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Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity
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DNMT3A deletion preserves CAR T cell functionality during prolonged stimulation.
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“Another study evaluated the effect of DNMT3A loss on CAR-T cells and showed that these cells had an increased ability to proliferate without acquiring a canonical exhaustion phenotype in the context of chronic stimulation [79].”
From Clonal hematopoiesis and inflammation – the perpetual cycle (2023) · cites this paper as [79]
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Cites
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
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limma powers differential expression analyses for RNA-sequencing and microarray studies
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Robinson, J. T., Thorvaldsdóttir, H., Winckler, W., Guttman, M., Lander, E. S., Getz, G., & Mesirov, J. P. (2011) · Nature Biotechnology · doi:10.1038/nbt.1754 · Cited by 15,390
ggplot2: Elegant Graphics for Data Analysis
Wickham, H. (2009) · doi:10.1007/978-0-387-98141-3 · Cited by 14,447
Tisagenlecleucel in children and young adults with B-cell lymphoblastic leukemia
Maude, S. L., Laetsch, T. W., Buechner, J., Rives, S., Boyer, M., Bittencourt, H., Bader, P., Verneris, M. R., Stefanski, H. E., Myers, G. D., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1709866 · Cited by 5,735
Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia
Maude, S. L., Frey, N., Shaw, P. A., Aplenc, R., Barrett, D. M., Bunin, N. J., Chew, A., Gonzalez, V. E., Zheng, Z., Lacey, S. F., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1407222 · Cited by 5,413
Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia
Park, J. H., Rivière, I., Gonen, M., Wang, X., Sénéchal, B., Curran, K. J., Sauter, C., Wang, Y., Santomasso, B., Mead, E., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1709919 · Cited by 2,688
Self-citationMachine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation
Malta, T. M., Sokolov, A., Gentles, A. J., Burzykowski, T., Poisson, L., Weinstein, J. N., Kamińska, B., Huelsken, J., Omberg, L., Gevaert, O., et al. (2018) · Cell · doi:10.1016/j.cell.2018.03.034 · Cited by 2,180
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Metadata
- Authors
- Prinzing, B., Zebley, C. C., Petersen, C. T., Fan, Y., Anido, A. A., Yi, Z., Nguyen, P., Houke, H., Bell, M., Haydar, D., Brown, C., Boi, S. K., Alli, S., Crawford, J. C., Riberdy, J. M., Park, J. J., Zhou, S., Velasquez, M. P., DeRenzo, C., Lazzarotto, C. R., Tsai, S. Q., Vogel, P., Pruett-Miller, S. M., Langfitt, D. M., Gottschalk, S., Youngblood, B., & Krenciute, G.
- Affiliations
- St. Jude Children's Research Hospital (US)
- Department of Hematology, St Jude Children’s Research Hospital, Memphis, TN 38105, USA.
- Department of Cell and Molecular Biology, St Jude Children’s Research Hospital, Memphis, TN 38105, USA.
- Corresponding author
- Prinzing, Brooke
- Zebley, Caitlin C.
- Petersen, Christopher T.
- Gottschalk, Stephen
- Youngblood, Ben
- Krenciute, Giedre
- ORCID
- Prinzing, Brooke
- Zebley, Caitlin C.
- Fan, Yiping
- Anido, Alejandro Allo
- Yi, Zhongzhen
- Nguyen, Phuong
- Houke, Haley
- Bell, Matthew
- Haydar, Dalia
- Brown, Charmaine
- Boi, Shannon K.
- Alli, Shanta
- Crawford, Jeremy Chase
- Riberdy, Janice M.
- Park, Jeoungeun J.
- Zhou, Sheng
- Velasquez, Mireya Paulina
- DeRenzo, Chris
- Lazzarotto, Cicera R.
- Tsai, Shengdar Q.
- Vogel, Peter
- Pruett-Miller, Shondra M.
- Langfitt, Deanna M.
- Gottschalk, Stephen
- Youngblood, Ben
- Krenciute, Giedre
- Venue
- Science Translational Medicine
- Published
- 2021-11-17
- Volume
- 13
- Issue
- 620
- Pages
- eabh0272-eabh0272
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC8733956
- OpenAlex
- W3213155546
- Cited by
- 349
- References
- 84
- Citations by year
- 2026: 68 · 2025: 78 · 2024: 83 · 2023: 82 · 2022: 37 · 2021: 1
- FWCI
- 18.85
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R50CA211481, K99CA256262, F31CA250401, R01CA173750, R00CA256262, P01CA096832, P30CA021765, R01CA237311)
- National Institute of Allergy and Infectious Diseases (R01AI114442, U01AI157189, UM1AI109565)
- National Institute of Neurological Disorders and Stroke (R01NS106379, R01NS121249)
- Topics
- Health Sciences › Medicine › Oncology › CAR-T cell therapy research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- CAR T-cell therapy, T cell exhaustion, DNMT3A, DNA methylation, epigenetic repression, IL-10, CD28, CCR7, TCF1, LEF1, antitumor immunity, T cell stemness, epigenetic silencing
- MeSH terms
- Humans, Neoplasms, T-Lymphocytes, Immunotherapy, Adoptive, CD28 Antigens, Xenograft Model Antitumor Assays, Epigenesis, Genetic
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