The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Cross-Resistance between Clofazimine and Bedaquiline through Upregulation of MmpL5 in Mycobacterium tuberculosis
Open accessAbstract
The antileprosy drug clofazimine is also of interest for the treatment of multidrug-resistant tuberculosis. To understand possible resistance mechanisms, clofazimine-resistant Mycobacterium tuberculosis mutants were isolated in vitro , and, unexpectedly, found to be cross-resistant to bedaquiline. Mutations in the transcriptional regulator Rv0678, with concomitant upregulation of the multisubstrate efflux pump, MmpL5, accounted for this cross-resistance. Mutation in Rv0678 should therefore be considered a confounding factor for the treatment of tuberculosis with clofazimine or bedaquiline.
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Citations
Cites
A Diarylquinoline Drug Active on the ATP Synthase of Mycobacterium tuberculosis
Andries, K., Verhasselt, P., Guillemont, J., Göhlmann, H. W. H., Neefs, J.-M., Winkler, H., Van Gestel, J., Timmerman, P., Zhu, M., Lee, E., et al. (2005) · Science · doi:10.1126/science.1106753 · Cited by 2,191 · cited 1×
“In previous work with bedaquiline-resistant H37Rv mutants isolated in vitro, it was found that 15 out of 53 resistant mutants carried mutations in atpE, the gene that encodes the target subunit of bedaquiline in ATP synthase (15, 16).”
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Short, Highly Effective, and Inexpensive Standardized Treatment of Multidrug-resistant Tuberculosis
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Towards a new combination therapy for tuberculosis with next generation benzothiazinones
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Reduction of Clofazimine by Mycobacterial Type 2 NADH:Quinone Oxidoreductase
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Self-citationDiscovery of a Siderophore Export System Essential for Virulence of Mycobacterium tuberculosis
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Cited by
Tiberi, S., du Plessis, N., Walzl, G., Vjecha, M. J., Rao, M., Ntoumi, F., Mfinanga, S., Kapata, N., Mwaba, P., McHugh, T. D., et al. (2018) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(18)30110-5 · Cited by 396
Dookie, N., Rambaran, S., Padayatchi, N., Mahomed, S., & Naidoo, K. (2018) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkx506 · Cited by 346
Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target
Zhang, B., Li, J., Yang, X., Wu, L., Zhang, J., Yang, Y., Zhao, Y., Zhang, L., Yang, X., Yang, X., et al. (2019) · Cell · doi:10.1016/j.cell.2019.01.003 · Cited by 263
Metadata
- Authors
- Hartkoorn, R. C., Uplekar, S., & Cole, S. T.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2014-05
- Volume
- 58
- Issue
- 5
- Pages
- 2979-2981
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2146344189
- Cited by
- 489
- References
- 16
- FWCI
- 24.45
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hartkoorn, R. C., Uplekar, S., & Cole, S. T. (2014). Cross-Resistance between Clofazimine and Bedaquiline through Upregulation of MmpL5 in Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.00037-14
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
