Text Mining for Metabolic Pathways, Signaling Cascades, and Protein Networks
Abstract
The complexity of the information stored in databases and publications on metabolic and signaling pathways, the high throughput of experimental data, and the growing number of publications make it imperative to provide systems to help the researcher navigate through these interrelated information resources. Text-mining methods have started to play a key role in the creation and maintenance of links between the information stored in biological databases and its original sources in the literature. These links will be extremely useful for database updating and curation, especially if a number of technical problems can be solved satisfactorily, including the identification of protein and gene names (entities in general) and the characterization of their types of interactions. The first generation of openly accessible text-mining systems, such as iHOP (Information Hyperlinked over Proteins), provides additional functions to facilitate the reconstruction of protein interaction networks, combine database and text information, and support the scientist in the formulation of novel hypotheses. The next challenge is the generation of comprehensive information regarding the general function of signaling pathways and protein interaction networks.
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Pathway data is estimated from text-mining projects to be present in at least 10% of the over 20 million articles currently indexed by PubMed.
“Pathway data recorded in the literature (estimated from text-mining projects23 to be present in at least 10% of the over 20 million articles currently indexed by PubMed).”
From The BioPAX community standard for pathway data sharing (2010) · cites this paper as [23]
Cites
The KEGG resource for deciphering the genome
Kanehisa, M. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkh063 · Cited by 5,121 · see citing works
The Gene Ontology (GO) database and informatics resource
Gene Ontology Consortium (2003) · Nucleic Acids Research · doi:10.1093/nar/gkh036 · Cited by 4,533 · see citing works
FatiGO: a web tool for finding significant associations of Gene Ontology terms with groups of genes
Al‐Shahrour, F., Díaz‐Uriarte, R., & Dopazo, J. (2004) · Bioinformatics · doi:10.1093/bioinformatics/btg455 · Cited by 1,118 · see citing works
IntAct: an open source molecular interaction database
Hermjakob, H. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkh052 · Cited by 1,013 · see citing works
A literature network of human genes for high-throughput analysis of gene expression
Jenssen, T.-K., Lægreid, A., Komorowski, J., & Hovig, E. J. (2001) · Nature Genetics · doi:10.1038/88213 · Cited by 839 · see citing works
EcoCyc: a comprehensive database resource for Escherichia coli
Keseler, I. M. (2004) · Nucleic Acids Research · doi:10.1093/nar/gki108 · Cited by 737 · see citing works
A gene network for navigating the literature
Hoffmann, R., & Valencia, A. (2004) · Nature Genetics · doi:10.1038/ng0704-664 · Cited by 535 · see citing works
Self-citationFriedman, C., Kra, P., Yu, H., Krauthammer, M. O., & Rzhetsky, A. (2001) · Bioinformatics · doi:10.1093/bioinformatics/17.suppl_1.s74 · Cited by 508 · see citing works
A literature network of human genes for high-throughput analysis of gene expression
Jenssen, T.-K., Lægreid, A., Komorowski, J., et al. (2001) · Nature Genetics · doi:10.1038/ng0501-21 · Cited by 487 · see citing works
Automatic extraction of biological information from scientific text: protein-protein interactions.
Blaschke, C., Andrade-Navarro, M. A., Ouzounis, C. A., & Valencia, A. (1999) · PubMed · Cited by 448 · see citing works
Self-citationAutomated extraction of information on protein–protein interactions from the biological literature
Ono, T., Hishigaki, H., Tanigami, A., & Takagi, T. (2001) · Bioinformatics · doi:10.1093/bioinformatics/17.2.155 · Cited by 398 · see citing works
Migraine and Magnesium: Eleven Neglected Connections
Swanson, D. R. (1988) · Perspectives in biology and medicine · doi:10.1353/pbm.1988.0009 · Cited by 396 · see citing works
Stapley, B. J., & Benoît, G. (1999) · Pacific Symposium on Biocomputing (PSB) · doi:10.1142/9789814447331_0050 · Cited by 273 · see citing works
Using ARROWSMITH: a computer-assisted approach to formulating and assessing scientific hypotheses
Smalheiser, N. R., & Swanson, D. R. (1998) · Computer Methods and Programs in Biomedicine · doi:10.1016/s0169-2607(98)00033-9 · Cited by 223 · see citing works
BioCreAtIvE Task 1A: gene mention finding evaluation
Yeh, A., Morgan, A. A., Colosimo, M., & Hirschman, L. (2005) · BMC Bioinformatics · doi:10.1186/1471-2105-6-s1-s2 · Cited by 205 · see citing works
Sekimizu, T., Park, & Tsujii, J. (1998) · PubMed · Cited by 196 · see citing works
Evaluation of BioCreAtIvE assessment of task 2
Blaschke, C., Andrés‐León, E., Krallinger, M., & Valencia, A. (2005) · BMC Bioinformatics · doi:10.1186/1471-2105-6-s1-s16 · Cited by 139 · see citing works
Self-citationThe frame-based module of the SUISEKI information extraction system
Blaschke, C., & Valencia, A. (2002) · IEEE Intelligent Systems and their Applications · doi:10.1109/5254.999215 · Cited by 118 · see citing works
Self-citationInformation extraction in molecular biology
Blaschke, C. (2002) · Briefings in Bioinformatics · doi:10.1093/bib/3.2.154 · Cited by 110 · see citing works
Self-citationThe potential use of SUISEKI as a protein interaction discovery tool.
Blaschke, C., & Valencia, A. (2001) · PubMed · Cited by 83 · see citing works
Self-citationMining functional information associated with expression arrays
Blaschke, C., Oliveros, J. C., & Valencia, A. (2001) · Functional & Integrative Genomics · doi:10.1007/s101420000036 · Cited by 80 · see citing works
Self-citationLife cycles of successful genes
Hoffmann, R., & Valencia, A. (2003) · Trends in Genetics · doi:10.1016/s0168-9525(02)00014-8 · Cited by 69 · see citing works
Self-citationAndrade-Navarro, M. A., & Valencia, A. (1997) · PubMed · Cited by 57 · see citing works
Self-citationLearning anchor verbs for biological interaction patterns from published text articles
Hatzivassiloglou, V., & Weng, W. (2002) · International Journal of Medical Informatics · doi:10.1016/s1386-5056(02)00054-0 · Cited by 27 · see citing works
A sentence sliding window approach to extract protein annotations from biomedical articles
Krallinger, M., Padrón, M. A. B., & Valencia, A. (2005) · BMC Bioinformatics · doi:10.1186/1471-2105-6-s1-s19 · Cited by 25 · see citing works
Self-citationValencia, A. (2002) · EMBO Reports · doi:10.1093/embo-reports/kvf104 · Cited by 23 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
The BioPAX community standard for pathway data sharing
Demir, E., Cary, M. P., Paley, S., Fukuda, K., Lemer, C., Vastrik, I., Wu, G., D'Eustachio, P., Schaefer, C., Luciano, J., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1666 · Cited by 745 · see citing works
Literature mining for the biologist: from information retrieval to biological discovery
Jensen, L. J., Šarić, J., & Peer Bork, B. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1768 · Cited by 632 · see citing works
Text mining and its potential applications in systems biology
Ananiadou, S., Kell, D. B., & Tsujii, J. (2006) · Trends in biotechnology · doi:10.1016/j.tibtech.2006.10.002 · Cited by 324 · see citing works
Information retrieval and text mining technologies for chemistry
Krallinger, M., Rabal, O., Lourenço, A., Oyarzabal, J., & Valencia, A. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00851 · Cited by 281 · see citing works
Self-citationDefrosting the Digital Library: Bibliographic Tools for the Next Generation Web
Hull, D., Pettifer, S. R., & Kell, D. B. (2008) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000204 · Cited by 209 · see citing works
Building mammalian signalling pathways with RNAi screens
Moffat, J., & Sabatini, D. M. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1860 · Cited by 202 · see citing works
Westergaard, D., Stærfeldt, H., Tønsberg, C., Jensen, L. J., & Brunak, S. (2018) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005962 · Cited by 198 · see citing works
A Comprehensive Benchmark of Kernel Methods to Extract Protein–Protein Interactions from Literature
Tikk, D., Thomas, P. E., Palaga, P., Hakenberg, J., & Leser, U. (2010) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000837 · Cited by 171 · see citing works
Kell, D. B. (2006) · FEBS Journal · doi:10.1111/j.1742-4658.2006.05136.x · Cited by 147 · see citing works
Fernández, J. M., Hoffmann, R., & Valencia, A. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm298 · Cited by 146 · see citing works
Self-citationGarten, Y., & Altman, R. B. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-s2-s6 · Cited by 125 · see citing works
Wang, E., Lenferink, A. E. G., & O'Connor‐McCourt, M. D. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7054-6 · Cited by 127 · see citing works
Online tools to support literature-based discovery in the life sciences
Weeber, M., Kors, J. A., & Mons, B. (2005) · Briefings in Bioinformatics · doi:10.1093/bib/6.3.277 · Cited by 106 · see citing works
Toward the design of ultrahigh-entropy alloys via mining six million texts
Pei, Z., Yin, J., Liaw, P. K., & Raabe, D. (2023) · Nature Communications · doi:10.1038/s41467-022-35766-5 · Cited by 100 · see citing works
Analysis of Biological Processes and Diseases Using Text Mining Approaches
Krallinger, M., Leitner, F., & Valencia, A. (2009) · Methods in molecular biology · doi:10.1007/978-1-60327-194-3_16 · Cited by 88 · see citing works
Self-citationText Mining for Drugs and Chemical Compounds: Methods, Tools and Applications
Vázquez, M., Krallinger, M., Leitner, F., & Valencia, A. (2011) · Molecular Informatics · doi:10.1002/minf.201100005 · Cited by 87 · see citing works
Self-citationBiological network extraction from scientific literature: state of the art and challenges
Li, C., Liakata, M., & Rebholz‐Schuhmann, D. (2013) · Briefings in Bioinformatics · doi:10.1093/bib/bbt006 · Cited by 81 · see citing works
Synapse proteomics of multiprotein complexes: en route from genes to nervous system diseases
Grant, S. G. N., Marshall, M. C., Page, K.-L., Cumiskey, M. A., & Armstrong, J. D. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi330 · Cited by 64 · see citing works
A text-mining system for extracting metabolic reactions from full-text articles
Czarnecki, J., Nobeli, I., Smith, A. M., & Shepherd, A. J. (2012) · BMC Bioinformatics · doi:10.1186/1471-2105-13-172 · Cited by 58 · see citing works
Hsing, M., Byler, K. G., & Cherkasov, A. (2008) · BMC Systems Biology · doi:10.1186/1752-0509-2-80 · Cited by 66 · see citing works
BBP: Brucella genome annotation with literature mining and curation
Xiang, Z., Zheng, W., & He, Y. O. (2006) · BMC Bioinformatics · doi:10.1186/1471-2105-7-347 · Cited by 53 · see citing works
Ness, B. V., Ramos, C., Haznadar, M., Hoering, A., Haessler, J., Crowley, J. J., Jacobus, S. J., Oken, M. M., Rajkumar, S. V., Greipp, P. R., et al. (2008) · BMC Medicine · doi:10.1186/1741-7015-6-26 · Cited by 52 · see citing works
Connecting the Dots between PubMed Abstracts
Hossain, M. S., Gresock, J., Edmonds, Y., Helm, R. F., Potts, M., & Ramakrishnan, N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029509 · Cited by 50 · see citing works
Extraction of biological interaction networks from scientific literature
Skusa, A., Ruegg, A., & Köhler, J. (2005) · Briefings in Bioinformatics · doi:10.1093/bib/6.3.263 · Cited by 50 · see citing works
Network integration and graph analysis in mammalian molecular systems biology
Ma’ayan, A. (2008) · IET Systems Biology · doi:10.1049/iet-syb:20070075 · Cited by 45 · see citing works
Integrated Bio-Entity Network: A System for Biological Knowledge Discovery
Bell, L., Chowdhary, R., Liu, J. S., Niu, X., & Zhang, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021474 · Cited by 37 · see citing works
Thieu, T., Joshi, S., Warren, S., & Korkin, D. (2012) · Bioinformatics · doi:10.1093/bioinformatics/bts042 · Cited by 36 · see citing works
Frenkel‐Morgenstern, M., Gorohovski, A., Tagore, S., Sekar, V., Vázquez, M., & Valencia, A. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx423 · Cited by 36 · see citing works
Self-citationUsing uncertainty to link and rank evidence from biomedical literature for model curation
Zerva, C., Batista-Navarro, R., Day, P. J., & Ananiadou, S. (2017) · Bioinformatics · doi:10.1093/bioinformatics/btx466 · Cited by 35 · see citing works
Sandbichler, A. M., Egg, M., Schwerte, T., & Pelster, B. (2011) · Journal of Experimental Biology · doi:10.1242/jeb.050062 · Cited by 34 · see citing works
CIDeR: multifactorial interaction networks in human diseases
Lechner, M., Höhn, V., Brauner, B., Dunger-Kaltenbach, I., Fobo, G., Frishman, G., Montrone, C., Kastenmüller, G., Wägele, B., & Ruepp, A. (2012) · Genome biology · doi:10.1186/gb-2012-13-7-r62 · Cited by 31 · see citing works
Remmerie, N., Vijlder, T. D., Laukens, K., Dang, T. H., Lemière, F., Mertens, I., Valkenborg, D., Blust, R., & Witters, E. (2011) · Phytochemistry · doi:10.1016/j.phytochem.2011.01.003 · Cited by 33 · see citing works
Frenkel‐Morgenstern, M., Gorohovski, A., Vučenović, D., Maestre, L., & Valencia, A. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1199 · Cited by 33 · see citing works
Self-citationParameter estimate of signal transduction pathways
Arisi, I., Cattaneo, A., & Rosato, V. (2006) · BMC Neuroscience · doi:10.1186/1471-2202-7-s1-s6 · Cited by 32 · see citing works
Integrative computational biology for cancer research
Fortney, K., & Jurišica, I. (2011) · Human Genetics · doi:10.1007/s00439-011-0983-z · Cited by 31 · see citing works
Language models for materials discovery and sustainability: Progress, challenges, and opportunities
Pei, Z., Yin, J., & Zhang, J. (2025) · Progress in Materials Science · doi:10.1016/j.pmatsci.2025.101495 · Cited by 30 · see citing works
Kell, D. B., & Dobson, P. D. (2009) · Cited by 30 · see citing works
Challenges in plant cellular pathway reconstruction based on gene expression profiling
van Baarlen, P., van Esse, H. P., Siezen, R. J., & Thomma, B. P. H. J. (2007) · Trends in Plant Science · doi:10.1016/j.tplants.2007.11.003 · Cited by 28 · see citing works
Ullah, M., Stich, S., Häupl, T., Eucker, J., Sittinger, M., & Ringe, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069754 · Cited by 26 · see citing works
Spasić, ., Simeonidis, E., Messiha, H. L., Paton, N. W., & Kell, D. B. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp175 · Cited by 20 · see citing works
In silico pathway reconstruction: Iron-sulfur cluster biogenesis in Saccharomyces cerevisiae
Alves, R., & Albert Sorribas, B. (2007) · BMC Systems Biology · doi:10.1186/1752-0509-1-10 · Cited by 19 · see citing works
Hoffmann, R. (2007) · Current Protocols in Bioinformatics · doi:10.1002/0471250953.bi0116s20 · Cited by 19 · see citing works
Self-citationiHOPerator: user-scripting a personalized bioinformatics Web, starting with the iHOP website
Good, B. M., Kawas, E. A., Kuo, B. Y.-L., & Wilkinson, M. D. (2006) · BMC Bioinformatics · doi:10.1186/1471-2105-7-534 · Cited by 19 · see citing works
Cancer systems biology: exploring cancer-associated genes on cellular networksPreprint
Wang, E., Lenferink, A. E. G., & O'Connor‐McCourt, M. D. (2007) · arXiv (Cornell University) · doi:10.48550/arxiv.0712.3753 · Cited by 19 · see citing works
PathNER: a tool for systematic identification of biological pathway mentions in the literature
Wu, C., Schwartz, J., & Nenadić, G. (2013) · BMC Systems Biology · doi:10.1186/1752-0509-7-s3-s2 · Cited by 17 · see citing works
Bioinformatics and cancer research: building bridges for translational research
Goméz-López, G., & Valencia, A. (2008) · Clinical & Translational Oncology · doi:10.1007/s12094-008-0161-5 · Cited by 16 · see citing works
Self-citationMirzarezaee, M., Araabi, B. N., & Sadeghi, M. (2010) · BMC Systems Biology · doi:10.1186/1752-0509-4-172 · Cited by 16 · see citing works
BioPP: a tool for web-publication of biological networks
Viswanathan, G. A., Nudelman, G., Patil, S., & Sealfon, S. C. (2007) · BMC Bioinformatics · doi:10.1186/1471-2105-8-168 · Cited by 16 · see citing works
Alves, R., Vilaprinyó, E., & Albert Sorribas, B. (2008) · Current Bioinformatics · doi:10.2174/157489308784340694 · Cited by 15 · see citing works
Gene expression in women conceiving spontaneously over the age of 45 years
Gielchinsky, Y., Bogoch, Y., Rechavi, G., Jacob‐Hirsch, J., Amariglio, N., Shveiky, D., Michal Linial, B., & Laufer, N. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.06.058 · Cited by 15 · see citing works
Novel metrics for evaluating the functional coherence of protein groups via protein semantic network
Zheng, B., & Lu, X. (2007) · Genome biology · doi:10.1186/gb-2007-8-7-r153 · Cited by 15 · see citing works
Villoslada, P., & Oksenberg, J. R. (2006) · Future Neurology · doi:10.2217/14796708.1.2.159 · Cited by 14 · see citing works
Rojas, A. M., Santamaría, A., Malik, R., Jensen, T. S., Körner, R., Morilla, I., Juan, D., Krallinger, M., Hansen, D. A., Hoffmann, R., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031813 · Cited by 13 · see citing works
Self-citationFunctional Genomics, Proteomics, Metabolomics and Bioinformatics for Systems Biology
Ballereau, S. J., Glaab, E., Kolodkin, A. N., Chaiboonchoe, A., Biryukov, M., Vlassis, N. A., Ahmed, H., Pellet, J., Baliga, N. S., Hood, L., et al. (2013) · Springer eBooks · doi:10.1007/978-94-007-6803-1_1 · Cited by 10 · see citing works
Harmston, N., Filsell, W., & Stumpf, M. P. H. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr640 · Cited by 9 · see citing works
Mixture of logistic models and an ensemble approach for protein-protein interaction extraction
Bell, L., Zhang, J., & Niu, X. (2011) · ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics (ACM-BCB) · doi:10.1145/2147805.2147853 · Cited by 7 · see citing works
Stochastic simulation and modelling of metabolic networks in a machine learning framework
Biba, M., Xhafa, F., Esposito, F., & Ferilli, S. (2011) · Simulation Modelling Practice and Theory · doi:10.1016/j.simpat.2011.05.002 · Cited by 6 · see citing works
High-Throughput Analyses and Curation of Protein Interactions in Yeast
Wodak, S. J., Vlasblom, J., & Pu, S. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-173-4_22 · Cited by 6 · see citing works
BioKB - Text Mining and Semantic Technologies for Biomedical Content Discovery
Biryukov, M., Grouès, V., Satagopam, V., & Schneider, R. (2018) · Figshare · doi:10.6084/m9.figshare.6994121 · Cited by 6 · see citing works
Integration of Biological Data with Semantic Networks
Hsing, M., & Cherkasov, A. R. (2006) · Current Bioinformatics · doi:10.2174/157489306777827946 · Cited by 6 · see citing works
Krallinger, M., Leitner, F., Vázquez, M., & Valencia, A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-444-53632-7.01107-2 · Cited by 5 · see citing works
Self-citationA guide for building biological pathways along with two case studies: hair and breast development
Trindade, D. R., Orsine, L. A., Barbosa-Silva, A., Donnard, E. R., & Ortega, J. M. (2014) · Methods · doi:10.1016/j.ymeth.2014.10.006 · Cited by 5 · see citing works
Defrosting the Digital Library
Hull, D., Pettifer, S. R., & Kell, D. B. (2011) · Apple Academic Press eBooks · doi:10.1201/b14542-2 · Cited by 4 · see citing works
Mining Host-Pathogen Interactions
Korkin, D., Thieu, T., Joshi, S., & Warre, S. (2011) · InTech eBooks · doi:10.5772/22016 · Cited by 4 · see citing works
Zhao, M., Chen, Y., Qu, D., & Qu, H. (2015) · BioMed Research International · doi:10.1155/2015/254838 · Cited by 4 · see citing works
Identification, modeling and simulation of key pathways underlying certain cancers
Guo, H., Zhu, Y., Li, D., & He, F. (2011) · Hereditas (Beijing) · doi:10.3724/sp.j.1005.2011.00809 · Cited by 4 · see citing works
Knowledge Acquisition from the Biomedical Literature
Hirschman, L., Hayes, W. S., & Valencia, A. (2007) · Springer eBooks · doi:10.1007/978-0-387-48438-9_4 · Cited by 3 · see citing works
Self-citationMethods in biomedical text mining
Rzhetsky, A., & Rodriguez‐Esteban, R. (2007) · Cited by 3 · see citing works
Collection of Disease Networks by Hybrid Curation Method and the Application for Pathway Analysis
Kushida, T., Asanuma, T., Okuda, Y., Shidahara, Y., & Takagi, T. (2009) · ... International Conference on Complex, Intelligent and Software Intensive Systems · doi:10.1109/cisis.2009.79 · Cited by 3 · see citing works
Hahn, U., & Valencia, A. (2006) · Bioinformatics · doi:10.1093/bioinformatics/btl084 · Cited by 3 · see citing works
Self-citationInsights into Global Mechanisms and Disease by Gene Expression Profiling
Sánchez‐Cabo, F., Rainer, J., Dopazo, A., Trajanoski, Z., & Hackl, H. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-027-0_13 · Cited by 2 · see citing works
Impact of Hydration on the α-Helical Structure of S-Peptide in RNase-S
Chathoth, N. E., Elangovan, R., & Anjukandi, P. (2025) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.5c00938 · Cited by 1 · see citing works
Biological Knowledge Extraction
Leitner, F., Hoffmann, R., & Valencia, A. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-440-7_22 · Cited by 1 · see citing works
Self-citationUsing Machine Learning Techniques for Modelling and Simulation of Metabolic Networks
Biba, M., Xhafa, F., Esposito, F., & Ferilli, S. (2011) · ... International Conference on Complex, Intelligent and Software Intensive Systems · doi:10.1109/cisis.2011.22 · Cited by 1 · see citing works
Knowledge-Driven, Data-Assisted Integrative Pathway Analytics
Reddy, P. S., Murray, S., & Liu, W. (2013) · IGI Global eBooks · doi:10.4018/978-1-4666-3604-0.ch009 · Cited by 1 · see citing works
Mining Information on Protein Function from Text
Krallinger, M., & Valencia, A. (2007) · doi:10.1002/9783527619368.ch34 · Cited by 1 · see citing works
Self-citationFine-Grained Protein Mutation Extraction from Biological Literature
Wang, R., Siu, S. W. I., & Böckmann, R. A. (2009) · International Conference on Electronics Computer Technology · doi:10.1109/icect.2009.10 · Cited by 1 · see citing works
Ling, M. H. (2009) · Minerva Access (University of Melbourne) · Cited by 1 · see citing works
Czarnecki, J. (2015) · Birkbeck Institutional Research Online (BiRO) - Theses · doi:10.18743/pub.00040135
Detecting Dysregulated Processes and Pathways
Stöckel, D., & Lenhof, H. (2014) · Wiley eBooks · doi:10.1002/9783527672165.ch14
Mining Time-series Sequences of Reactions for Biologically Active Patterns in Metabolic Pathways.
Biba, M., Esposito, F., Ferilli, S., Mauro, N. D., & Basile, T. M. A. (2007)
Biological Network Modeling and Analysis
Janowski, S., Kaltschmidt, B., & Kaltschmidt, C. (2014) · Approaches in Integrative Bioinformatics · doi:10.1007/978-3-642-41281-3_8 · Cited by 1 · see citing works
Connecting Text Mining and Pathways using the PathText Resource
Sætre, R., Kemper, B., Oda, K., Okazaki, N., Matsuoka, Y., Kikuchi, N., Kitano, H., Tsuruoka, Y., Ananiadou, S., & Tsujii, J. (2008) · Language Resources and Evaluation Conference (LREC) · doi:10.63317/2ni9suv85xzx
HETEROGENEOUS MOLECULAR NETWORKS
Schächter, V. (2007) · Complex systems and interdisciplinary science · doi:10.1142/9789812772367_0007
Knowledge-Driven, Data-Assisted Integrative Pathway Analytics
Reddy, P. S., Murray, S., & Liu, W. (2011) · IGI Global eBooks · doi:10.4018/978-1-60960-491-2.ch010
Pellegrini, S., Melissari, E., & RUSSO, M. D. (2013) · ARCHIVES ITALIENNES DE BIOLOGIE · doi:10.12871/00039829201324
Cladosporium fulvum effector proteins and their role in pathogen virulence
van Esse, H. P. (2008) · doi:10.18174/122004
FAIRsharing record for: Biological Pathway eXchange
FAIRsharing Team (2015) · FAIRsharing.org · doi:10.25504/fairsharing.sfkmej
- Authors
- Hoffmann, R., Krallinger, M., Andres, E., Tamames, J., Blaschke, C., & Valencia, A.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Protein Design Group, National Center for Biotechnology, CNB-CSIC, Darwin 3, Cantoblanco, 28049 Madrid, Spain.
- BioAlmai, Tres Cantos, Madrid, Spain.
- Venue
- Science's STKE
- Published
- 2005-05-10
- Volume
- 2005
- Issue
- 283
- Pages
- pe21-pe21
- ISSN
- 1525-8882 (ISSN-L)
- OpenAlex
- W2126469373
- Cited by
- 88
- References
- 26
- Citations by year
- 2025: 2 · 2023: 1 · 2018: 2 · 2017: 3 · 2015: 2 · 2014: 4 · 2013: 7 · 2012: 5
- FWCI
- 4.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science s STKE (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (acceptedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biomedical Text Mining and Ontologies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Keywords
- text mining, metabolic pathways, signaling pathways, protein-protein interaction network, entity recognition, IHOP
- MeSH terms
- Animals, Dictionaries as Topic, Enzymes, Genes, Humans, Metabolism, Terminology as Topic, Proteins, Signal Transduction, Databases, Factual, Information Storage and Retrieval, Information Management, Knowledge Bases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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