu, S. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03519-z · Cited by 72

Optogenetic engineering of STING signaling allows remote immunomodulation to enhance cancer immunotherapy

Dou, Y., Chen, R., Liu, S., Lee, Y., Ji, J., Liu, X., Ke, Y., Wang, R., Zhou, Y., & Huang, Y. (2023) · Nature Communications · doi:10.1038/s41467-023-41164-2 · Cited by 58

Targeting STING in cancer: Challenges and emerging opportunities

Zhao, K., Huang, J., Zhao, Y., Wang, S., Xu, J., & Yin, K. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188983 · Cited by 57

The interplay between autophagy and cGAS-STING signaling and its implications for cancer

Schmid, M., Fischer, P., Engl, M., Widder, J., Gruber, S., & Slade, D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1356369 · Cited by 61

Lactobacillus rhamnosus GG alleviates radiation-induced intestinal injury by modulating intestinal immunity and remodeling gut microbiota

Zhang, L., Xu, J.-Y., Xing, Y., Wu, P., Jin, Y.-W., Wei, W., Zhao, L., Yang, J., Chen, G., & Qin, L. (2024) · Microbiological Research · doi:10.1016/j.micres.2024.127821 · Cited by 53

Lymphocyte Changes in Severe COVID-19: Delayed Over-Activation of STING?

Berthelot, J., Lioté, F., Maugars, Y., & Sibilia, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.607069 · Cited by 53

STING agonist and IDO inhibitor combination therapy inhibits tumor progression in murine models of colorectal cancer

Shi, J., Liu, C., Luo, S., Cao, T., Lin, B., Zhou, M., Zhang, X., Wang, S., Zheng, T., & Li, X. (2021) · Cellular Immunology · doi:10.1016/j.cellimm.2021.104384 · Cited by 52

Tumor-targeting nanocarriers amplified immunotherapy of cold tumors by STING activation and inhibiting immune evasion

Zhao, J., Tong, A., Liu, J., Xu, M., & Mi, P. (2025) · Science Advances · doi:10.1126/sciadv.adr1728 · Cited by 51

Unlocking the promise of systemic STING agonist for cancer immunotherapy

Sun, X., Zhou, X., Lei, Y. L., & Moon, J. J. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.03.047 · Cited by 48

Cancer immunotherapy strategies that target the cGAS-STING pathway

Tian, Z., Zeng, Y., Peng, Y., Liu, J., & Wu, F. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.996663 · Cited by 47

Ionizable STING-Activating Nanoadjuvants Enhance Tumor Immunogenicity and Potentiate Immunotherapy Efficacy in Solid Tumors

Xian, S., Chen, X., Ren, S., Chen, X., & Wang, H. (2024) · Cancer Research · doi:10.1158/0008-5472.can-23-3511 · Cited by 41

STING-Activating Polymer–Drug Conjugates for Cancer Immunotherapy

Sheehy, T. L., Kwiatkowski, A. J., Arora, K., Kimmel, B. R., Schulman, J. A., Gibson-Corley, K. N., & Wilson, J. T. (2024) · ACS Central Science · doi:10.1021/acscentsci.4c00579 · Cited by 40

Metabolic dynamics instruct CD8 + T‐cell differentiation and functions

Bevilacqua, A., Li, Z., & Ho, P. (2022) · European Journal of Immunology · doi:10.1002/eji.202149486 · Cited by 41

A next-generation STING agonist MSA-2: From mechanism to application

Yang, J., Luo, Z., Ma, J., Wang, Y., & Cheng, N. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.05.042 · Cited by 41

How could we forget immunometabolism in SARS-CoV2 infection or COVID-19?

Kumar, V. (2020) · International Reviews of Immunology · doi:10.1080/08830185.2020.1840567 · Cited by 39

Inhibiting mtDNA‐STING‐NLRP3 / IL ‐1β axis‐mediated neutrophil infiltration protects neurons in Alzheimer's disease

Xia, X., He, X., Zhao, T., Yang, J., Bi, Z., Fu, Q., Liu, J., Ao, D., Wei, Y., & Wei, X. (2023) · Cell Proliferation · doi:10.1111/cpr.13529 · Cited by 38

Id2 epigenetically controls CD8+ T-cell exhaustion by disrupting the assembly of the Tcf3-LSD1 complex

Li, Y., Han, M., Wei, H., Huang, W., Chen, Z., Zhang, T., Qian, M., Lin, J., Nan, G., Sun, X., et al. (2024) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01118-6 · Cited by 39

Mechanisms and Applications of Manganese-Based Nanomaterials in Tumor Diagnosis and Therapy

Ma, X., He, C., Wang, Y., Cao, X., Jin, Z., Ge, Y., Cao, Z., An, M., & Hao, L. (2025) · Biomaterials Research · doi:10.34133/bmr.0158 · Cited by 37

cGAS and cancer therapy: a double-edged sword

Du, J., Qian, M., Yuan, T., Chen, R., He, Q., Yang, B., Ling, Q., & Zhu, H. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00839-6 · Cited by 40

Arf1 Ablation in Colorectal Cancer Cells Activates a Super Signal Complex in DC to Enhance Anti‐Tumor Immunity

Ma, H., Fang, W., Li, Q., Wang, Y., & Hou, X. S. (2023) · Advanced Science · doi:10.1002/advs.202305089 · Cited by 35

CAR-T therapy and targeted treatments: Emerging combination strategies in solid tumors

Liu, J., Jiao, X., Ma, D., Fang, Y., & Gao, Q. (2024) · Med · doi:10.1016/j.medj.2024.03.001 · Cited by 35

The multifaceted functions of cGAS

Liu, H., Wang, F., Cao, Y., Dang, Y., & Ge, B. (2022) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjac031 · Cited by 38

Irradiation combined with PD-L1−/− and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING-mediated T cell activation

Zhao, X., Hu, S., Zeng, L., Liu, X., Song, Y., Zhang, Y., Chen, Q., Bai, Y., Zhang, J., Zhang, H., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104690 · Cited by 36

Enhancing immunotherapy outcomes by targeted remodeling of the tumor microenvironment via combined cGAS-STING pathway strategies

Huang, M., Cha, Z., Liu, R., Lin, M., Gafoor, N. A., Kong, T., Ge, F., & Chen, W. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1399926 · Cited by 36

DNA‐Capturing Manganese‐Coordinated Chitosan Microparticles Potentiate Radiotherapy via Activating the cGAS‐STING Pathway and Maintaining Tumor‐Infiltrating CD8 + T‐Cell Stemness

Zhang, S., Wang, C., Zhu, Y., Gao, J., Yan, Y., Chen, M., Yan, X., Liu, Z., & Feng, L. (2025) · Advanced Materials · doi:10.1002/adma.202418583 · Cited by 36

Understanding the toxicity induced by radiation-triggered neuroinflammation and the on-demand design of targeted peptide nanodrugs

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Breaking barriers: The cGAS‐STING pathway as a novel frontier in cancer immunotherapy

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Nanomaterial-mediated modulation of the cGAS-STING signaling pathway for enhanced cancer immunotherapy

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The Role of STING-Mediated Activation of Dendritic Cells in Cancer Immunotherapy

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The pleiotropic roles of cGAS–STING signaling in the tumor microenvironment

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cGAS‐STING signaling in cancer: Regulation and therapeutic targeting

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A Polymeric mRNA Vaccine Featuring Enhanced Site‐Specific mRNA Delivery and Inherent STING‐Stimulating Performance for Tumor Immunotherapy

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Lovastatin/SN38 co-loaded liposomes amplified ICB therapeutic effect via remodeling the immunologically-cold colon tumor and synergized stimulation of cGAS-STING pathway

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ZFP91 disturbs metabolic fitness and antitumor activity of tumor-infiltrating T cells

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Stimulatory and inhibitory activity of STING ligands on tumor-reactive human gamma/delta T cells

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Advanced nanomaterials targeting activation of STING for enhanced cancer immunotherapy

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Atrx deletion impairs CGAS/STING signaling and increases sarcoma response to radiation and oncolytic herpesvirus

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γδ T Cell‐mediated Tumor Immunity is Tightly Regulated by STING and TGF‐β Signaling Pathways

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STING Deletion Protects Against Amyloid β‐induced Alzheimer's Disease Pathogenesis

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STING in cancer immunoediting: Modeling tumor-immune dynamics throughout cancer development

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Cholesterol biosynthesis induced by radiotherapy inhibits cGAS–STING activation and contributes to colorectal cancer treatment resistance

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The multiple faces of cGAS-STING in antitumor immunity: prospects and challenges

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Bidirectional regulation of the cGAS-STING pathway in the immunosuppressive tumor microenvironment and its association with immunotherapy

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The STING pathway: Therapeutic vulnerabilities in ovarian cancer

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A cytotoxic T cell inspired oncolytic nanosystem promotes lytic cell death by lipid peroxidation and elicits antitumor immune responses

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Dynamic STING repression orchestrates immune cell development and function

Knox, K., Jeltema, D., Dobbs, N., Yang, K., Xing, C., Song, K., Tang, Z., Torres-Ramirez, G., Wang, J., Gao, S., et al. (2025) · Science Immunology · doi:10.1126/sciimmunol.ado9933 · Cited by 23

Fumarate integrates metabolism and immunity in diseases

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cGAS-STING signaling in cancer immunity and immunotherapy

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The cGAS/STING pathway in cancer: translating innate DNA sensing into therapeutic potential

Wang, Y., Angulo-Lozano, J. C., Wang, Y., & Deng, L. (2026) · Journal of Clinical Investigation · doi:10.1172/jci204552 · Cited by 2

The cGAS–STING pathway in cancer immunotherapy: prognostic value and therapeutic potential

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cGAS-STING signalings potentiate tumor progression via sustaining cancer stemness

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Intuitive CD8+ T cells sense DNA

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