Cited by 136TGF-β signaling in diseasesLiver physiology and pathologyInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.

TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesis

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Abstract

TGFβ2 and TGFβ3 isoforms are activated via unique mechanisms and are associated with fibrosis in human diseases.

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Metadata

Authors
Sun, T., Huang, Z., Liang, W.-C., Yin, J., Lin, W. Y., Wu, J., Vernes, J.-M., Lutman, J., Caplazi, P., Jeet, S., Wong, T., Wong, M., DePianto, D. J., Morshead, K. B., Sun, K.-H., Modrusan, Z., Vander Heiden, J. A., Abbas, A. R., Zhang, H., Xu, M., N’Diaye, E.-N., Roose-Girma, M., Wolters, P. J., Yadav, R., Sukumaran, S., Ghilardi, N., Corpuz, R., Emson, C., Meng, Y. G., Ramalingam, T. R., Lupardus, P., Brightbill, H. D., Seshasayee, D., Wu, Y., & Arron, J. R.
Affiliations
  • Genentech (US)
  • Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Department of OMNI Bioinformatics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • University of California, San Francisco (US)
Corresponding author
  • Sun, Tianhe
  • Arron, Joseph R.
Venue
Science Translational Medicine
Published
2021-08-04
Volume
13
Issue
605
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W3188006245
Cited by
134
References
91
Citations by year
2026: 21 · 2025: 33 · 2024: 24 · 2023: 38 · 2022: 16 · 2021: 2
FWCI
6.43
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
Genentech (N/A)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Keywords
TGF-beta2, TGF-beta3, fibrosis, pulmonary fibrosis, liver fibrosis, allosteric inhibition, TGF-β1, conditional knockout mice, co-crystal structure, antifibrotic therapy
MeSH terms
Animals, Disease Models, Animal, Female, Fibrosis, Humans, Protein Isoforms, Mice, Transforming Growth Factor beta2, Transforming Growth Factor beta3

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