The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.
TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesis
Open accessAbstract
TGFβ2 and TGFβ3 isoforms are activated via unique mechanisms and are associated with fibrosis in human diseases.
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“Although studies have long implicated TGFβ1 as the dominant fibrogenic driver, a recent study also implicates TGFβ2 and TGFβ3 as potent fibrogenic stimuli, but which lack the pro-inflammatory effects of TGFβ1 antagonism that have limited the latter’s appeal as a therapeutic target (147).”
From Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH) (2023) · cites this paper as [147]
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“TGFβ1 was the first, and remains the most potent fibrogenic stimulus towards HSCs and other tissue myofibroblasts, but as noted above, TGFβ2 and TGFβ3 merit consideration as safer therapeutic targets (147).”
From Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH) (2023) · cites this paper as [147]
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Cites
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Cited by
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TGF-β signaling in health and disease
Massagué, J., & Sheppard, D. (2023) · Cell · doi:10.1016/j.cell.2023.07.036 · Cited by 890
Bain, C. C., & MacDonald, A. S. (2022) · Mucosal Immunology · doi:10.1038/s41385-021-00480-w · Cited by 266
Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH)
Wang, S., & Friedman, S. L. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adi0759 · Cited by 158
TGFβ control of immune responses in cancer: a holistic immuno-oncology perspective
Nixon, B. G., Gao, S., Wang, X., & Li, M. O. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00796-z · Cited by 144
Enomoto, Y., Katsura, H., Fujimura, T., Ogata, A., Baba, S., Yamaoka, A., Kihara, M., Abe, T., Nishimura, O., Kadota, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40617-y · Cited by 123
Metadata
- Authors
- Sun, T., Huang, Z., Liang, W.-C., Yin, J., Lin, W. Y., Wu, J., Vernes, J.-M., Lutman, J., Caplazi, P., Jeet, S., Wong, T., Wong, M., DePianto, D. J., Morshead, K. B., Sun, K.-H., Modrusan, Z., Vander Heiden, J. A., Abbas, A. R., Zhang, H., Xu, M., N’Diaye, E.-N., Roose-Girma, M., Wolters, P. J., Yadav, R., Sukumaran, S., Ghilardi, N., Corpuz, R., Emson, C., Meng, Y. G., Ramalingam, T. R., Lupardus, P., Brightbill, H. D., Seshasayee, D., Wu, Y., & Arron, J. R.
- Affiliations
- Genentech (US)
- Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
- Department of OMNI Bioinformatics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
- University of California, San Francisco (US)
- Corresponding author
- Sun, Tianhe
- Arron, Joseph R.
- ORCID
- Sun, Tianhe
- Huang, Zhiyu
- Liang, Wei-Ching
- Yin, Jianping
- Lin, Wei Yu
- Wu, Jia
- Lutman, Jeff
- Caplazi, Patrick
- Jeet, Surinder
- Wong, Tiffany
- Wong, Manda
- DePianto, Daryle J.
- Morshead, Katrina B.
- Sun, Kai-Hui
- Modrusan, Zora
- Vander Heiden, Jason A.
- Abbas, Alexander R.
- Zhang, Hua
- Xu, Min
- Roose-Girma, Meron
- Wolters, Paul J.
- Yadav, Rajbharan
- Sukumaran, Siddharth
- Ghilardi, Nico
- Corpuz, Racquel
- Emson, Claire
- Meng, Y. Gloria
- Ramalingam, Thirumalai R.
- Lupardus, Patrick
- Brightbill, Hans D.
- Seshasayee, Dhaya
- Wu, Yan
- Arron, Joseph R.
- Venue
- Science Translational Medicine
- Published
- 2021-08-04
- Volume
- 13
- Issue
- 605
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W3188006245
- Cited by
- 134
- References
- 91
- Citations by year
- 2026: 21 · 2025: 33 · 2024: 24 · 2023: 38 · 2022: 16 · 2021: 2
- FWCI
- 6.43
- Type
- journal article
- Language
- en
- Open access
- green
- escholarship.org
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Genentech (N/A)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Keywords
- TGF-beta2, TGF-beta3, fibrosis, pulmonary fibrosis, liver fibrosis, allosteric inhibition, TGF-β1, conditional knockout mice, co-crystal structure, antifibrotic therapy
- MeSH terms
- Animals, Disease Models, Animal, Female, Fibrosis, Humans, Protein Isoforms, Mice, Transforming Growth Factor beta2, Transforming Growth Factor beta3
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