The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Human brain mapping with multithousand-channel PtNRGrids resolves spatiotemporal dynamics
Open accessAbstract
Electrophysiological devices are critical for mapping eloquent and diseased brain regions and for therapeutic neuromodulation in clinical settings and are extensively used for research in brain-machine interfaces. However, the existing clinical and experimental devices are often limited in either spatial resolution or cortical coverage. Here, we developed scalable manufacturing processes with a dense electrical connection scheme to achieve reconfigurable thin-film, multithousand-channel neurophysiological recording grids using platinum nanorods (PtNRGrids). With PtNRGrids, we have achieved a multithousand-channel array of small (30 μm) contacts with low impedance, providing high spatial and temporal resolution over a large cortical area. We demonstrated that PtNRGrids can resolve submillimeter functional organization of the barrel cortex in anesthetized rats that captured the tissue structure. In the clinical setting, PtNRGrids resolved fine, complex temporal dynamics from the cortical surface in an awake human patient performing grasping tasks. In addition, the PtNRGrids identified the spatial spread and dynamics of epileptic discharges in a patient undergoing epilepsy surgery at 1-mm spatial resolution, including activity induced by direct electrical stimulation. Collectively, these findings demonstrated the power of the PtNRGrids to transform clinical mapping and research with brain-machine interfaces.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Advances in engineering and materials science are promising major improvements in electrode number and density, potentially reaching many thousands for both depth electrode and ECoG approaches [20].”
From Ethical considerations for the use of brain–computer interfaces for cognitive enhancement (2024) · cites this paper as [20]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Again, new approaches may alleviate some of these difficulties, for instance through the development of highly flexible probes and conformal ECoG grids [20].”
From Ethical considerations for the use of brain–computer interfaces for cognitive enhancement (2024) · cites this paper as [20]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
EPILEPSY AND THE FUNCTIONAL ANATOMY OF THE HUMAN BRAIN
Penfield, W., & Jasper, H. (1954) · Southern Medical Journal · doi:10.1097/00007611-195407000-00024 · Cited by 4,092
Neuronal ensemble control of prosthetic devices by a human with tetraplegia
Hochberg, L. R., Serruya, M. D., Friehs, G. M., Mukand, J. A., Saleh, M., Caplan, A. H., Branner, A., Chen, D., Penn, R. D., & Donoghue, J. P. (2006) · Nature · doi:10.1038/nature04970 · Cited by 3,295
Reach and grasp by people with tetraplegia using a neurally controlled robotic arm
Hochberg, L. R., Bacher, D., Jarosiewicz, B., Masse, N. Y., Simeral, J. D., Vogel, J., Haddadin, S., Liu, J., Cash, S. S., van der Smagt, P., et al. (2012) · Nature · doi:10.1038/nature11076 · Cited by 2,719
Meta-analyzing left hemisphere language areas: phonology, semantics, and sentence processing.
Vigneau, M., Beaucousin, V., Hervé, P. Y., Duffau, H., Crivello, F., Houdé, O., Mazoyer, B., & Tzourio-Mazoyer, N. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.11.002 · Cited by 1,851
An Integrated Brain-Machine Interface Platform With Thousands of Channels
Musk, E., & Neuralink (2019) · Journal of Medical Internet Research · doi:10.2196/16194 · Cited by 1,206
What is the Bereitschaftspotential?
Shibasaki, H., & Hallett, M. (2006) · Clinical Neurophysiology · doi:10.1016/j.clinph.2006.04.025 · Cited by 1,169
Viventi, J., Kim, D.-H., Vigeland, L., Frechette, E. S., Blanco, J. A., Kim, Y.-S., Avrin, A. E., Tiruvadi, V. R., Hwang, S.-W., Vanleer, A. C., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2973 · Cited by 1,136
Phonetic Feature Encoding in Human Superior Temporal Gyrus
Mesgarani, N., Cheung, C., Johnson, K., & Chang, E. F. (2014) · Science · doi:10.1126/science.1245994 · Cited by 993
NeuroGrid: recording action potentials from the surface of the brain
Khodagholy, D., Gelinas, J. N., Thesen, T., Doyle, W., Devinsky, O., Malliaras, G. G., & Buzsáki, G. (2015) · Nature Neuroscience · doi:10.1038/nn.3905 · Cited by 938
Speech synthesis from neural decoding of spoken sentences
Anumanchipalli, G. K., Chartier, J., & Chang, E. F. (2019) · Nature · doi:10.1038/s41586-019-1119-1 · Cited by 883
The Functional Organization of the Barrel Cortex
Petersen, C. C. H. (2007) · Neuron · doi:10.1016/j.neuron.2007.09.017 · Cited by 732
Ray, S., Crone, N. E., Niebur, E., Franaszczuk, P. J., & Hsiao, S. S. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2848-08.2008 · Cited by 722
The organization of the rat motor cortex: A microstimulation mapping study
Neafsey, E. J., Bold, E. L., HAAS, G., Hurley-Gius, K. M., Quirk, G. J., Sievert, C. F., & Terreberry, R. R. (1986) · Brain Research · doi:10.1016/s0006-8993(86)80191-3 · Cited by 705
Dewan, M. C., Rattani, A., Fieggen, G. A. G., Arráez, M. Á. E., Servadei, F., Boop, F. A., Johnson, W. D., Warf, B. C., & Park, K. B. (2018) · Journal of neurosurgery · doi:10.3171/2017.11.jns171500 · Cited by 649
Maynard, E. M., Nordhausen, C. T., & Normann, R. A. (1997) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/s0013-4694(96)95176-0 · Cited by 640
The organization of the rat motor cortex: A microstimulation mapping study
Neafsey, E. J., Bold, E. L., Haas, G., Hurley-Gius, K. M., Quirk, G. J., Sievert, C. F., & Terreberry, R. R. (1986) · Brain Research Reviews · doi:10.1016/0165-0173(86)90011-1 · Cited by 626
Duffau, H., Lopes, M., Arthuis, F., Bitar, A., Sichez, J., van Effenterre, R., & Capelle, L. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.048520 · Cited by 596
Lachaux, J.-P., Axmacher, N., Mormann, F., Halgren, E., & Crone, N. E. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.06.008 · Cited by 535
Propagating waves mediate information transfer in the motor cortex
Rubino, D., Robbins, K. A., & Hatsopoulos, N. G. (2006) · Nature Neuroscience · doi:10.1038/nn1802 · Cited by 508
Pfurtscheller, G., Graimann, B., Huggins, J. E., Levine, S. P., & Schuh, L. A. (2003) · Clinical Neurophysiology · doi:10.1016/s1388-2457(03)00067-1 · Cited by 448
A Conformal, Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology
Viventi, J., Kim, D., Moss, J. D., Kim, Y., Blanco, J. A., Annetta, N. V., Hicks, A., Xiao, J., Huang, Y., Callans, D. J., et al. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3000738 · Cited by 419
An Electrocorticographic Brain Interface in an Individual with Tetraplegia
Wang, W., Collinger, J. L., Degenhart, A. D., Tyler‐Kabara, E. C., Schwartz, A. B., Moran, D. W., Weber, D. J., Wodlinger, B., Vinjamuri, R. K., Ashmore, R. C., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055344 · Cited by 408
Event-related synchronization of mu rhythm in the EEG over the cortical hand area in man
Pfurtscheller, G., & Neuper, C. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90127-9 · Cited by 371
Wood, C. C., Spencer, D. D., Allison, T., McCarthy, G., Williamson, P. D., & Goff, W. R. (1988) · Journal of neurosurgery · doi:10.3171/jns.1988.68.1.0099 · Cited by 363
Mitochondrial dysfunction and free radical damage in the Huntington R6/2 transgenic mouse
Tabrizi, S. J., Workman, J. M., Hart, P. E., Mangiarini, L., Mahal, A., Bates, G. P., Cooper, J. A. D., & Schapira, A. H. V. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200001)47:1 · Cited by 353
Cedzich, C., Taniguchi, M., Schäfer, S. S., & Schramm, J. (1996) · Neurosurgery · doi:10.1097/00006123-199605000-00023 · Cited by 342
Decoding flexion of individual fingers using electrocorticographic signals in humans
Kubanek, J., Miller, K. J., Ojemann, J. G., Wolpaw, J. R., & Schalk, G. (2009) · Journal of Neural Engineering · doi:10.1088/1741-2560/6/6/066001 · Cited by 292
Restoration of sensory information via bionic hands
Bensmaı̈a, S. J., Tyler, D. J., & Micera, S. (2020) · Nature Biomedical Engineering · doi:10.1038/s41551-020-00630-8 · Cited by 264
Decoding natural grasp types from human ECoG
Pistohl, T., Schulze‐Bonhage, A., Aertsen, A., Mehring, C., & Ball, T. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.06.084 · Cited by 253
Spontaneous travelling cortical waves gate perception in behaving primates
Davis, Z. W., Muller, L., Martínez-Trujillo, J., B, T. J. S. A., & Reynolds, J. H. (2020) · Nature · doi:10.1038/s41586-020-2802-y · Cited by 251
Muller, L., Piantoni, G., Koller, D. P., Cash, S. S., Halgren, E., & B, T. J. S. A. (2016) · eLife · doi:10.7554/elife.17267 · Cited by 215
Chiang, C.-H., Won, S. M., Orsborn, A. L., Yu, K. J., Trumpis, M., Bent, B., Wang, C., Xue, Y., Min, S., Woods, V., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay4682 · Cited by 211
Real-time control of a prosthetic hand using human electrocorticography signals: Technical note
Yanagisawa, T., Hirata, M., Saitoh, Y., Goto, T., Kishima, H., Fukuma, R., Yokoi, H., Kamitani, Y., & Yoshimine, T. (2011) · Journal of Neurosurgery · doi:10.3171/2011.1.jns101421 · Cited by 208
Simeral, J. D., Hosman, T., Saab, J., Flesher, S. N., Vilela, M., Franco, B., Kelemen, J. N., Brandman, D. M., Ciancibello, J. G., Rezaii, P. G., et al. (2021) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2021.3069119 · Cited by 165
Finite Element Analysis of the Current-Density and Electric Field Generated by Metal Microelectrodes
McIntyre, C. C., & Grill, W. M. (2001) · Annals of Biomedical Engineering · doi:10.1114/1.1352640 · Cited by 164
Electrocorticographic amplitude predicts finger positions during slow grasping motions of the hand
Acharya, S., Fifer, M. S., Benz, H. L., Crone, N. E., & Thakor, N. V. (2010) · Journal of Neural Engineering · doi:10.1088/1741-2560/7/4/046002 · Cited by 156
Janča, R., Ježdík, P., Čmejla, R., Tomášek, M., Worrell, G. A., Stead, M., Wagenaar, J., Jefferys, J. G. R., Kršek, P., Komárek, V., et al. (2014) · Brain Topography · doi:10.1007/s10548-014-0379-1 · Cited by 147
Translating the Brain-Machine Interface
Thakor, N. V. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3007303 · Cited by 128
Romstöck, J. (2002) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.72.2.221 · Cited by 125
The Argo: a high channel count recording system for neural recording in vivo
Sahasrabuddhe, K., Khan, A. A., Singh, A. P., Stern, T. M., Ng, Y., Tadić, A., Orel, P., LaReau, C., Pouzzner, D., Nishimura, K., et al. (2021) · Journal of Neural Engineering · doi:10.1088/1741-2552/abd0ce · Cited by 124
Intraoperative ElectroCorticoGraphy (ECog): indications, techniques, and utility in epilepsy surgery
Yang, T., Hakimian, S., & Schwartz, T. H. (2014) · Epileptic Disorders · doi:10.1684/epd.2014.0675 · Cited by 113
Electrical Stimulation Mapping of the Brain: Basic Principles and Emerging Alternatives
Ritaccio, A. L., Brunner, P., & Schalk, G. (2018) · Journal of Clinical Neurophysiology · doi:10.1097/wnp.0000000000000440 · Cited by 113
Decoding spoken English from intracortical electrode arrays in dorsal precentral gyrus
Wilson, G. H., Stavisky, S. D., Willett, F. R., Avansino, D. T., Kelemen, J. N., Hochberg, L. R., Henderson, J. M., Druckmann, S., & Shenoy, K. V. (2020) · Journal of Neural Engineering · doi:10.1088/1741-2552/abbfef · Cited by 103
Integration of EEG, MRI, and SPECT in Localizing the Seizure Focus for Epilepsy Surgery
So, E. L. (2000) · Epilepsia · doi:10.1111/j.1528-1157.2000.tb01534.x · Cited by 95
Fifer, M. S., Hotson, G., Wester, B. A., McMullen, D. P., Wang, Y., Johannes, M. S., Katyal, K. D., Helder, J. B., Para, M. P., Vogelstein, R. J., et al. (2013) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2013.2286955 · Cited by 90
Inoue, T., Shimizu, H., Nakasato, N., Kumabe, T., & Yoshimoto, T. (1999) · NeuroImage · doi:10.1006/nimg.1999.0501 · Cited by 87
Ganji, M., Paulk, A. C., Yang, J. C., Vahidi, N. W., Lee, S. H., Liu, R., Hossain, L., Arneodo, E. M., Thunemann, M., Shigyo, M., et al. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b02296 · Cited by 82
Self-citationSynaptic Organization of the Barrel Cortex
Keller, A. (1995) · Cerebral cortex · doi:10.1007/978-1-4757-9616-2_5 · Cited by 80
Balzamo, E., Marquis, P., Chauvel, P., & Régis, J. M. (2004) · Clinical Neurophysiology · doi:10.1016/j.clinph.2004.02.012 · Cited by 77
Functional mapping of the motor cortex of the rat using transdural electrical stimulation
Fonoff, E. T., Pereira, J. F., de Camargo, L. V., Dale, C. S., Pagano, R. L., Ballester, G., & Teixeira, M. J. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.03.018 · Cited by 76
Haseeb, A., Asano, E., Juhász, C., Shah, A. K., Sood, S., & Chugani, H. T. (2007) · Epilepsy Research · doi:10.1016/j.eplepsyres.2007.07.007 · Cited by 66
Donos, C., Mı̂ndruță, I., Ciurea, J., Mălîia, M. D., & Barborică, A. (2015) · Clinical Neurophysiology · doi:10.1016/j.clinph.2015.02.013 · Cited by 66
Jacobs, J., Zijlmans, M., Zelmann, R., Olivier, A., Hall, J. A., Gotman, J., & Dubeau, F. (2009) · Epilepsia · doi:10.1111/j.1528-1167.2009.02389.x · Cited by 65
Autoclave Sterilization of PEDOT:PSS Electrophysiology Devices
Uguz, I., Ganji, M., Hama, A., Tanaka, A., Inal, S., Youssef, A., Owens, R. M., Quilichini, P., Ghestem, A., Bernard, C., et al. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201600870 · Cited by 60
Self-citationMicroelectrode recordings in human epilepsy: a case for clinical translation
Chari, A., Thornton, R. C., Tisdall, M. M., & Scott, R. C. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa082 · Cited by 53
Vesicular glutamate transporters VGLUT1 and VGLUT2 in the developing mouse barrel cortex
Liguz‐Lecznar, M., & Skangiel-Kramska, J. (2007) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2006.12.005 · Cited by 47
Flexible, high-resolution thin-film electrodes for human and animal neural research
Chiang, C., Wang, C., Barth, K. J., Rahimpour, S., Trumpis, M., Duraivel, S., Rachinskiy, I., Dubey, A., Wingel, K., Wong, M. K., et al. (2021) · Journal of Neural Engineering · doi:10.1088/1741-2552/ac02dc · Cited by 47
Vargas-Irwin, C. E., Feldman, J. M., King, B., Simeral, J. D., Sorice, B. L., Oakley, E. M., Cash, S. S., Eskandar, E. N., Friehs, G. M., Hochberg, L. R., et al. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00450 · Cited by 45
High-density mapping of primate digit representations with a 1152-channel µECoG array
Kaiju, T., Inoue, M., Hirata, M., & Suzuki, T. (2021) · Journal of Neural Engineering · doi:10.1088/1741-2552/abe245 · Cited by 42
Intraoperative mapping of expressive language cortex using passive real-time electrocorticography
Taplin, A. M., de Pesters, A., Brunner, P., Hermes, D., Dalfino, J. C., Adamo, M. A., Ritaccio, A. L., & Schalk, G. (2016) · Epilepsy & Behavior Case Reports · doi:10.1016/j.ebcr.2016.03.003 · Cited by 33
Visualization of Cortical Modules in Flattened Mammalian Cortices
Lauer, S. M., Schneeweiß, U., Brecht, M., & Ray, S. (2018) · Journal of Visualized Experiments · doi:10.3791/56992 · Cited by 22
The effects of blood vessels on electrocorticography
Bleichner, M. G., Vansteensel, M. J., Huiskamp, G. J. M., Hermes, D., Aarnoutse, E. J., Ferrier, C. H., & Ramsey, N. F. (2011) · Journal of Neural Engineering · doi:10.1088/1741-2560/8/4/044002 · Cited by 15
Research works printed but not linked: 1
- K. Iwamoto in Novel Patterning Technologies for Semiconductors MEMS/NEMS and MOEMS 2020 (International Society for Optics and Photonics 2020) vol. 11324 p. 1132405.
Cited by
Sorted by citations
Technology Roadmap for Flexible Sensors
Luo, Y., Abidian, M. R., Ahn, J., Akinwande, D., Andrews, A. M., Antonietti, M., Bao, Z., Magnus Berggren, A., Berkey, C. A., Bettinger, C. J., et al. (2023) · ACS Nano · doi:10.1021/acsnano.2c12606 · Cited by 1,453
Flexible Electrodes for Brain–Computer Interface System
Wang, J., Wang, T., Liu, H., Wang, K., Kumi, M., Feng, Z., Li, P., & Huang, W. (2023) · Advanced Materials · doi:10.1002/adma.202211012 · Cited by 142
Zeng, Q., & Huang, Z. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202301223 · Cited by 104
Wu, M., Yao, K., Huang, N., Li, H., Zhou, J., Shi, R., Li, J., Huang, X., Li, J., Jia, H., et al. (2023) · Advanced Science · doi:10.1002/advs.202300504 · Cited by 99
A shape-morphing cortex-adhesive sensor for closed-loop transcranial ultrasound neurostimulation
Lee, S., Kum, J., Kim, S., Jung, H., An, S., Choi, S. J., Choi, J. H., Kim, J., Yu, K. J., Lee, W., et al. (2024) · Nature Electronics · doi:10.1038/s41928-024-01240-x · Cited by 96
Metadata
- Authors
- Tchoe, Y., Bourhis, A. M., Cleary, D. R., Stedelin, B., Lee, J., Tonsfeldt, K. J., Brown, E. C., Siler, D. A., Paulk, A. C., Yang, J. C., Oh, H., Ro, Y. G., Lee, K., Russman, S. M., Ganji, M., Galton, I., Ben-Haim, S., Raslan, A. M., & Dayeh, S. A.
- Affiliations
- University of California San Diego (US)
- Oregon Health & Science University (US)
- Massachusetts General Hospital (US)
- Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA 92093, USA.
- Corresponding author
- Tchoe, Youngbin
- Bourhis, Andrew M.
- Cleary, Daniel R.
- Dayeh, Shadi A.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2022-01-19
- Volume
- 14
- Issue
- 628
- Pages
- eabj1441-eabj1441
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC9650779
- OpenAlex
- W4206535166
- Cited by
- 135
- References
- 62
- Citations by year
- 2026: 19 · 2025: 45 · 2024: 32 · 2023: 25 · 2022: 14
- FWCI
- 12.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Scholarworks@UNIST (Ulsan National Institute of Science and Technology) (submittedVersion)
- Funders
- National Institutes of Health (1dp2eb029757-01)
- National Institute of Mental Health (R01MH111359, F32MH120886)
- National Institute on Drug Abuse (R01DA050159)
- National Institute of Neurological Disorders and Stroke (R01NS123655, UG3NS123723)
- National Institute of Biomedical Imaging and Bioengineering (DP2-EB029757)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- platinum nanorods, high-density neural recording, grasping tasks, epileptic discharges, epilepsy surgery, electrical stimulation, brain-computer interface, neuromodulation
- MeSH terms
- Animals, Brain, Brain Mapping, Electric Stimulation, Epilepsy, Humans, Wakefulness, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
