The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Filopodia: The Fingers That Do the Walking
Abstract
Filopodia are actin-based structures composed of parallel bundles of actin filaments and various actin-associated proteins, and they play important roles in cell-cell signaling, guidance toward chemoattractants, and adhesion to the extracellular matrix. Two mechanisms for the formation of filopodia have been suggested, each using different sets of actin-regulating proteins, creating some controversy in the field. New molecules, some of unknown functions, have also been implicated in filopodium formation, suggesting that other possible mechanisms of filopodium formation exist. We discuss established and novel proteins that mediate the formation and dynamics of filopodia, different mechanisms of filopodium formation, and the various functions that distinct filopodia perform.
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Cites
The establishment of polarity by hippocampal neurons in culture.
Dotti, C., Sullivan, C., & Banker, G. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-04-01454.1988 · Cited by 1,862
Wound healing recapitulates morphogenesis in Drosophila embryos
Wood, W., Jacinto, A., Grose, R., Woolner, S., Gale, J., Wilson, C., & Martin, P. (2002) · Nature Cell Biology · doi:10.1038/ncb875 · Cited by 435
Organization of Actin Networks in Intact Filopodia
Medalia, O., Beck, M., Ecke, M., Weber, I., Neujahr, R., Baumeister, W., & Gerisch, G. (2007) · Current Biology · doi:10.1016/j.cub.2006.11.022 · Cited by 170
Cited by
Mammalian Rho GTPases: new insights into their functions from in vivo studies
Heasman, S. J., & Ridley, A. J. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2476 · Cited by 1,871
Hotulainen, P., Llano, O., Smirnov, S., Tanhuanpää, K., Faix, J., Rivera, C., & Lappalainen, P. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200809046 · Cited by 360
Shulman, Z., Shinder, V., Klein, E., Grabovsky, V., Yeger, O., Geron, E., Montresor, A., Bolomini-Vittori, M., Feigelson, S. W., Kirchhausen, T., et al. (2009) · Immunity · doi:10.1016/j.immuni.2008.12.020 · Cited by 268
IRSp53: crossing the road of membrane and actin dynamics in the formation of membrane protrusions
Scita, G., Confalonieri, S., Lappalainen, P., & Suetsugu, S. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2007.12.002 · Cited by 256
Molecular basis for SH3 domain regulation of F-BAR–mediated membrane deformation
Rao, Y., Ma, Q., Vahedi-Faridi, A., Sundborger, A., Pechstein, A., Puchkov, D., Luo, L., Shupliakov, O., Saenger, W., & Haucke, V. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003478107 · Cited by 149
Metadata
- Authors
- Gupton, S. L., & Gertler, F. B.
- Venue
- Science's STKE
- Published
- 2007-08-21
- Volume
- 2007
- Issue
- 400
- Pages
- re5-re5
- ISSN
- 1525-8882 (ISSN-L)
- OpenAlex
- W2101361069
- Cited by
- 254
- References
- 3
- FWCI
- 8.68
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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